Naoki Aikawa

Summary

Country: Japan

Publications

  1. doi Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coagulation: subanalysis from the phase 3 trial
    Naoki Aikawa
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan
    Shock 35:349-54. 2011
  2. doi Clinical effects of micafungin, a novel echinocandin antifungal agent, on systemic fungal infections in surgery, emergency, and intensive-care medicine: evaluation using the AKOTT algorithm
    Naoki Aikawa
    Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Infect Chemother 15:219-27. 2009
  3. doi A Phase II study of polyclonal anti-TNF-α (AZD9773) in Japanese patients with severe sepsis and/or septic shock
    Naoki Aikawa
    Keio University School of Medicine, 2 5 10 Minato Chuo ku, Tokyo, 104 0043, Japan
    J Infect Chemother 19:931-40. 2013
  4. doi Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study
    Naoki Aikawa
    Department of Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    Pulm Pharmacol Ther 24:549-54. 2011
  5. ncbi [Influence of the diagnosis and treatment guidelines for mycosis profunda (deep mycosis) in the field of emergency and critical care medicine--the influences of conformity and non-conformity to the guidelines on the outcomes of patients]
    Shigeto Oda
    Department of Emergency and Critical Care Medicine, Chiba University School of Medicine, Japan
    Jpn J Antibiot 61:29-41. 2008
  6. ncbi Application of the recent American practice resources for risk stratification system for patients presenting to a Japanese emergency department because of syncope
    Masaru Suzuki
    Department of Emergency Medicine, Keio University, Tokyo, Japan
    Int Heart J 48:513-22. 2007
  7. ncbi [Efficacy of micafungin sodium on fungal infection in critical care]
    Yoshihisa Tateishi
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Japan
    Nihon Ishinkin Gakkai Zasshi 47:293-7. 2006
  8. ncbi Current status of diagnosis and treatment of invasive fungal infections in Japan: the influence of the new Japanese guidelines
    Naoki Aikawa
    Keio University Hospital, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Infect Chemother 11:278-87. 2005
  9. ncbi Long-term survival of Japanese patients transported to an emergency department because of syncope
    Masaru Suzuki
    Department of Emergency Medicine, School of Medicine, Keio University, Tokyo, Japan
    Ann Emerg Med 44:215-21. 2004
  10. ncbi Thrombolysis candidates for the treatment of stroke at an emergency department in Japan
    Keiji Yamaguchi
    Department of Emergency Medicine, School of Medicine, Keio University, Tokyo, Japan
    Acad Emerg Med 9:754-8. 2002

Collaborators

Detail Information

Publications15

  1. doi Thrombomodulin alfa in the treatment of infectious patients complicated by disseminated intravascular coagulation: subanalysis from the phase 3 trial
    Naoki Aikawa
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan
    Shock 35:349-54. 2011
    ..Mortality rates of patients who recovered from DIC were 3.7% (1/27) in the TM-α group and 15% (3/20) in the heparin group. These results suggest TM-α may be valuable in the treatment of DIC associated with infection...
  2. doi Clinical effects of micafungin, a novel echinocandin antifungal agent, on systemic fungal infections in surgery, emergency, and intensive-care medicine: evaluation using the AKOTT algorithm
    Naoki Aikawa
    Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Infect Chemother 15:219-27. 2009
    ....
  3. doi A Phase II study of polyclonal anti-TNF-α (AZD9773) in Japanese patients with severe sepsis and/or septic shock
    Naoki Aikawa
    Keio University School of Medicine, 2 5 10 Minato Chuo ku, Tokyo, 104 0043, Japan
    J Infect Chemother 19:931-40. 2013
    ..A similar pattern of response was observed with interleukin-6 (IL-6) and IL-8. AZD9773 was generally well tolerated with dose-proportional pharmacokinetics in Japanese patients with severe sepsis/septic shock...
  4. doi Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study
    Naoki Aikawa
    Department of Emergency and Critical Care Medicine, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    Pulm Pharmacol Ther 24:549-54. 2011
    ..The Pharmaceuticals and Medical Devices Agency (PMDA) has ordered to conduct a postmarket clinical study in order to reevaluate the efficacy and safety of Sivelestat in actual clinical settings in Japan...
  5. ncbi [Influence of the diagnosis and treatment guidelines for mycosis profunda (deep mycosis) in the field of emergency and critical care medicine--the influences of conformity and non-conformity to the guidelines on the outcomes of patients]
    Shigeto Oda
    Department of Emergency and Critical Care Medicine, Chiba University School of Medicine, Japan
    Jpn J Antibiot 61:29-41. 2008
    ....
  6. ncbi Application of the recent American practice resources for risk stratification system for patients presenting to a Japanese emergency department because of syncope
    Masaru Suzuki
    Department of Emergency Medicine, Keio University, Tokyo, Japan
    Int Heart J 48:513-22. 2007
    ..The objective of the present study was to determine if risk stratification using these practice resources is valid in a series of Japanese patients...
  7. ncbi [Efficacy of micafungin sodium on fungal infection in critical care]
    Yoshihisa Tateishi
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Japan
    Nihon Ishinkin Gakkai Zasshi 47:293-7. 2006
    ..The drug was well tolerated and discontinuation of its treatment due to adverse events was not experienced during the study period...
  8. ncbi Current status of diagnosis and treatment of invasive fungal infections in Japan: the influence of the new Japanese guidelines
    Naoki Aikawa
    Keio University Hospital, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Infect Chemother 11:278-87. 2005
    ..Definitive diagnoses of invasive fungal infection are too scarce at the national level. The cooperation of clinicians for organizing more definitive diagnoses would be appreciated when the guidelines are revised...
  9. ncbi Long-term survival of Japanese patients transported to an emergency department because of syncope
    Masaru Suzuki
    Department of Emergency Medicine, School of Medicine, Keio University, Tokyo, Japan
    Ann Emerg Med 44:215-21. 2004
    ..The aim of this study is to clarify the long-term mortality of patients with syncope who are brought to an emergency department (ED) in Japan...
  10. ncbi Thrombolysis candidates for the treatment of stroke at an emergency department in Japan
    Keiji Yamaguchi
    Department of Emergency Medicine, School of Medicine, Keio University, Tokyo, Japan
    Acad Emerg Med 9:754-8. 2002
    ..To study the proportion and characteristics of potential candidates for the intravenous administration of tissue plasminogen activator (IV-tPA) among patients with cerebral infarction in a Japanese emergency department (ED)...
  11. ncbi Characteristics of elderly patients presenting to the emergency department with injury
    William Ng
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Keio J Med 51:11-6. 2002
    ..As such, injuries in the elderly are a common reason for presentation to the ED. Knowledge about the characteristics of injuries presenting to the ED would be invaluable in devising strategies to prevent injury in the elderly...
  12. pmc Population pharmacokinetics of Arbekacin in patients infected with methicillin-resistant Staphylococcus aureus
    Yusuke Tanigawara
    Department of Hospital Pharmacy, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Antimicrob Agents Chemother 50:3754-62. 2006
    ..3 liters in patients with sepsis. The population pharmacokinetic parameters of arbekacin obtained here are useful for optimal use of this aminoglycoside in the treatment of MRSA-infected patients...
  13. ncbi [Influence of the diagnosis and treatment guidelines for mycosis profunda (deep mycosis) in the field of emergency and critical care medicine--with reference to patient background]
    Hideki Ishikawa
    Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Japan
    Jpn J Antibiot 61:18-28. 2008
    ....
  14. ncbi Multicenter prospective study of procalcitonin as an indicator of sepsis
    Naoki Aikawa
    Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Keio University Hospital, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Infect Chemother 11:152-9. 2005
    ..2%, while that of blood culture was 42.6%. PCT is thus essential for discriminating bacterial infection from SIRS, and is superior in this respect to conventional serum markers and blood culture...
  15. ncbi [Compulsory postgraduate clinical training and surgical education]
    Naoki Aikawa
    Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 104:280-4. 2003
    ..In accordance with the introduction of new system, the current surgical training system is to be renovated and the terms for surgical trainees to be eligible for surgical specialty boards must be reviewed...