Yasushi Yatabe

Summary

Affiliation: Aichi Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Epidermal growth factor receptor mutations in lung cancers
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan
    Pathol Int 57:233-44. 2007
  2. ncbi request reprint [Recent changes in the therapeutic strategy for NSCLC in association with new anti-cancer agents]
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostic, Aichi Cancer Center Hospital, Nagoya 464 8681, Japan
    Rinsho Byori 61:328-33. 2013
  3. ncbi request reprint [Molecular diagnosis of lung cancer in association with treatment of choice]
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya 464 8681, Japan
    Rinsho Byori 60:786-95. 2012
  4. ncbi request reprint EGFR mutation is specific for terminal respiratory unit type adenocarcinoma
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Surg Pathol 29:633-9. 2005
  5. ncbi request reprint CK20 expression, CDX2 expression, K-ras mutation, and goblet cell morphology in a subset of lung adenocarcinomas
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    J Pathol 203:645-52. 2004
  6. doi request reprint Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya 464 8681, Japan
    Cancer Res 68:2106-11. 2008
  7. ncbi request reprint Maspin expression in normal lung and non-small-cell lung cancers: cellular property-associated expression under the control of promoter DNA methylation
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Oncogene 23:4041-9. 2004
  8. doi request reprint Heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Clin Oncol 29:2972-7. 2011
  9. pmc A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Kanokoden, Nagoya 464 8681, Japan
    J Mol Diagn 8:335-41. 2006
  10. pmc Do all lung adenocarcinomas follow a stepwise progression?
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Lung Cancer 74:7-11. 2011

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Epidermal growth factor receptor mutations in lung cancers
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan
    Pathol Int 57:233-44. 2007
    ..In the present study the current knowledge of EGFR mutations is reviewed, insights from which raise many further questions, and thus suggest new directions for future research...
  2. ncbi request reprint [Recent changes in the therapeutic strategy for NSCLC in association with new anti-cancer agents]
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostic, Aichi Cancer Center Hospital, Nagoya 464 8681, Japan
    Rinsho Byori 61:328-33. 2013
    ..In this article, transition of the therapeutic strategy for NSCLC, characteristics of targeted gene alterations and efficacies of the targeted therapy are reviewed...
  3. ncbi request reprint [Molecular diagnosis of lung cancer in association with treatment of choice]
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya 464 8681, Japan
    Rinsho Byori 60:786-95. 2012
    ..More recently, similar marked responses to an ALK inhibitor in patients with ALK fusion lung cancers were demonstrated. In this article, we review such recent advances in lung cancer, focusing on EGFR mutation and ALK fusion....
  4. ncbi request reprint EGFR mutation is specific for terminal respiratory unit type adenocarcinoma
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Surg Pathol 29:633-9. 2005
    ..These findings further confirm that TRU-type-adenocarcinoma is a distinct adenocarcinoma subset in which a particular molecular pathway is involved...
  5. ncbi request reprint CK20 expression, CDX2 expression, K-ras mutation, and goblet cell morphology in a subset of lung adenocarcinomas
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    J Pathol 203:645-52. 2004
    ..However, some lung adenocarcinomas may express CDX2 strongly: in this case, CK20 also tends to be positive...
  6. doi request reprint Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya 464 8681, Japan
    Cancer Res 68:2106-11. 2008
    ..Taken together, our results show that mutation occurs early in the development of lung adenocarcinoma, and that amplification may be acquired in association with tumor progression...
  7. ncbi request reprint Maspin expression in normal lung and non-small-cell lung cancers: cellular property-associated expression under the control of promoter DNA methylation
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Oncogene 23:4041-9. 2004
    ..Separate analysis of methylation status in positive and negative portions of individual tumors provided an instance of intratumor diversity associated with promoter DNA methylation...
  8. doi request reprint Heterogeneous distribution of EGFR mutations is extremely rare in lung adenocarcinoma
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Clin Oncol 29:2972-7. 2011
    ..Some studies have shown that epidermal growth factor receptor (EGFR) mutations can be heterogeneously distributed in individual tumors. In this study, we re-evaluated the distribution of EGFR mutations within tumors...
  9. pmc A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Kanokoden, Nagoya 464 8681, Japan
    J Mol Diagn 8:335-41. 2006
    ..In conclusion, the assay is a rapid, sensitive method using paraffin sections of biopsy specimens without a tumor cell-enrichment procedure and is quite useful to select a treatment of choice in clinical practice...
  10. pmc Do all lung adenocarcinomas follow a stepwise progression?
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Lung Cancer 74:7-11. 2011
    ..In this review, we hypothesize a novel scenario for the progression of lung adenocarcinoma, which does not support a linear progression schema...
  11. doi request reprint EGFR mutations and the terminal respiratory unit
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Cancer Metastasis Rev 29:23-36. 2010
    ....
  12. ncbi request reprint Decreased expression of 14-3-3sigma in neuroendocrine tumors is independent of origin and malignant potential
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Oncogene 21:8310-9. 2002
    ....
  13. ncbi request reprint TTF-1 expression in pulmonary adenocarcinomas
    Yasushi Yatabe
    Department of Anatomic and Molecular Diagnostic Pathology, Aichi Cancer Center Hospital, Aichi Cancer Center Research Institute, Nagoya, Japan
    Am J Surg Pathol 26:767-73. 2002
    ..01), less frequent RB loss (p <0.05), and preserved expression of p27 (p <0.01). The results supported the TTF-1 lineage marker and suggested that molecular pathogenesis may in part be characterized by cellular lineage...
  14. doi request reprint Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
    Ryoichi Onozato
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    J Thorac Oncol 4:5-11. 2009
    ..The purpose of this study was to clarify in the role of MET activation in lung carcinogenesis...
  15. doi request reprint Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib
    Kenichi Suda
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    J Thorac Oncol 6:1152-61. 2011
    ..However, recent clinical studies revealed that gefitinib or erlotinib are highly effective in the treatment of non-small cell lung cancer with EGFR mutations...
  16. ncbi request reprint Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Clin Oncol 23:2513-20. 2005
    ..To evaluate the relationship between mutations of the epidermal growth factor receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent lung cancer after pulmonary resection...
  17. doi request reprint hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type
    Toshiki Okasaka
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Hum Genet 54:739-45. 2009
    ..These results indicate that rs1052133 contributes to the risk of adenocarcinoma of lung...
  18. doi request reprint Stepwise examination for differential diagnosis of primary lung cancer and breast cancer relapse presenting as a solitary pulmonary nodule in patients after mastectomy
    Toshiki Okasaka
    Division of Thoracic Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Surg Oncol 98:510-4. 2008
    ..Definitive diagnosis of these nodules, however, is often difficult. We assessed the feasibility of our diagnostic approach for these nodules and estimated the frequency of primary lung cancer occurrence in patients after mastectomy...
  19. doi request reprint The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Carcinogenesis 34:1510-5. 2013
    ..0054). In conclusion, ALDH2 and alcohol drinking showed interaction for risk factors of stomach cancer, indicating that acetaldehyde plays a role in stomach carcinogenesis. ..
  20. doi request reprint mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines
    Junichi Shimizu
    Department of Thoracic Oncology, Aichi Cancer Center Hospital, Aichi, Japan
    Respirology 13:510-7. 2008
    ..The aim of this study was to test whether similar associations would be seen between mRNA expression for the RRM1, ERCC1 and ERCC2 genes and in vitro chemosensitivity in lung cancer...
  21. doi request reprint Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 99:1202-8. 2008
    ..023). In conclusion, soy consumption may exert a protective association against the development of NSCLCs with EGFR mutations, providing possible insights into mechanisms of their genesis...
  22. doi request reprint Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer
    Hirotaka Osada
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Res 68:1647-55. 2008
    ....
  23. doi request reprint Subcategorization of lung cancer based on tumor size and degree of visceral pleural invasion
    Noriaki Sakakura
    Department of Thoracic Surgery, Division of Epidemiology and Prevention, Aichi Cancer Center Hospital, Nagoya, Japan
    Ann Thorac Surg 86:1084-90. 2008
    ..Lung cancer staging system proposed in 2007 adopts detailed tumor size cut-off values. Alternatively, visceral pleural invasion is deemed an important prognosticator, but has not been easily incorporated into the staging system...
  24. doi request reprint Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma
    Takayuki Kosaka
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    J Thorac Oncol 4:22-9. 2009
    ..We examined for EGFR, KRAS or TP53 mutations in a consecutive large cohort of patients with lung adenocarcinoma, and evaluated their prognostic impact...
  25. ncbi request reprint Effects of genetic polymorphisms in the ABCB1 gene on clinical outcomes in patients with gastric cancer treated by second-line chemotherapy
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, Japan
    Asian Pac J Cancer Prev 11:447-52. 2010
    ..The purpose of this analysis was to evaluate the impact of genetic polymorphisms of the ABCB1 gene on clinical outcomes in patients with advanced gastric cancer (AGC) treated with second-line chemotherapy...
  26. doi request reprint YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation
    Toshihiko Yokoyama
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 29:2139-46. 2008
    ..Future studies of transcriptional targets of YAP1 in MPMs may shed light on the molecular mechanisms of MPM development and lead to new therapeutic strategies...
  27. ncbi request reprint Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1
    Hisaaki Tanaka
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 67:6007-11. 2007
    ....
  28. ncbi request reprint Docetaxel plus 5-fluorouracil and cisplatin (DCF) induction chemotherapy for locally advanced borderline-resectable T4 esophageal cancer
    Tomoya Yokota
    Department of Clinical Oncology, Aichi Cancer Center Hospital, Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Anticancer Res 31:3535-41. 2011
    ..This study aimed to evaluate the efficacy of docetaxel plus 5-fluorouracil and cisplatin (DCF) induction chemotherapy for locally advanced borderline-resectable T4 esophageal cancer...
  29. doi request reprint Clinical outcomes of advanced non-small cell lung cancer patients screened for epidermal growth factor receptor gene mutations
    Kimihide Yoshida
    Department of Thoracic Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Cancer Res Clin Oncol 136:527-35. 2010
    ..To evaluate the relationship between the epidermal growth factor receptor (EGFR) mutation status and the effectiveness of gefitinib monotherapy or chemotherapy in patients with advanced non-small cell lung cancer (NSCLC)...
  30. pmc Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 22:477-83. 2012
    ..We assessed the impact of genetic polymorphisms in the base excision repair (BER) pathway on PC risk among Japanese...
  31. doi request reprint Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Hospital, Nagoya University Graduate School of Medicene, Nagoya, Japan
    Eur J Cancer Prev 21:193-8. 2012
    ..Interaction between folate consumption, drinking, and ALDH2 genotype was remarkable (three-way interaction, P<0.001). We observed significant interaction among folate, drinking, and ALDH2 genotype in the Japanese population...
  32. doi request reprint Diagnostic approach to pancreatic tumors with the specimens of endoscopic ultrasound-guided fine needle aspiration
    Waki Hosoda
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Pathol Int 60:358-64. 2010
    ..The usefulness of these markers was confirmed using 13 additional pancreatic tumors, prospectively. Although minimal in selection, these markers are helpful in making diagnosis from EUS-FNA specimens of the major pancreatic tumors...
  33. ncbi request reprint Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    Takayuki Kosaka
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Clin Cancer Res 12:5764-9. 2006
    ..Part of this "acquired resistance" is attributable to a secondary mutation resulting in threonine to methionine at codon 790 (T790M) of EGFR...
  34. doi request reprint Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population
    Ji Young Park
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8618, Japan
    Carcinogenesis 31:660-5. 2010
    ..036) and was consistently observed in the analysis among never-drinkers (interaction P = 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer...
  35. ncbi request reprint Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers
    Hirotaka Osada
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Oncogene 21:2418-24. 2002
    ....
  36. ncbi request reprint Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer
    Kimihide Yoshida
    Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
    J Thorac Oncol 2:22-8. 2007
    ..We evaluated the efficacy of gefitinib monotherapy prospectively in patients with advanced or pretreated non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations...
  37. doi request reprint Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways
    Kiyoshi Yanagisawa
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 70:9949-58. 2010
    ....
  38. doi request reprint Cycleave polymerase chain reaction method is practically applicable for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)/V-raf murine sarcoma viral oncogene homolog B1 (BRAF) genotyping in colorectal cancer
    Tomoya Yokota
    Department of Clinical Oncology, Aichi Cancer Center Hospital, Kanokoden, Chikusa ku, Nagoya, Japan
    Transl Res 156:98-105. 2010
    ..In conclusion, cycleave PCR is practically applicable to KRAS/BRAF genotyping using small amounts of biopsied tumor cells. Care must be taken in the selection of pathological specimens for KRAS/BRAF testing...
  39. ncbi request reprint Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 28:1718-25. 2007
    ..Further evaluation is warranted...
  40. ncbi request reprint HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women
    Satoyo Hosono
    Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Epidemiol 20:295-301. 2010
    ..We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women...
  41. ncbi request reprint Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction
    Hideki Endoh
    Department of Thoracic Surgery, Aichi Cancer Center, Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Clin Oncol 22:811-9. 2004
    ....
  42. doi request reprint miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer
    Eri Nishikawa
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 71:6165-73. 2011
    ..Our results elucidate an ASH1 effector axis in NE-lung cancers that is functionally pivotal in controlling NE features and the alleviation from YAP1-mediated growth inhibition...
  43. doi request reprint Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib
    Tatsuya Katayama
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    J Thorac Oncol 4:1415-9. 2009
    ..We speculate that erlotinib, instead of high dose of gefitinib, may be also effective for the treatment of central nervous system (CNS) lesions, as trough serum concentration of erlotinib is nine times higher than that of gefitinib...
  44. doi request reprint Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 101:1875-80. 2010
    ..Facial flushing was less useful to predict UAT cancer risk than genotyping ALDH2 polymorphism...
  45. doi request reprint Prognosis of patients with advanced gastric cancer by HER2 status and trastuzumab treatment
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
    Gastric Cancer 16:261-7. 2013
    ..The purpose of this study was to evaluate the impact of human epidermal growth factor receptor 2 (HER2) status and trastuzumab treatment on the prognosis of patients with advanced gastric cancer (AGC)...
  46. doi request reprint HNF4α as a marker for invasive mucinous adenocarcinoma of the lung
    Masato Sugano
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Surg Pathol 37:211-8. 2013
    ....
  47. doi request reprint Association between a genome-wide association study-identified locus and the risk of lung cancer in Japanese population
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Thorac Oncol 7:790-8. 2012
    ..To examine the impact of 15p25 and 5p15 on lung cancer risk and smoking intensity, we conducted a case-control study in Japanese population. We also examined whether these loci modify the effect of smoking behavior on lung cancer risk...
  48. doi request reprint A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population
    Aiko Sueta
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Breast Cancer Res Treat 132:711-21. 2012
    ..Risk models which include a genetic risk score are possibly useful in distinguishing women at high risk of breast cancer from those at low risk, particularly in the context of targeted prevention...
  49. doi request reprint Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers
    Kenji Tomizawa
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Lung Cancer 74:139-44. 2011
    ..However its prognostic and predictive implications are not yet established...
  50. ncbi request reprint LKB1 gene mutations in Japanese lung cancer patients
    Ryoichi Onozato
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Cancer Sci 98:1747-51. 2007
    ..LKB1 gene mutations appear to be frequent in male, smoking patients of Caucasian origin, in contrast to EGFR or HER2 mutations that are frequent in non-smoking, female patients of Asian origin...
  51. doi request reprint Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas
    Yasushi Matsuyama
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Carcinog 50:301-9. 2011
    ....
  52. doi request reprint Effect of gefitinib on the survival of patients with recurrence of lung adenocarcinoma after surgery: a retrospective case-matching cohort study
    Tatsuya Katayama
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Nagoya, Japan
    Surg Oncol 19:e144-9. 2010
    ....
  53. doi request reprint Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells
    Koji Kawaguchi
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Carcinogenesis 30:1097-105. 2009
    ....
  54. ncbi request reprint PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients
    Hideki Endoh
    Department of Thoracic Surgery, Aichi Cancer Center Central Hospital, Nagoya, Japan
    J Thorac Oncol 1:629-34. 2006
    ..In this study, we searched for mutations or changes in the expression of genes downstream to EGFR and evaluated their relationship with the effectiveness of gefitinib...
  55. doi request reprint Clinical impact of K-ras mutation analysis in EUS-guided FNA specimens from pancreatic masses
    Takeshi Ogura
    Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
    Gastrointest Endosc 75:769-74. 2012
    ..EUS-guided FNA (EUS-FNA) is considered optimal for differentially diagnosing pancreatic masses. However, the sensitivity of EUS-FNA ranges from 65% to 95%, respectively, which requires improvement...
  56. doi request reprint ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 20:1665-72. 2011
    ....
  57. pmc Association between an 8q24 locus and the risk of colorectal cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    BMC Cancer 9:379. 2009
    ..Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited...
  58. pmc Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data
    Takaomi Koga
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Mol Diagn 6:90-5. 2004
    ..This suggests that MGB1 can serve as a differential molecular marker. In practice, prospective examination, using the nine cases with a history of breast cancer, confirmed the usefulness of MGB1 in differential diagnosis...
  59. doi request reprint Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses
    Hiromichi Ebi
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 69:4027-35. 2009
    ..Our results clearly show the existence of gene set-definable, intrinsic heterogeneities in lung adenocarcinomas, which seem to be related to both clinical behavior and sensitivity to agents affecting the identified pathways...
  60. ncbi request reprint Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications
    Takayuki Kosaka
    Departments of Thoracic Surgery and Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Cancer Res 64:8919-23. 2004
    ..EGFR mutations define a distinct subset of pulmonary adenocarcinoma without KRAS mutations, which is not caused by tobacco carcinogens...
  61. ncbi request reprint Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients
    Hirotaka Osada
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 112:26-32. 2004
    ..Results of clustering analyses imply that class II HDAC genes may be regulated by a similar mechanism and deregulated during cancer development...
  62. ncbi request reprint Gene expression-based, individualized outcome prediction for surgically treated lung cancer patients
    Shuta Tomida
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Oncogene 23:5360-70. 2004
    ..Overall, these findings should advance not only our understanding of the biology of lung cancer but also our ability to individualize postoperative therapies based on the predicted outcome...
  63. doi request reprint Immunohistochemical detection of EGFR mutation using mutation-specific antibodies in lung cancer
    Atsuko Kitamura
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Cancer Res 16:3349-55. 2010
    ..We used immunohistochemistry to examine recently developed antibodies specific to major hotspot mutations of L858R and DEL E746-A750...
  64. doi request reprint Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer
    Kenichi Suda
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Nagoya, Japan
    Clin Cancer Res 16:5489-98. 2010
    ..In this study, we explored their relationship using in vitro models and autopsy specimens...
  65. doi request reprint Epidermal growth factor receptor mutations in small cell lung cancer
    Akiko Tatematsu
    Department of Pathology, Aichi Cancer Center Hospital, Kanokoden, Chukusa ku, Nagoya, Japan
    Clin Cancer Res 14:6092-6. 2008
    ..According to this adenocarcinoma-specific nature of EGFR mutation, analysis of EGFR mutations with small cell lung cancers (SCLC) may provide a clue to its histogenesis...
  66. doi request reprint Lapatinib plus trastuzumab for a patient with heavily pre-treated gastric cancer that progressed after trastuzumab
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Aichi, Japan
    Jpn J Clin Oncol 41:663-5. 2011
    ..In this case, trastuzumab plus lapatinib resulted in durable stable disease, despite the appearance of progression during prior chemotherapy with trastuzumab...
  67. doi request reprint Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer
    Qin Miao Huang
    Division of Molecular Carcinogenesis, Nagoya University Graduate School of Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Res 70:8407-16. 2010
    ..Together, our findings suggest that reduced expression of POLD4 plays a role in genomic instability in lung cancer...
  68. doi request reprint Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers
    Byonggu An
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    Int J Cancer 127:2095-105. 2010
    ....
  69. ncbi request reprint Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
    Junichi Takamizawa
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Res 64:3753-6. 2004
    ..This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration...
  70. ncbi request reprint Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis
    Shigeru B H Ko
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Invest 56:318-21. 2009
    ..Further study would be required to elucidate the precise molecular mechanism for the role of AQP1 in pancreatic fluid secretion from the pancreas in diseases characterized by the impaired ductal fluid secretion such as cystic fibrosis...
  71. doi request reprint Phase II study of combination chemotherapy with biweekly cetuximab and irinotecan for pre-treated metastatic colorectal cancer harboring wild-type KRAS
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
    Jpn J Clin Oncol 40:699-701. 2010
    ..The primary endpoint is response rate. The secondary endpoints include adverse events, progression-free survival and overall survival. The pharmacokinetics of cetuximab will also be evaluated in five patients...
  72. doi request reprint Current concept of endoscopic ultrasound-guided fine needle aspiration for pancreatic cancer
    Nobumasa Mizuno
    Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan nobumasa aichi cc jp
    Pancreatology 11:40-6. 2011
    ..This review highlights the diagnostic potential of EUS-FNA, as well as its current indications and contraindications, complications, and techniques...
  73. doi request reprint ABO blood group alleles and the risk of pancreatic cancer in a Japanese population
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 102:1076-80. 2011
    ..Further studies are necessary to define the mechanisms by which the ABO gene or closely linked genetic variants influence PC risk...
  74. ncbi request reprint RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication
    Hideki Endoh
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Int J Cancer 106:45-51. 2003
    ..0247). Epigenetic silencing of RASSF1A is a frequent event in non-small lung cancer and will provide novel opportunities to develop diagnosis and therapy of NSCLC...
  75. ncbi request reprint Clinical features and prognosis of gastric MALT lymphoma with special reference to responsiveness to H. pylori eradication and API2-MALT1 status
    Tsuneya Nakamura
    Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Gastroenterol 103:62-70. 2008
    ..We analyzed a consecutive series of gastric MALT lymphomas at our institution regarding treatment, clinical course, and prognosis, with special reference to responsiveness to H. pylori eradication and presence of API2-MALT1...
  76. ncbi request reprint The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status
    Takeshi Suzuki
    Department of Pulmonary Medicine, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Lung Cancer 42:35-41. 2003
    ..These findings warrant future study to clarify how ZD1839 inhibits lung cancer cell growth and to find a useful marker for prediction of sensitivity to this novel and promising agent for the treatment of lung cancers...
  77. doi request reprint Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    FEBS J 277:301-8. 2010
    ..The biological significance of such mutations and their relationship with other activated genes in lung cancers are also discussed...
  78. doi request reprint Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma
    Reiko Takayama
    Department of Gastroenterology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 0021, Japan
    J Gastroenterol 45:52-9. 2010
    ..Serum biomarkers for the early detection of pancreatic cancer are not currently available. We evaluated the usefulness of a novel serum marker, REG4, in the diagnosis of pancreatic cancer, as compared to carbohydrate antigen (CA) 19-9...
  79. ncbi request reprint Neuroendocrine tumor metastasis to the thyroid gland
    Hiroko Yamada
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Clin Oncol 12:63-7. 2007
    ..Head and neck surgeons should be aware that a particular subset of lung cancers may develop a metastatic solitary nodule in the thyroid, as presented. An effective therapeutic strategy is largely dependent on the differential diagnosis...
  80. ncbi request reprint Reduced expression of Dicer associated with poor prognosis in lung cancer patients
    Yoko Karube
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 96:111-5. 2005
    ....
  81. ncbi request reprint Overexpression of pituitary tumor transforming gene 1 in HCC is associated with angiogenesis and poor prognosis
    Tsutomu Fujii
    Department of Surgery II, Graduate School and Faculty of Medicine, Nagoya University, Nagoya, Japan
    Hepatology 43:1267-75. 2006
    ..PTTG1 is overexpressed in HCC and our results suggest that PTTG1 mRNA expression has prognostic significance for the survival of postoperative patients with HCC...
  82. ncbi request reprint Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers
    Eiichi Sasaki
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Aichi, Japan
    Mod Pathol 20:208-14. 2007
    ..Secondly, as primary lung adenocarcinomas may express estrogen receptors, MGB1 expression provides further discrimination of the origin of breast cancers...
  83. ncbi request reprint [Translational research on lung cancer--EGFR gene mutation]
    Takayuki Kosaka
    Dept of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Gan To Kagaku Ryoho 32:750-8. 2005
    ..It is ultimately necessary to identify non-tobacco-related carcinogens that cause EGFR mutations for effective prevention of lung cancer...
  84. ncbi request reprint Throwing new light on lung cancer pathogenesis: updates on three recent topics
    Shuta Tomida
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Aichi, Japan
    Cancer Sci 96:63-8. 2005
    ..Second, we deal with EGFR mutations, which shows revealing specificities in various aspects. Finally, advances in the expression profiling analysis of both transcriptomes and proteomes of lung cancers are summarized...
  85. doi request reprint Intraoperative diagnosis of cancer metastasis in sentinel lymph node of oral cancer patients
    Akihiro Terada
    Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Oral Oncol 44:838-43. 2008
    ..6%, respectively. All indexes of intraoperative frozen section analysis were superior to imprint cytology. In our experience, multislice frozen section analysis surpasses imprint cytology in intraoperative diagnosis of SLN biopsy...
  86. ncbi request reprint Prognostic models in patients with non-small-cell lung cancer using artificial neural networks in comparison with logistic regression
    Taizo Hanai
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Chikusa ku, Nagoya 469 8603, Japan
    Cancer Sci 94:473-7. 2003
    ....
  87. ncbi request reprint Phenotypic composition of salivary gland tumors: an application of principal [corrected] component analysis to tissue microarray data
    Hideto Iwafuchi
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan
    Mod Pathol 17:803-10. 2004
    ..Individual subtypes were clustered among the three dimensions of the components. This implies that salivary gland tumors may be well characterized by using only three components...
  88. ncbi request reprint Increased expression of COX-2 in the development of human lung cancers
    Takashi Takahashi
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Environ Pathol Toxicol Oncol 21:177-81. 2002
    ..Taken together, these findings suggest that an increase in COX-2 expression maybe associated with the development of lung cancer and possibly with the acquisition of an invasive and metastatic phenotype...
  89. ncbi request reprint Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers
    Kotaro Mizuno
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Oncogene 21:2328-33. 2002
    ..This is the first description of aberrant hypermethylation of the CHFR gene in any type of human cancer, and provides further evidence of the involvement of multiple checkpoint alterations in lung cancer...
  90. ncbi request reprint Senile EBV+ B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients
    Takashi Oyama
    Department of Hematology and Chemotherapy, Aichi Cancer Center, Nagoya, Japan
    Am J Surg Pathol 27:16-26. 2003
    ..Further investigations are needed to clarify the pathogenesis of this disease and to determine the optimal treatment strategy...
  91. ncbi request reprint High-level expression of CD109 is frequently detected in lung squamous cell carcinomas
    Tomoko Sato
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Int 57:719-24. 2007
    ..Although the detailed function of CD109 protein is unclear, these results suggest that CD109 expression may play a role in the development of lung squamous cell carcinoma...
  92. ncbi request reprint Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer
    Hiroyuki Konishi
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Oncogene 22:1892-905. 2003
    ....
  93. doi request reprint Coincidence of mammary and sentinel lymph node papilloma
    Shu Ichihara
    Department of Pathology, Nagoya Medical Center, Nagoya, Japan
    Am J Surg Pathol 32:784-92. 2008
    ..It remains undetermined whether the nodal papilloma was derived from the papilloma of the mastectomy or if it arose de novo from the breast tissue inclusion of the sentinel node...
  94. ncbi request reprint A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer
    Kiyoshi Yanagisawa
    Institute for Advanced Research, Nagoya University, Furo cho, Chikusa ku, Nagoya, Aichi 464 8601, Japan
    J Natl Cancer Inst 99:858-67. 2007
    ..Among patients with non-small-cell lung cancer (NSCLC), those with poor prognosis cannot be distinguished from those with good prognosis...
  95. doi request reprint EGFR T790M mutation: a double role in lung cancer cell survival?
    Kenichi Suda
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    J Thorac Oncol 4:1-4. 2009
    ..Clarification of the pathways leading to acquired resistance is essential to maximize the efficacy of EGFR-TKI therapy for patients with lung cancer...
  96. pmc EGFR mutations in patients with brain metastases from lung cancer: association with the efficacy of gefitinib
    Shinji Shimato
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuro Oncol 8:137-44. 2006
    ..Gefitinib appears to be effective in treating brain metastases in a subgroup of patients. Our data suggested a possible association between the efficacy of gefitinib in the treatment of brain metastases and EGFR mutations...
  97. doi request reprint Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity
    Masayasu Hara
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya, Aichi 464 8681, Japan
    Cancer Sci 99:1471-8. 2008
    ..Combination therapy with cetuximab and IL-2 would thus offer a new potential therapeutic approach for a subset of EGFR-overexpressing gastric cancers...
  98. ncbi request reprint Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 98:96-101. 2007
    ..In conclusion, our case-control study clearly demonstrated that the impacts of smoking and sex on the risk of EGFRmut NSCLC are different from those for EGFRwt NSCLC. Further epidemiological evaluation is warranted...
  99. ncbi request reprint Biological and clinical implications of EGFR mutations in lung cancer
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, 464 8681, Japan
    Int J Clin Oncol 11:190-8. 2006
    ..These populations precisely coincide with those populations with higher response rates to TKIs. We and others subsequently confirmed and extended these findings...
  100. ncbi request reprint A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
    Yoji Hayashita
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Japan
    Cancer Res 65:9628-32. 2005
    ....
  101. ncbi request reprint [Molecular diagnosis of solid tumors]
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital
    Nihon Rinsho 63:434-40. 2005
    ..In these molecular targeted therapies, diagnostic tools to verify the presence of an appropriate molecular target is crucial to the success, and thus the methods and its interpretation are discussed in this review...