Hideo Tanaka

..Included are general information and quality of data of cancer registration at each participating registry and five-year relative survival rates of cancer of the stomach, colo-rectum, liver, lung, breast and cervix...

..Molecular clock analysis of HCV sequences revealed that the spread of HCV took place earlier in Japan than in other countries. This might influence recent temporal trends in hepatocellular carcinoma (HCC) incidence...

..Tooth loss impairs oral function. The aim of the present review was to evaluate the causal association between smoking and tooth loss on the basis of high-quality studies...

..09 (1.30–12.85)]. These results indicate that alcohol has an impact on PC risk when the effects of alcohol consumption and metabolism are combined. Acetaldehyde may be involved in the mechanisms underlying PC development...

..In conclusion, our study in Japanese subjects suggested that early adulthood obesity is associated with the risk of NHL, particularly DLBCL...

..To investigate the association between toothbrushing frequency and upper aerodigestive tract (UADT) cancer, the authors conducted a large-scale case-control study...

..These findings show that multiple ADH gene polymorphisms were associated with UAT cancer in this Japanese population. Further studies in various ethnicities are required...

..036) and was consistently observed in the analysis among never-drinkers (interaction P = 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer...

..We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women...

..Facial flushing was less useful to predict UAT cancer risk than genotyping ALDH2 polymorphism...

..Interaction between folate consumption, drinking, and ALDH2 genotype was remarkable (three-way interaction, P<0.001). We observed significant interaction among folate, drinking, and ALDH2 genotype in the Japanese population...

..These findings suggest that FGFR2 intronic SNPs affect the reproductive hormone-related pathway and contribute to the development of female breast cancer in the Japanese population...

..We assessed the impact of genetic polymorphisms in the base excision repair (BER) pathway on PC risk among Japanese...

..Risk models which include a genetic risk score are possibly useful in distinguishing women at high risk of breast cancer from those at low risk, particularly in the context of targeted prevention...

..These results suggest that CYP19A1 polymorphisms might play an important role in the etiology of endometrial cancer, and that the effect of these polymorphisms might be influenced by BMI...

..Here, we conducted a case-control study comprising 222 histologically diagnosed incident endometrial cancer cases and 2162 age- and menstrual-status matched non-cancer controls...

..These results indicate that rs1052133 contributes to the risk of adenocarcinoma of lung...

..17-6.00) in the MTR 2756 AA genotype, and 3.35 (1.34-8.36) in the MTRR 66 G allele carriers. These results suggest that the folate-related enzyme polymorphism modifies the association between drinking habit and pancreatic cancer risk...

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..To examine the impact of 15p25 and 5p15 on lung cancer risk and smoking intensity, we conducted a case-control study in Japanese population. We also examined whether these loci modify the effect of smoking behavior on lung cancer risk...

..This association was modified by tumor receptor status. These findings suggest that the protective effects of vitamin D and calcium intake against breast cancer risk may differ by menopausal status and receptor status...

..In conclusion, we observed a significant association between IGF1 polymorphisms and stomach cancer risk among a Japanese population. Examination of the biological significance of IGF1 is warranted...

..With regard to breast cancer, however, evidence is scarce...

..Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited...

..In this study, we found that a high intake of yoghurt may lower the risk of developing UADT cancer in a Japanese population. Further investigation of this association is warranted...

..In addition, this effect might differ by treatment method...

..Further studies are necessary to define the mechanisms by which the ABO gene or closely linked genetic variants influence PC risk...

..In contrast, no association with risk was seen for a change in anthropometric factors since age 20 years. These findings suggested that body size in early life as well as in adult is associated with an increased risk of thyroid cancer...

..464 × 10(-3) , p = 0.006 and 0.364 × 10(-3) , p = 0.008). In conclusion, the shift from nonfilter to filter cigarettes appears to have merely altered the most frequent type of lung cancer, from SQ to AD...

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..This divergence of views is also discussed...

..No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation...

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..Smoking appeared to be positively associated with malignant lymphoma risk, but this finding may vary by subtype...

..We found that polymorphisms in CYP19A1 influence sex hormone levels in Japanese postmenopausal women...

..The results demonstrate an increased risk for HCC among asymptomatic HCV-positive individuals in Japan. Coinfection with HBV and HCV carried a superadditive risk for HCC...

..Contrary to our expectation, our findings indicate that Japanese dentists were not at increased risk of developing liver cancer compared with the general population...

..The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia...

..The aim of this study is to clarify the difference of risk of recurrence after hepatic resection between patients with hepatitis B- and hepatitis C-related hepatocellular carcinoma (HCC)...

..MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression...

..These findings may help us to predict future changes in the mortality rates of stomach cancer...

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..Preoperative smoking cessation has been suggested to be effective in reducing various postoperative complications. However, the optimal duration of preoperative smoking cessation for reducing wound complications is unclear...

..To characterize the time trend of the male liver cancer incidence rate in Japan...

..73; 95% CI, 0.54-0.97; trend p = 0.03). These findings indicate that the protective effect of soy against breast cancer risk differs by receptor status...

..However, early-stage esophageal cancer can be cured by endoscopic resection (ER). The long-term survival of esophageal mucosal squamous cell carcinoma after ER was investigated by calculating the standard mortality rate (SMR)...

..CONCLUSIONS: These findings indicate that a male cancer patient's personality as assessed by the egogram has predictive significance for whether the patient will have a smoking habit after discharge...

..We also discuss the relevant literature and implications for future studies of hepatitis and HCC in China...

..O/E=1.01, 95%CI=0.72-1.39). Contrary to expectation, these findings indicate that Japanese dentists had almost the same overall risk of developing lung cancer as the general population...

..To detect gene-environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005...

..These findings indicate that this program is effective and can be implemented in similar workplaces where the prevalence of smoking is high and smokers' readiness to cease smoking is low...

..Therefore, the possibility of population stratification must be considered when enrolling the islander population of this area, such as in the J-MICC study...

..Projecting individualized probabilities of developing breast cancer is needed for counseling and chemoprevention for Japanese women, in whom breast cancer incidence has been rapidly increasing...