Takeshi Suzuki

Summary

Affiliation: Aichi Cancer Center
Country: Japan

Publications

  1. ncbi request reprint FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling
    Hajime Kono
    Department of Allergy and Rheumatology, Faculty of Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Hum Mol Genet 14:2881-92. 2005
  2. doi request reprint Anthropometric factors at age 20 years and risk of thyroid cancer
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Causes Control 19:1233-42. 2008
  3. ncbi request reprint Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Sci 97:760-7. 2006
  4. doi request reprint Effect of soybean on breast cancer according to receptor status: a case-control study in Japan
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
    Int J Cancer 123:1674-80. 2008
  5. ncbi request reprint Effect of familial history and smoking on common cancer risks in Japan
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer 109:2116-23. 2007
  6. doi request reprint Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Int J Cancer 125:1961-4. 2009
  7. ncbi request reprint One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:1439-46. 2007
  8. doi request reprint Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 17:2742-7. 2008
  9. doi request reprint Inverse association between toothbrushing and upper aerodigestive tract cancer risk in a Japanese population
    Fumihito Sato
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    Head Neck 33:1628-37. 2011
  10. doi request reprint Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese
    Junya Kanda
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Cancer Sci 100:296-302. 2009

Detail Information

Publications75

  1. ncbi request reprint FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling
    Hajime Kono
    Department of Allergy and Rheumatology, Faculty of Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Hum Mol Genet 14:2881-92. 2005
    ..Collectively, the present findings indicate that the Ile232Thr substitution affects the localization and function of FcgammaRIIB and that the molecular mechanism may link the polymorphism and susceptibility to SLE...
  2. doi request reprint Anthropometric factors at age 20 years and risk of thyroid cancer
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Causes Control 19:1233-42. 2008
    ..In contrast, no association with risk was seen for a change in anthropometric factors since age 20 years. These findings suggested that body size in early life as well as in adult is associated with an increased risk of thyroid cancer...
  3. ncbi request reprint Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Sci 97:760-7. 2006
    ..These findings suggest that dietary antioxidant intake prevents HNSCC in smokers and drinkers...
  4. doi request reprint Effect of soybean on breast cancer according to receptor status: a case-control study in Japan
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
    Int J Cancer 123:1674-80. 2008
    ..73; 95% CI, 0.54-0.97; trend p = 0.03). These findings indicate that the protective effect of soy against breast cancer risk differs by receptor status...
  5. ncbi request reprint Effect of familial history and smoking on common cancer risks in Japan
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer 109:2116-23. 2007
    ..The authors further evaluated the effect modification by habitual smoking with adjustment for other confounding environmental factors...
  6. doi request reprint Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Int J Cancer 125:1961-4. 2009
    ..No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation...
  7. ncbi request reprint One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:1439-46. 2007
    ..04), MTR A2756G (P = 0.04) and MTRR A66G (P = 0.03) polymorphisms. The results suggest that there may be interactions between one-carbon metabolism-related polymorphisms and alcohol drinking for HNSCC risk...
  8. doi request reprint Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 17:2742-7. 2008
    ..17-6.00) in the MTR 2756 AA genotype, and 3.35 (1.34-8.36) in the MTRR 66 G allele carriers. These results suggest that the folate-related enzyme polymorphism modifies the association between drinking habit and pancreatic cancer risk...
  9. doi request reprint Inverse association between toothbrushing and upper aerodigestive tract cancer risk in a Japanese population
    Fumihito Sato
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    Head Neck 33:1628-37. 2011
    ..To investigate the association between toothbrushing frequency and upper aerodigestive tract (UADT) cancer, the authors conducted a large-scale case-control study...
  10. doi request reprint Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese
    Junya Kanda
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Cancer Sci 100:296-302. 2009
    ..09 (1.30–12.85)]. These results indicate that alcohol has an impact on PC risk when the effects of alcohol consumption and metabolism are combined. Acetaldehyde may be involved in the mechanisms underlying PC development...
  11. doi request reprint One-carbon metabolism-related gene polymorphisms and risk of breast cancer
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 29:356-62. 2008
    ..008). Our findings indicated that the MTHFR and MTRR polymorphisms were associated with individual susceptibility to breast cancer among postmenopausal women...
  12. doi request reprint Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 99:1202-8. 2008
    ..023). In conclusion, soy consumption may exert a protective association against the development of NSCLCs with EGFR mutations, providing possible insights into mechanisms of their genesis...
  13. doi request reprint hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type
    Toshiki Okasaka
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Hum Genet 54:739-45. 2009
    ..These results indicate that rs1052133 contributes to the risk of adenocarcinoma of lung...
  14. doi request reprint Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 101:1875-80. 2010
    ..Facial flushing was less useful to predict UAT cancer risk than genotyping ALDH2 polymorphism...
  15. doi request reprint Association between obesity and the risk of malignant lymphoma in Japanese: a case-control study
    Junya Kanda
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 126:2416-25. 2010
    ..In conclusion, our study in Japanese subjects suggested that early adulthood obesity is associated with the risk of NHL, particularly DLBCL...
  16. doi request reprint Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 18:3097-102. 2009
    ..These findings show that multiple ADH gene polymorphisms were associated with UAT cancer in this Japanese population. Further studies in various ethnicities are required...
  17. doi request reprint Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population
    Ji Young Park
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8618, Japan
    Carcinogenesis 31:660-5. 2010
    ..036) and was consistently observed in the analysis among never-drinkers (interaction P = 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer...
  18. ncbi request reprint Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 28:1718-25. 2007
    ..Further evaluation is warranted...
  19. ncbi request reprint HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women
    Satoyo Hosono
    Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Epidemiol 20:295-301. 2010
    ..We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women...
  20. doi request reprint Opposite impact of NKG2D genotype by lifestyle exposure to risk of aerodigestive tract cancer among Japanese
    Hiroki Furue
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 123:181-6. 2008
    ..These results suggest an opposite impact of NKG2D genotype by lifestyle exposure to the risk of aerodigestive tract cancer among a Japanese population...
  21. pmc Association between an 8q24 locus and the risk of colorectal cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    BMC Cancer 9:379. 2009
    ..Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited...
  22. ncbi request reprint Gene-gene and gene-environment interactions between alcohol drinking habit and polymorphisms in alcohol-metabolizing enzyme genes and the risk of head and neck cancer in Japan
    Akio Hiraki
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Cancer Sci 98:1087-91. 2007
    ....
  23. ncbi request reprint Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan
    Takakazu Kawase
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Epidemiol 19:244-50. 2009
    ..With regard to breast cancer, however, evidence is scarce...
  24. ncbi request reprint A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Carcinogenesis 27:1018-23. 2006
    ..38, 0.80-2.38). In conclusion, while we failed to find any significant association with the ALDH2 polymorphism itself, significant interaction between ALDH2 and ADH2 polymorphism was observed. Replication in the future study is warranted...
  25. ncbi request reprint Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 15:1791-8. 2006
    ....
  26. ncbi request reprint Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 16:2406-15. 2007
    ..Further studies are needed to investigate mechanisms of action of DHA relevant to antitumor effects in the stomach...
  27. ncbi request reprint Weight gain during adulthood and body weight at age 20 are associated with the risk of endometrial cancer in Japanese women
    Satoyo Hosono
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 21:466-73. 2011
    ..Here, we conducted a case-control study comprising 222 histologically diagnosed incident endometrial cancer cases and 2162 age- and menstrual-status matched non-cancer controls...
  28. ncbi request reprint Dietary risk factors for colon and rectal cancers: a comparative case-control study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 16:125-35. 2006
    ..In Japan, the incidence rate of colon cancer has more rapidly increased than that of rectal cancer. The differential secular trends may be due to different dietary factors in the development of colon and rectal cancers...
  29. ncbi request reprint Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Cancer 121:377-85. 2007
    ....
  30. ncbi request reprint Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 97:1226-35. 2006
    ....
  31. doi request reprint Association between vitamin D and calcium intake and breast cancer risk according to menopausal status and receptor status in Japan
    Takakazu Kawase
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 101:1234-40. 2010
    ..This association was modified by tumor receptor status. These findings suggest that the protective effects of vitamin D and calcium intake against breast cancer risk may differ by menopausal status and receptor status...
  32. ncbi request reprint Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Hum Mutat 28:506-10. 2007
    ..In conclusion, this study showed a significant impact of the ADH1C polymorphism on habitual drinking, regardless of the ADH1B/ALDH2 polymorphisms...
  33. doi request reprint FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan
    Takakazu Kawase
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Int J Cancer 125:1946-52. 2009
    ..These findings suggest that FGFR2 intronic SNPs affect the reproductive hormone-related pathway and contribute to the development of female breast cancer in the Japanese population...
  34. doi request reprint Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese
    Hiroki Furue
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Carcinogenesis 29:316-20. 2008
    ..Harboring the HNK1 is reported to reduce the overall cancer risk. To elucidate its impact on colorectal cancer (CRC), we conducted the present case-control study...
  35. ncbi request reprint A past history of gastric ulcers and Helicobacter pylori infection increase the risk of gastric malignant lymphoma
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 27:1391-7. 2006
    ..These results suggested the risk of gastric lymphoma increased by interaction between H. pylori infection and gastric ulcer history. Further studies are warranted...
  36. doi request reprint Teeth loss and risk of cancer at 14 common sites in Japanese
    Akio Hiraki
    Division of Epidemiology and Prevention, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 17:1222-7. 2008
    ..To clarify the significance of tooth loss to the risk of 14 common cancers, we conducted a large-scale, case-control study based on the Hospital-based Epidemiologic Research Program at Aichi Cancer Center...
  37. ncbi request reprint Smoking increases the treatment failure for Helicobacter pylori eradication
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Am J Med 119:217-24. 2006
    ..pylori) eradication is encountered in approximately 10-20% of patients, and many studies have pointed to a link with smoking. To investigate the effects of smoking on eradication outcome, we performed a meta-analysis...
  38. ncbi request reprint Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 98:96-101. 2007
    ..In conclusion, our case-control study clearly demonstrated that the impacts of smoking and sex on the risk of EGFRmut NSCLC are different from those for EGFRwt NSCLC. Further epidemiological evaluation is warranted...
  39. doi request reprint Association of alcohol intake and smoking with malignant lymphoma risk in Japanese: a hospital-based case-control study at Aichi Cancer Center
    Junya Kanda
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 18:2436-41. 2009
    ..Smoking appeared to be positively associated with malignant lymphoma risk, but this finding may vary by subtype...
  40. doi request reprint Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women
    Kumiko Kidokoro
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Hum Genet 54:78-85. 2009
    ..We found that polymorphisms in CYP19A1 influence sex hormone levels in Japanese postmenopausal women...
  41. ncbi request reprint Amrubicin monotherapy for elderly patients with previously treated lung cancer
    Makoto Nakao
    Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences, Nagoya, Japan
    Intern Med 49:1857-62. 2010
    ..The present study evaluates the toxicity and effect of amrubicin especially in elderly patients with previously treated lung cancer...
  42. ncbi request reprint One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Carcinogenesis 26:2164-71. 2005
    ..In conclusion, we found consistently significant interactions between one-carbon metabolism-related polymorphisms and alcohol drinking...
  43. ncbi request reprint Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
    Kenji Wakai
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Epidemiol 21:223-35. 2011
    ..To detect gene-environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005...
  44. ncbi request reprint Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents
    Toyoaki Hida
    Department of Internal Medicine, Aichi Cancer Center Hospital, Nagoya 464 8681, Japan
    Clin Cancer Res 8:2443-7. 2002
    ....
  45. doi request reprint Low-serum culture system improves the adipogenic ability of visceral adipose tissue-derived stromal cells
    Hiroshi Nagasaki
    Department of Metabolic Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cell Biol Int 35:559-68. 2011
    ..The present findings suggest that visceral ADSC-adipocytes expanded in low-serum culture would be useful for adiposcience and pharmacological evaluations...
  46. ncbi request reprint Allogeneic hematopoietic stem cell transplantation as part of postremission therapy improves survival for adult patients with high-risk acute lymphoblastic leukemia: a metaanalysis
    Masamitsu Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer 106:2657-63. 2006
    ..Therefore, optimal postremission therapy is a matter of vital concern. In particular, the clinical efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) should be clarified...
  47. ncbi request reprint CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B
    Yuki Hitomi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Japan
    Hum Mol Genet 13:2907-17. 2004
    ..These results indicated that the presence of CD72-*2 allele decreases risk for human SLE conferred by FCGR2B-232Thr, possibly by increasing the AS isoform of CD72...
  48. ncbi request reprint The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status
    Takeshi Suzuki
    Department of Pulmonary Medicine, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Lung Cancer 42:35-41. 2003
    ..These findings warrant future study to clarify how ZD1839 inhibits lung cancer cell growth and to find a useful marker for prediction of sensitivity to this novel and promising agent for the treatment of lung cancers...
  49. doi request reprint Reduced risk of endometrial cancer from alcohol drinking in Japanese
    Satoyo Hosono
    Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine
    Cancer Sci 99:1195-201. 2008
    ..Further investigation of these findings is warranted...
  50. ncbi request reprint Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan
    Chun xia Yang
    Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, China
    Carcinogenesis 26:1285-90. 2005
    ..31 (95% CI, 0.10-0.94), indicating risk with heavy drinking to be 69% decreased in individuals harboring the 677TT genotype. We failed to find any significant interaction between either of the polymorphisms and smoking...
  51. doi request reprint Effects of risk representation and scope on willingness to pay for reduced risks: evidence from Tokyo Bay, Japan
    Guofang Zhai
    Sino French Center for Urban, Regional and Planning Studies, Nanjing University, Nanjing, Jiangsu, 210093, PR China
    Risk Anal 28:513-22. 2008
    ..05 when the common denominator becomes large enough. The findings suggest that improved methods are required for estimating the rates of tradeoff between fatality risk and other goods among consumers...
  52. ncbi request reprint Recent improvement in the survival of patients with advanced nonsmall cell lung cancer enrolled in phase III trials of first-line, systemic chemotherapy
    Katsuyuki Hotta
    Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan
    Cancer 109:939-48. 2007
    ..The objective of the current investigation was to determine the time trends in outcomes for the patients in those trials...
  53. ncbi request reprint Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia
    Murray H Kown
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, California 94305, USA
    Ann Thorac Surg 76:1246-51. 2003
    ..This study compared the angiogenic effects of developmental endothelial locus-1 (DEL-1), vascular endothelial growth factor (VEGF), as well as the negative control, beta-galactosidase (beta-gal), in a porcine model of cardiac ischemia...
  54. ncbi request reprint Economic and geographic backgrounds of land reclamation in Japanese ports
    Takeshi Suzuki
    Coastal and Marine Department, National Institute for Land and Infrastructure Management Yokosuka, Ministry of Land, Infrastructure and Transport, 3 1 1 Nagase, Yokosuka, 239 0826, Kanagawa, Japan
    Mar Pollut Bull 47:226-9. 2003
    ..Land price had some effects for deepening water depth of reclamation in both periods...
  55. pmc Common sites of retroviral integration in mouse hematopoietic tumors identified by high-throughput, single nucleotide polymorphism-based mapping and bacterial artificial chromosome hybridization
    Haifa Shen
    Mouse Cancer Genetics Program, National Cancer Institute Frederick, Maryland 21702, USA
    J Virol 77:1584-8. 2003
    ..This mapping method is applicable to many different species, including ones where few genetic markers and little genomic sequence information are available. It can also be used to map endogenous proviruses...
  56. ncbi request reprint Immunohistochemical characterization of the intracellular pool of water channel aquaporin-2 in the rat kidney
    Yuki Tajika
    Department of Anatomy and Cell Biology, Gunma University School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Anat Sci Int 77:189-95. 2002
    ..Partial colocalization of AQP2 with early endosomes suggests that the endosomal system might be involved in the trafficking of AQP2...
  57. ncbi request reprint Treatment by mycophenolate mofetil of advanced graft vascular disease in non-human primate recipients of orthotopic aortic allografts
    Jochen Klupp
    Transplantation Immunology, Department of Cardiothoracic Surgery, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5407, USA
    Am J Transplant 3:817-29. 2003
    ..We found a significant correlation between the mean MMF tolerated dose and the inhibition of progression of IV (r = -0.88, p = 0.015). When high MMF doses were tolerated, MMF slowed progression of GVD...
  58. ncbi request reprint [Consultation for diagnosis and monitoring of cancer using genetic markers]
    Kenji Sano
    Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto 390 8621
    Rinsho Byori 54:132-6. 2006
    ..Here are some case presentations outlining the contributions of genetic markers to analysis, diagnosis and monitoring of malignancy and malignancy-related diseases...
  59. ncbi request reprint Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris
    Toshiaki Otsuka
    Department of Internal Medicine and Cardiology, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    Circ J 70:402-8. 2006
    ..However, it remains unclear regarding whether this pathway regulates the coronary vasomotion of atherosclerotic lesions...
  60. ncbi request reprint Spatial raft coalescence represents an initial step in Fc gamma R signaling
    Hajime Kono
    Department of Allergy and Rheumatology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 169:193-203. 2002
    ..These findings support the concept that ligand-binding subunit is responsible for raft coalescence, and that this event triggers initial biochemical signaling...
  61. pmc Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
    Takeshi Suzuki
    Cancer Genetic Unit, Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
    EMBO J 25:3422-31. 2006
    ....
  62. ncbi request reprint Intraspecific sequence variation of chloroplast DNA among the component species of evergreen broad-leaved forests in Japan
    Kyoko Aoki
    Department of Botany, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    J Plant Res 116:337-44. 2003
    ..It is suggested that these regions of cpDNA would be useful for detecting intraspecific variation in plant species, and could provide valuable information for various research purposes...
  63. ncbi request reprint Genomic structure and promoter activity of the E1AF gene, a member of the ETS oncogene family
    Setsuko Ishida
    Department of Microbiology, Hokkaido Institute of Public Health, N 19, W 12, Kita ku, Sapporo 060 0819, Japan
    Biochem Biophys Res Commun 339:325-30. 2006
    ..Moreover, the E1AF promoter was activated by E1AF itself and estrogen receptor. These findings suggest that E1AF is a housekeeping gene, whose expression is controlled in specific tissues...
  64. ncbi request reprint Relationship between the mismatch of 123I-BMIPP and 201Tl myocardial single-photon emission computed tomography and autonomic nervous system activity in patients with acute myocardial infarction
    Hiroyuki Yamanaka
    First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Int Heart J 47:193-207. 2006
    ....
  65. ncbi request reprint Interleukin-17 gene expression in patients with rheumatoid arthritis
    Mika Kohno
    Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
    Mod Rheumatol 18:15-22. 2008
    ..Expression of IL-17 gene in PBMC may be associated with the inflammatory process of RA. IL-17/TNF-alpha expression ratio is a potentially suitable marker of response to anti-TNF-alpha therapy...
  66. ncbi request reprint Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments
    Yuki Tajika
    Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Histochem Cell Biol 124:1-12. 2005
    ..Altogether, our data suggest that Rab11 and microtubules maintain the proper distribution of the subapical AQP2 storage compartment, and actin filaments regulate the trafficking of AQP2 from early endosomes to the storage compartment...
  67. ncbi request reprint Aerobic composting of chips from clear-cut trees with various co-materials
    Takeshi Suzuki
    Faculty of Agriculture, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
    Bioresour Technol 95:121-8. 2004
    ..This equation should enable us to determine the degree of compost maturity after 10 months based on the initial mixing ratio...
  68. ncbi request reprint High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas
    Min Sun Shin
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852, USA
    Cancer Res 64:4419-27. 2004
    ..The combined use of proviral tagging and analyses of gene expression thus provides a powerful approach to understanding of genes that collaborate in tumorigenesis...
  69. ncbi request reprint Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Schwann cells
    Hiromi Sekido
    Drug Development Research Laboratories, Sanwa Kagaku Kenkyusho Co, Ltd, Inabe, Japan
    Biochem Biophys Res Commun 320:241-8. 2004
    ..The effects of AGE-1 on these measures were equivocal. The series of events elicited by AGE-2 and -3 may be responsible for some of the aspects of pathogenetic mechanisms in patients with diabetic neuropathy...
  70. ncbi request reprint Phylogeography of the component species of broad-leaved evergreen forests in Japan, based on chloroplast DNA variation
    Kyoko Aoki
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Plant Res 117:77-94. 2004
    ....
  71. ncbi request reprint Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis
    Makoto Sugihara
    University of Tsukuba, Tsukuba, Ibaraki, Japan
    Arthritis Rheum 56:2160-9. 2007
    ..The aims of this study were to understand the posttranscriptional control of TNFalpha production in patients with rheumatoid arthritis (RA), and to identify parameters that may predict the efficacy of anti-TNFalpha therapy...
  72. ncbi request reprint Immunolocalization of the water channel, aquaporin-5 (AQP5), in the rat digestive system
    Toshiyuki Matsuzaki
    Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Arch Histol Cytol 66:307-15. 2003
    ..AQP5 appears to play an important role in water transfer in these glands...
  73. ncbi request reprint Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman's disease
    Masashi Matsuyama
    Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    Intern Med 46:771-4. 2007
    ..These results indicate that tocilizumab is effective for the treatment of MCD. This is the first report on tocilizumab efficacy for Castleman's disease after approval for use for Castleman's disease...
  74. pmc RTCGD: retroviral tagged cancer gene database
    Keiko Akagi
    Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD 21701, USA
    Nucleic Acids Res 32:D523-7. 2004
    ..Researchers can identify integrations of interest and compare their results with those for multiple tumor models and tumor types using RTCGD...
  75. ncbi request reprint Effect of local delivery of L-arginine on in-stent restenosis in humans
    Takeshi Suzuki
    Division of Cardiovascular Medicine, Stanford University, Stanford, California 94305, USA
    Am J Cardiol 89:363-7. 2002
    ..048). Thus, these results showed that local delivery of L-arginine reduces in-stent neointimal hyperplasia in humans, indicating that this approach may be a novel strategy to prevent in-stent restenosis...