Hideaki Nakamura

Summary

Affiliation: Aichi Cancer Center
Country: Japan

Publications

  1. ncbi Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT gene
    Hideaki Nakamura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Department of Molecular Pathogenesis, Nagoya University School of Medicine, Nagoya, Japan
    J Radiat Res 43:167-74. 2002
  2. ncbi Cytotoxic and mutagenic effects of chronic low-dose-rate irradiation on TERT-immortalized human cells
    Hideaki Nakamura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Radiat Res 163:283-8. 2005
  3. ncbi hTERT-immortalized cells useful for analyzing effects of low-dose-rate radiation on human cells
    Hideaki Nakamura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Radiat Res 49:9-15. 2008
  4. ncbi AT cells show dissimilar hypersensitivity to heavy-ion and X-rays irradiation
    Shoichiro Kitajima
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Radiat Res 51:251-5. 2010
  5. ncbi DNA repair defect in AT cells and their hypersensitivity to low-dose-rate radiation
    Hideaki Nakamura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Radiat Res 165:277-82. 2006
  6. ncbi Hypersensitivity to cisplatin after hRev3 mRNA knockdown in head and neck squamous cell carcinoma cells
    Makoto Adachi
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Mol Med Report 1:695-8. 2008
  7. ncbi No induction of p53 phosphorylation and few focus formation of phosphorylated H2AX suggest efficient repair of DNA damage during chronic low-dose-rate irradiation in human cells
    Kanji Ishizaki
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Radiat Res 45:521-5. 2004
  8. ncbi Pretreatment with 5-FU enhances cisplatin cytotoxicity in head and neck squamous cell carcinoma cells
    Kei Ijichi
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Cancer Chemother Pharmacol 62:745-52. 2008
  9. ncbi SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor
    Mary Ann Suico
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 348:880-8. 2006
  10. ncbi Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells
    Tomoaki Koga
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
    FEBS Lett 579:2811-6. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT gene
    Hideaki Nakamura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Department of Molecular Pathogenesis, Nagoya University School of Medicine, Nagoya, Japan
    J Radiat Res 43:167-74. 2002
    ..These results suggest that cells immortalized by hTERT introduction retain their original characteristics except for immortalization, and that they may be useful for analyzing various effects of radiation on human cells...
  2. ncbi Cytotoxic and mutagenic effects of chronic low-dose-rate irradiation on TERT-immortalized human cells
    Hideaki Nakamura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Radiat Res 163:283-8. 2005
    ..The present study indicates that the genetic effects of low-dose-rate radiation on nonproliferating normal human cells are quantitatively and qualitatively less severe than the effect of high-dose-rate radiation...
  3. ncbi hTERT-immortalized cells useful for analyzing effects of low-dose-rate radiation on human cells
    Hideaki Nakamura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Radiat Res 49:9-15. 2008
    ..This paper reviews briefly the current research at our laboratory. The hTERT-immortalized cells may be useful in determining the effects of low-dose and low-dose-rate radiation on human cells...
  4. ncbi AT cells show dissimilar hypersensitivity to heavy-ion and X-rays irradiation
    Shoichiro Kitajima
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Radiat Res 51:251-5. 2010
    ..The DSBs remaining after heavy-ion irradiation suggested defects in the AT cells' DSB repair ability...
  5. ncbi DNA repair defect in AT cells and their hypersensitivity to low-dose-rate radiation
    Hideaki Nakamura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Radiat Res 165:277-82. 2006
    ..In conclusion, AT cells may not be able to repair some fraction of DNA damage and are severely affected by low-dose-rate radiation...
  6. ncbi Hypersensitivity to cisplatin after hRev3 mRNA knockdown in head and neck squamous cell carcinoma cells
    Makoto Adachi
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Mol Med Report 1:695-8. 2008
    ..This study suggests that hRev3 knockdown with siRNAs increases sensitivity to cisplatin. Inhibition of the hRev3 gene may therefore prove to be a novel clinical strategy for reducing resistance to platinum-based chemotherapy in HNSCC...
  7. ncbi No induction of p53 phosphorylation and few focus formation of phosphorylated H2AX suggest efficient repair of DNA damage during chronic low-dose-rate irradiation in human cells
    Kanji Ishizaki
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Radiat Res 45:521-5. 2004
    ..These results strongly suggest that DNA damage induced by low-dose-rate radiation such as a double-strand break is efficiently repaired during chronic irradiation...
  8. ncbi Pretreatment with 5-FU enhances cisplatin cytotoxicity in head and neck squamous cell carcinoma cells
    Kei Ijichi
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Cancer Chemother Pharmacol 62:745-52. 2008
    ..To investigate more effective schedule, we analyzed the cytotoxicity in different treatment sequence with two agents in vitro and the mechanism for different effectiveness...
  9. ncbi SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor
    Mary Ann Suico
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 348:880-8. 2006
    ..These findings contribute to our understanding of the regulation of the ETS factor MEF...
  10. ncbi Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells
    Tomoaki Koga
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
    FEBS Lett 579:2811-6. 2005
    ..These were proven by EMSA and blocking Sp1 using RNAi or mithramycin A treatment of HEK293 cells. Our results suggest that Sp1 constitutively regulates the MEF gene...
  11. ncbi Immunohistochemical detection of hepatocellular carcinoma in the setting of ongoing necrosis after radiofrequency ablation
    Tomoo Itoh
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Hokkaido, Japan
    Mod Pathol 15:110-5. 2002
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