Keitaro Matsuo

Summary

Affiliation: Aichi Cancer Center
Country: Japan

Publications

  1. pmc A49T, V89L and TA repeat polymorphisms of steroid 5alpha-reductase type II and breast cancer risk in Japanese women
    Chunxia Yang
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Breast Cancer Res 4:R8. 2002
  2. ncbi Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk of endometrial cancer in Japanese subjects
    Yoshimitsu Niwa
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Lett 219:183-90. 2005
  3. pmc Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 22:477-83. 2012
  4. pmc Weight gain during adulthood and body weight at age 20 are associated with the risk of endometrial cancer in Japanese women
    Satoyo Hosono
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 21:466-73. 2011
  5. ncbi Cigarette smoking and pancreatic cancer risk: a revisit with an assessment of the nicotine dependence phenotype
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Asian Pac J Cancer Prev 14:4409-13. 2013
  6. pmc A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
    Hyung Cheol Kim
    Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, 363 951, Korea
    Breast Cancer Res 14:R56. 2012
  7. ncbi The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Carcinogenesis 34:1510-5. 2013
  8. pmc Decreasing trend in mortality of chronic myelogenous leukemia patients after introduction of imatinib in Japan and the U.S
    Dai Chihara
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Oncologist 17:1547-50. 2012
  9. doi Time to first cigarette and upper aerodigestive tract cancer risk in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 21:1986-92. 2012
  10. pmc Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study
    Rieko Okada
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Nephrol 13:2. 2012

Detail Information

Publications151 found, 100 shown here

  1. pmc A49T, V89L and TA repeat polymorphisms of steroid 5alpha-reductase type II and breast cancer risk in Japanese women
    Chunxia Yang
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Breast Cancer Res 4:R8. 2002
    ..To test the hypothesis that these three polymorphisms are associated with risk of breast cancer, a case-control study was conducted with patients of Aichi Cancer Center Hospital...
  2. ncbi Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk of endometrial cancer in Japanese subjects
    Yoshimitsu Niwa
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Lett 219:183-90. 2005
    ..82, 95% CI=1.36-5.82), especially of type-I tumors (OR=3.24, 95% CI=1.53-6.87). In contrast, there was no significant difference in the p53 Arg72Pro genotype frequency between the controls and cases...
  3. pmc Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 22:477-83. 2012
    ..We assessed the impact of genetic polymorphisms in the base excision repair (BER) pathway on PC risk among Japanese...
  4. pmc Weight gain during adulthood and body weight at age 20 are associated with the risk of endometrial cancer in Japanese women
    Satoyo Hosono
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 21:466-73. 2011
    ..Here, we conducted a case-control study comprising 222 histologically diagnosed incident endometrial cancer cases and 2162 age- and menstrual-status matched non-cancer controls...
  5. ncbi Cigarette smoking and pancreatic cancer risk: a revisit with an assessment of the nicotine dependence phenotype
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Asian Pac J Cancer Prev 14:4409-13. 2013
    ..We assessed the impact of smoking behavior, particularly TTFC, on PC risk in a Japanese population...
  6. pmc A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
    Hyung Cheol Kim
    Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk Do, 363 951, Korea
    Breast Cancer Res 14:R56. 2012
    ..Furthermore, GWAS-identified loci were primarily identified in women of European descent...
  7. ncbi The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Carcinogenesis 34:1510-5. 2013
    ..0054). In conclusion, ALDH2 and alcohol drinking showed interaction for risk factors of stomach cancer, indicating that acetaldehyde plays a role in stomach carcinogenesis. ..
  8. pmc Decreasing trend in mortality of chronic myelogenous leukemia patients after introduction of imatinib in Japan and the U.S
    Dai Chihara
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Oncologist 17:1547-50. 2012
    ..S. using vital statistics data for Japan and data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute for the U.S...
  9. doi Time to first cigarette and upper aerodigestive tract cancer risk in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 21:1986-92. 2012
    ....
  10. pmc Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study
    Rieko Okada
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Nephrol 13:2. 2012
    ....
  11. ncbi Association between body mass index and the colorectal cancer risk in Japan: pooled analysis of population-based cohort studies in Japan
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Ann Oncol 23:479-90. 2012
    ..Obesity has been recognized as important risk factors for colorectal cancer. However, limited evidence is available on colorectal cancer and body mass index (BMI) in Asian population...
  12. ncbi Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Hospital, Nagoya University Graduate School of Medicene, Nagoya, Japan
    Eur J Cancer Prev 21:193-8. 2012
    ..Interaction between folate consumption, drinking, and ALDH2 genotype was remarkable (three-way interaction, P<0.001). We observed significant interaction among folate, drinking, and ALDH2 genotype in the Japanese population...
  13. ncbi Interaction between CYP19A1 polymorphisms and body mass index in the risk of endometrial cancer in postmenopausal Japanese women
    Satoyo Hosono
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Asian Pac J Cancer Prev 12:2747-52. 2011
    ..These results suggest that CYP19A1 polymorphisms might play an important role in the etiology of endometrial cancer, and that the effect of these polymorphisms might be influenced by BMI...
  14. pmc Causal assessment of smoking and tooth loss: a systematic review of observational studies
    Takashi Hanioka
    Department of Preventive and Public Health Dentistry, Fukuoka Dental College, Fukuoka, Japan
    BMC Public Health 11:221. 2011
    ..Tooth loss impairs oral function. The aim of the present review was to evaluate the causal association between smoking and tooth loss on the basis of high-quality studies...
  15. ncbi Effect of hepatitis C virus infection on the risk of non-Hodgkin's lymphoma: a meta-analysis of epidemiological studies
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 95:745-52. 2004
    ..59-7.06) and T-NHL (2.51, 95% CI: 1.39-4.56). In conclusion, we found a strongly positive association between anti-HCV seropositive test subjects and risk of NHL. Further biological studies examining this association are warranted...
  16. ncbi Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 15:1009-13. 2006
    ..Heavy drinker status was also strongly associated with ADH2 Arg alleles. In conclusion, this study showed the strong effect of ADH2 His(47)Arg polymorphism on habitual drinking regardless of ALDH2 genotype...
  17. ncbi Methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms and reduced risk of malignant lymphoma
    Keitaro Matsuo
    Aichi Cancer Center, Division of Epidemiology and Prevention, Nagoya, Japan
    Am J Hematol 77:351-7. 2004
    ..Lack of association with MTR polymorphism was also confirmed...
  18. doi Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 99:1202-8. 2008
    ..023). In conclusion, soy consumption may exert a protective association against the development of NSCLCs with EGFR mutations, providing possible insights into mechanisms of their genesis...
  19. ncbi Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Hum Mutat 28:506-10. 2007
    ..In conclusion, this study showed a significant impact of the ADH1C polymorphism on habitual drinking, regardless of the ADH1B/ALDH2 polymorphisms...
  20. ncbi Lack of association between DNA base excision repair gene XRCC1 Gln399Arg polymorphism and risk of malignant lymphoma in Japan
    Keitaro Matsuo
    Aichi Cancer Center, Division of Epidemiology and Prevention, 1 1 Kanokoden Chikusa ku, Nagoya 464 8681, Japan
    Cancer Genet Cytogenet 149:77-80. 2004
    ..These data suggest that XRCC1 Gln399Arg polymorphism plays a limited role in lymphomagenesis. Further study on the interaction between the polymorphism and environmental exposure is required...
  21. pmc Association between an 8q24 locus and the risk of colorectal cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    BMC Cancer 9:379. 2009
    ..Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited...
  22. ncbi Clustered incidence of acute promyelocytic leukemia during gefitinib treatment for non-small-cell lung cancer: experience at a single institution
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Am J Hematol 81:349-54. 2006
    ..Although we cannot exclude an effect of past exposure of other cytotoxic agents and radiotherapy as a cause of APL, APL inducibility of gefitinib should be clarified in the further study...
  23. ncbi Insulin-like growth factor (IGF)-I and IGF-binding protein 3 and the risk of premenopausal breast cancer: a meta-analysis of literature
    Aravind Sugumar
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 111:293-7. 2004
    ..60; 95% CI = 0.84-3.02; p = 0.15). In conclusion, we found a marginally significant association between circulating IGF-I levels and the risk of premenopausal breast cancer...
  24. ncbi A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Carcinogenesis 27:1018-23. 2006
    ..38, 0.80-2.38). In conclusion, while we failed to find any significant association with the ALDH2 polymorphism itself, significant interaction between ALDH2 and ADH2 polymorphism was observed. Replication in the future study is warranted...
  25. doi Cigarette smoking and pancreas cancer risk: an evaluation based on a systematic review of epidemiologic evidence in the Japanese population
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Jpn J Clin Oncol 41:1292-302. 2011
    ..Therefore, we reviewed epidemiologic studies on the association between cigarette smoking and pancreas cancer in the Japanese population...
  26. ncbi Alcohol, smoking, and dietary status and susceptibility to malignant lymphoma in Japan: results of a hospital-based case-control study at Aichi Cancer Center
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi Cancer Center Hospital, Chikusa ku, Nagoya 464 86811
    Jpn J Cancer Res 92:1011-7. 2001
    ..From the previous study on genetic background for ML [Matsuo et al., Blood, 97, 3205 - 3209 (2001)], genetic variation combined with limited environmental factors should be targeted in future studies...
  27. ncbi Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 98:96-101. 2007
    ..In conclusion, our case-control study clearly demonstrated that the impacts of smoking and sex on the risk of EGFRmut NSCLC are different from those for EGFRwt NSCLC. Further epidemiological evaluation is warranted...
  28. doi HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism
    Takakazu Kawase
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Blood 113:2851-8. 2009
    ..Donor selection made in consideration of these results might allow the separation of GVL from acute GVHD, especially in HLA-DPB1 mismatch combinations...
  29. doi hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type
    Toshiki Okasaka
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Hum Genet 54:739-45. 2009
    ..These results indicate that rs1052133 contributes to the risk of adenocarcinoma of lung...
  30. doi Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 17:2742-7. 2008
    ..17-6.00) in the MTR 2756 AA genotype, and 3.35 (1.34-8.36) in the MTRR 66 G allele carriers. These results suggest that the folate-related enzyme polymorphism modifies the association between drinking habit and pancreatic cancer risk...
  31. ncbi One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:1439-46. 2007
    ..04), MTR A2756G (P = 0.04) and MTRR A66G (P = 0.03) polymorphisms. The results suggest that there may be interactions between one-carbon metabolism-related polymorphisms and alcohol drinking for HNSCC risk...
  32. ncbi The CYP19 gene codon 39 Trp/Arg polymorphism increases breast cancer risk in subsets of premenopausal Japanese
    Kaoru Hirose
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 13:1407-11. 2004
    ..31, 95% CI 1.88-28.5) or a high body mass index (OR 2.77, 95% CI 1.12-6.87). Additional larger studies should be done to confirm that the rare CYP19 variant increases the risk of breast cancer among premenopausal Japanese women...
  33. ncbi Association between obesity and the risk of malignant lymphoma in Japanese: a case-control study
    Junya Kanda
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 126:2416-25. 2010
    ..In conclusion, our study in Japanese subjects suggested that early adulthood obesity is associated with the risk of NHL, particularly DLBCL...
  34. ncbi No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Gastric Cancer 13:43-9. 2010
    ..We investigated the association of the AICDA 7888 C/T polymorphism with H. pylori infection and the risk of gastric cancer and atrophic gastritis in Japanese subjects...
  35. doi Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese
    Junya Kanda
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Cancer Sci 100:296-302. 2009
    ..09 (1.30–12.85)]. These results indicate that alcohol has an impact on PC risk when the effects of alcohol consumption and metabolism are combined. Acetaldehyde may be involved in the mechanisms underlying PC development...
  36. doi Inverse association between toothbrushing and upper aerodigestive tract cancer risk in a Japanese population
    Fumihito Sato
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    Head Neck 33:1628-37. 2011
    ..To investigate the association between toothbrushing frequency and upper aerodigestive tract (UADT) cancer, the authors conducted a large-scale case-control study...
  37. doi Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 18:3097-102. 2009
    ..These findings show that multiple ADH gene polymorphisms were associated with UAT cancer in this Japanese population. Further studies in various ethnicities are required...
  38. ncbi Opposite impact of NKG2D genotype by lifestyle exposure to risk of aerodigestive tract cancer among Japanese
    Hiroki Furue
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 123:181-6. 2008
    ..These results suggest an opposite impact of NKG2D genotype by lifestyle exposure to the risk of aerodigestive tract cancer among a Japanese population...
  39. ncbi Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese
    Asahi Hishida
    Department of Molecular Medicine and Clinical Science, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leuk Lymphoma 45:957-64. 2004
    ..08; 95% CI, 1.11-3.90, P = 0.023). Further examination with a sufficiently larger population and other ethnicities are required to confirm our findings...
  40. ncbi One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Carcinogenesis 26:2164-71. 2005
    ..In conclusion, we found consistently significant interactions between one-carbon metabolism-related polymorphisms and alcohol drinking...
  41. ncbi Gene-gene and gene-environment interactions between alcohol drinking habit and polymorphisms in alcohol-metabolizing enzyme genes and the risk of head and neck cancer in Japan
    Akio Hiraki
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Cancer Sci 98:1087-91. 2007
    ....
  42. ncbi Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 28:1718-25. 2007
    ..Further evaluation is warranted...
  43. ncbi One-carbon metabolism-related gene polymorphisms and risk of breast cancer
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 29:356-62. 2008
    ..008). Our findings indicated that the MTHFR and MTRR polymorphisms were associated with individual susceptibility to breast cancer among postmenopausal women...
  44. pmc HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women
    Satoyo Hosono
    Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Epidemiol 20:295-301. 2010
    ..We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women...
  45. ncbi NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese
    Nobuyuki Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Clin Oncol 7:103-8. 2002
    ..This study was conducted to screen possible cancer sites associated with this polymorphism by a prevalent case-control design...
  46. ncbi Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Sci 97:760-7. 2006
    ..These findings suggest that dietary antioxidant intake prevents HNSCC in smokers and drinkers...
  47. ncbi Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population
    Ji Young Park
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8618, Japan
    Carcinogenesis 31:660-5. 2010
    ..036) and was consistently observed in the analysis among never-drinkers (interaction P = 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer...
  48. ncbi Dietary risk factors for colon and rectal cancers: a comparative case-control study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 16:125-35. 2006
    ..In Japan, the incidence rate of colon cancer has more rapidly increased than that of rectal cancer. The differential secular trends may be due to different dietary factors in the development of colon and rectal cancers...
  49. ncbi Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 101:1875-80. 2010
    ..Facial flushing was less useful to predict UAT cancer risk than genotyping ALDH2 polymorphism...
  50. doi Alcohol drinking and esophageal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Jpn J Clin Oncol 41:677-92. 2011
    ..We conclude that there is convincing evidence that alcohol drinking increases the risk of esophageal cancer in the Japanese population...
  51. ncbi Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya Aichi, Japan
    Carcinogenesis 25:1395-401. 2004
    ..936) and that with light smoking was 2.67 (95% CI 1.00-7.68, P = 0.049). These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure...
  52. ncbi Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions
    Chun xia Yang
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Asian Pac J Cancer Prev 6:256-62. 2005
    ..Interactions between ALDH2 and ADH2 need further clarification...
  53. doi Prolonged survival of patients with metastatic colorectal cancer following first-line oxaliplatin-based chemotherapy with molecular targeting agents and curative surgery
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    Oncology 81:167-74. 2011
    ..The ability of molecular targeting agents to improve overall survival (OS) in metastatic colorectal cancer (MCRC) patients who underwent oxaliplatin-based chemotherapy remains controversial...
  54. ncbi Effects of genetic polymorphisms in the ABCB1 gene on clinical outcomes in patients with gastric cancer treated by second-line chemotherapy
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, Japan
    Asian Pac J Cancer Prev 11:447-52. 2010
    ..The purpose of this analysis was to evaluate the impact of genetic polymorphisms of the ABCB1 gene on clinical outcomes in patients with advanced gastric cancer (AGC) treated with second-line chemotherapy...
  55. ncbi Increased risk of colorectal cancer due to interactions between meat consumption and the CD36 gene A52C polymorphism among Japanese
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Nutr Cancer 51:170-7. 2005
    ..03 (95% CI=1.12-7.90). Our findings suggest that interactions between moderate-high meat consumption and the CD36 gene A52C polymorphism may increase the risk of colorectal cancer...
  56. ncbi Polymorphism in the hMSH2 gene (gIVS 12-6T-->C) and risk of non-Hodgkin lymphoma in a Japanese population
    Asahi Hishida
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, 464 8681, Nagoya, Japan
    Cancer Genet Cytogenet 147:71-4. 2003
    ..44-2.54), or CT and CC genotypes combined together (OR=1.44, 95% CI, 0.94-2.23) demonstrated significant OR. Further investigations with sufficiently larger populations and in other ethnicities are required to verify this association...
  57. doi A retrospective comparison of S-1 plus cisplatin and capecitabine plus cisplatin for patients with advanced or recurrent gastric cancer
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi, 464 8681, Japan
    Int J Clin Oncol 18:539-46. 2013
    ..On the other hand, several non-Japanese studies have shown the efficacy of capecitabine plus cisplatin (XP), which has been used as the reference arm in recent global studies of AGC...
  58. doi Prospective monitoring of BCR-ABL1 transcript levels in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia undergoing imatinib-combined chemotherapy
    Masamitsu Yanada
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 143:503-10. 2008
    ....
  59. doi Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy
    Masamitsu Yanada
    Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haematologica 93:287-90. 2008
    ..027), and increase the risk of treatment failure by 2.8-fold...
  60. doi Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancer
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, and Department of Epidemiology, Nagoya University Graduate School of Medicine, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Aichi, Japan
    Cancer Epidemiol Biomarkers Prev 19:1311-9. 2010
    ..However, to our knowledge, there are no reports that evaluate simultaneously the effects of folate intake and genetic polymorphisms on clinical outcome of gastric cancer patients...
  61. doi Clinical outcomes of advanced non-small cell lung cancer patients screened for epidermal growth factor receptor gene mutations
    Kimihide Yoshida
    Department of Thoracic Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Cancer Res Clin Oncol 136:527-35. 2010
    ..To evaluate the relationship between the epidermal growth factor receptor (EGFR) mutation status and the effectiveness of gefitinib monotherapy or chemotherapy in patients with advanced non-small cell lung cancer (NSCLC)...
  62. pmc Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan
    Takakazu Kawase
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Epidemiol 19:244-50. 2009
    ..With regard to breast cancer, however, evidence is scarce...
  63. ncbi A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 12:258-65. 2002
    ..This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999; 8: 669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma...
  64. ncbi Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 15:1791-8. 2006
    ....
  65. ncbi Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 97:1226-35. 2006
    ....
  66. doi Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Gastroenterol 44:1165-71. 2009
    ..pylori seropositivity and gastric atrophy in Japanese people...
  67. ncbi Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681 Japan
    Asian Pac J Cancer Prev 6:62-8. 2005
    ..Our findings suggest a significant interaction between alcohol consumption and the CD36 gene A52C polymorphism related to the metabolism of long-chain fatty acids and oxidized LDL in the etiology of colorectal cancer...
  68. ncbi Significant association of interleukin 8 -251T/A polymorphism with smoking behavior in a Japanese population
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Hum Genet 50:567-73. 2005
    ..33-0.82, P=0.004) for ever having smoked and 0.55 (0.33-0.92, P=0.023) for being a current smoker. Our results suggest that the inflammatory-prone genotype of IL8 may act to deter initiation or characteristics of the smoking habit...
  69. ncbi Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese
    Hiroki Furue
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Carcinogenesis 29:316-20. 2008
    ..Harboring the HNK1 is reported to reduce the overall cancer risk. To elucidate its impact on colorectal cancer (CRC), we conducted the present case-control study...
  70. ncbi Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the risk of Japanese breast cancer
    Xin En Huang
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
    Breast Cancer 10:307-11. 2003
    ....
  71. ncbi Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms
    Tomotaka Sugimura
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Oral Pathol Med 35:11-8. 2006
    ....
  72. pmc Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Gastroenterol 9:51. 2009
    ....
  73. ncbi High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism
    Takakazu Kawase
    Division of Immunology, Aichi Cancer Center, Nagoya, Japan
    Blood 110:2235-41. 2007
    ..Furthermore, the identification of high-risk mismatch, that is, nonpermissive mismatch, would be beneficial for the selection of a suitable donor...
  74. ncbi Gastric cancer risk and erythrocyte composition of docosahexaenoic acid with anti-inflammatory effects
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 16:2406-15. 2007
    ..Further studies are needed to investigate mechanisms of action of DHA relevant to antitumor effects in the stomach...
  75. ncbi Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Int J Cancer 125:1961-4. 2009
    ..No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation...
  76. doi Association of fluoropyrimidines, platinum agents, taxanes, and irinotecan in any line of chemotherapy with survival in patients with advanced gastric cancer
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Gastric Cancer 14:155-60. 2011
    ....
  77. doi PRKCH gene polymorphism is associated with the risk of severe gastric atrophy
    Yasuyuki Goto
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, 466 8550, Japan
    Gastric Cancer 13:90-4. 2010
    ..To elucidate its applicability in the development of GA and GC, this study aimed to investigate the associations of the PRKCH polymorphism with the risks of GA and GC...
  78. ncbi FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan
    Takakazu Kawase
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Int J Cancer 125:1946-52. 2009
    ..These findings suggest that FGFR2 intronic SNPs affect the reproductive hormone-related pathway and contribute to the development of female breast cancer in the Japanese population...
  79. ncbi Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Cancer 121:377-85. 2007
    ....
  80. ncbi Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women
    Kumiko Kidokoro
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Hum Genet 54:78-85. 2009
    ..We found that polymorphisms in CYP19A1 influence sex hormone levels in Japanese postmenopausal women...
  81. ncbi A past history of gastric ulcers and Helicobacter pylori infection increase the risk of gastric malignant lymphoma
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 27:1391-7. 2006
    ..These results suggested the risk of gastric lymphoma increased by interaction between H. pylori infection and gastric ulcer history. Further studies are warranted...
  82. ncbi Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer
    Kimihide Yoshida
    Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
    J Thorac Oncol 2:22-8. 2007
    ..We evaluated the efficacy of gefitinib monotherapy prospectively in patients with advanced or pretreated non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations...
  83. ncbi Helicobacter pylori seropositivity and the myeloperoxidase G-463A polymorphism in combination with interleukin-1B C-31T in Japanese health checkup examinees
    Nobuyuki Katsuda
    Nagoya Kita Health Center, Nagoya, Japan
    Jpn J Clin Oncol 33:192-7. 2003
    ....
  84. pmc Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms
    Daphne W Bell
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Clin Cancer Res 14:4079-84. 2008
    ....
  85. ncbi Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer
    Hiromichi Ebi
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Res 67:11158-65. 2007
    ....
  86. ncbi Comparison of lifestyle risk factors by family history for gastric, breast, lung and colorectal cancer
    Xin En Huang
    Department of Chemotherapy, Jiangsu Cancer Hospital and Research Institute, Nanjing 210009, China
    Asian Pac J Cancer Prev 5:419-27. 2004
    ..Habitual smoking increased, while frequent physical exercise and raw vegetables intake decreased cancer risk, regardless of the CFH status...
  87. ncbi Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking
    Chang Ming Gao
    Department of Epidemiology, Jiangsu Province Institute of Cancer Research, Nanjing, China
    Asian Pac J Cancer Prev 5:133-8. 2004
    ....
  88. ncbi Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan
    Chun xia Yang
    Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, China
    Carcinogenesis 26:1285-90. 2005
    ..31 (95% CI, 0.10-0.94), indicating risk with heavy drinking to be 69% decreased in individuals harboring the 677TT genotype. We failed to find any significant interaction between either of the polymorphisms and smoking...
  89. ncbi Aldehyde dehydrogenase 2 (ALDH2) genotype affects rectal cancer susceptibility due to alcohol consumption
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 12:70-6. 2002
    ..The alcohol related enzyme encoding gene ALDH2 has polymorphism Glu487Lys, and 487Lys allele is closely linked with phenotypic loss of enzyme activity...
  90. ncbi Dietary patterns and the risk of breast cancer in Japanese women
    Kaoru Hirose
    Department of Planning and Information, Aichi Prefectural Institute of Public Health, 7 6 Azanagare, Tsujimachi, Kita ku, Nagoya 462 8576, Japan
    Cancer Sci 98:1431-8. 2007
    ..027). The authors found the prudent dietary pattern to be negatively associated with breast cancer risk. In addition, the fatty and Japanese patterns may increase breast cancer risk among obese women...
  91. ncbi Phase I/II enzyme gene polymorphisms and esophageal cancer risk: a meta-analysis of the literature
    Chun xia Yang
    Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:2531-8. 2005
    ..Although their significance with regard to esophageal carcinogenicity has been examined epidemiologically, it remains controversial. The present systematic review of the literature was performed to clarify associations...
  92. ncbi Re: Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk
    Asahi Hishida
    J Natl Cancer Inst 94:1807-8. 2002
  93. ncbi Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese
    Daisuke Tanaka
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    Nagoya J Med Sci 67:117-24. 2005
    ..52 (0.71-3.28) and 0.31 (0.71-1.34), respectively. Although prevalent cases were used, this study suggested that the influence of DPYD T85C posed only a limited risk for the six malignancies...
  94. doi Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Cancer Sci 99:303-8. 2008
    ....
  95. ncbi Coffee consumption and the risk of endometrial cancer: Evidence from a case-control study of female hormone-related cancers in Japan
    Kaoru Hirose
    Department of Planning and Information, Aichi Prefectural Institute of Public Health, 7 6 Azanagare, Tsujimachi, Kita ku, Nagoya, Japan
    Cancer Sci 98:411-5. 2007
    ..Given the scarcity of studies of coffee intake and endometrial cancer and other hormone-dependent cancer risk, additional investigations are warranted...
  96. ncbi Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma
    Asahi Hishida
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Haematologica 88:159-66. 2003
    ..We examined the associations between susceptibility to malignant lymphoma and these polymorphisms...
  97. ncbi Significant reduction in breast cancer risk for Japanese women with interleukin 1B -31 CT/TT relative to CC genotype
    Lucy Sayuri Ito
    Department of Neurology, School of Medicine, Sao Paulo University, Sao Paulo, Brazil
    Jpn J Clin Oncol 32:398-402. 2002
    ....
  98. ncbi Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women
    Asahi Hishida
    First Department of Internal Medicine, Nagoya University Graduate School of Medicine, Japan
    Breast Cancer 10:63-9. 2003
    ..This is a prevalent case-control study to examine the reported risk reduction for Japanese women...
  99. doi Subcategorization of lung cancer based on tumor size and degree of visceral pleural invasion
    Noriaki Sakakura
    Department of Thoracic Surgery, Division of Epidemiology and Prevention, Aichi Cancer Center Hospital, Nagoya, Japan
    Ann Thorac Surg 86:1084-90. 2008
    ..Lung cancer staging system proposed in 2007 adopts detailed tumor size cut-off values. Alternatively, visceral pleural invasion is deemed an important prognosticator, but has not been easily incorporated into the staging system...
  100. doi Stepwise examination for differential diagnosis of primary lung cancer and breast cancer relapse presenting as a solitary pulmonary nodule in patients after mastectomy
    Toshiki Okasaka
    Division of Thoracic Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Surg Oncol 98:510-4. 2008
    ..Definitive diagnosis of these nodules, however, is often difficult. We assessed the feasibility of our diagnostic approach for these nodules and estimated the frequency of primary lung cancer occurrence in patients after mastectomy...
  101. ncbi The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Okayama University, Okayama, Japan
    Clin Cancer Res 13:5763-8. 2007
    ..In this study, we extensively investigated the impact of sex and smoking on the EGFR mutation...