Hidemi Ito

Summary

Affiliation: Aichi Cancer Center
Country: Japan

Publications

  1. pmc eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population
    Takahiro Higashibata
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Lipids Health Dis 11:150. 2012
  2. ncbi request reprint An intervention study of smoking cessation with feedback on genetic cancer susceptibility in Japan
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusaku Nagoya, Japan
    Prev Med 42:102-8. 2006
  3. ncbi request reprint Estimation of cancer incidences in Aichi prefecture: use of a model area with good quality registry data
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Research Institute, Japan
    Asian Pac J Cancer Prev 5:320-7. 2004
  4. doi request reprint Nonfilter and filter cigarette consumption and the incidence of lung cancer by histological type in Japan and the United States: analysis of 30-year data from population-based cancer registries
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 128:1918-28. 2011
  5. ncbi request reprint Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya Aichi, Japan
    Carcinogenesis 25:1395-401. 2004
  6. ncbi request reprint Monoamine oxidase polymorphisms and smoking behaviour in Japanese
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya Aichi 464 8681, Japan
    Pharmacogenetics 13:73-9. 2003
  7. ncbi request reprint Significant association of interleukin 8 -251T/A polymorphism with smoking behavior in a Japanese population
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Hum Genet 50:567-73. 2005
  8. doi request reprint Inverse association between toothbrushing and upper aerodigestive tract cancer risk in a Japanese population
    Fumihito Sato
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    Head Neck 33:1628-37. 2011
  9. doi request reprint Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 18:3097-102. 2009
  10. ncbi request reprint A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Carcinogenesis 27:1018-23. 2006

Detail Information

Publications80

  1. pmc eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population
    Takahiro Higashibata
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Lipids Health Dis 11:150. 2012
    ..The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia...
  2. ncbi request reprint An intervention study of smoking cessation with feedback on genetic cancer susceptibility in Japan
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusaku Nagoya, Japan
    Prev Med 42:102-8. 2006
    ..To evaluate whether feedback of genetic information regarding an L-myc polymorphism, identified as impacting on tobacco-related cancer risk, has an influence on smoking cessation, an intervention study was conducted...
  3. ncbi request reprint Estimation of cancer incidences in Aichi prefecture: use of a model area with good quality registry data
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Research Institute, Japan
    Asian Pac J Cancer Prev 5:320-7. 2004
    ..It is suggested that the cancer incidence in the Aichi prefecture is indeed being underestimated and that the actual figures may be closer to the estimates provided here...
  4. doi request reprint Nonfilter and filter cigarette consumption and the incidence of lung cancer by histological type in Japan and the United States: analysis of 30-year data from population-based cancer registries
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 128:1918-28. 2011
    ..464 × 10(-3) , p = 0.006 and 0.364 × 10(-3) , p = 0.008). In conclusion, the shift from nonfilter to filter cigarettes appears to have merely altered the most frequent type of lung cancer, from SQ to AD...
  5. ncbi request reprint Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya Aichi, Japan
    Carcinogenesis 25:1395-401. 2004
    ..936) and that with light smoking was 2.67 (95% CI 1.00-7.68, P = 0.049). These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure...
  6. ncbi request reprint Monoamine oxidase polymorphisms and smoking behaviour in Japanese
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya Aichi 464 8681, Japan
    Pharmacogenetics 13:73-9. 2003
    ..These findings among male smokers support the view that MAO affects a smokers' requirement for nicotine and may explain why some people are predisposed to tobacco addiction and why some individuals find it difficult to stop smoking...
  7. ncbi request reprint Significant association of interleukin 8 -251T/A polymorphism with smoking behavior in a Japanese population
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Hum Genet 50:567-73. 2005
    ..33-0.82, P=0.004) for ever having smoked and 0.55 (0.33-0.92, P=0.023) for being a current smoker. Our results suggest that the inflammatory-prone genotype of IL8 may act to deter initiation or characteristics of the smoking habit...
  8. doi request reprint Inverse association between toothbrushing and upper aerodigestive tract cancer risk in a Japanese population
    Fumihito Sato
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    Head Neck 33:1628-37. 2011
    ..To investigate the association between toothbrushing frequency and upper aerodigestive tract (UADT) cancer, the authors conducted a large-scale case-control study...
  9. doi request reprint Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 18:3097-102. 2009
    ..These findings show that multiple ADH gene polymorphisms were associated with UAT cancer in this Japanese population. Further studies in various ethnicities are required...
  10. ncbi request reprint A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Carcinogenesis 27:1018-23. 2006
    ..38, 0.80-2.38). In conclusion, while we failed to find any significant association with the ALDH2 polymorphism itself, significant interaction between ALDH2 and ADH2 polymorphism was observed. Replication in the future study is warranted...
  11. doi request reprint hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type
    Toshiki Okasaka
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Hum Genet 54:739-45. 2009
    ..These results indicate that rs1052133 contributes to the risk of adenocarcinoma of lung...
  12. ncbi request reprint Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 101:1875-80. 2010
    ..Facial flushing was less useful to predict UAT cancer risk than genotyping ALDH2 polymorphism...
  13. doi request reprint The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Carcinogenesis 34:1510-5. 2013
    ..0054). In conclusion, ALDH2 and alcohol drinking showed interaction for risk factors of stomach cancer, indicating that acetaldehyde plays a role in stomach carcinogenesis. ..
  14. ncbi request reprint Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 15:1009-13. 2006
    ..Heavy drinker status was also strongly associated with ADH2 Arg alleles. In conclusion, this study showed the strong effect of ADH2 His(47)Arg polymorphism on habitual drinking regardless of ALDH2 genotype...
  15. doi request reprint Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population
    Ji Young Park
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8618, Japan
    Carcinogenesis 31:660-5. 2010
    ..036) and was consistently observed in the analysis among never-drinkers (interaction P = 0.041). These results suggest that ALDH2 Lys/Lys, a null enzyme activity genotype, modifies the impact of smoking on the risk of lung cancer...
  16. doi request reprint Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 99:1202-8. 2008
    ..023). In conclusion, soy consumption may exert a protective association against the development of NSCLCs with EGFR mutations, providing possible insights into mechanisms of their genesis...
  17. pmc Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 22:477-83. 2012
    ..We assessed the impact of genetic polymorphisms in the base excision repair (BER) pathway on PC risk among Japanese...
  18. doi request reprint Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Hospital, Nagoya University Graduate School of Medicene, Nagoya, Japan
    Eur J Cancer Prev 21:193-8. 2012
    ..Interaction between folate consumption, drinking, and ALDH2 genotype was remarkable (three-way interaction, P<0.001). We observed significant interaction among folate, drinking, and ALDH2 genotype in the Japanese population...
  19. ncbi request reprint HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women
    Satoyo Hosono
    Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Epidemiol 20:295-301. 2010
    ..We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women...
  20. ncbi request reprint Polymorphism in the hMSH2 gene (gIVS 12-6T-->C) and risk of non-Hodgkin lymphoma in a Japanese population
    Asahi Hishida
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, 464 8681, Nagoya, Japan
    Cancer Genet Cytogenet 147:71-4. 2003
    ..44-2.54), or CT and CC genotypes combined together (OR=1.44, 95% CI, 0.94-2.23) demonstrated significant OR. Further investigations with sufficiently larger populations and in other ethnicities are required to verify this association...
  21. ncbi request reprint Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 97:1226-35. 2006
    ....
  22. ncbi request reprint Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Sci 97:760-7. 2006
    ..These findings suggest that dietary antioxidant intake prevents HNSCC in smokers and drinkers...
  23. doi request reprint Association between obesity and the risk of malignant lymphoma in Japanese: a case-control study
    Junya Kanda
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 126:2416-25. 2010
    ..In conclusion, our study in Japanese subjects suggested that early adulthood obesity is associated with the risk of NHL, particularly DLBCL...
  24. doi request reprint A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population
    Aiko Sueta
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Breast Cancer Res Treat 132:711-21. 2012
    ..Risk models which include a genetic risk score are possibly useful in distinguishing women at high risk of breast cancer from those at low risk, particularly in the context of targeted prevention...
  25. ncbi request reprint Weight gain during adulthood and body weight at age 20 are associated with the risk of endometrial cancer in Japanese women
    Satoyo Hosono
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 21:466-73. 2011
    ..Here, we conducted a case-control study comprising 222 histologically diagnosed incident endometrial cancer cases and 2162 age- and menstrual-status matched non-cancer controls...
  26. ncbi request reprint Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 15:1791-8. 2006
    ....
  27. doi request reprint Alcohol and dietary folate intake and the risk of breast cancer: a case-control study in Japan
    Tania Islam
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Eur J Cancer Prev 22:358-66. 2013
    ..In addition, the effects of folate/alcohol may vary according to the tumor subtype...
  28. ncbi request reprint Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions
    Chun xia Yang
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Asian Pac J Cancer Prev 6:256-62. 2005
    ..Interactions between ALDH2 and ADH2 need further clarification...
  29. ncbi request reprint ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 20:1665-72. 2011
    ....
  30. ncbi request reprint Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Hum Mutat 28:506-10. 2007
    ..In conclusion, this study showed a significant impact of the ADH1C polymorphism on habitual drinking, regardless of the ADH1B/ALDH2 polymorphisms...
  31. ncbi request reprint Dietary risk factors for colon and rectal cancers: a comparative case-control study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 16:125-35. 2006
    ..In Japan, the incidence rate of colon cancer has more rapidly increased than that of rectal cancer. The differential secular trends may be due to different dietary factors in the development of colon and rectal cancers...
  32. ncbi request reprint Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes
    Nobuyuki Hamajima
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Gastric Cancer 6:230-6. 2003
    ..The present study examined the associations of H. pylori with functional polymorphisms, TNF-A G-308A, C-857T, and T-1031C and TNF-B A252G in Japanese subjects...
  33. ncbi request reprint A past history of gastric ulcers and Helicobacter pylori infection increase the risk of gastric malignant lymphoma
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 27:1391-7. 2006
    ..These results suggested the risk of gastric lymphoma increased by interaction between H. pylori infection and gastric ulcer history. Further studies are warranted...
  34. doi request reprint Association between a genome-wide association study-identified locus and the risk of lung cancer in Japanese population
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Thorac Oncol 7:790-8. 2012
    ..To examine the impact of 15p25 and 5p15 on lung cancer risk and smoking intensity, we conducted a case-control study in Japanese population. We also examined whether these loci modify the effect of smoking behavior on lung cancer risk...
  35. doi request reprint Inverse association between yoghurt intake and upper aerodigestive tract cancer risk in a Japanese population
    Daisuke Kawakita
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Eur J Cancer Prev 21:453-9. 2012
    ..In this study, we found that a high intake of yoghurt may lower the risk of developing UADT cancer in a Japanese population. Further investigation of this association is warranted...
  36. pmc Association between an 8q24 locus and the risk of colorectal cancer in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    BMC Cancer 9:379. 2009
    ..Although the association with the identified loci was strong, information on its impact in combination with lifestyle factors is limited...
  37. ncbi request reprint Cytotoxic T-lymphocyte antigen 4 gene polymorphisms in sarcoidosis patients
    Noriko Hattori
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 22:27-32. 2005
    ..In the present study we investigated CTLA-4 polymorphisms of promoter -318(C/T) and exon 1 +49(A/G) in sarcoidosis patients and control subjects to determine whether these genetic variations affect sarcoidosis...
  38. ncbi request reprint One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya 464 8681, Japan
    Carcinogenesis 26:2164-71. 2005
    ..In conclusion, we found consistently significant interactions between one-carbon metabolism-related polymorphisms and alcohol drinking...
  39. ncbi request reprint Cigarette smoking and pancreatic cancer risk: a revisit with an assessment of the nicotine dependence phenotype
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Asian Pac J Cancer Prev 14:4409-13. 2013
    ..We assessed the impact of smoking behavior, particularly TTFC, on PC risk in a Japanese population...
  40. doi request reprint Time to first cigarette and upper aerodigestive tract cancer risk in Japan
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 21:1986-92. 2012
    ....
  41. doi request reprint Cigarette smoking and esophageal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Jpn J Clin Oncol 42:63-73. 2012
    ..Therefore, we reviewed epidemiologic studies on the association between cigarette smoking and esophageal cancer among the Japanese population...
  42. doi request reprint Association between insulin-like growth factor-1 polymorphisms and stomach cancer risk in a Japanese population
    Daisuke Ennishi
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 102:2231-5. 2011
    ..In conclusion, we observed a significant association between IGF1 polymorphisms and stomach cancer risk among a Japanese population. Examination of the biological significance of IGF1 is warranted...
  43. ncbi request reprint Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 98:96-101. 2007
    ..In conclusion, our case-control study clearly demonstrated that the impacts of smoking and sex on the risk of EGFRmut NSCLC are different from those for EGFRwt NSCLC. Further epidemiological evaluation is warranted...
  44. ncbi request reprint Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese
    Kiyonori Kuriki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Cancer 121:377-85. 2007
    ....
  45. doi request reprint Factors associated with weight gain after smoking cessation therapy in Japan
    Chie Taniguchi
    Chie Taniguchi, RN, is Research Nurse, Department of Nursing, National Hospital Organization Nagoya Medical Center and Department of Nursing, Nagoya University Graduate School of Medicine, Japan Hideo Tanaka, MD, PhD, is Chief Isao Oze, MD, PhD, is Senior Researcher and Hidemi Ito, MD, PhD, is Section Head, Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan Hideo Saka, MD, is Chair, Department of Respiratory Medicine and Medical Oncology, National Hospital Organization Nagoya Medical Center, Japan Kazunobu Tachibana, MD, PhD, is Director, Department of Education and Training, Department of Respiratory Medicine, National Hospital Organization Kinki chuo Chest Medical Center, Japan Akihiro Tokoro, MD, is Psycho oncologist, Department of Psychosomatic Medicine, National Hospital Organization Kinki chuo Chest Medical Center, Japan Yasuhiro Nozaki, MD, PhD, is Chief
    Nurs Res 62:414-21. 2013
    ..Smoking cessation is often followed by weight gain, which may attenuate motivation to sustain a quit attempt...
  46. ncbi request reprint Coffee and green tea consumption is associated with upper aerodigestive tract cancer in Japan
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, Japan
    Int J Cancer 135:391-400. 2014
    ..These findings suggest that consumption of coffee might be associated with a decreased risk of UADT cancer, whereas that of green tea might be associated with an increased risk. ..
  47. doi request reprint Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma
    Keiko Shinjo
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 33:1277-85. 2012
    ..CIMP classification using our six-marker panel has implications for personalized medical strategies for lung cancer patients; in particular, DNA methylation inhibitor might be of therapeutic benefit to patients with CIMP-positive tumors...
  48. ncbi request reprint Interaction between CYP19A1 polymorphisms and body mass index in the risk of endometrial cancer in postmenopausal Japanese women
    Satoyo Hosono
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Asian Pac J Cancer Prev 12:2747-52. 2011
    ..These results suggest that CYP19A1 polymorphisms might play an important role in the etiology of endometrial cancer, and that the effect of these polymorphisms might be influenced by BMI...
  49. doi request reprint Impact of smoking status on clinical outcome in oral cavity cancer patients
    Daisuke Kawakita
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Oral Oncol 48:186-91. 2012
    ..In addition, this effect might differ by treatment method...
  50. ncbi request reprint A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 12:258-65. 2002
    ..This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999; 8: 669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma...
  51. doi request reprint Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancer
    Kohei Shitara
    Department of Clinical Oncology, Aichi Cancer Center Hospital, and Department of Epidemiology, Nagoya University Graduate School of Medicine, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Aichi, Japan
    Cancer Epidemiol Biomarkers Prev 19:1311-9. 2010
    ..However, to our knowledge, there are no reports that evaluate simultaneously the effects of folate intake and genetic polymorphisms on clinical outcome of gastric cancer patients...
  52. doi request reprint ABO blood group alleles and the risk of pancreatic cancer in a Japanese population
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 102:1076-80. 2011
    ..Further studies are necessary to define the mechanisms by which the ABO gene or closely linked genetic variants influence PC risk...
  53. ncbi request reprint Lymphotoxin-alpha polymorphisms and the risk of endometrial cancer in Japanese subjects
    Yoshimitsu Niwa
    Department of Gynecology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Gynecol Oncol 104:586-90. 2007
    ..To test the association of endometrial cancer with the lymphotoxin-alpha (LTalpha) C804A and A252G polymorphisms, a hospital-based incident case-control study was performed in Japanese subjects...
  54. ncbi request reprint Association between smoking habits and dopamine receptor D2 taqI A A2 allele in Japanese males: a confirmatory study
    Nobuyuki Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 12:297-304. 2002
    ..No association for Japanese females suggested that female smoking behavior is differently affected in biological and/or psychological manner...
  55. ncbi request reprint A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population
    Sanae Kabata Ikehara
    Department of Epidemiology, Nagoya University Graduate School of Medicine, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Hum Genet 51:927-33. 2006
    ..These observations suggest that IL1B-31TT and IL1B-511CC are associated with disease progression...
  56. ncbi request reprint Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC)
    Manami Inoue
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Int J Epidemiol 32:257-62. 2003
    ....
  57. ncbi request reprint Smoking increases the treatment failure for Helicobacter pylori eradication
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Am J Med 119:217-24. 2006
    ..pylori) eradication is encountered in approximately 10-20% of patients, and many studies have pointed to a link with smoking. To investigate the effects of smoking on eradication outcome, we performed a meta-analysis...
  58. ncbi request reprint Differences in incidence and trends of haematological malignancies in Japan and the United States
    Dai Chihara
    Division of Epidemiology and Prevention, Aichi Cancer Centre Research Institute, Nagoya, Japan
    Br J Haematol 164:536-45. 2014
    ..Differences in the incidence and trends for specific subtypes also showed a marked contrast across subtypes, which, in turn, may provide significant new insights into disease aetiology in the future...
  59. ncbi request reprint Varenicline is more effective in attenuating weight gain than nicotine patch 12 months after the end of smoking cessation therapy: an observational study in Japan
    Chie Taniguchi
    Department of Nursing, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan Department of Nursing and Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Nicotine Tob Res 16:1026-9. 2014
    ..Although both varenicline and nicotine patch have a beneficial effect in controlling postcessation weight gain, it is not well known whether there is a difference in the effect...
  60. ncbi request reprint Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection
    Shozo Togawa
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Helicobacter 10:172-8. 2005
    ..However, the host genetic factors that influence the progression of gastric atrophy have not been elucidated. In this study, we examined the effects of cytokine polymorphisms on H. pylori-induced gastric atrophy...
  61. pmc Decreasing trend in mortality of chronic myelogenous leukemia patients after introduction of imatinib in Japan and the U.S
    Dai Chihara
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    Oncologist 17:1547-50. 2012
    ..S. using vital statistics data for Japan and data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute for the U.S...
  62. ncbi request reprint Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
    Kenji Wakai
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Epidemiol 21:223-35. 2011
    ..To detect gene-environment interactions in the development of lifestyle-related diseases, and especially cancer, the Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched in 2005...
  63. ncbi request reprint Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma
    Asahi Hishida
    Division of Epidemiology and Prevention, Aichi Cancer Center, Nagoya, Japan
    Haematologica 88:159-66. 2003
    ..We examined the associations between susceptibility to malignant lymphoma and these polymorphisms...
  64. doi request reprint Increase in incidence of adult T-cell leukemia/lymphoma in non-endemic areas of Japan and the United States
    Dai Chihara
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 103:1857-60. 2012
    ..0% [-1.6, 1.7]). This result indicates that the disease has been spread by carriers to non-endemic areas, and suggests the necessity of establishing a standard preventive strategy...
  65. ncbi request reprint Lack of consistency in the associations of Helicobacter pylori seropositivity with Se and Le polymorphisms among Japanese
    Nobuyuki Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Gastric Cancer 5:194-200. 2002
    ....
  66. doi request reprint Cigarette smoking and pancreas cancer risk: an evaluation based on a systematic review of epidemiologic evidence in the Japanese population
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Jpn J Clin Oncol 41:1292-302. 2011
    ..Therefore, we reviewed epidemiologic studies on the association between cigarette smoking and pancreas cancer in the Japanese population...
  67. ncbi request reprint Matrix metalloproteinase-1 polymorphism of promoter region in sarcoidosis and tuberculosis patients
    Shigemitsu Ninomiya
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 21:19-24. 2004
    ..This polymorphism, 1G/2G, has been reported to associate with several malignant tumors and lung diseases. In this study, we investigated whether this polymorphism is associated with sarcoidosis or tuberculosis...
  68. doi request reprint Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour
    Yasuyuki Okamoto
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Gut 61:392-401. 2012
    ..Our aim was to establish epigenetic profiles associated with the malignant transformation of GISTs...
  69. ncbi request reprint [Descriptive epidemiology of myeloid leukemia]
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    Nihon Rinsho 67:1847-51. 2009
    ..Estimated incidence of AML and CML in male and female in Japan are approximately half of those from SEER data in the United State. No clear change in incidence of AML/CML was observed between 1993 and 2002...
  70. pmc Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis
    Hai xing Ju
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Am J Pathol 178:1835-46. 2011
    ..In addition, most methylation status in stage IV CRCs seems to be established before metastasis...
  71. ncbi request reprint Association of XRCC1 Arg399Gln and OGG1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects
    Yoshimitsu Niwa
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 99:43-9. 2005
    ..In this study, genetic polymorphisms, XRCC1 Arg399Gln and OGG1 Ser326Cys were examined with reference to cervical cancer risk in a population-based incident case-control study in Japan...
  72. ncbi request reprint Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents
    Toyoaki Hida
    Department of Internal Medicine, Aichi Cancer Center Hospital, Nagoya 464 8681, Japan
    Clin Cancer Res 8:2443-7. 2002
    ....
  73. pmc TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth
    Makiko Fujii
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    J Exp Med 209:479-94. 2012
    ..These data suggest that CTGF is an important modulator of MM growth and pathology and represents a novel therapeutic target for this disease...
  74. ncbi request reprint Predicting relapse after cessation of Lamivudine monotherapy for chronic hepatitis B virus infection
    Kiyoaki Ito
    Department of Gastroenterology, Chukyo Hospital, Nagoya, Japan
    Clin Infect Dis 38:490-5. 2004
    ..27-0.9). More-prolonged lamivudine therapy is required after seroconversion, and persistent duration of an HBV DNA level of <0.7 log IU/mL for >6 months can more accurately aid in the decision of when to stop lamivudine therapy...
  75. ncbi request reprint Different risk relations with smoking for non-small-cell lung cancer: comparison of TP53 and TP73 genotypes
    Akio Hiraki
    Department of Respiratory Medicine, National Sanyo Hospital, Yamaguchi, Japan
    Asian Pac J Cancer Prev 4:107-12. 2003
    ..The association between TP53/TP73 gene polymorphisms and tobacco smoking was evaluated with regard to risk of non-small cell lung cancer (NSCLC)...
  76. ncbi request reprint Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan
    Chun xia Yang
    Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, China
    Carcinogenesis 26:1285-90. 2005
    ..31 (95% CI, 0.10-0.94), indicating risk with heavy drinking to be 69% decreased in individuals harboring the 677TT genotype. We failed to find any significant interaction between either of the polymorphisms and smoking...
  77. ncbi request reprint Association between smoking habits and tryptophan hydroxylase gene C218A polymorphism among the Japanese population
    Shoichi Mizuno
    Group of Epidemiology and Health Promotion, Tokyo Metropolitan Institute of Gerontology, Japan
    J Epidemiol 14:94-9. 2004
    ..Genes in serotonin system are one of the candidates because of serotonin's role in mood regulation. A polymorphism C218A in intron 7 of the tryptophan hydroxylase (TPH) gene has been hypothesized in relation to smoking predisposition...
  78. ncbi request reprint Comparison of lifestyle risk factors by family history for gastric, breast, lung and colorectal cancer
    Xin En Huang
    Department of Chemotherapy, Jiangsu Cancer Hospital and Research Institute, Nanjing 210009, China
    Asian Pac J Cancer Prev 5:419-27. 2004
    ..Habitual smoking increased, while frequent physical exercise and raw vegetables intake decreased cancer risk, regardless of the CFH status...
  79. ncbi request reprint Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase beta subunit (ADH2) and aldehyde dehydrogenase 2 (ALDH2)
    Akiko Tamakoshi
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Alcohol Alcohol 38:407-10. 2003
    ....
  80. ncbi request reprint A pilot study on genotype announcement to induce smoking cessation by Japanese smokers
    Nobuyuki Hamajima
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550 Japan
    Asian Pac J Cancer Prev 5:409-13. 2004
    ..Genotype announcements related to susceptibility to hazardous effects of smoking may be effective to induce smoking cessation...