Yoshiki Akatsuka

Summary

Affiliation: Aichi Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling
    Yoshiki Akatsuka
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Br J Haematol 123:671-5. 2003
  2. ncbi request reprint Minor histocompatibility antigens as targets for immunotherapy using allogeneic immune reactions
    Yoshiki Akatsuka
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya 464 8681, Japan
    Cancer Sci 98:1139-46. 2007
  3. ncbi request reprint Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest
    Yoshiki Akatsuka
    Division of Immunology, Aichi Cancer Center, Nagoya, Aichi, Japan
    Transplantation 74:1773-80. 2002
  4. pmc Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens
    Yoshiki Akatsuka
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Exp Med 197:1489-500. 2003
  5. ncbi request reprint Epstein-Barr virus (EBV) latent membrane protein-1-specific cytotoxic T lymphocytes targeting EBV-carrying natural killer cell malignancies
    Ayako Demachi-Okamura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Eur J Immunol 36:593-602. 2006
  6. ncbi request reprint Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles
    Eisei Kondo
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Blood 103:630-8. 2004
  7. pmc Three immunoproteasome-associated subunits cooperatively generate a cytotoxic T-lymphocyte epitope of Epstein-Barr virus LMP2A by overcoming specific structures resistant to epitope liberation
    Yoshinori Ito
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Virol 80:883-90. 2006
  8. ncbi request reprint Full-length EBNA1 mRNA-transduced dendritic cells stimulate cytotoxic T lymphocytes recognizing a novel HLA-Cw*0303- and -Cw*0304-restricted epitope on EBNA1-expressing cells
    Yoshinori Ito
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Gen Virol 88:770-80. 2007
  9. doi request reprint Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: application for allogeneic transplantation
    Hiroki Torikai
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Hematol 87:467-73. 2008
  10. ncbi request reprint Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant
    Tetsuya Nishida
    Division of Immunology, Aichi Cancer Centre Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Br J Haematol 124:629-35. 2004

Detail Information

Publications46

  1. ncbi request reprint Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling
    Yoshiki Akatsuka
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Br J Haematol 123:671-5. 2003
    ..These data suggest that the increased risk of acute GVHD associated with recipient HA-8 disparity was not sufficient to change other clinical outcomes...
  2. ncbi request reprint Minor histocompatibility antigens as targets for immunotherapy using allogeneic immune reactions
    Yoshiki Akatsuka
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya 464 8681, Japan
    Cancer Sci 98:1139-46. 2007
    ....
  3. ncbi request reprint Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest
    Yoshiki Akatsuka
    Division of Immunology, Aichi Cancer Center, Nagoya, Aichi, Japan
    Transplantation 74:1773-80. 2002
    ..In this report, we describe a new approach that permits both direct visualization of CD8 T-cell responses to mHAgs and cloning of T cells reacting with mHAgs presented by individual HLA alleles of interest...
  4. pmc Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens
    Yoshiki Akatsuka
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Exp Med 197:1489-500. 2003
    ..Minigene transfection and epitope reconstitution assays with synthetic peptides identified both HLA-A*2402- and B*4403-restricted mHAg epitopes to be encoded by distinct polymorphisms within BCL2A1...
  5. ncbi request reprint Epstein-Barr virus (EBV) latent membrane protein-1-specific cytotoxic T lymphocytes targeting EBV-carrying natural killer cell malignancies
    Ayako Demachi-Okamura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Eur J Immunol 36:593-602. 2006
    ..Overall, these data suggest that immunotherapy targeting LMP1 in EBV-associated NK lymphomas and CAEBV might serve as an alternative treatment modality...
  6. ncbi request reprint Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles
    Eisei Kondo
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Blood 103:630-8. 2004
    ..The study thus demonstrated an efficient strategy for identifying CTL epitopes presented by a variety of HLA alleles...
  7. pmc Three immunoproteasome-associated subunits cooperatively generate a cytotoxic T-lymphocyte epitope of Epstein-Barr virus LMP2A by overcoming specific structures resistant to epitope liberation
    Yoshinori Ito
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Virol 80:883-90. 2006
    ....
  8. ncbi request reprint Full-length EBNA1 mRNA-transduced dendritic cells stimulate cytotoxic T lymphocytes recognizing a novel HLA-Cw*0303- and -Cw*0304-restricted epitope on EBNA1-expressing cells
    Yoshinori Ito
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Gen Virol 88:770-80. 2007
    ..These data demonstrate that EBNA1 mRNA-transduced DCs may be useful tools for inducing EBNA1-specific CTLs that might be of clinical interest for CTL therapy of EBV-associated malignancies...
  9. doi request reprint Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: application for allogeneic transplantation
    Hiroki Torikai
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Hematol 87:467-73. 2008
    ....
  10. ncbi request reprint Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant
    Tetsuya Nishida
    Division of Immunology, Aichi Cancer Centre Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Br J Haematol 124:629-35. 2004
    ..These data suggest that disparity of haematopoietic cell-specific mHA, ACC-1, is unlikely at least to augment GVHD, and that T cells specific for ACC-1 may also be used for immunotherapy of recurring leukaemia without GVHD...
  11. doi request reprint Epstein-Barr virus nuclear antigen 1-specific CD4+ T cells directly kill Epstein-Barr virus-carrying natural killer and T cells
    Ayako Demachi-Okamura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 99:1633-42. 2008
    ....
  12. pmc Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens
    Edus H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 115:3869-78. 2010
    ..This study has been registered at http://clinicaltrials.gov as NCT00107354...
  13. ncbi request reprint Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402-restricted Epstein-Barr virus-specific CD8+ T cells
    Kiyotaka Kuzushima
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 101:1460-8. 2003
    ..In conclusion, the 3 epitopes thus defined could be useful for studying EBV-specific CD8(+) T-cell responses among populations positive for HLA A*2402...
  14. pmc HapMap scanning of novel human minor histocompatibility antigens
    Michi Kamei
    Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 113:5041-8. 2009
    ..The HapMap data set represents an invaluable resource for investigating human variation, with obvious applications in genetic mapping of clinically relevant human traits...
  15. ncbi request reprint Characterization of murine CD160+ CD8+ T lymphocytes
    Kunio Tsujimura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Immunol Lett 106:48-56. 2006
    ..These results together show that CD160 is expressed on the majority of CD8(+) memory T cells as well as recently activated CD8(+) T cells...
  16. doi request reprint Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA
    Takakazu Kawase
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 111:3286-94. 2008
    ..Thus, once CTL clones are generated, this method should substantially facilitate discovery of minor H antigens applicable to targeted allo-immune therapies and also contribute to our understanding of human allo-immunity...
  17. ncbi request reprint Identification of an HLA-A24-restricted cytotoxic T lymphocyte epitope from human papillomavirus type-16 E6: the combined effects of bortezomib and interferon-gamma on the presentation of a cryptic epitope
    Satoko Morishima
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 120:594-604. 2007
    ..Thus, these findings together indicate that E6(49-57) is a candidate epitope for immunotherapy and immunological monitoring of such patients...
  18. ncbi request reprint A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene
    Hiroki Torikai
    Division of Immunology, Aichi Cancer Center Research Institute, Aichi Cancer Center Hospital, Nagoya, Japan
    J Immunol 173:7046-54. 2004
    ..This finding underscores the in vivo immunological relevance of minor histocompatibility Ags derived from unconventional open reading frame products...
  19. ncbi request reprint Interferon-gamma differentially regulates susceptibility of lung cancer cells to telomerase-specific cytotoxic T lymphocytes
    Kouhei Tajima
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 110:403-12. 2004
    ....
  20. ncbi request reprint Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen
    Takakazu Kawase
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Blood 110:1055-63. 2007
    ..These findings suggest that the HMSD-v-encoded mHA (designated ACC-6) could serve as a target antigen for immunotherapy against hematologic malignancies...
  21. ncbi request reprint A UGT2B17-positive donor is a risk factor for higher transplant-related mortality and lower survival after bone marrow transplantation
    Seitaro Terakura
    Department of Haematology, Nagoya University Graduate School of Medicine, Aichi, Japan
    Br J Haematol 129:221-8. 2005
    ..Thus, the enzyme function of UGT2B17 in donor cells may affect the outcome of allogeneic HSCT...
  22. pmc DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells
    Kellie V Rosinski
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 111:4817-26. 2008
    ..This study is registered at http://clinicaltrials.gov as NCT00107354...
  23. ncbi request reprint Potential limitations in using minor histocompatibility antigen-specific cytotoxic T cells for targeting solid tumor cells
    Mikinori Miyazaki
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Clin Immunol 107:198-201. 2003
    ..However, impaired antigen processing and presentation observed in this study may result in escape from CTL recognition in vivo, as well as in vitro, as observed in this study...
  24. ncbi request reprint Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor
    Yasuo Morishima
    Aichi Cancer Center Hospital, Department of Hematology and Cell Therapy, Nagoya, Japan
    Biol Blood Marrow Transplant 13:315-28. 2007
    ..Furthermore, KIR-L-MM induced adverse effects on acute GVHD (aGVHD) and rejection, and brought no survival benefits to patients with T-cell-replete UR-BMT...
  25. ncbi request reprint Thymus leukemia antigen (TL)-specific cytotoxic T lymphocytes recognize the alpha1/alpha2 domain of TL free from antigenic peptides
    Kunio Tsujimura
    Division of Immunology, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int Immunol 15:1319-26. 2003
    ....
  26. doi request reprint Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation
    Itzel Bustos Villalobos
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Blood 115:3158-61. 2010
    ..Accordingly, the status of mismatched HLA on relapsed leukemic cells should be checked before donor lymphocyte infusion...
  27. pmc The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene
    Hiroki Isomura
    Division of Virology, Aichi Cancer Center Research Institute, Kanokoden, Nagoya, Japan
    PLoS ONE 5:e11901. 2010
    ..UL76 and UL77 are cistons on the same viral mRNA and a conventional 5' mRNA for UL77 has not been detected. The vast majority of eukaryotic mRNAs are monocistronic, i.e., they encode only a single protein...
  28. ncbi request reprint The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma
    Takashi Ishida
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
    Clin Cancer Res 10:7529-39. 2004
    ....
  29. pmc Autophagy creates a CTL epitope that mimics tumor-associated antigens
    Ayako Demachi-Okamura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    PLoS ONE 7:e47126. 2012
    ..Therefore, ubiquitously expressed proteins may be sources of specific tumor-associated antigens when processed through a unique mechanism involving autophagy...
  30. ncbi request reprint Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea
    Kunio Tsujimura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya 464 8681
    Cancer Sci 95:914-9. 2004
    ....
  31. doi request reprint Mismatched human leukocyte antigen class II-restricted CD8⁺ cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation
    Tomoya Hirosawa
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 102:1281-6. 2011
    ..These findings underscore unexpectedly significant CD8 T cell responses in the context of HLA class II...
  32. doi request reprint Identification of a human leukocyte antigen-A24-restricted T-cell epitope derived from interleukin-13 receptor alpha2 chain, a glioma-associated antigen
    Shinji Shimato
    Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan
    J Neurosurg 109:117-22. 2008
    ..In this study, the authors first investigated the suitability of IL-13Ralpha2 as a target antigen of malignant glioma cells, and then identified a potential HLA-A24-restricted peptide derived from IL-13Ralpha2...
  33. ncbi request reprint Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells
    Eisei Kondo
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Immunol 169:2164-71. 2002
    ..ELISPOT assays revealed that the CTL lines used multiple HLA alleles as restricting elements. Thus, CD40-B cells transduced retrovirally with Ag-encoding cDNA can be potent APC and facilitate to generate Ag-specific CTL in vitro...
  34. ncbi request reprint [Antigen-specific allogeneic immunotherapy--selective augmentation of GVL effects]
    Yoshiki Akatsuka
    Division of Immunology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
    Gan To Kagaku Ryoho 35:713-9. 2008
    ..Here, current and future strategies to selectively enhance GVL effects without inducing detrimental GVHD will be discussed in parallel with their background information and basic concepts...
  35. pmc Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production
    Max S Topp
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Exp Med 198:947-55. 2003
    ....
  36. pmc Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen
    Sebastian Ochsenreither
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 119:5492-501. 2012
    ..The pro-oncogenic activity, high expression levels, and multitude of immunogenic epitopes make it a viable target for pursuing T cell-based therapy approaches...
  37. ncbi request reprint Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response
    Helen P Mutimer
    Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Infect Dis 186:701-5. 2002
    ..These results imply that reconstitution of CMV-specific T cells plays a role in IRU and suggest that the specificity of T cells engaged in the control of CMV at local sites of reactivation may be broad...
  38. doi request reprint An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules
    Shinji Kondo
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan Department of Gynecology, Graduate School of Medicine, Nagoya 466 8550, Japan
    Hum Immunol 74:1103-10. 2013
    ..Our data indicate that HLA-modified cancer cells can be used as an artificial antigen-presenting cell to generate antigen-specific CTLs in a manner restricted by an HLA allele of interest. ..
  39. pmc Recovery from and consequences of severe iatrogenic lymphopenia (induced to treat autoimmune diseases)
    Jan Storek
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109 1024, USA
    Clin Immunol 113:285-98. 2004
    ..In conclusion, peripheral expansion of CD8 but not CD4 T cells is highly efficient. Prolonged CD4 lymphopenia is associated with relatively few infections, possibly due to antibodies produced by persisting pretransplant plasma cells...
  40. ncbi request reprint [Possibility of selective induction of a GVL effect without increasing GVHD]
    Yoshiki Akatsuka
    Rinsho Ketsueki 49:607-15. 2008
  41. ncbi request reprint The Fifth Nagoya International Blood And Marrow Transplantation Symposium: unlimited possibilities of hematopoietic cell transplantation: lessons from the past and prospects for the future
    Hikaru Nakajima
    Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA
    Int J Hematol 79:200-4. 2004
    ....
  42. ncbi request reprint [Role of minor histocompatibility antigens in hematopoietic cell transplantation]
    Yoshiki Akatsuka
    Rinsho Ketsueki 47:1353-63. 2006
  43. ncbi request reprint Generation of peptide-specific CD8+ T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4+ T cells
    Hiroaki Naota
    Second Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Immunol Methods 314:54-66. 2006
    ..Messenger RNA-transduced CD4(+) PHA blasts are thus useful antigen presenting cells for analysis of CD8(+) T cell responses and induction of specific T cells for potential immunotherapy...
  44. ncbi request reprint Bone marrow may be a reservoir of long-lived memory T cells specific for minor histocompatibility antigen
    Yoshiki Akatsuka
    Br J Haematol 135:413-4. 2006
  45. doi request reprint CD16+ CD56- NK cells in the peripheral blood of cord blood transplant recipients: a unique subset of NK cells possibly associated with graft-versus-leukemia effect
    Xuzhang Lu
    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Eur J Haematol 81:18-25. 2008
    ....
  46. ncbi request reprint [Principal and perspective of adoptive immuno-cell therapy for hematological malignancies]
    Yoshiki Akatsuka
    Rinsho Ketsueki 48:1328-38. 2007