Hiroshi Abe

Summary

Country: Japan

Publications

  1. doi An intracellular buildup reaction of active siRNA species from short RNA fragments
    Hideto Maruyama
    Nano Medical Engineering Laboratory, RIKEN, 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Chem Commun (Camb) 50:1284-7. 2014
  2. doi Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference
    Naoko Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, Wako Shi, Saitama, Japan
    Bioconjug Chem 22:2082-92. 2011
  3. ncbi Very rapid DNA-templated reaction for efficient signal amplification and its steady-state kinetic analysis of the turnover cycle
    Aya Shibata
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Am Chem Soc 135:14172-8. 2013
  4. doi Rolling circle amplification in a prokaryotic translation system using small circular RNA
    Naoko Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198 Japan
    Angew Chem Int Ed Engl 52:7004-8. 2013
  5. doi Detection of pre-mRNA splicing in vitro by an RNA-templated fluorogenic reaction
    Yasutsugu Tamura
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Insutitute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 22:7248-51. 2012
  6. doi Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions
    Aya Shibata
    Nano Medical Engineering Laboratory, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Analyst 138:7326-30. 2013
  7. doi Long-lived luminogenic probe for detection of RNA in a crude solution of living bacterial cells
    Hisao Saneyoshi
    Nano Medical Engineering Laboratory, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Am Chem Soc 135:13632-5. 2013
  8. doi Structure formation and catalytic activity of DNA dissolved in organic solvents
    Hiroshi Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Angew Chem Int Ed Engl 51:6475-9. 2012
  9. doi Synthesis of dumbbell-shaped cyclic RNAs for RNA interference
    Naoko Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, Saitama, Japan
    Curr Protoc Nucleic Acid Chem . 2012
  10. doi Cationic cholesterol-modified gelatin as an in vitro siRNA delivery vehicle
    Pallavi Ananda Kadengodlu
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wakoshi, Saitama 351 0198, Japan
    Mol Biosyst 9:965-8. 2013

Collaborators

Detail Information

Publications27

  1. doi An intracellular buildup reaction of active siRNA species from short RNA fragments
    Hideto Maruyama
    Nano Medical Engineering Laboratory, RIKEN, 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Chem Commun (Camb) 50:1284-7. 2014
    ..This strategy could decrease undesired immune responses and provide more latitude for RNAi technology in the design and concentration of introduced RNA compared to traditional siRNA methods. ..
  2. doi Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference
    Naoko Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, Wako Shi, Saitama, Japan
    Bioconjug Chem 22:2082-92. 2011
    ..We conclude that an RNA dumbbell with DNA loops is the most promising design for in vivo applications for RNA medicine...
  3. ncbi Very rapid DNA-templated reaction for efficient signal amplification and its steady-state kinetic analysis of the turnover cycle
    Aya Shibata
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Am Chem Soc 135:14172-8. 2013
    ..With maximized turnover efficiency, it was demonstrated that the probe could offer a high turnover number of 1500 times to enable sensitive levels of detection with a detection limit of 0.5 pM in the catalytic templated reactions. ..
  4. doi Rolling circle amplification in a prokaryotic translation system using small circular RNA
    Naoko Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198 Japan
    Angew Chem Int Ed Engl 52:7004-8. 2013
    ....
  5. doi Detection of pre-mRNA splicing in vitro by an RNA-templated fluorogenic reaction
    Yasutsugu Tamura
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Insutitute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 22:7248-51. 2012
    ..Also, we successfully applied RETF probes to the detection of emerging mature mRNA in an in vitro splicing process...
  6. doi Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions
    Aya Shibata
    Nano Medical Engineering Laboratory, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Analyst 138:7326-30. 2013
    ....
  7. doi Long-lived luminogenic probe for detection of RNA in a crude solution of living bacterial cells
    Hisao Saneyoshi
    Nano Medical Engineering Laboratory, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Am Chem Soc 135:13632-5. 2013
    ..Target DNA/RNA-assisted time-gated luminescence analysis is a powerful tool for elimination of autofluorescence and detection of target RNA in living bacterial cells. ..
  8. doi Structure formation and catalytic activity of DNA dissolved in organic solvents
    Hiroshi Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Angew Chem Int Ed Engl 51:6475-9. 2012
    ..A complex containing iron(III) protoporphyrin IX (hemin) and G-quadruplex-forming PEG-DNA catalyzed an oxidative reaction in methanol (see scheme)...
  9. doi Synthesis of dumbbell-shaped cyclic RNAs for RNA interference
    Naoko Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, Saitama, Japan
    Curr Protoc Nucleic Acid Chem . 2012
    ..In this unit, we describe the synthesis of RNA dumbbells from the design, its enzymatic synthesis, and to the purification...
  10. doi Cationic cholesterol-modified gelatin as an in vitro siRNA delivery vehicle
    Pallavi Ananda Kadengodlu
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wakoshi, Saitama 351 0198, Japan
    Mol Biosyst 9:965-8. 2013
    ..It was found that the polymeric micelle exhibited excellent stability and increased the biological stability of the siRNA in serum...
  11. ncbi An epidermal growth factor derivative with binding affinity for hydroxyapatite and titanium surfaces
    Jeonghwa Kang
    Nano Medical Engineering Laboratory, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan Department of Biological Sciences, Tokyo Metropolitan University, 1 1 Minami Osawa, Tokyo 192 0397, Japan
    Biomaterials 34:9747-53. 2013
    ..In conclusion, the modified EGF had significantly higher binding affinity for apatite and titanium than soluble EGF, and the bound EGF significantly enhanced cell growth by long-lasting activation of intracellular signal transduction. ..
  12. doi Triphenylphosphinecarboxamide: an effective reagent for the reduction of azides and its application to nucleic acid detection
    Hisao Saneyoshi
    Nano Medical Engineering Laboratory, RIKEN, 2 1, Hirosawa, Wako, Saitama 351 0198, Japan
    Org Lett 16:30-3. 2014
    ..The TPPc derivatives were also applied to nucleic acid sensing using a RhAz-oligonucleotide conjugate in a DNA-templated fluorogenic reaction. ..
  13. doi Branched RNA nanostructures for RNA interference
    Yuko Nakashima
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Chem Commun (Camb) 47:8367-9. 2011
    ..Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days...
  14. doi RNA-templated molecule release induced protein expression in bacterial cells
    Aya Shibata
    Nano Medical Engineering Laboratory, Advance Science Institute, RIKEN, 2 1, Hirosawa, Wako, Saitama 351 0198, Japan
    Chem Commun (Camb) 49:270-2. 2013
    ..The releasing system, which was triggered by the reduction of an azidomethyl group, was successfully applied to protein expression induced by the release of IPTG triggered by endogenous RNA in bacterial cells...
  15. doi Sustained delivery of siRNA from dopamine-coated stainless steel surfaces
    Binata Joddar
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, Wako Shi, Saitama, Japan
    Acta Biomater 9:6753-61. 2013
    ..Therefore, this method of surface immobilization of siRNA onto dopamine-coated surfaces might be effective for nucleic acid delivery from stents...
  16. doi In vitro selection of a photo-responsive peptide aptamer using ribosome display
    Mingzhe Liu
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Chem Commun (Camb) 48:11871-3. 2012
    ..This is the first example of the introduction of a peptide aptamer in the photo-control of dynamic molecular recognition...
  17. pmc Positively charged cholesterol-recombinant human gelatins foster the cellular uptake of proteins and murine immune reactions
    Pallavi A Kadengodlu
    Nano Medical Engineering Laboratory, RIKEN Advance Science Institute, Wako, Saitama, Japan
    Int J Nanomedicine 7:5437-50. 2012
    ..The aim of this study was to synthesize novel and effective compounds for vaccine delivery in vivo...
  18. ncbi Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to (19) F NMR and Bioluminogenic Probes
    Mika Ito
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198 Japan Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo shi, Hokkaido 060 0812 Japan
    Chembiochem 13:1428-32. 2012
    ..We describe the design of (19) F NMR and bioluminescence probes of GST activity by using the universal caging group. The probes were successfully applied in vitro and in living cells...
  19. doi One-Pot Ring-Closing Metathesis/1,3-Dipolar Cycloaddition through Assisted Tandem Ruthenium Catalysis: Synthesis of a Dye with Isoindolo[2,1-a]quinoline Structure
    Mitsuhiro Arisawa
    Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812 Japan Rigaku Corporation, X ray Research Laboratory, 3 9 12 Matsubara cho, Akishima, Tokyo 196 8666 Japan Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama 351 0198 Japan
    Angew Chem Int Ed Engl 52:1003-7. 2013
    ..This reaction offers a new synthetic method for π-conjugated small molecules from simple aniline derivatives...
  20. doi Transmembrane molecular transport through nanopores formed by protein nanotubes
    Baiju G Nair
    Nano Medical Engineering Laboratory, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Chem Commun (Camb) 50:602-4. 2014
    ..Protein nanotubes formed by layer-by-layer (LbL) assembly can penetrate cells and act as nanopores for direct transmembrane delivery of chemical compounds. ..
  21. doi Polycation-assisted DNA detection by reduction triggered fluorescence amplification probe
    Hisao Saneyoshi
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako, Saitama 351 0198, Japan Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 23:6851-3. 2013
    ..The method described herein represents a simple and enzyme-free detection. ..
  22. doi Fluorescence detection of intron lariat RNA with reduction-triggered fluorescent probes
    Kazuhiro Furukawa
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1, Hirosawa, Wako Shi, Saitama, 351 0198 Japan Department of Life Science and Medical Bio Science, Waseda University, 2 2, Wakamatsu cho, Shinjuku ku, Tokyo 162 8480 Japan Department of Molecular, Cellular, and Developmental Biology, Yale University
    Angew Chem Int Ed Engl 50:12020-3. 2011
    ..The chemical reaction between the two substrates leads to the formation of unquenched fluorescein and the emission of a fluorescence signal. Prelariat and lariat structures can be distinguished by using this method...
  23. ncbi [Nanostructured RNA for RNA interference]
    Hiroshi Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, Japan
    Yakugaku Zasshi 133:373-8. 2013
    ..Consequently, dumbbell or branched design offered prolonged RNAi effect due to high biological stability...
  24. ncbi Automatic pseudorotaxane formation targeting on nucleic acids using a pair of reactive oligodeoxynucleotides
    Kazumitsu Onizuka
    Nano Medical Engineering Laboratory, RIKEN, 2 1, Hirosawa, Wako, Saitama 351 0198, Japan
    J Am Chem Soc 136:7201-4. 2014
    ..This new pseudorotaxane formation represents a promising method for developing new DNA nanotechnologies and antisense oligonucleotides. ..
  25. doi Oligonucleotide-templated reactions for sensing nucleic acids
    Aya Shibata
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute 2 1, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Molecules 17:2446-63. 2012
    ..Major scientific interests are focused on the development of signal amplification systems and signal generation systems. We introduce the recent advances of oligonucleotide-templated reaction in consideration of the above two points...
  26. doi PEGylated antibody in organic media
    Mingzhe Liu
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, Wako Shi, Saitama, Japan
    J Biosci Bioeng 111:564-8. 2011
    ..In conclusion, PEGylated antibodies can be employed as analytical tools for water-insoluble analytes...
  27. doi Synthesis and characterization of small circular double-stranded RNAs
    Naoko Abe
    Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Chem Commun (Camb) 47:2125-7. 2011
    ..The structural analysis by atomic force microscopy gave direct images for the interpretation of the structural strain present in circular dsRNAs. Finally, we demonstrated that circular dsRNA caused RNAi effect in cells...