Christopher Janson

Summary

Publications

  1. ncbi request reprint Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI
    C G Janson
    UMDNJ Robert Wood Johnson Medical School, Dept of Neurosurgery, Camden, NJ 08103, USA
    Neuropediatrics 37:209-21. 2006
  2. ncbi request reprint Essay: White daisies on my mind (Requiem for an Alzheimer patient)
    C G Janson
    UMDNJ Robert Wood Johnson Medical School, Camden, NJ 08103, USA
    Neurology 65:654-6. 2005
  3. doi request reprint Immortalization and functional characterization of rat arachnoid cell lines
    C Janson
    Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroscience 177:23-34. 2011
  4. doi request reprint Bowstringing as a complication of deep brain stimulation: case report
    Christopher Janson
    Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Neurosurgery 66:E1205; discussion E1205. 2010
  5. ncbi request reprint Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene
    Christopher G Janson
    Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Camden, NJ, USA
    Ann Neurol 59:428-31. 2006
  6. doi request reprint Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease
    Mitra Assadi
    Robert Wood Johnson Medical School, Neurology, 3 Cooper Plaza, Suite 320, Camden, NJ 08103, USA
    Eur J Paediatr Neurol 14:354-9. 2010
  7. ncbi request reprint Serial 1H-MRS in GM2 gangliosidoses
    Mitra Assadi
    Division of Neurology, University of Medicine and Dentistry of New Jersey, 3 Cooper Plaza, Suite 320, Camden, NJ 08103, USA
    Eur J Pediatr 167:347-52. 2008
  8. ncbi request reprint Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease
    S W J McPhee
    Cell and Gene Therapy Center, UMDNJ Robert Wood Johnson Medical School, 401 Haddon Avenue, Suite 395, Camden, NJ 08103, USA
    Brain Res Mol Brain Res 135:112-21. 2005
  9. ncbi request reprint Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease
    P Leone
    CNS Gene Therapy Center, Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Opin Mol Ther 1:487-92. 1999
  10. ncbi request reprint Immune responses to AAV in a phase I study for Canavan disease
    S W J McPhee
    Department of Surgery, Division of Neurosurgery, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 401 Haddon Avenue, Camden, NJ 08103, USA
    J Gene Med 8:577-88. 2006

Detail Information

Publications10

  1. ncbi request reprint Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI
    C G Janson
    UMDNJ Robert Wood Johnson Medical School, Dept of Neurosurgery, Camden, NJ 08103, USA
    Neuropediatrics 37:209-21. 2006
    ..The resultant model can be used to non-invasively monitor the natural history of Canavan disease or related leukodystrophies in future studies involving drug, gene therapy, or stem cell treatments...
  2. ncbi request reprint Essay: White daisies on my mind (Requiem for an Alzheimer patient)
    C G Janson
    UMDNJ Robert Wood Johnson Medical School, Camden, NJ 08103, USA
    Neurology 65:654-6. 2005
  3. doi request reprint Immortalization and functional characterization of rat arachnoid cell lines
    C Janson
    Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroscience 177:23-34. 2011
    ....
  4. doi request reprint Bowstringing as a complication of deep brain stimulation: case report
    Christopher Janson
    Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Neurosurgery 66:E1205; discussion E1205. 2010
    ..There are no previous reports of this specific complication, which presumably has been more broadly classified under hardware-related complications...
  5. ncbi request reprint Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene
    Christopher G Janson
    Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Camden, NJ, USA
    Ann Neurol 59:428-31. 2006
    ..Future studies of ASPA enzyme structure and gene regulation in these subjects could lead to a better understanding of Canavan's pathophysiology and improvements in ASPA gene therapy...
  6. doi request reprint Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease
    Mitra Assadi
    Robert Wood Johnson Medical School, Neurology, 3 Cooper Plaza, Suite 320, Camden, NJ 08103, USA
    Eur J Paediatr Neurol 14:354-9. 2010
    ..Diffusion Tensor Imaging was available in two patients and suggested micro-structural improvement in the corpus callosum. The results suggest that lithium administration may be beneficial in patients with Canavan disease...
  7. ncbi request reprint Serial 1H-MRS in GM2 gangliosidoses
    Mitra Assadi
    Division of Neurology, University of Medicine and Dentistry of New Jersey, 3 Cooper Plaza, Suite 320, Camden, NJ 08103, USA
    Eur J Pediatr 167:347-52. 2008
    ..1H-MRS may be a valuable tool in monitoring the disease progress and response to therapy in GM2 gangliosidoses. Elevation in the mI may prove to be more sensitive than the other metabolite alterations...
  8. ncbi request reprint Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease
    S W J McPhee
    Cell and Gene Therapy Center, UMDNJ Robert Wood Johnson Medical School, 401 Haddon Avenue, Suite 395, Camden, NJ 08103, USA
    Brain Res Mol Brain Res 135:112-21. 2005
    ..This study provides evidence that AAV-2-mediated aspartoacylase gene transfer to the brain improves biochemical and behavioral deficits in tremor rat mutants (tm/tm) and supports the rationale of human gene transfer for Canavan disease...
  9. ncbi request reprint Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease
    P Leone
    CNS Gene Therapy Center, Department of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Curr Opin Mol Ther 1:487-92. 1999
    ....
  10. ncbi request reprint Immune responses to AAV in a phase I study for Canavan disease
    S W J McPhee
    Department of Surgery, Division of Neurosurgery, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 401 Haddon Avenue, Camden, NJ 08103, USA
    J Gene Med 8:577-88. 2006
    ..rAAV-ASPA has been developed for gene delivery to the central nervous system (CNS) for Canavan disease. This study represents the first use of a viral vector in an attempt to ameliorate a neurodegenerative disorder...