Genomes and Genes


Anne F M Jansen



  1. Jansen A, Dinkla A, Roest H, Bleeker Rovers C, Schoffelen T, Joosten L, et al. Viable Coxiella burnetii Induces Differential Cytokine Responses in Chronic Q Fever Patients Compared to Heat-Killed Coxiella burnetii. Infect Immun. 2018;86: pubmed publisher
    ..burnetii should be interpreted with caution for innate cytokines, but heat-killed C. burnetii-induced adaptive cytokine production is representative of stimulation with viable bacteria. ..
  2. Jansen A, Schoffelen T, Bleeker Rovers C, Wever P, Jaeger M, Oosting M, et al. Genetic variations in innate immunity genes affect response to Coxiella burnetii and are associated with susceptibility to chronic Q fever. Clin Microbiol Infect. 2019;25:631.e11-631.e15 pubmed publisher
    ..RAB7A (rs13081864) and P2RX7 (rs3751143) are associated with the development of chronic Q fever, whereas RAB5A (rs8682), P2RX7 (rs1718119), MAP1LC3A (rs1040747) and ATG5 (rs2245214) may have protective effects. ..
  3. Raijmakers R, Koeken V, Jansen A, Keijmel S, Roerink M, Joosten L, et al. Cytokine profiles in patients with Q fever fatigue syndrome. J Infect. 2019;78:349-357 pubmed publisher
  4. Jansen A, Raijmakers R, Keijmel S, van der Molen R, Vervoort G, Van der Meer J, et al. Autoimmunity and B-cell dyscrasia in acute and chronic Q fever: A review of the literature. Eur J Intern Med. 2018;54:6-12 pubmed publisher
    ..We conclude that immunological (epi)phenomena are not rare during Q fever and may obscure the infectious etiology of the disease. ..
  5. Jansen A, van Deuren M, Miller J, Litzman J, De Gracia J, Sáenz Cuesta M, et al. Prognosis of Good syndrome: mortality and morbidity of thymoma associated immunodeficiency in perspective. Clin Immunol. 2016;171:12-17 pubmed publisher
    ..008). In this cohort survival was not associated with gender (HR 0.9, 95% CI 0.3-3.0), autoimmune diseases (HR 2.9, 95% CI 0.8-10.1) or immunosuppressive use (HR 0.3, 95% CI: 0.1-1.2). ..
  6. Jansen A, Schoffelen T, Textoris J, Mege J, Bleeker Rovers C, Roest H, et al. Involvement of matrix metalloproteinases in chronic Q fever. Clin Microbiol Infect. 2017;23:487.e7-487.e13 pubmed publisher
    ..5 ng/mL, interquartile range 22.3-45.7 ng/mL) than controls (20.6 ng/mL, 15.9-33.8 ng/mL). Coxiella burnetii-induced MMP production may contribute to the development of chronic Q fever. ..
  7. Jansen A, Schoffelen T, Textoris J, Mege J, Nabuurs Franssen M, Raijmakers R, et al. CXCL9, a promising biomarker in the diagnosis of chronic Q fever. BMC Infect Dis. 2017;17:556 pubmed publisher
    ..CXCL9 protein, measured in serum or as C. burnetii stimulated production, is a promising biomarker for the diagnosis of chronic Q fever. ..