Anne F M Jansen
Jansen A, Dinkla A, Roest H, Bleeker Rovers C, Schoffelen T, Joosten L, et al
. Viable Coxiella burnetii Induces Differential Cytokine Responses in Chronic Q Fever Patients Compared to Heat-Killed Coxiella burnetii. Infect Immun. 2018;86: pubmed publisher
..burnetii should be interpreted with caution for innate cytokines, but heat-killed C. burnetii-induced adaptive cytokine production is representative of stimulation with viable bacteria. ..
Jansen A, Schoffelen T, Bleeker Rovers C, Wever P, Jaeger M, Oosting M, et al
. Genetic variations in innate immunity genes affect response to Coxiella burnetii and are associated with susceptibility to chronic Q fever. Clin Microbiol Infect. 2019;25:631.e11-631.e15 pubmed publisher
..RAB7A (rs13081864) and P2RX7 (rs3751143) are associated with the development of chronic Q fever, whereas RAB5A (rs8682), P2RX7 (rs1718119), MAP1LC3A (rs1040747) and ATG5 (rs2245214) may have protective effects. ..
Raijmakers R, Koeken V, Jansen A, Keijmel S, Roerink M, Joosten L, et al
. Cytokine profiles in patients with Q fever fatigue syndrome. J Infect. 2019;78:349-357 pubmed publisher
Jansen A, Raijmakers R, Keijmel S, van der Molen R, Vervoort G, Van der Meer J, et al
. Autoimmunity and B-cell dyscrasia in acute and chronic Q fever: A review of the literature. Eur J Intern Med. 2018;54:6-12 pubmed publisher
..We conclude that immunological (epi)phenomena are not rare during Q fever and may obscure the infectious etiology of the disease. ..
Jansen A, van Deuren M, Miller J, Litzman J, De Gracia J, Sáenz Cuesta M, et al
. Prognosis of Good syndrome: mortality and morbidity of thymoma associated immunodeficiency in perspective. Clin Immunol. 2016;171:12-17 pubmed publisher
..008). In this cohort survival was not associated with gender (HR 0.9, 95% CI 0.3-3.0), autoimmune diseases (HR 2.9, 95% CI 0.8-10.1) or immunosuppressive use (HR 0.3, 95% CI: 0.1-1.2). ..
Jansen A, Schoffelen T, Textoris J, Mege J, Bleeker Rovers C, Roest H, et al
. Involvement of matrix metalloproteinases in chronic Q fever. Clin Microbiol Infect. 2017;23:487.e7-487.e13 pubmed publisher
..5Â ng/mL, interquartile range 22.3-45.7Â ng/mL) than controls (20.6Â ng/mL, 15.9-33.8Â ng/mL). Coxiella burnetii-induced MMP production may contribute to the development of chronic Q fever. ..
Jansen A, Schoffelen T, Textoris J, Mege J, Nabuurs Franssen M, Raijmakers R, et al
. CXCL9, a promising biomarker in the diagnosis of chronic Q fever. BMC Infect Dis. 2017;17:556 pubmed publisher
..CXCL9 protein, measured in serum or as C. burnetii stimulated production, is a promising biomarker for the diagnosis of chronic Q fever. ..