Shah Jahan

Summary

Publications

  1. doi request reprint Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC
    Shah Jahan
    Department of Immunology, University of Health Sciences Lahore, Pakistan
    Infect Genet Evol 12:236-9. 2012
  2. pmc Hepatitis C virus to hepatocellular carcinoma
    Shah Jahan
    Department of Immunology, University of Health Sciences, Lahore, Pakistan
    Infect Agent Cancer 7:2. 2012
  3. pmc Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line
    Shah Jahan
    Centre of Excellence in Molecular Biology, University of the Punjab, Pakistan
    Virol J 8:522. 2011
  4. pmc Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV
    Shah Jahan
    Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:295. 2011
  5. pmc Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis
    Shah Jahan
    Applied and Functional Genomics Laboratory, National Centre of Excellence in Molecular Biology, University of Punjab, Lahore 53700, Pakistan
    Virol J 8:155. 2011
  6. pmc Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs
    Saba Khaliq
    Applied and Functional Genomics Laboratory, National Center of Excellence in Molecular Biology, University of Punjab, Lahore 53700, Pakistan
    Virol J 7:318. 2010
  7. pmc HCV entry receptors as potential targets for siRNA-based inhibition of HCV
    Shah Jahan
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Pakistan
    Genet Vaccines Ther 9:15. 2011
  8. pmc Association of laboratory parameters with viral factors in patients with hepatitis C
    Bushra Ijaz
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:361. 2011
  9. pmc Down-regulation of IRES containing 5'UTR of HCV genotype 3a using siRNAs
    Saba Khaliq
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:221. 2011
  10. pmc Inhibition of HCV 3a genotype entry through host CD81 and HCV E2 antibodies
    Usman A Ashfaq
    Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    J Transl Med 9:194. 2011

Collaborators

Detail Information

Publications19

  1. doi request reprint Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC
    Shah Jahan
    Department of Immunology, University of Health Sciences Lahore, Pakistan
    Infect Genet Evol 12:236-9. 2012
    ..Regulation of apoptosis in hepatocytes by HCV Core is so important in progression of HCC. This review focuses on the dual character of HCV Core on regulation of apoptosis and progression of HCC...
  2. pmc Hepatitis C virus to hepatocellular carcinoma
    Shah Jahan
    Department of Immunology, University of Health Sciences, Lahore, Pakistan
    Infect Agent Cancer 7:2. 2012
    ..This Review illustrates viral and host factors which induce Oxidative stress, steatosis and leads toward HCC. It also expresses Molecular cascade which leads oxidative stress and steatosis to HCC...
  3. pmc Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line
    Shah Jahan
    Centre of Excellence in Molecular Biology, University of the Punjab, Pakistan
    Virol J 8:522. 2011
    ..We analyzed the effect of HCV core of genotype 1a and 3a on cell proliferation by MTT assay and on phosphrylation of Akt by western blotting in Huh-7 cells...
  4. pmc Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV
    Shah Jahan
    Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:295. 2011
    ....
  5. pmc Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis
    Shah Jahan
    Applied and Functional Genomics Laboratory, National Centre of Excellence in Molecular Biology, University of Punjab, Lahore 53700, Pakistan
    Virol J 8:155. 2011
    ..We also studied the ability of HCV Core and Cox-2 siRNA either alone or in combination to inhibit viral replication and cell proliferation in HCV serum infected Huh-7 cells...
  6. pmc Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs
    Saba Khaliq
    Applied and Functional Genomics Laboratory, National Center of Excellence in Molecular Biology, University of Punjab, Lahore 53700, Pakistan
    Virol J 7:318. 2010
    ..Due to the limited efficiency of current therapy, RNA interference (RNAi) a novel regulatory and powerful silencing approach for molecular therapeutics through a sequence-specific RNA degradation process represents an alternative option...
  7. pmc HCV entry receptors as potential targets for siRNA-based inhibition of HCV
    Shah Jahan
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Pakistan
    Genet Vaccines Ther 9:15. 2011
    ..abstract:..
  8. pmc Association of laboratory parameters with viral factors in patients with hepatitis C
    Bushra Ijaz
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:361. 2011
    ....
  9. pmc Down-regulation of IRES containing 5'UTR of HCV genotype 3a using siRNAs
    Saba Khaliq
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:221. 2011
    ..HCV translation is mediated by a highly conserved internal ribosome entry site (IRES) within the 5'UTR region making it a relevant target for new drug development...
  10. pmc Inhibition of HCV 3a genotype entry through host CD81 and HCV E2 antibodies
    Usman A Ashfaq
    Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    J Transl Med 9:194. 2011
    ..HCV glycoproteins play an important role in HCV entry by binding with CD81 receptors. Hence inhibition of virus at entry step is an important target to identify antiviral drugs against HCV...
  11. pmc A comparison of four fibrosis indexes in chronic HCV: development of new fibrosis-cirrhosis index (FCI)
    Waqar Ahmad
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore 53700, Pakistan
    BMC Gastroenterol 11:44. 2011
    ..Hepatitis C can lead to liver fibrosis and cirrhosis. We compared readily available non-invasive fibrosis indexes for the fibrosis progression discrimination to find a better combination of existing non-invasive markers...
  12. doi request reprint Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis
    Mahwish Khan
    Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Arch Virol 155:1735-53. 2010
    ..In this review, we have tried to summarize the current knowledge regarding HCV-induced steatosis and the regulation of expression of host genes and receptors that aid in the viral life cycle and promote liver diseases...
  13. doi request reprint Hepatitis C virus entry: role of host and viral factors
    Baila Samreen
    National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Infect Genet Evol 12:1699-709. 2012
    ..In the current review we try to summarize the current knowledge about mechanism and interaction of cellular and viral factors involved in HCV cell entry and its implication as therapeutic target to inhibit HCV infection...
  14. pmc HCV genotype distribution and possible transmission risks in Lahore, Pakistan
    Waqar Ahmad
    Applied and Functional Genomics lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore 53700, Pakistan
    World J Gastroenterol 16:4321-8. 2010
    ..To investigate the prevalence of hepatitis C virus (HCV) genotypes and their association with possible transmission routes in the general population of Lahore, as the data exclusively related to this city is limited...
  15. doi request reprint Sequence variability of HCV Core region: important predictors of HCV induced pathogenesis and viral production
    Saba Khaliq
    Functional and Applied Genomics Laboratory, National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Infect Genet Evol 11:543-56. 2011
    ..In the present review, we emphasize on the pathogenicity cause by HCV Core and effect of amino acid sequence variation in disease progression and HCV life cycle...
  16. doi request reprint Hepatitis C virus p7: molecular function and importance in hepatitis C virus life cycle and potential antiviral target
    Saba Khaliq
    Functional and Applied Genomics Laboratory, National Center of Excellence in Molecular Biology, University of Punjab, Lahore, Pakistan
    Liver Int 31:606-17. 2011
    ..In the present review, we focused to bring together the recent development to explore the potential role of p7 protein in HCV infection and its inhibition as a therapy...
  17. pmc A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation
    Waqar Ahmad
    Applied and Functional Genomics Laboratory, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:53. 2011
    ....
  18. pmc siRNAs: potential therapeutic agents against hepatitis C virus
    Usman A Ashfaq
    Division of Molecular Medicine, National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Virol J 8:276. 2011
    ..In the present review, we focused that combination of siRNAs against virus and host genes will be a better option to treat HCV...
  19. doi request reprint RNAi as a new therapeutic strategy against HCV
    Saba Khaliq
    Functional and Applied Genomics Laboratory, National Center of Excellence in Molecular Biology, University of the Punjab, Lahore 53700, Pakistan
    Biotechnol Adv 28:27-34. 2010
    ..In the present review, we focused on the recent development in the potential use and issues regarding siRNA as a therapy for HCV...