Evelyne Jacqz-Aigrain

Summary

Publications

  1. doi request reprint How to optimize the evaluation and use of antibiotics in neonates
    Evelyne Jacqz-Aigrain
    Department of Pharmacology, Universite Paris Diderot, 5 rue Thomas Mann, Paris F75013, France
    Pediatr Clin North Am 59:1117-28. 2012
  2. doi request reprint Drug policy in Europe Research and funding in neonates: current challenges, future perspectives, new opportunities
    Evelyne Jacqz-Aigrain
    Department of Paediatric Pharmacology and Pharmacogenetics, CIC Inserm 9202, University Diderot, Paris VII, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Early Hum Dev 87:S27-30. 2011
  3. doi request reprint Population pharmacokinetics and pharmacogenetics of mycophenolic acid following administration of mycophenolate mofetil in de novo pediatric renal-transplant patients
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    J Clin Pharmacol 50:1280-91. 2010
  4. doi request reprint Pharmacogenetic determinant of the drug interaction between tacrolimus and omeprazole
    Wei Zhao
    AP HP, Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, INSERM, Paris, France
    Ther Drug Monit 34:739-41. 2012
  5. doi request reprint Population pharmacokinetics and pharmacogenetics of once daily prolonged-release formulation of tacrolimus in pediatric and adolescent kidney transplant recipients
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Universite Paris Diderot, Assistance Publique Hopitaux de Paris, Paris, France
    Eur J Clin Pharmacol 69:189-95. 2013
  6. doi request reprint Developmental pharmacogenetics of immunosuppressants in pediatric organ transplantation
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Clinical Investigation Center CIC Inserm 9202, Hopital Robert Debre, Paris, France
    Ther Drug Monit 32:688-99. 2010
  7. doi request reprint Limited sampling strategy using Bayesian estimation for estimating individual exposure of the once-daily prolonged-release formulation of tacrolimus in kidney transplant children
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Assistance Publique Hopitaux de Paris AP HP, INSERM Clinical Investigation Center CIC9202 Hôpital Robert Debré, 48 Boulevard Serurier, 75935 Paris Cedex 19, France
    Eur J Clin Pharmacol 69:1181-5. 2013
  8. doi request reprint Individualization of valganciclovir prophylaxis for cytomegalovirus infection in pediatric kidney transplant patients
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Didero, France
    Ther Drug Monit 34:326-30. 2012
  9. pmc Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy
    Tiphaine Adam de Beaumais
    Department of Pediatric Pharmacology and Pharmacogenetics, Robert Debre Hospital, Paris, France
    Br J Clin Pharmacol 71:575-84. 2011
  10. pmc Randomized controlled trials of antibiotics for neonatal infections: a systematic review
    Florentia Kaguelidou
    Department of Paediatric Pharmacology and Pharmacogenetics, INSERM CIC9202, APHP, Hopital Robert Debre, 75019, Paris Sorbonne Paris Cité, Univ Paris Diderot, 75019, Paris, France
    Br J Clin Pharmacol 76:21-9. 2013

Collaborators

Detail Information

Publications30

  1. doi request reprint How to optimize the evaluation and use of antibiotics in neonates
    Evelyne Jacqz-Aigrain
    Department of Pharmacology, Universite Paris Diderot, 5 rue Thomas Mann, Paris F75013, France
    Pediatr Clin North Am 59:1117-28. 2012
    ..However, evaluation of efficacy and toxicity in the neonate should always be discussed with regulatory agencies and are highly recommended when feasible...
  2. doi request reprint Drug policy in Europe Research and funding in neonates: current challenges, future perspectives, new opportunities
    Evelyne Jacqz-Aigrain
    Department of Paediatric Pharmacology and Pharmacogenetics, CIC Inserm 9202, University Diderot, Paris VII, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Early Hum Dev 87:S27-30. 2011
    ..An additional important initiative called GRIP (Global Research in Paediatrics) will focus on paediatric clinical pharmacology training and will facilitate the development and safe use of medicine in children...
  3. doi request reprint Population pharmacokinetics and pharmacogenetics of mycophenolic acid following administration of mycophenolate mofetil in de novo pediatric renal-transplant patients
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    J Clin Pharmacol 50:1280-91. 2010
    ..Body weight, concomitant medication, and UGT2B7 genotype contribute significantly to the interindividual variability of MMF disposition in pediatric renal-transplant patients...
  4. doi request reprint Pharmacogenetic determinant of the drug interaction between tacrolimus and omeprazole
    Wei Zhao
    AP HP, Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, INSERM, Paris, France
    Ther Drug Monit 34:739-41. 2012
    ..The determinant role of individual pharmacogenetic profile in the occurrence of tacrolimus nephrotoxicity is presented and discussed...
  5. doi request reprint Population pharmacokinetics and pharmacogenetics of once daily prolonged-release formulation of tacrolimus in pediatric and adolescent kidney transplant recipients
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Universite Paris Diderot, Assistance Publique Hopitaux de Paris, Paris, France
    Eur J Clin Pharmacol 69:189-95. 2013
    ....
  6. doi request reprint Developmental pharmacogenetics of immunosuppressants in pediatric organ transplantation
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Clinical Investigation Center CIC Inserm 9202, Hopital Robert Debre, Paris, France
    Ther Drug Monit 32:688-99. 2010
    ..In this review, we focus on the impact of age and pharmacogenetics on these immunosuppressants in children undergoing organ transplantation...
  7. doi request reprint Limited sampling strategy using Bayesian estimation for estimating individual exposure of the once-daily prolonged-release formulation of tacrolimus in kidney transplant children
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Assistance Publique Hopitaux de Paris AP HP, INSERM Clinical Investigation Center CIC9202 Hôpital Robert Debré, 48 Boulevard Serurier, 75935 Paris Cedex 19, France
    Eur J Clin Pharmacol 69:1181-5. 2013
    ..The objective of this study was to develop and validate a reliable and clinically applicable LSS using Bayesian estimation for estimating tacrolimus(PR) AUC in pediatric kidney transplant patients..
  8. doi request reprint Individualization of valganciclovir prophylaxis for cytomegalovirus infection in pediatric kidney transplant patients
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Didero, France
    Ther Drug Monit 34:326-30. 2012
    ..The objective of this study was to develop and validate a reliable and clinically applicable limited sampling strategy using Bayesian estimation for individualizing valganciclovir dose in pediatric kidney transplant patients...
  9. pmc Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy
    Tiphaine Adam de Beaumais
    Department of Pediatric Pharmacology and Pharmacogenetics, Robert Debre Hospital, Paris, France
    Br J Clin Pharmacol 71:575-84. 2011
    ..We investigated the impact of non-genetic covariates and pharmacogenetic polymorphisms affecting thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) on 6-MP metabolism and response...
  10. pmc Randomized controlled trials of antibiotics for neonatal infections: a systematic review
    Florentia Kaguelidou
    Department of Paediatric Pharmacology and Pharmacogenetics, INSERM CIC9202, APHP, Hopital Robert Debre, 75019, Paris Sorbonne Paris Cité, Univ Paris Diderot, 75019, Paris, France
    Br J Clin Pharmacol 76:21-9. 2013
    ..We reviewed medical literature to assess the characteristics and quality of randomized controlled trials on antibiotics in neonatal infections...
  11. doi request reprint Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoring
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
    Arch Dis Child 98:449-53. 2013
    ..The aim of this work was to evaluate the results of vancomycin therapeutic drug monitoring (TDM) under three different dosing regimens and to optimise vancomycin therapy...
  12. doi request reprint Limited sampling strategy for estimating individual exposure of tacrolimus in pediatric kidney transplant patients
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Universite Paris VII, Paris, France
    Ther Drug Monit 33:681-7. 2011
    ..The objective of the present study was to develop and validate reliable and clinically applicable LSS using Bayesian estimation and the multiple regression analysis for estimating tacrolimus AUC in pediatric kidney transplant patients...
  13. doi request reprint Physiopathology of idiopathic nephrotic syndrome: lessons from glucocorticoids and epigenetic perspectives
    Valery Elie
    Department of Pediatric Pharmacology and Pharmacogenetics, Clinical Investigation Center CIC Inserm 9202, Hopital Robert Debre, 48 Boulevard Serurier, 75935 Paris Cedex 19, France
    Pediatr Nephrol 27:1249-56. 2012
    ..In the present review, the data supporting these different (and probably combinatorial) hypotheses have been reviewed in order to identify and discuss the possible pathways implicated in the physiopathology of INS...
  14. doi request reprint Use of antibacterial agents in the neonate: 50 years of experience with vancomycin administration
    Evelyne Jacqz-Aigrain
    Universite Paris Diderot, Sorbonne Paris Cité, Paris, France
    Semin Fetal Neonatal Med 18:28-34. 2013
    ..Modelling and simulation approaches have clear advantages in dosing optimisation of antimicrobial agents in the neonate. Neonatologists and paediatric pharmacologists should work closely together to achieve this goal...
  15. pmc Population pharmacokinetics of abacavir in infants, toddlers and children
    Wei Zhao
    Sorbonne Paris Cité, Universite Paris Diderot, Paris, France Assistance Publique Hôpitaux de Paris, Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France INSERM Clinical Investigation Center CIC9202, Paris, France
    Br J Clin Pharmacol 75:1525-35. 2013
    ..To characterize the pharmacokinetics of abacavir in infants, toddlers and children and to assess the influence of covariates on drug disposition across these populations...
  16. doi request reprint Mycophenolate mofetil for steroid-dependent nephrotic syndrome: a phase II Bayesian trial
    Veronique Baudouin
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Pediatric Nephrology Department, Universite Paris 7, 48 Boulevard Serurier, 75019, Paris, France
    Pediatr Nephrol 27:389-96. 2012
    ..MMF reduces relapse rate and steroid dose in children with SDNS and should be proposed before cyclosporine and cyclophosphamide...
  17. pmc Population pharmacokinetics and maximum a posteriori probability Bayesian estimator of abacavir: application of individualized therapy in HIV-infected infants and toddlers
    Wei Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Universite Paris VII, 48 Boulevard Serurier, Paris Cedex 19, France
    Br J Clin Pharmacol 73:641-50. 2012
    ..The recommended paediatric dose is 8 mg kg(-1) twice daily up to a maximum of 300 mg twice daily. Weight was identified as the central covariate influencing pharmacokinetics of abacavir in children...
  18. ncbi request reprint [A complete clinical trial register is already a reality in the paediatric field]
    Evelyne Jacqz-Aigrain
    Hopital Robert Debre, Paris, France
    Therapie 61:121-4. 2006
    ..It will also allow for active monitoring of new or evolved knowledge of drug therapies...
  19. pmc Population pharmacokinetics and Bayesian estimator of mycophenolic acid in children with idiopathic nephrotic syndrome
    Wei Zhao
    Department of Paediatric Pharmacology and Pharmacogenetics, Clinical Investigation Centre INSERM, Hopital Robert Debre, Paris, France
    Br J Clin Pharmacol 69:358-66. 2010
    ....
  20. doi request reprint [Therapeutic drug monitoring of 6-thioguanine nucleotides in paediatric acute lymphoblastic leukaemia: interest and limits]
    May Fakhoury
    Laboratoire de Pharmacologie Pédiatrique et Pharmacogénétique, Hopital Robert Debre, Paris, France
    Therapie 65:187-93. 2010
    ..Follow-up of ALL treatment should preferentially be based on repeated determinations of intracellular active metabolites (6-thioguanine nucleotides) and methylated metabolites in addition to haematological surveillance...
  21. doi request reprint Determination of ciprofloxacin in plasma by micro-liquid chromatography-mass spectrometry: an adapted method for neonates
    Christel Grondin
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    Biomed Chromatogr 25:827-32. 2011
    ..The method was successfully applied to routine monitoring of ciprofloxacin in pediatric patients and also used in preclinical studies. It will be used to determine the population pharmacokinetic parameters of ciprofloxacin in neonates...
  22. pmc European survey on the use of prophylactic fluconazole in neonatal intensive care units
    Florentia Kaguelidou
    Paediatric Pharmacology and Pharmacogenetics Department, APHP, Hopital Robert Debre, INSERM CIC9202, Universite Paris 7, Paris, France
    Eur J Pediatr 171:439-45. 2012
    ..Non-users of fluconazole prophylaxis were more likely to be influenced by the local incidence of candidiasis, the risk of increasing antifungal resistance and the absence of specific recommendations by paediatric societies...
  23. ncbi request reprint mRNA expression of MDR1 and major metabolising enzymes in human fetal tissues
    May Fakhoury
    Department of Paediatric Pharmacology and Pharmacogenetics, Robert Debre Hospital, 75935 Paris Cedex 19, France
    Drug Metab Pharmacokinet 24:529-36. 2009
    ..Independently from age, the highest expression levels were observed in the liver and the lowest in the brain for the majority of genes tested. There was significant increase in gene expression with age in duodenal and hepatic tissues...
  24. doi request reprint Effects of recombinant human growth hormone for 1 year on body composition and muscle strength in children on long-term steroid therapy: randomized controlled, delayed-start study
    Dominique Simon
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Service d endocrinologie pédiatrique, 75019 Paris, France
    J Clin Endocrinol Metab 98:2746-54. 2013
    ..Recombinant human GH (rhGH) improves growth and body composition in glucocorticoid-treated children. Its effects on muscle strength are poorly evaluated...
  25. doi request reprint Recruitment in pediatric clinical research was influenced by study characteristics and pediatricians' perceptions: a multicenter survey
    Florentia Kaguelidou
    AP HP, Hopital Robert Debre, Unité d Epidémiologie Clinique, 48 Boulevard Serurier, 75019, Paris, France INSERM, CIC 9202, 75019 Paris, France Université Paris Diderot, Sorbonne Paris Cité, 75013, Paris, France AP HP, Hopital Robert Debre, Unité de Pharmacologie Pédiatrique et Pharmacogénétique, 48 Boulevard Serurier, 75019, Paris, France Electronic address
    J Clin Epidemiol 66:1151-7. 2013
    ..The aim of this survey was to quantify refusal rates and identify factors of refusal pertaining to studies and recruiting pediatricians in the research recruitment process...
  26. doi request reprint Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia
    Tiphaine Adam de Beaumais
    Department of Pediatric Pharmacology and Pharmacogenetics, Robert Debre Hospital, 48 Boulevard Serurier, 75019 Paris, France
    Eur J Clin Pharmacol 68:1233-42. 2012
    ..Additional single nucleotide polymorphisms (SNPs) in genes encoding enzymes involved in 6-MP metabolism and 6-MP transporters may also be responsible for this inter-individual 6-MP response variability...
  27. doi request reprint Pharmacogenetics and individualized therapy in children: immunosuppressants, antidepressants, anticancer and anti-inflammatory drugs
    Valery Elie
    Department of Paediatric Pharmacology and Pharmacogenetics, Assistance Publique Hopitaux de Paris, Clinical Investigation Center APHP Inserm CIC9202, University Paris VII Diderot, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Pharmacogenomics 12:827-43. 2011
    ..Additional pharmacogenetic and epigenetic studies should be performed to allow the individualization of therapy in children...
  28. doi request reprint Ciprofloxacin use in neonates: a systematic review of the literature
    Florentia Kaguelidou
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, APHP INSERM CIC9202 Université Paris 7, Paris, France
    Pediatr Infect Dis J 30:e29-37. 2011
    ..Given the concerns about its toxicity in this population and the necessity for its use in specific clinical situations, we conducted a systematic review of the use of ciprofloxacin in neonates...
  29. doi request reprint Tacrolimus nephrotoxicity: beware of the association of diarrhea, drug interaction and pharmacogenetics
    Sandrine Leroy
    Department of Pediatric Nephrology, Armand Trousseau Hospital, AP HP and University Paris VI, 26 avenue du Docteur Arnold Netter, Paris, France
    Pediatr Nephrol 25:965-9. 2010
    ....
  30. ncbi request reprint Pain control: non-steroidal anti-inflammatory agents
    Evelyne Jacqz-Aigrain
    Department of Paediatric Pharmacology, Robert Debre Hospital, 48 Boulevard Serurier, 75019 Paris, France
    Semin Fetal Neonatal Med 11:251-9. 2006
    ..Future studies should define concentration-response relationships for these drugs that are age and pathology specific...