Hilde Jacobs

Summary

Publications

  1. doi request reprint An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoHER and quercetin
    Hilde Jacobs
    Department of Toxicology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Free Radic Biol Med 51:2118-23. 2011
  2. doi request reprint Differences in pharmacological activities of the antioxidant flavonoid monoHER in humans and mice are caused by variations in its metabolic profile
    H Jacobs
    Department of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Clin Pharmacol Ther 90:852-9. 2011
  3. pmc An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network
    Hilde Jacobs
    Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 5:e13880. 2010
  4. pmc The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB
    H Jacobs
    Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Br J Cancer 104:437-40. 2011
  5. doi request reprint Identification of the metabolites of the antioxidant flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside in mice
    Hilde Jacobs
    Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Drug Metab Dispos 39:750-6. 2011
  6. doi request reprint Characterization of the glutathione conjugate of the semisynthetic flavonoid monoHER
    Hilde Jacobs
    Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    Free Radic Biol Med 46:1567-73. 2009

Detail Information

Publications6

  1. doi request reprint An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoHER and quercetin
    Hilde Jacobs
    Department of Toxicology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Free Radic Biol Med 51:2118-23. 2011
    ..These findings demonstrate that even structurally comparable flavonoids behave differently, which will be reflected in the biological effects of these flavonoids...
  2. doi request reprint Differences in pharmacological activities of the antioxidant flavonoid monoHER in humans and mice are caused by variations in its metabolic profile
    H Jacobs
    Department of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Clin Pharmacol Ther 90:852-9. 2011
    ..This study adds to the growing appreciation of flavonoid metabolites as bioactive compounds...
  3. pmc An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network
    Hilde Jacobs
    Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 5:e13880. 2010
    ..The advantage of monoHER is that it can safely channel the reactivity of radicals into the antioxidant network where the reactivity is completely neutralized...
  4. pmc The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB
    H Jacobs
    Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Br J Cancer 104:437-40. 2011
    ....
  5. doi request reprint Identification of the metabolites of the antioxidant flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside in mice
    Hilde Jacobs
    Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Drug Metab Dispos 39:750-6. 2011
    ..Therefore, these metabolites might contribute to the observed protection of monoHER against doxorubicin-induced cardiotoxicity...
  6. doi request reprint Characterization of the glutathione conjugate of the semisynthetic flavonoid monoHER
    Hilde Jacobs
    Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands
    Free Radic Biol Med 46:1567-73. 2009
    ..The formation of this thiol-reactive oxidation product is potentially harmful. Thus, the supposed beneficial effect of monoHER as an antioxidant may be accompanied by the formation of products with an electrophilic, toxic potential...