Heidi I L Jacobs

Summary

Publications

  1. doi Parietal cortex matters in Alzheimer's disease: an overview of structural, functional and metabolic findings
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
    Neurosci Biobehav Rev 36:297-309. 2012
  2. pmc Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, University Maastricht, 6200 MD Maastricht, The Netherlands
    Hum Brain Mapp 34:77-95. 2013
  3. doi Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker?
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
    Alzheimers Dement 9:93-7. 2013
  4. ncbi Patterns of gray and white matter changes in individuals at risk for Alzheimer's disease
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, The Netherlands
    Curr Alzheimer Res 9:1097-105. 2012
  5. doi Functional integration of parietal lobe activity in early Alzheimer disease
    H I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands
    Neurology 78:352-60. 2012
  6. doi Atrophy of the parietal lobe in preclinical dementia
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Brain Cogn 75:154-63. 2011
  7. doi Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    J Alzheimers Dis 25:477-90. 2011
  8. doi White matter hyperintensities are positively associated with cortical thickness in Alzheimer's disease
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands European Graduate School of Neuroscience EURON, Maastricht University, Maastricht, The Netherlands Cognitive Neuroscience, Institute of Neuroscience and Medicine 3, Research Centre Julich, Julich, Germany
    J Alzheimers Dis 39:409-22. 2014
  9. pmc The effects of FreeSurfer version, workstation type, and Macintosh operating system version on anatomical volume and cortical thickness measurements
    Ed H B M Gronenschild
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Alzheimer Center Limburg, The Netherlands
    PLoS ONE 7:e38234. 2012

Detail Information

Publications9

  1. doi Parietal cortex matters in Alzheimer's disease: an overview of structural, functional and metabolic findings
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
    Neurosci Biobehav Rev 36:297-309. 2012
    ..In this model myelin breakdown is a beginning of the chain of pathological events leading to AD pathology and an AD diagnosis...
  2. pmc Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, University Maastricht, 6200 MD Maastricht, The Netherlands
    Hum Brain Mapp 34:77-95. 2013
    ..This suggests that, although BP and WMSA are causally related, these differential metrics of vascular health may act via independent pathways to influence brain structure, EF and PS...
  3. doi Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker?
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
    Alzheimers Dement 9:93-7. 2013
    ..Gray matter atrophy, an important biomarker for early Alzheimer's disease, might be due to white matter changes within gray matter...
  4. ncbi Patterns of gray and white matter changes in individuals at risk for Alzheimer's disease
    Heidi I L Jacobs
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, The Netherlands
    Curr Alzheimer Res 9:1097-105. 2012
    ..This suggests that a combination of cognitive decline and structural brain changes might be an ideal biomarker for AD pathogenesis...
  5. doi Functional integration of parietal lobe activity in early Alzheimer disease
    H I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands
    Neurology 78:352-60. 2012
    ..We focused on functional characteristics of the parietal lobe and examined compensation or disconnection mechanisms by combining a fMRI task with effective connectivity measures from Granger causality mapping (GCM)...
  6. doi Atrophy of the parietal lobe in preclinical dementia
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Brain Cogn 75:154-63. 2011
    ..Future studies should investigate the surplus value of the inferior parietal lobe as a potential marker for the diagnosis of AD compared to other brain regions, such as the medial temporal lobe and the prefrontal lobe...
  7. doi Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands
    J Alzheimers Dis 25:477-90. 2011
    ..Diagnosis of preclinical AD may lead to more false positive outcomes if only the MTL atrophy is considered...
  8. doi White matter hyperintensities are positively associated with cortical thickness in Alzheimer's disease
    Heidi I L Jacobs
    School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands European Graduate School of Neuroscience EURON, Maastricht University, Maastricht, The Netherlands Cognitive Neuroscience, Institute of Neuroscience and Medicine 3, Research Centre Julich, Julich, Germany
    J Alzheimers Dis 39:409-22. 2014
    ..Alternatively, it might reflect a region-specific and disease-stage dependent compensatory hypertrophy in response to a compromised network. ..
  9. pmc The effects of FreeSurfer version, workstation type, and Macintosh operating system version on anatomical volume and cortical thickness measurements
    Ed H B M Gronenschild
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Alzheimer Center Limburg, The Netherlands
    PLoS ONE 7:e38234. 2012
    ..Moreover, in view of the large and significant cross-version differences, it is concluded that formal assessment of the accuracy of FreeSurfer is desirable...