Efemwonkiekie W Iyamu

Summary

Publications

  1. doi request reprint The redox state of the glutathione/glutathione disulfide couple mediates intracellular arginase activation in HCT-116 colon cancer cells
    Efemwonkiekie W Iyamu
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Dig Dis Sci 55:2520-8. 2010
  2. doi request reprint Oxidant-mediated modification of the cellular thiols is sufficient for arginase activation in cultured cells
    Efemwonkiekie W Iyamu
    Division of Hematology and Oncology, Children s Mercy Hospital, Kansas City, MO 64108, USA
    Mol Cell Biochem 360:159-68. 2012
  3. pmc Cysteine-iron promotes arginase activity by driving the Fenton reaction
    Efemwonkiekie W Iyamu
    Division of Hematology and Oncology, Children s Mercy Hospital and Clinics, Pediatric Research Center, 2401 Gillham Road, 3730 01, Kansas City, MO 64108, USA
    Biochem Biophys Res Commun 376:116-20. 2008
  4. ncbi request reprint In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes
    Efemwonkiekie W Iyamu
    Division of Hematology and Oncology, Children s Mercy Hospital, University of Missouri Medical Center, Kansas City, MO 64108, USA
    Br J Haematol 139:337-43. 2007

Detail Information

Publications4

  1. doi request reprint The redox state of the glutathione/glutathione disulfide couple mediates intracellular arginase activation in HCT-116 colon cancer cells
    Efemwonkiekie W Iyamu
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Dig Dis Sci 55:2520-8. 2010
    ..Recently, we showed that cysteine, in the presence of molecular iron, promotes arginase activity by driving the Fenton reaction. However, the exact mechanism of arginase activation in the cell induced by oxidative stress is unknown...
  2. doi request reprint Oxidant-mediated modification of the cellular thiols is sufficient for arginase activation in cultured cells
    Efemwonkiekie W Iyamu
    Division of Hematology and Oncology, Children s Mercy Hospital, Kansas City, MO 64108, USA
    Mol Cell Biochem 360:159-68. 2012
    ..control). Our presented data demonstrate, for the first time that the intracellular arginase activation is may be enhanced in part, via a cellular thiol-mediated mechanism...
  3. pmc Cysteine-iron promotes arginase activity by driving the Fenton reaction
    Efemwonkiekie W Iyamu
    Division of Hematology and Oncology, Children s Mercy Hospital and Clinics, Pediatric Research Center, 2401 Gillham Road, 3730 01, Kansas City, MO 64108, USA
    Biochem Biophys Res Commun 376:116-20. 2008
    ..OH radicals in the stimulation of arginase activity, and thus provides novel avenues for therapeutic modalities in hemoglobinopathies and other inflammation-mediated diseases...
  4. ncbi request reprint In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes
    Efemwonkiekie W Iyamu
    Division of Hematology and Oncology, Children s Mercy Hospital, University of Missouri Medical Center, Kansas City, MO 64108, USA
    Br J Haematol 139:337-43. 2007
    ..The outcome of this study may provide a template for the rational design of specific agents either alone or in combination with CQ for the inhibition of arginase activity...