Per Ole Iversen

Summary

Publications

  1. ncbi request reprint A murine model for studying hematopoiesis and immunity in heart failure
    Per Ole Iversen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Methods Mol Biol 360:269-75. 2007
  2. pmc Body composition in older acute stroke patients after treatment with individualized, nutritional supplementation while in hospital
    Lisa Ha
    Department of Internal Medicine, Østfold Hospital Trust Fredrikstad, 1603 Fredrikstad, Norway
    BMC Geriatr 10:75. 2010
  3. ncbi request reprint [Treatment of tuberculosis in three of Oslo's central and eastern parts in 1994-2000]
    Per Ole Iversen
    Medisinsk avdeling Lovisenberg Diakonale Sykehus
    Tidsskr Nor Laegeforen 123:815-7. 2003
  4. ncbi request reprint [Angiogenesis and hematological malignancies]
    Per Ole Iversen
    Institutt for ernaeringsforskning, Universitetet i Oslo, 0316 Oslo
    Tidsskr Nor Laegeforen 123:3198-200. 2003
  5. ncbi request reprint Human cytokines modulate arterial vascular tone via endothelial receptors
    P O Iversen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Pflugers Arch 439:93-100. 1999
  6. ncbi request reprint Reduced immune responses to an aseptic inflammation in mice with congestive heart failure
    Per O Iversen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    Eur J Haematol 75:156-63. 2005
  7. doi request reprint Reduced nutritional status among multiple myeloma patients during treatment with high-dose chemotherapy and autologous stem cell support
    Per Ole Iversen
    Department of Hematology, Oslo University Hospital, Ullevaal, Oslo, Norway
    Clin Nutr 29:488-91. 2010
  8. ncbi request reprint A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia
    Per O Iversen
    Department of Nutrition, University of Oslo, Norway
    Clin Cancer Res 12:3525-31. 2006
  9. ncbi request reprint [Nutritional situation for mothers and children in South Africa]
    Per Ole Iversen
    Avdeling for ernaeringsvitenskap, Institutt for medisinske basalfag, Universitetet i Oslo
    Tidsskr Nor Laegeforen 129:1362-5. 2009
  10. ncbi request reprint Impaired nutritional status during intensive chemotherapy in Russian and Norwegian cohorts with acute myeloid leukemia
    Per Ole Iversen
    Department of Hematology, Ullevaal University Hospital, and Department of Nutrition, University of Oslo, Oslo, Norway
    Leuk Lymphoma 49:1916-24. 2008

Detail Information

Publications44

  1. ncbi request reprint A murine model for studying hematopoiesis and immunity in heart failure
    Per Ole Iversen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Methods Mol Biol 360:269-75. 2007
    ....
  2. pmc Body composition in older acute stroke patients after treatment with individualized, nutritional supplementation while in hospital
    Lisa Ha
    Department of Internal Medicine, Østfold Hospital Trust Fredrikstad, 1603 Fredrikstad, Norway
    BMC Geriatr 10:75. 2010
    ..Here we aimed to assess if the nutritional intervention altered body composition in men and women in this study cohort, and also to examine the correlation between the methods for assessing body-, fat- and fat-free mass...
  3. ncbi request reprint [Treatment of tuberculosis in three of Oslo's central and eastern parts in 1994-2000]
    Per Ole Iversen
    Medisinsk avdeling Lovisenberg Diakonale Sykehus
    Tidsskr Nor Laegeforen 123:815-7. 2003
  4. ncbi request reprint [Angiogenesis and hematological malignancies]
    Per Ole Iversen
    Institutt for ernaeringsforskning, Universitetet i Oslo, 0316 Oslo
    Tidsskr Nor Laegeforen 123:3198-200. 2003
    ..Recent findings suggest that angiogenesis also takes place in haematological malignancies. These findings suggest that angiogenesis might be a potential target for therapy...
  5. ncbi request reprint Human cytokines modulate arterial vascular tone via endothelial receptors
    P O Iversen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Pflugers Arch 439:93-100. 1999
    ..Therefore cytokines might significantly modify blood supply to inflamed or ischemic tissues with elevated local concentrations of cytokines...
  6. ncbi request reprint Reduced immune responses to an aseptic inflammation in mice with congestive heart failure
    Per O Iversen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    Eur J Haematol 75:156-63. 2005
    ..Heart failure after myocardial infarction in mice may severely compromise their ability to combat an inflammatory challenge...
  7. doi request reprint Reduced nutritional status among multiple myeloma patients during treatment with high-dose chemotherapy and autologous stem cell support
    Per Ole Iversen
    Department of Hematology, Oslo University Hospital, Ullevaal, Oslo, Norway
    Clin Nutr 29:488-91. 2010
    ..g., nausea/vomiting, appetite loss and fatigue. It is unknown whether nutritional status in MM is affected by treatment. Hence we assessed nutritional status before, during and (1/2) year after treatment-start...
  8. ncbi request reprint A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia
    Per O Iversen
    Department of Nutrition, University of Oslo, Norway
    Clin Cancer Res 12:3525-31. 2006
    ....
  9. ncbi request reprint [Nutritional situation for mothers and children in South Africa]
    Per Ole Iversen
    Avdeling for ernaeringsvitenskap, Institutt for medisinske basalfag, Universitetet i Oslo
    Tidsskr Nor Laegeforen 129:1362-5. 2009
    ..Poverty prevails and conditions are bad with respect to sanitation, health and living conditions; a situation which is likely to affect nutritional health. We have reviewed the nutritional status in South Africa...
  10. ncbi request reprint Impaired nutritional status during intensive chemotherapy in Russian and Norwegian cohorts with acute myeloid leukemia
    Per Ole Iversen
    Department of Hematology, Ullevaal University Hospital, and Department of Nutrition, University of Oslo, Oslo, Norway
    Leuk Lymphoma 49:1916-24. 2008
    ..Our data suggest a catabolic metabolism during intensive chemotherapy for AML, leading to impaired nutritional status, hypofunction of the pituitary-gonadal axis and decreased health-related quality of life...
  11. ncbi request reprint [Gaucher disease]
    Per Ole Iversen
    Hematologisk avdeling Ullevål universitetssykehus 0407 Oslo
    Tidsskr Nor Laegeforen 123:304-7. 2003
  12. ncbi request reprint Impaired circadian variations of haemostatic and fibrinolytic parameters in tetraplegia
    Per Ole Iversen
    Department of Haematology, Ullevaal University Hospital, Oslo, Norway
    Br J Haematol 119:1011-6. 2002
    ..This could possibly reflect a deregulated autonomic nervous system, leading to a dysfunctional link between central and peripheral circadian oscillators...
  13. ncbi request reprint [Nutrition is medicine, too--and education is necessary]
    Per Ole Iversen
    Institutt for ernaeringsforskning Universitetet i Oslo Postboks 1046 Blindern 0316 Oslo
    Tidsskr Nor Laegeforen 122:1232. 2002
  14. ncbi request reprint Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis
    Per Ole Iversen
    Institute for Nutrition Research, University of Oslo, Norway
    Blood 100:4123-8. 2002
    ..We conclude that leptin stimulates leukemic cell growth in vivo by promoting angiogenesis. Inhibition of binding of leptin to its receptor might be a new adjunct therapy in AML...
  15. ncbi request reprint Targeting Raf-1 gene expression by a DNA enzyme inhibits juvenile myelomonocytic leukemia cell growth
    Per Ole Iversen
    Institute for Nutrition Research, University of Oslo, and Department of Immunology, Molecular Medicine Group, The Norwegian Radium Hospital, Oslo, Norway
    Blood 99:4147-53. 2002
    ..The DNA enzyme efficiently catabolized mRNA-Raf-1 with subsequent inhibition of JMML cell growth, suggesting its potential as a mechanism-based therapy in this fatal leukemia...
  16. ncbi request reprint Decreased hematopoiesis in bone marrow of mice with congestive heart failure
    Per Ole Iversen
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    Am J Physiol Regul Integr Comp Physiol 282:R166-72. 2002
    ..We conclude that the TNF-alpha/Fas pathway in lymphocytes is activated in the bone marrow during heart failure, which may play a pathogenic role in the observed decrease in hematopoiesis...
  17. ncbi request reprint DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure
    P O Iversen
    Institute for Nutrition Research, University of Oslo, 0316 Oslo, Norway
    Am J Physiol Heart Circ Physiol 281:H2211-7. 2001
    ..Our findings indicate that DNA enzyme-based therapy may hold promise in the treatment of this debilitating disease...
  18. ncbi request reprint Depressed immunity and impaired proliferation of hematopoietic progenitor cells in patients with complete spinal cord injury
    P O Iversen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Blood 96:2081-3. 2000
    ..Possibly, this reflects cellular defects caused by the malfunctioning neuronal regulation of immune and bone marrow function...
  19. doi request reprint A combined immunostimulatory and immunoinhibitory short interference RNA reduces hypercoagulability in a rat model of acute promyelocytic leukaemia
    Per Ole Iversen
    Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Thromb Haemost 104:350-4. 2010
    ..05) upon treatment with the siRNA. The bifunctional siRNA reduces the hypercoagulable state in APL in addition to its direct anti-leukaemic properties, supporting testing of this small molecule in human APL...
  20. ncbi request reprint Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis
    Per Ole Iversen
    Department of Nutrition, Institute of Basic Medical Research, University of Oslo, Norway
    Clin Cancer Res 11:6793-9. 2005
    ..Using a novel method to isolate bone marrow interstitial fluid, we examined if this fluid from 10 adult AML patients could affect normal bone marrow hematopoiesis...
  21. doi request reprint Hypercoagulability in patients with haematological neoplasia: no apparent initiation by tissue factor
    Helene F S Negaard
    Department of Haematology, Ulleval University Hospital Trust, Oslo, Norway
    Thromb Haemost 99:1040-8. 2008
    ..In conclusion we found a hypercoagulable state in patients with haematological malignancy that did not seem to be initiated by TF...
  22. doi request reprint Alterations in regulators of the extracellular matrix in non-Hodgkin lymphomas
    Helene F S Negaard
    Department of Haematology, Oslo University Hospital Ulleval, Oslo, Norway
    Leuk Lymphoma 50:998-1004. 2009
    ..After therapy, serum MMP-2 increased while MMP-9 decreased (P < 0.05), the others being unchanged. Several compounds affecting ECM may be involved in angiogenic activity in NHL...
  23. ncbi request reprint Preserved granulocyte formation and function, as well as bone marrow innervation, in subjects with complete spinal cord injury
    Per Ole Iversen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Br J Haematol 126:870-7. 2004
    ..We conclude that terminal differentiation and formation of granulocytes, as well as their functional capacity, do not depend appreciably on supraspinal nervous regulation...
  24. ncbi request reprint Differences in circadian variations of tissue factor pathway inhibitor type 1 between able-bodied and spinal cord injured
    Anders E A Dahm
    Department of Haematology, Ullevaal University Hospital, Oslo, Norway
    Thromb Res 118:281-7. 2006
    ..Hence, in the current study we aimed at exploring the intra-individual variation with focus on the possible circadian variations of TFPI...
  25. pmc Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma
    Dag R Sorensen
    Department of Comparative Medicine, The National Hospital, University of Oslo, Oslo, Norway
    Neoplasia 4:474-9. 2002
    ..0009) or endostatin (P<.025) alone. Thus, the combined treatment may represent an attractive therapeutic strategy against malignant gliomas...
  26. doi request reprint Maternal familial hypercholesterolaemia (FH) confers altered haemostatic profile in offspring with and without FH
    Ingunn Narverud
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Thromb Res 131:178-82. 2013
    ....
  27. ncbi request reprint Demonstration of altered signaling responses in bone marrow extracellular fluid during increased hematopoiesis in rats using a centrifugation method
    Helge Wiig
    Department of Physiology, University of Bergen, 5009 Bergen, Norway
    Am J Physiol Heart Circ Physiol 286:H2028-34. 2004
    ....
  28. ncbi request reprint Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat
    Eirunn Knudsen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Eur J Haematol 69:284-96. 2002
    ..Macrophage-derived IL-1beta, MIP-2, and KC are possible mediators of neutrophil homing to inflamed tissues...
  29. doi request reprint Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid
    Christine Henriksen
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
    Pediatrics 121:1137-45. 2008
    ..The objective of our study was to evaluate the effect of supplementation with docosahexaenoic acid and arachidonic acid for human milk-fed preterm infants. The primary end point was cognitive development at 6 months of age...
  30. ncbi request reprint Ribozymes, DNAzymes and small interfering RNAs as therapeutics
    Mouldy Sioud
    Institute for Cancer Research, Department of Immunology, Molecular Medicine Group, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Curr Drug Targets 6:647-53. 2005
    ..Their potential use in cell cultures and in animal models for disease is also highlighted...
  31. ncbi request reprint No major role for the transcription factor NF-κB in bone marrow function during peritonitis in the mouse
    Eirunn Knudsen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Int J Hematol 100:111-8. 2014
    ....
  32. doi request reprint Reduced antioxidant defense and increased oxidative stress in spinal cord injured patients
    Nasser Ezzathkah Bastani
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Arch Phys Med Rehabil 93:2223-8.e2. 2012
    ..To determine the plasma and urine levels of antioxidants and oxidative stress biomarkers in subjects with spinal cord injury (SCI) the first year after injury...
  33. doi request reprint G-CSF enhances the proliferation and mobilization, but not the maturation rate, of murine myeloid cells
    Eirunn Knudsen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Eur J Haematol 87:302-11. 2011
    ..To further clarify the role of G-CSF, we now have examined its effect on murine granulopoiesis in situ...
  34. ncbi request reprint Inhibition of gene expression by nucleic acid enzymes in rodent models of human disease
    Per Ole Iversen
    Institute for Nutrition, University of Oslo, Norway
    Methods Mol Biol 252:451-6. 2004
    ..The described protocols should facilitate the in vivo evaluation of other oligonucleotide-based therapy such as small interfering RNAs (siRNAs)...
  35. doi request reprint Pregnancy outcomes in familial hypercholesterolemia: a registry-based study
    Ieva Toleikyte
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    Circulation 124:1606-14. 2011
    ..We determined whether heterozygous FH women are at higher risk of premature birth (<37 gestational weeks), delivering children with low birth weight (<2500 g) and/or with congenital malformations compared to women in general...
  36. ncbi request reprint [Nutrition for preterm infants]
    Christine Henriksen
    Institutt for ernaeringsforskning, Universitetet i Oslo, Postboks 1046 Blindern, 0316 Oslo
    Tidsskr Nor Laegeforen 124:1392-5. 2004
    ..In spite of an increased survival rate over the past 30 years, many challenges remain in the treatment of premature infants; their nutritional need is an important aspect...
  37. ncbi request reprint The components required for amino acid neurotransmitter signaling are present in adipose tissues
    Anne Nicolaysen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Lipid Res 48:2123-32. 2007
    ..The presence of glutamate, GABA, their vesicular transporters, and their receptors indicates a paracrine signaling role for amino acids in adipose tissues...
  38. pmc Nutritional status among older residents with dementia in open versus special care units in municipal nursing homes: an observational study
    Carine Aukner
    Atlantis Medical College, Oslo, Norway
    BMC Geriatr 13:26. 2013
    ..The aim of this study was therefore to examine the nutritional status of residents with dementia in both open units and in special care units...
  39. doi request reprint Symptoms in advanced pancreatic cancer are of importance for energy intake
    Asta Bye
    Regional Centre for Excellence in Palliative Care, Oslo University Hospital, Oslo, Norway
    Support Care Cancer 21:219-27. 2013
    ..However, little is known about the actual EI in this disease. Aims were to assess EI, weight loss and symptoms during the disease course and investigate associations between symptoms and EI...
  40. doi request reprint Improved plasma lipids and body weight in overweight/obese patients with type III hyperlipoproteinemia after 4 weeks on a low glycemic diet
    Kjetil Retterstøl
    Lipid Clinic, Rikshospitalet University Hospital Trust, Oslo, Norway
    Clin Nutr 28:213-5. 2009
    ..The optimal diet for type III hyperlipoproteinemia is unknown. We examined blood lipids and body weight following low or high glycemic index diets in comparison with a lipid-lowering diet...
  41. ncbi request reprint [Fetal nutrition and future health]
    Tore Henriksen
    Kvinneklinikken, Rikshospitalet, 0027 Oslo
    Tidsskr Nor Laegeforen 125:442-4. 2005
    ..Maternal weight and metabolic status is closely associated with the growth and development of the fetus. Thus, diet and physical activity become particularly important aspects of the health of young women...
  42. ncbi request reprint Increase in matrix metalloproteinases from endothelial cells exposed to umbilical cord plasma from high birth weight newborns
    Erlingur Johannsson
    Center for Sport and Health Sciences, Iceland University of Education, Laugarvatn, Iceland
    Am J Physiol Regul Integr Comp Physiol 292:R1563-8. 2007
    ..Although not identified, cord plasma of HBW infants may contain factors that increase endothelial cell MMP. These findings may indicate an association between fetal nutritional conditions and endothelial cell functions...
  43. ncbi request reprint [Gestational diabetes in women from South Asia]
    Alka Chawla
    Avdeling for ernaeringsvitenskap, Medisinsk klinikk, Aker universitetssykehus
    Tidsskr Nor Laegeforen 126:1041-3. 2006
    ..More knowledge is needed to prevent and treat this disease effectively. Here we give a brief overview of the epidemiology and risk factors associated with gestational diabetes...
  44. doi request reprint The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential therapeutic consequences
    Helge Wiig
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Microcirculation 15:283-96. 2008
    ..Here, we provide an overview of the structural components of the interstitium and discuss the importance the sterical and electrostatical components have on the dynamics of transcapillary fluid exchange...