A murine model for studying hematopoiesis and immunity in heart failurePer Ole Iversen
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Methods Mol Biol 360:269-75. 2007
....
Nutritional status among older residents with dementia in open versus special care units in municipal nursing homes: an observational studyCarine Aukner
Atlantis Medical College, Oslo, Norway
BMC Geriatr 13:26. 2013
..The aim of this study was therefore to examine the nutritional status of residents with dementia in both open units and in special care units...
- Body composition in older acute stroke patients after treatment with individualized, nutritional supplementation while in hospital
Lisa Ha
Department of Internal Medicine, Østfold Hospital Trust Fredrikstad, 1603 Fredrikstad, Norway
BMC Geriatr 10:75. 2010
..Here we aimed to assess if the nutritional intervention altered body composition in men and women in this study cohort, and also to examine the correlation between the methods for assessing body-, fat- and fat-free mass...
- [Angiogenesis and hematological malignancies]
Per Ole Iversen
Institutt for ernaeringsforskning, Universitetet i Oslo, 0316 Oslo
Tidsskr Nor Laegeforen 123:3198-200. 2003
..Recent findings suggest that angiogenesis also takes place in haematological malignancies. These findings suggest that angiogenesis might be a potential target for therapy...
- Reduced immune responses to an aseptic inflammation in mice with congestive heart failure
Per O Iversen
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
Eur J Haematol 75:156-63. 2005
..Heart failure after myocardial infarction in mice may severely compromise their ability to combat an inflammatory challenge...
- [Nutrition is medicine, too--and education is necessary]
Per Ole Iversen
Institutt for ernaeringsforskning Universitetet i Oslo Postboks 1046 Blindern 0316 Oslo
Tidsskr Nor Laegeforen 122:1232. 2002
Reduced nutritional status among multiple myeloma patients during treatment with high-dose chemotherapy and autologous stem cell supportPer Ole Iversen
Department of Hematology, Oslo University Hospital, Ullevaal, Oslo, Norway
Clin Nutr 29:488-91. 2010
..g., nausea/vomiting, appetite loss and fatigue. It is unknown whether nutritional status in MM is affected by treatment. Hence we assessed nutritional status before, during and (1/2) year after treatment-start...
- A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia
Per O Iversen
Department of Nutrition, University of Oslo, Norway
Clin Cancer Res 12:3525-31. 2006
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- Impaired nutritional status during intensive chemotherapy in Russian and Norwegian cohorts with acute myeloid leukemia
Per Ole Iversen
Department of Hematology, Ullevaal University Hospital, and Department of Nutrition, University of Oslo, Oslo, Norway
Leuk Lymphoma 49:1916-24. 2008
..Our data suggest a catabolic metabolism during intensive chemotherapy for AML, leading to impaired nutritional status, hypofunction of the pituitary-gonadal axis and decreased health-related quality of life...
- [Nutritional situation for mothers and children in South Africa]
Per Ole Iversen
Avdeling for ernaeringsvitenskap, Institutt for medisinske basalfag, Universitetet i Oslo
Tidsskr Nor Laegeforen 129:1362-5. 2009
..Poverty prevails and conditions are bad with respect to sanitation, health and living conditions; a situation which is likely to affect nutritional health. We have reviewed the nutritional status in South Africa...
- [Treatment of tuberculosis in three of Oslo's central and eastern parts in 1994-2000]
Per Ole Iversen
Medisinsk avdeling Lovisenberg Diakonale Sykehus
Tidsskr Nor Laegeforen 123:815-7. 2003
- [Gaucher disease]
Per Ole Iversen
Tidsskr Nor Laegeforen 123:304-7. 2003
- Impaired circadian variations of haemostatic and fibrinolytic parameters in tetraplegia
Per Ole Iversen
Department of Haematology, Ullevaal University Hospital, Oslo, Norway
Br J Haematol 119:1011-6. 2002
..This could possibly reflect a deregulated autonomic nervous system, leading to a dysfunctional link between central and peripheral circadian oscillators...
- DNA enzyme targeting TNF-alpha mRNA improves hemodynamic performance in rats with postinfarction heart failure
P O Iversen
Institute for Nutrition Research, University of Oslo, 0316 Oslo, Norway
Am J Physiol Heart Circ Physiol 281:H2211-7. 2001
..Our findings indicate that DNA enzyme-based therapy may hold promise in the treatment of this debilitating disease...
- Decreased hematopoiesis in bone marrow of mice with congestive heart failure
Per Ole Iversen
Institute for Nutrition Research, University of Oslo, Oslo, Norway
Am J Physiol Regul Integr Comp Physiol 282:R166-72. 2002
..We conclude that the TNF-alpha/Fas pathway in lymphocytes is activated in the bone marrow during heart failure, which may play a pathogenic role in the observed decrease in hematopoiesis...
- Human cytokines modulate arterial vascular tone via endothelial receptors
P O Iversen
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
Pflugers Arch 439:93-100. 1999
..Therefore cytokines might significantly modify blood supply to inflamed or ischemic tissues with elevated local concentrations of cytokines...
- Targeting Raf-1 gene expression by a DNA enzyme inhibits juvenile myelomonocytic leukemia cell growth
Per Ole Iversen
Institute for Nutrition Research, University of Oslo, and Department of Immunology, Molecular Medicine Group, The Norwegian Radium Hospital, Oslo, Norway
Blood 99:4147-53. 2002
..The DNA enzyme efficiently catabolized mRNA-Raf-1 with subsequent inhibition of JMML cell growth, suggesting its potential as a mechanism-based therapy in this fatal leukemia...
- Depressed immunity and impaired proliferation of hematopoietic progenitor cells in patients with complete spinal cord injury
P O Iversen
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Blood 96:2081-3. 2000
..Possibly, this reflects cellular defects caused by the malfunctioning neuronal regulation of immune and bone marrow function...
- Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis
Per Ole Iversen
Institute for Nutrition Research, University of Oslo, Norway
Blood 100:4123-8. 2002
..We conclude that leptin stimulates leukemic cell growth in vivo by promoting angiogenesis. Inhibition of binding of leptin to its receptor might be a new adjunct therapy in AML...
- A combined immunostimulatory and immunoinhibitory short interference RNA reduces hypercoagulability in a rat model of acute promyelocytic leukaemia
Per Ole Iversen
Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Thromb Haemost 104:350-4. 2010
..05) upon treatment with the siRNA. The bifunctional siRNA reduces the hypercoagulable state in APL in addition to its direct anti-leukaemic properties, supporting testing of this small molecule in human APL...
- Hypercoagulability in patients with haematological neoplasia: no apparent initiation by tissue factor
Helene F S Negaard
Department of Haematology, Ulleval University Hospital Trust, Oslo, Norway
Thromb Haemost 99:1040-8. 2008
..In conclusion we found a hypercoagulable state in patients with haematological malignancy that did not seem to be initiated by TF...
- Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis
Per Ole Iversen
Department of Nutrition, Institute of Basic Medical Research, University of Oslo, Norway
Clin Cancer Res 11:6793-9. 2005
..Using a novel method to isolate bone marrow interstitial fluid, we examined if this fluid from 10 adult AML patients could affect normal bone marrow hematopoiesis...
- Alterations in regulators of the extracellular matrix in non-Hodgkin lymphomas
Helene F S Negaard
Department of Haematology, Oslo University Hospital Ulleval, Oslo, Norway
Leuk Lymphoma 50:998-1004. 2009
..After therapy, serum MMP-2 increased while MMP-9 decreased (P < 0.05), the others being unchanged. Several compounds affecting ECM may be involved in angiogenic activity in NHL...
- Preserved granulocyte formation and function, as well as bone marrow innervation, in subjects with complete spinal cord injury
Per Ole Iversen
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Br J Haematol 126:870-7. 2004
..We conclude that terminal differentiation and formation of granulocytes, as well as their functional capacity, do not depend appreciably on supraspinal nervous regulation...
- Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma
Dag R Sorensen
Department of Comparative Medicine, The National Hospital, University of Oslo, Oslo, Norway
Neoplasia 4:474-9. 2002
..0009) or endostatin (P<.025) alone. Thus, the combined treatment may represent an attractive therapeutic strategy against malignant gliomas...
- Differences in circadian variations of tissue factor pathway inhibitor type 1 between able-bodied and spinal cord injured
Anders E A Dahm
Department of Haematology, Ullevaal University Hospital, Oslo, Norway
Thromb Res 118:281-7. 2006
..Hence, in the current study we aimed at exploring the intra-individual variation with focus on the possible circadian variations of TFPI...
- Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid
Christine Henriksen
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
Pediatrics 121:1137-45. 2008
..The objective of our study was to evaluate the effect of supplementation with docosahexaenoic acid and arachidonic acid for human milk-fed preterm infants. The primary end point was cognitive development at 6 months of age...
- Ribozymes, DNAzymes and small interfering RNAs as therapeutics
Mouldy Sioud
Institute for Cancer Research, Department of Immunology, Molecular Medicine Group, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
Curr Drug Targets 6:647-53. 2005
..Their potential use in cell cultures and in animal models for disease is also highlighted...
- Demonstration of altered signaling responses in bone marrow extracellular fluid during increased hematopoiesis in rats using a centrifugation method
Helge Wiig
Department of Physiology, University of Bergen, 5009 Bergen, Norway
Am J Physiol Heart Circ Physiol 286:H2028-34. 2004
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- Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat
Eirunn Knudsen
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
Eur J Haematol 69:284-96. 2002
..Macrophage-derived IL-1beta, MIP-2, and KC are possible mediators of neutrophil homing to inflamed tissues...
- Reduced antioxidant defense and increased oxidative stress in spinal cord injured patients
Nasser Ezzathkah Bastani
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Arch Phys Med Rehabil 93:2223-8.e2. 2012
..To determine the plasma and urine levels of antioxidants and oxidative stress biomarkers in subjects with spinal cord injury (SCI) the first year after injury...
- Inhibition of gene expression by nucleic acid enzymes in rodent models of human disease
Per Ole Iversen
Institute for Nutrition, University of Oslo, Norway
Methods Mol Biol 252:451-6. 2004
..The described protocols should facilitate the in vivo evaluation of other oligonucleotide-based therapy such as small interfering RNAs (siRNAs)...
- G-CSF enhances the proliferation and mobilization, but not the maturation rate, of murine myeloid cells
Eirunn Knudsen
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
Eur J Haematol 87:302-11. 2011
..To further clarify the role of G-CSF, we now have examined its effect on murine granulopoiesis in situ...
- Pregnancy outcomes in familial hypercholesterolemia: a registry-based study
Ieva Toleikyte
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
Circulation 124:1606-14. 2011
..We determined whether heterozygous FH women are at higher risk of premature birth (<37 gestational weeks), delivering children with low birth weight (<2500 g) and/or with congenital malformations compared to women in general...
- The components required for amino acid neurotransmitter signaling are present in adipose tissues
Anne Nicolaysen
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
J Lipid Res 48:2123-32. 2007
..The presence of glutamate, GABA, their vesicular transporters, and their receptors indicates a paracrine signaling role for amino acids in adipose tissues...
- [Nutrition for preterm infants]
Christine Henriksen
Institutt for ernaeringsforskning, Universitetet i Oslo, Postboks 1046 Blindern, 0316 Oslo
Tidsskr Nor Laegeforen 124:1392-5. 2004
..In spite of an increased survival rate over the past 30 years, many challenges remain in the treatment of premature infants; their nutritional need is an important aspect...
- Maternal familial hypercholesterolaemia (FH) confers altered haemostatic profile in offspring with and without FH
Ingunn Narverud
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway The Lipid Clinic, Oslo University Hospital Rikshospitalet, Oslo, Norway
Thromb Res 131:178-82. 2013
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- Improved plasma lipids and body weight in overweight/obese patients with type III hyperlipoproteinemia after 4 weeks on a low glycemic diet
Kjetil Retterstøl
Lipid Clinic, Rikshospitalet University Hospital Trust, Oslo, Norway
Clin Nutr 28:213-5. 2009
..The optimal diet for type III hyperlipoproteinemia is unknown. We examined blood lipids and body weight following low or high glycemic index diets in comparison with a lipid-lowering diet...
- The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential therapeutic consequences
Helge Wiig
Department of Biomedicine, University of Bergen, Bergen, Norway
Microcirculation 15:283-96. 2008
..Here, we provide an overview of the structural components of the interstitium and discuss the importance the sterical and electrostatical components have on the dynamics of transcapillary fluid exchange...
- Increase in matrix metalloproteinases from endothelial cells exposed to umbilical cord plasma from high birth weight newborns
Erlingur Johannsson
Center for Sport and Health Sciences, Iceland University of Education, Laugarvatn, Iceland
Am J Physiol Regul Integr Comp Physiol 292:R1563-8. 2007
..Although not identified, cord plasma of HBW infants may contain factors that increase endothelial cell MMP. These findings may indicate an association between fetal nutritional conditions and endothelial cell functions...
- [Gestational diabetes in women from South Asia]
Alka Chawla
Avdeling for ernaeringsvitenskap, Medisinsk klinikk, Aker universitetssykehus
Tidsskr Nor Laegeforen 126:1041-3. 2006
..Generally, advice on diet and physical activity can prevent diabetes. Similar interventions might also be useful among the increasing population of immigrant fertile women in Norway...
- [Fetal nutrition and future health]
Tore Henriksen
Kvinneklinikken, Rikshospitalet, 0027 Oslo
Tidsskr Nor Laegeforen 125:442-4. 2005
..Maternal weight and metabolic status is closely associated with the growth and development of the fetus. Thus, diet and physical activity become particularly important aspects of the health of young women...
