- Profilin I is essential for cell survival and cell division in early mouse development
European Molecular Biology Laboratory Monterotondo, Mouse Biology Program, Via Ramarini 32, 00016 Monterotondo, Italy
Proc Natl Acad Sci U S A 98:3832-6. 2001
..Our results indicate that mouse profilin I is an essential protein that has dosage-dependent effects on cell division and survival during embryogenesis...
- Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms
A Di Nardo
EMBL Monterotondo, Mouse Biology Programme, Via Ramarini 32, Rome, Italy
J Cell Sci 113:3795-803. 2000
- Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 81:41-51. 1995
..Neither gelsolin nor other proteins with similar actin filament-severing activity are expressed in early embryonic cells, indicating that this mechanism of actin filament dynamics is not essential for motility during early embryogenesis...
- Molecular genetic approaches to understanding the actin cytoskeleton
J D Sutherland
European Molecular Biology Laboratory Mouse Biology Programme via Ramarini 32 00016 Monterotondo Italy
Curr Opin Cell Biol 11:142-51. 1999
..Yeast, Dictyostelium, Caenorhabditis elegans, Drosophila, and mice have contributed much in recent years to a better understanding of both the numerous functions and modes of regulation of the actin cytoskeleton...
- Mena is required for neurulation and commissure formation
L M Lanier
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Neuron 22:313-25. 1999
..Mena-deficient mice that are heterozygous for a Profilin I deletion die in utero and display defects in neurulation, demonstrating an important functional role for Mena in regulation of the actin cytoskeleton...
- Ca2(+)-binding proteins as components of the cytoskeleton
Max Planck Institute for Biochemistry, Martinsried, FRG
Adv Exp Med Biol 269:99-102. 1990
- Distinct biochemical characteristics of the two human profilin isoforms
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Eur J Biochem 229:621-8. 1995
..Potential structural differences of profilin I and profilin II that might explain the difference in actin binding are discussed...
- In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly
Mouse Biology Programme, EMBL, Monterotondo Rome, Italy
EMBO J 17:967-76. 1998
..Our findings strongly suggest that in brain profilin I and profilin II complexes link the actin cytoskeleton and endocytic membrane flow, directing actin and clathrin assembly to distinct membrane domains...
- Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing
Hematology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Cell Biol 154:775-84. 2001
..These primary effects on macrophage motile function suggest that CapG may be a useful target for the regulation of macrophage-mediated inflammatory responses...