W Witke

Summary

Country: Italy

Publications

  1. ncbi Profilin I is essential for cell survival and cell division in early mouse development
    W Witke
    European Molecular Biology Laboratory Monterotondo, Mouse Biology Program, Via Ramarini 32, 00016 Monterotondo, Italy
    Proc Natl Acad Sci U S A 98:3832-6. 2001
  2. ncbi Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms
    A Di Nardo
    EMBL Monterotondo, Mouse Biology Programme, Via Ramarini 32, Rome, Italy
    J Cell Sci 113:3795-803. 2000
  3. ncbi Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin
    W Witke
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 81:41-51. 1995
  4. ncbi Molecular genetic approaches to understanding the actin cytoskeleton
    J D Sutherland
    European Molecular Biology Laboratory Mouse Biology Programme via Ramarini 32 00016 Monterotondo Italy
    Curr Opin Cell Biol 11:142-51. 1999
  5. ncbi Mena is required for neurulation and commissure formation
    L M Lanier
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 22:313-25. 1999
  6. ncbi Ca2(+)-binding proteins as components of the cytoskeleton
    M Schleicher
    Max-Planck-Institute for Biochemistry, Martinsried, FRG
    Adv Exp Med Biol 269:99-102. 1990
  7. ncbi Distinct biochemical characteristics of the two human profilin isoforms
    R Gieselmann
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Biochem 229:621-8. 1995
  8. ncbi In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly
    W Witke
    Mouse Biology Programme, EMBL, Monterotondo Rome, Italy
    EMBO J 17:967-76. 1998
  9. ncbi Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing
    W Witke
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 154:775-84. 2001

Collaborators

Detail Information

Publications9

  1. ncbi Profilin I is essential for cell survival and cell division in early mouse development
    W Witke
    European Molecular Biology Laboratory Monterotondo, Mouse Biology Program, Via Ramarini 32, 00016 Monterotondo, Italy
    Proc Natl Acad Sci U S A 98:3832-6. 2001
    ..Our results indicate that mouse profilin I is an essential protein that has dosage-dependent effects on cell division and survival during embryogenesis...
  2. ncbi Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms
    A Di Nardo
    EMBL Monterotondo, Mouse Biology Programme, Via Ramarini 32, Rome, Italy
    J Cell Sci 113:3795-803. 2000
    ....
  3. ncbi Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin
    W Witke
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 81:41-51. 1995
    ..Neither gelsolin nor other proteins with similar actin filament-severing activity are expressed in early embryonic cells, indicating that this mechanism of actin filament dynamics is not essential for motility during early embryogenesis...
  4. ncbi Molecular genetic approaches to understanding the actin cytoskeleton
    J D Sutherland
    European Molecular Biology Laboratory Mouse Biology Programme via Ramarini 32 00016 Monterotondo Italy
    Curr Opin Cell Biol 11:142-51. 1999
    ..Yeast, Dictyostelium, Caenorhabditis elegans, Drosophila, and mice have contributed much in recent years to a better understanding of both the numerous functions and modes of regulation of the actin cytoskeleton...
  5. ncbi Mena is required for neurulation and commissure formation
    L M Lanier
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 22:313-25. 1999
    ..Mena-deficient mice that are heterozygous for a Profilin I deletion die in utero and display defects in neurulation, demonstrating an important functional role for Mena in regulation of the actin cytoskeleton...
  6. ncbi Ca2(+)-binding proteins as components of the cytoskeleton
    M Schleicher
    Max-Planck-Institute for Biochemistry, Martinsried, FRG
    Adv Exp Med Biol 269:99-102. 1990
  7. ncbi Distinct biochemical characteristics of the two human profilin isoforms
    R Gieselmann
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Biochem 229:621-8. 1995
    ..Potential structural differences of profilin I and profilin II that might explain the difference in actin binding are discussed...
  8. ncbi In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly
    W Witke
    Mouse Biology Programme, EMBL, Monterotondo Rome, Italy
    EMBO J 17:967-76. 1998
    ..Our findings strongly suggest that in brain profilin I and profilin II complexes link the actin cytoskeleton and endocytic membrane flow, directing actin and clathrin assembly to distinct membrane domains...
  9. ncbi Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing
    W Witke
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 154:775-84. 2001
    ..These primary effects on macrophage motile function suggest that CapG may be a useful target for the regulation of macrophage-mediated inflammatory responses...