Research Topics
Species | Luca PaniSummaryAffiliation: Via Palabanda Country: Italy Publications
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Detail Information
Publications
Antipsychotic efficacy: relationship to optimal D2-receptor occupancyLuca Pani
PharmaNess S c a r l, Technological Park Sardegna Ricerche, Pula CA, Italy
Eur Psychiatry 22:267-75. 2007....- The atypical antipsychotic quetiapine increases both noradrenaline and dopamine release in the rat prefrontal cortexLuigi Pira
Neuroscienze PharmaNess SCARL, Via Palabanda 9, 09124 Cagliari, Italy
Eur J Pharmacol 504:61-4. 2004..It is argued that the marked increase of dopaminergic transmission in the prefrontal cortex induced by quetiapine might be relevant to its therapeutical action... - Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring ratsLuisella Saba
Neuroscienze PharmaNess S c ar l, Cagliari, Italy
Brain Res Mol Brain Res 137:252-7. 2005.... - Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptorsSimone Tambaro
Neuroscienze PharmaNess S c ar l, Via Palabanda 9, 09124 Cagliari, Italy
Eur J Pharmacol 525:150-3. 2005..It is suggested that activation of pre-junctional cannabinoid receptors on sympathetic nerves of the vas deferens modulates ATP neurotransmission... - Effects of acute and chronic valproate treatments on p-CREB levels in the rat amygdala and nucleus accumbensMaria Antonietta Casu
Neuroscienze PharmaNess S c a r l, POLARIS, Edificio 5, Loc Piscinamanna, 09010 Pula, Cagliari, Italy
Brain Res 1141:15-24. 2007.... 
Quetiapine anxiolytic-like effect in the Vogel conflict test is serotonin dependentCarla Pisu
Institute of Biomedical Technology, C N R, Section of Cagliari bPharmaNess Scarl, Pula, Italy
Behav Pharmacol 21:649-53. 2010..1 mg/kg, subcutaneously) might prevent such an effect. Our results show that 10 mg/kg quetiapine exhibits an anxiolytic effect, that is, at least in part, 5HT1A-mediated, because it is completely eliminated by WAY100635...- Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical studyMaria Antonietta Casu
Neuroscienze PharmaNess SCARL, Via Palabanda, 9 09125 Cagliari, Italy
Brain Res 1048:41-7. 2005..This might be a mechanism by which delta9-THC interferes with motor and cognitive functions... - Multiplex genotyping of CYP3A4, CYP3A5, CYP2C9 and CYP2C19 SNPs using MALDI-TOF mass spectrometryMatteo Falzoi
Istituto Tecnologie Biomediche del Consiglio Nazionale delle Ricerche CNR ITB, Parco Scientifico e Tecnologico della Sardegna, Ed 5, Loc Piscinamanna, 09010 Pula CA Italy
Pharmacogenomics 11:559-71. 2010..Among them, CYP3A4, CYP3A5, CYP2C9 and CYP2C19 isoforms of CYP450 enzymes are involved in the metabolism of many commonly prescribed drugs... - Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to "early onset" vacuous chewingGiorgio Marchese
Neuroscienze S.c.a.r.l, and B.B. Brodie Department of Neuroscience, University of Cagliari, Italy
Eur J Neurosci 15:1187-96. 2002..These results suggest that haloperidol induces a morphological impairment of the dopaminergic nigro-striatal neurons which is directly associated with the arising, permanency and disappearance of VCMs in rats... - Evaluation of tamsulosin and alfuzosin activity in the rat vas deferens: relevance to ejaculation delaysSimone Tambaro
Neuroscienze PharmaNess SCARL, Via Palabanda 9, 09124 Calgliari, Italy
J Pharmacol Exp Ther 312:710-7. 2005..The fact that tamsulosin unusually enhances noradrenaline-induced intermittent spike contractions and nerve stimulation-induced twitches in the prostatic portions might be linked to its greater propensity to cause sexual dysfunctions... - Practical application of pharmacotherapy with long-acting risperidone for patients with schizophreniaSamuel J Keith
Department of Psychiatry, University of New Mexico, Albuquerque 87131 1161, USA
Psychiatr Serv 55:997-1005. 2004..This article provides practical advice to physicians on the characteristics of patients who would benefit from treatment with long-acting atypical antipsychotic agents and offers suggestions on how to initiate treatment... - Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroidAnna Porcella
CNR Institute of Neurogenetics and Neuropharmacology, Cagliari, Monserrato, Italy
Eur J Endocrinol 147:255-61. 2002..The aim of this study was to characterize the CB1 functional expression in the rat thyroid by a multi-methods approach... - The cerebellar GABAA alpha6 subunit is differentially modulated by chronic ethanol exposure in normal (R100R) and mutated (Q100Q) sNP ratsAngela Sanna
Molecular Biology, Neuroscienze S c a r l, Via Palabanda 9, I 09123 Cagliari, Italy
Brain Res 998:148-54. 2004..These data may contribute to elucidating the mechanisms of alcohol avoidance in rat lines selected for this behavior when exposed to ethanol solution... - Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tractMaria Antonietta Casu
Neuroscienze Scarl, Via Palabanda, 9 09124-I, Cagliari, Italy
Eur J Pharmacol 459:97-105. 2003..Moreover, the dose of 0.3 microg/kg of HU 210, devoid per se of any activity on mouse intestinal propulsion, blocked the increased gastroenteric transit induced by the cannabinoid CB(1) antagonist SR 141716A... - Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamideGabriele Murineddu
Dipartimento Farmaco Chimico Tossicologico, , via F. Muroni 23/A, 07100 Sassari, Italy
J Med Chem 49:7502-12. 2006..Furthermore, compounds 2a and 2b, as well as lead structures 1a,b, were also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells... - Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring ratsMaria Antonietta Casu
Neuroscienze Scarl, Via Palabanda 9, 09125 Cagliari, Italy
Brain Res 948:192-202. 2002..This genetically-determined difference may be involved in the opposite alcohol preference and consumption of sP and sNP rats... - Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP)Angela Sanna
C.N.R. Institute of Neurogenetic and Neuropharmacology, Cagliari, Italy
Brain Res 967:98-105. 2003..These data contribute to the characterization of the function of GABA(A) alpha(6) subunit and its involvement in determining alcohol related behavior... - Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychoticPaola Devoto
B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria, SS 554 Km 4 500, 09042, Monserrato, Italy
Psychopharmacology (Berl) 167:79-84. 2003..A recent study of ours suggested that extracellular DA in the PFC originates not only from dopaminergic but also from noradrenergic terminals, its release being controlled by alpha(2)-adrenoceptors... - Molecular characterization of new polymorphisms at the beta2, alpha1, gamma2 GABA(A) receptor subunit genes associated to a rat nonpreferring ethanol phenotypeElena Congeddu
C.N.R. Institute of Neurogenetic and Neuropharmacology, Via Boccaccio 8, Solargius (CA, Italy
Brain Res Mol Brain Res 110:289-97. 2003.... - Practical issues with amisulpride in the management of patients with schizophreniaLuca Pani
Institute of Biomedical Technologies, National Research Council CNR, Milan, ItalyPharmaNess Scarl, Sardegna Ricerche, Pula Cagliari, Italy
Clin Drug Investig 28:465-77. 2008.... - Contrasting effects of diazepam and repeated restraint stress on latent inhibition in miceRaymond Mongeau
Neuroscienze PharmaNess S c a r l, Scientific and Technological Park of Sardinia, ma c o Sardegna Ricerche, Ed 5, Loc Piscinamanna, 09010 PULA CA, Italy
Behav Brain Res 183:147-55. 2007..It is suggested that stress and anxiolytic drugs can have opposite effects on attention or perseveration processes during learning of conflicting contingency responses... - Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamideGabriele Murineddu
Dipartimento Farmaco Chimico Tossicologico, , via F. Muroni 23/A, 07100 Sassari, Italy
J Med Chem 48:7351-62. 2005.... - Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptorsGabriele Murineddu
Dipartimento Farmaco Chimico Tossicologico, , via F. Muroni 23/A, 07100 Sassari, Italy
Bioorg Med Chem 13:3309-20. 2005..Compounds 2a and c increased intestinal propulsion in mouse. Their pro-kinetic effects were reversed by the reference CB agonist CP-55,940. Consequently, in vivo CB(1) antagonistic activity was highlighted for these compounds... - Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effectGiorgio Marchese
Neuroscienze S.c.a.r.l, Cagliari, Italy
Eur J Pharmacol 447:109-14. 2002..These results suggested that a peripheral dopamine D(2) receptor agonists could be a useful tool in alleviating amisulpride-induced hyperprolactinemia without possibly affecting its central effect... - Effect of the amisulpride isomers on rat catalepsyGiorgio Marchese
Neuroscienze S.c.a.r.l, C.N.R, Cagliari, Italy
Eur J Pharmacol 444:69-74. 2002..These results indicate that the weak cataleptic properties of (RS)-amisulpride might partially rely on its (R+)-isomer and provide a further explanation for the atypical properties of amisulpride as an antipsychotic... - Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptorStefania Ruiu
Institute of Neurogenetic and Neuropharmacology, Via Boccaccio 8, 09047 Selargius, Italy
J Pharmacol Exp Ther 306:363-70. 2003..042 +/- 0.01 mg/kg i.p.) and hot-plate test (ID50 = 0.018 +/- 0.006 mg/kg i.p.). These results indicated that NESS 0327 is a novel cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor... 
Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implicationsGiorgio Marchese
Neuroscienze S.c.a r.l, Cagliari 09123, Italy
Br J Pharmacol 140:520-6. 2003..The preferential use of CLOZ rather than HP in the treatment of psychotic symptoms in cannabis abusers was discussed...- Immunocytochemical study of the forebrain serotonergic innervation in Sardinian alcohol-preferring ratsMaria Antonietta Casu
Neuroscienze Scarl, Via Palabanda 9, 09125 Cagliari, Italy
Psychopharmacology (Berl) 172:341-51. 2004..Several lines of evidence suggest an inverse relationship between alcohol abuse and central serotonergic neurotransmission... - Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidolGiorgio Marchese
Neuroscienze S.c.a.r.l, Cagliari, Italy
Eur J Pharmacol 483:65-9. 2004.... - Haloperidol versus risperidone on rat "early onset" vacuous chewingGiorgio Marchese
Neuroscienze S c ar l, Via Palabanda 9, 09123, Cagliari, Italy
Behav Brain Res 149:9-16. 2004..The present results indicated that haloperidol possessed a much higher propensity to induce rat "early onset" VCMs than risperidone... - Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in micePaola Casti
Neuroscienze S.c.a r.l, Cagliari, Italy
Neuropharmacology 47:128-35. 2004.... - Consensus on the use of substituted benzamides in psychiatric patientsGiorgio Racagni
Center of Neuropharmacology, University of Milan, Milan, Italy
Neuropsychobiology 50:134-43. 2004..Based on experimental data, amisulpride is a treatment of choice for dopaminergic transmission disorders, both in depression and in schizophrenia... - Reduced TH-immunoreactive fibers in the limbic system of Sardinian alcohol-preferring ratsMaria Antonietta Casu
Neuroscienze S c a r l, Via Palabanda 9, 09125 Cagliari, Italy
Brain Res 924:242-51. 2002....