Luca Pani

Summary

Affiliation: Via Palabanda
Country: Italy

Publications

  1. ncbi request reprint Antipsychotic efficacy: relationship to optimal D2-receptor occupancy
    Luca Pani
    PharmaNess S c a r l, Technological Park Sardegna Ricerche, Pula CA, Italy
    Eur Psychiatry 22:267-75. 2007
  2. ncbi request reprint The atypical antipsychotic quetiapine increases both noradrenaline and dopamine release in the rat prefrontal cortex
    Luigi Pira
    Neuroscienze PharmaNess SCARL, Via Palabanda 9, 09124 Cagliari, Italy
    Eur J Pharmacol 504:61-4. 2004
  3. ncbi request reprint Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats
    Luisella Saba
    Neuroscienze PharmaNess S c ar l, Cagliari, Italy
    Brain Res Mol Brain Res 137:252-7. 2005
  4. ncbi request reprint Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors
    Simone Tambaro
    Neuroscienze PharmaNess S c ar l, Via Palabanda 9, 09124 Cagliari, Italy
    Eur J Pharmacol 525:150-3. 2005
  5. ncbi request reprint Effects of acute and chronic valproate treatments on p-CREB levels in the rat amygdala and nucleus accumbens
    Maria Antonietta Casu
    Neuroscienze PharmaNess S c a r l, POLARIS, Edificio 5, Loc Piscinamanna, 09010 Pula, Cagliari, Italy
    Brain Res 1141:15-24. 2007
  6. doi request reprint Quetiapine anxiolytic-like effect in the Vogel conflict test is serotonin dependent
    Carla Pisu
    Institute of Biomedical Technology, C N R, Section of Cagliari bPharmaNess Scarl, Pula, Italy
    Behav Pharmacol 21:649-53. 2010
  7. ncbi request reprint Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study
    Maria Antonietta Casu
    Neuroscienze PharmaNess SCARL, Via Palabanda, 9 09125 Cagliari, Italy
    Brain Res 1048:41-7. 2005
  8. doi request reprint Multiplex genotyping of CYP3A4, CYP3A5, CYP2C9 and CYP2C19 SNPs using MALDI-TOF mass spectrometry
    Matteo Falzoi
    Istituto Tecnologie Biomediche del Consiglio Nazionale delle Ricerche CNR ITB, Parco Scientifico e Tecnologico della Sardegna, Ed 5, Loc Piscinamanna, 09010 Pula CA Italy
    Pharmacogenomics 11:559-71. 2010
  9. ncbi request reprint Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to "early onset" vacuous chewing
    Giorgio Marchese
    Neuroscienze S c a r l, and B B Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Neurosci 15:1187-96. 2002
  10. ncbi request reprint Evaluation of tamsulosin and alfuzosin activity in the rat vas deferens: relevance to ejaculation delays
    Simone Tambaro
    Neuroscienze PharmaNess SCARL, Via Palabanda 9, 09124 Calgliari, Italy
    J Pharmacol Exp Ther 312:710-7. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Antipsychotic efficacy: relationship to optimal D2-receptor occupancy
    Luca Pani
    PharmaNess S c a r l, Technological Park Sardegna Ricerche, Pula CA, Italy
    Eur Psychiatry 22:267-75. 2007
    ....
  2. ncbi request reprint The atypical antipsychotic quetiapine increases both noradrenaline and dopamine release in the rat prefrontal cortex
    Luigi Pira
    Neuroscienze PharmaNess SCARL, Via Palabanda 9, 09124 Cagliari, Italy
    Eur J Pharmacol 504:61-4. 2004
    ..It is argued that the marked increase of dopaminergic transmission in the prefrontal cortex induced by quetiapine might be relevant to its therapeutical action...
  3. ncbi request reprint Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats
    Luisella Saba
    Neuroscienze PharmaNess S c ar l, Cagliari, Italy
    Brain Res Mol Brain Res 137:252-7. 2005
    ....
  4. ncbi request reprint Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors
    Simone Tambaro
    Neuroscienze PharmaNess S c ar l, Via Palabanda 9, 09124 Cagliari, Italy
    Eur J Pharmacol 525:150-3. 2005
    ..It is suggested that activation of pre-junctional cannabinoid receptors on sympathetic nerves of the vas deferens modulates ATP neurotransmission...
  5. ncbi request reprint Effects of acute and chronic valproate treatments on p-CREB levels in the rat amygdala and nucleus accumbens
    Maria Antonietta Casu
    Neuroscienze PharmaNess S c a r l, POLARIS, Edificio 5, Loc Piscinamanna, 09010 Pula, Cagliari, Italy
    Brain Res 1141:15-24. 2007
    ....
  6. doi request reprint Quetiapine anxiolytic-like effect in the Vogel conflict test is serotonin dependent
    Carla Pisu
    Institute of Biomedical Technology, C N R, Section of Cagliari bPharmaNess Scarl, Pula, Italy
    Behav Pharmacol 21:649-53. 2010
    ..1 mg/kg, subcutaneously) might prevent such an effect. Our results show that 10 mg/kg quetiapine exhibits an anxiolytic effect, that is, at least in part, 5HT1A-mediated, because it is completely eliminated by WAY100635...
  7. ncbi request reprint Effect of delta9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study
    Maria Antonietta Casu
    Neuroscienze PharmaNess SCARL, Via Palabanda, 9 09125 Cagliari, Italy
    Brain Res 1048:41-7. 2005
    ..This might be a mechanism by which delta9-THC interferes with motor and cognitive functions...
  8. doi request reprint Multiplex genotyping of CYP3A4, CYP3A5, CYP2C9 and CYP2C19 SNPs using MALDI-TOF mass spectrometry
    Matteo Falzoi
    Istituto Tecnologie Biomediche del Consiglio Nazionale delle Ricerche CNR ITB, Parco Scientifico e Tecnologico della Sardegna, Ed 5, Loc Piscinamanna, 09010 Pula CA Italy
    Pharmacogenomics 11:559-71. 2010
    ..Among them, CYP3A4, CYP3A5, CYP2C9 and CYP2C19 isoforms of CYP450 enzymes are involved in the metabolism of many commonly prescribed drugs...
  9. ncbi request reprint Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to "early onset" vacuous chewing
    Giorgio Marchese
    Neuroscienze S c a r l, and B B Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Neurosci 15:1187-96. 2002
    ..These results suggest that haloperidol induces a morphological impairment of the dopaminergic nigro-striatal neurons which is directly associated with the arising, permanency and disappearance of VCMs in rats...
  10. ncbi request reprint Evaluation of tamsulosin and alfuzosin activity in the rat vas deferens: relevance to ejaculation delays
    Simone Tambaro
    Neuroscienze PharmaNess SCARL, Via Palabanda 9, 09124 Calgliari, Italy
    J Pharmacol Exp Ther 312:710-7. 2005
    ..The fact that tamsulosin unusually enhances noradrenaline-induced intermittent spike contractions and nerve stimulation-induced twitches in the prostatic portions might be linked to its greater propensity to cause sexual dysfunctions...
  11. ncbi request reprint Practical application of pharmacotherapy with long-acting risperidone for patients with schizophrenia
    Samuel J Keith
    Department of Psychiatry, University of New Mexico, Albuquerque 87131 1161, USA
    Psychiatr Serv 55:997-1005. 2004
    ..This article provides practical advice to physicians on the characteristics of patients who would benefit from treatment with long-acting atypical antipsychotic agents and offers suggestions on how to initiate treatment...
  12. ncbi request reprint Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
    Anna Porcella
    CNR Institute of Neurogenetics and Neuropharmacology, Cagliari, Monserrato, Italy
    Eur J Endocrinol 147:255-61. 2002
    ..The aim of this study was to characterize the CB1 functional expression in the rat thyroid by a multi-methods approach...
  13. ncbi request reprint The cerebellar GABAA alpha6 subunit is differentially modulated by chronic ethanol exposure in normal (R100R) and mutated (Q100Q) sNP rats
    Angela Sanna
    Molecular Biology, Neuroscienze S c a r l, Via Palabanda 9, I 09123 Cagliari, Italy
    Brain Res 998:148-54. 2004
    ..These data may contribute to elucidating the mechanisms of alcohol avoidance in rat lines selected for this behavior when exposed to ethanol solution...
  14. ncbi request reprint Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda, 9 09124 I, Cagliari, Italy
    Eur J Pharmacol 459:97-105. 2003
    ..Moreover, the dose of 0.3 microg/kg of HU 210, devoid per se of any activity on mouse intestinal propulsion, blocked the increased gastroenteric transit induced by the cannabinoid CB(1) antagonist SR 141716A...
  15. ncbi request reprint Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide
    Gabriele Murineddu
    Dipartimento Farmaco Chimico Tossicologico, Universita di Sassari, via F Muroni 23 A, 07100 Sassari, Italy
    J Med Chem 49:7502-12. 2006
    ..Furthermore, compounds 2a and 2b, as well as lead structures 1a,b, were also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells...
  16. ncbi request reprint Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda 9, 09125 Cagliari, Italy
    Brain Res 948:192-202. 2002
    ..This genetically-determined difference may be involved in the opposite alcohol preference and consumption of sP and sNP rats...
  17. ncbi request reprint Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP)
    Angela Sanna
    C N R Institute of Neurogenetic and Neuropharmacology, Cagliari, Italy
    Brain Res 967:98-105. 2003
    ..These data contribute to the characterization of the function of GABA(A) alpha(6) subunit and its involvement in determining alcohol related behavior...
  18. ncbi request reprint Co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex induced by clozapine, the prototype atypical antipsychotic
    Paola Devoto
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria, SS 554 Km 4 500, 09042, Monserrato, Italy
    Psychopharmacology (Berl) 167:79-84. 2003
    ..A recent study of ours suggested that extracellular DA in the PFC originates not only from dopaminergic but also from noradrenergic terminals, its release being controlled by alpha(2)-adrenoceptors...
  19. ncbi request reprint Molecular characterization of new polymorphisms at the beta2, alpha1, gamma2 GABA(A) receptor subunit genes associated to a rat nonpreferring ethanol phenotype
    Elena Congeddu
    C N R Institute of Neurogenetic and Neuropharmacology, Via Boccaccio 8, Solargius CA, Italy
    Brain Res Mol Brain Res 110:289-97. 2003
    ....
  20. ncbi request reprint Practical issues with amisulpride in the management of patients with schizophrenia
    Luca Pani
    Institute of Biomedical Technologies, National Research Council CNR, Milan, ItalyPharmaNess Scarl, Sardegna Ricerche, Pula Cagliari, Italy
    Clin Drug Investig 28:465-77. 2008
    ....
  21. ncbi request reprint Contrasting effects of diazepam and repeated restraint stress on latent inhibition in mice
    Raymond Mongeau
    Neuroscienze PharmaNess S c a r l, Scientific and Technological Park of Sardinia, ma c o Sardegna Ricerche, Ed 5, Loc Piscinamanna, 09010 PULA CA, Italy
    Behav Brain Res 183:147-55. 2007
    ..It is suggested that stress and anxiolytic drugs can have opposite effects on attention or perseveration processes during learning of conflicting contingency responses...
  22. ncbi request reprint Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide
    Gabriele Murineddu
    Dipartimento Farmaco Chimico Tossicologico, Universita di Sassari, via F Muroni 23 A, 07100 Sassari, Italy
    J Med Chem 48:7351-62. 2005
    ....
  23. ncbi request reprint Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4,5-dihydro-1H-benzo[g]indazole-based ligands for cannabinoid receptors
    Gabriele Murineddu
    Dipartimento Farmaco Chimico Tossicologico, Universita di Sassari, via F Muroni 23 A, 07100 Sassari, Italy
    Bioorg Med Chem 13:3309-20. 2005
    ..Compounds 2a and c increased intestinal propulsion in mouse. Their pro-kinetic effects were reversed by the reference CB agonist CP-55,940. Consequently, in vivo CB(1) antagonistic activity was highlighted for these compounds...
  24. ncbi request reprint Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect
    Giorgio Marchese
    Neuroscienze S c a r l, Cagliari, Italy
    Eur J Pharmacol 447:109-14. 2002
    ..These results suggested that a peripheral dopamine D(2) receptor agonists could be a useful tool in alleviating amisulpride-induced hyperprolactinemia without possibly affecting its central effect...
  25. ncbi request reprint Effect of the amisulpride isomers on rat catalepsy
    Giorgio Marchese
    Neuroscienze S c a r l, C N R, Cagliari, Italy
    Eur J Pharmacol 444:69-74. 2002
    ..These results indicate that the weak cataleptic properties of (RS)-amisulpride might partially rely on its (R+)-isomer and provide a further explanation for the atypical properties of amisulpride as an antipsychotic...
  26. ncbi request reprint Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor
    Stefania Ruiu
    Institute of Neurogenetic and Neuropharmacology, Via Boccaccio 8, 09047 Selargius, Italy
    J Pharmacol Exp Ther 306:363-70. 2003
    ..042 +/- 0.01 mg/kg i.p.) and hot-plate test (ID50 = 0.018 +/- 0.006 mg/kg i.p.). These results indicated that NESS 0327 is a novel cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor...
  27. pmc Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications
    Giorgio Marchese
    Neuroscienze S c a r l, Cagliari 09123, Italy
    Br J Pharmacol 140:520-6. 2003
    ..The preferential use of CLOZ rather than HP in the treatment of psychotic symptoms in cannabis abusers was discussed...
  28. ncbi request reprint Immunocytochemical study of the forebrain serotonergic innervation in Sardinian alcohol-preferring rats
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda 9, 09125 Cagliari, Italy
    Psychopharmacology (Berl) 172:341-51. 2004
    ..Several lines of evidence suggest an inverse relationship between alcohol abuse and central serotonergic neurotransmission...
  29. ncbi request reprint Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol
    Giorgio Marchese
    Neuroscienze S c a r l, Cagliari, Italy
    Eur J Pharmacol 483:65-9. 2004
    ....
  30. ncbi request reprint Haloperidol versus risperidone on rat "early onset" vacuous chewing
    Giorgio Marchese
    Neuroscienze S c ar l, Via Palabanda 9, 09123, Cagliari, Italy
    Behav Brain Res 149:9-16. 2004
    ..The present results indicated that haloperidol possessed a much higher propensity to induce rat "early onset" VCMs than risperidone...
  31. ncbi request reprint Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice
    Paola Casti
    Neuroscienze S c a r l, Cagliari, Italy
    Neuropharmacology 47:128-35. 2004
    ....
  32. ncbi request reprint Consensus on the use of substituted benzamides in psychiatric patients
    Giorgio Racagni
    Center of Neuropharmacology, University of Milan, Milan, Italy
    Neuropsychobiology 50:134-43. 2004
    ..Based on experimental data, amisulpride is a treatment of choice for dopaminergic transmission disorders, both in depression and in schizophrenia...
  33. ncbi request reprint Reduced TH-immunoreactive fibers in the limbic system of Sardinian alcohol-preferring rats
    Maria Antonietta Casu
    Neuroscienze S c a r l, Via Palabanda 9, 09125 Cagliari, Italy
    Brain Res 924:242-51. 2002
    ....