Giuseppe Matarese

Summary

Affiliation: Via Ponte Don Melillo
Country: Italy

Publications

  1. pmc Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses
    Giuseppe Matarese
    Dipartimento di Medicina e Chirurgia, Universita degli Studi di Salerno, 84081 Salerno, Italy
    Proc Natl Acad Sci U S A 110:6193-8. 2013
  2. doi At the crossroad of T cells, adipose tissue, and diabetes
    Giuseppe Matarese
    Dipartimento di Medicina, Facolta di Medicina, Universita di Salerno, Baronissi, Salerno, Italy
    Immunol Rev 249:116-34. 2012
  3. pmc In vivo veritas, in vitro artificia
    Giuseppe Matarese
    Dipartimento di Medicina e Chirurgia, Universita degli Studi di Salerno, Baronissi Campus, Salerno 84081, Italy
    Trends Mol Med 18:439-42. 2012
  4. ncbi Ob-stopping obesity, metabolic and immune-mediated disorders
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli 80131, Italy
    Structure 20:385-7. 2012
  5. doi Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway
    Mario Galgani
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy
    J Immunol 185:7474-9. 2010
  6. ncbi A key role of leptin in the control of regulatory T cell proliferation
    Veronica De Rosa
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, 80131 Napoli, Italy
    Immunity 26:241-55. 2007
  7. pmc An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli 80131, Italy
    Immunity 33:929-41. 2010
  8. doi Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli 80131, Italy
    J Immunol 189:2941-53. 2012
  9. pmc Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis
    Anna Maria Malfitano
    Dipartimento di Farmacia, Universita di Salerno, Fisciano, Salerno, Italy
    PLoS ONE 8:e62511. 2013
  10. pmc Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis
    Veronica De Rosa
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Naples, Italy
    J Clin Invest 116:447-55. 2006

Collaborators

Detail Information

Publications37

  1. pmc Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses
    Giuseppe Matarese
    Dipartimento di Medicina e Chirurgia, Universita degli Studi di Salerno, 84081 Salerno, Italy
    Proc Natl Acad Sci U S A 110:6193-8. 2013
    ..These observations unmask a previously unsuspected role of hypothalamic feeding circuits in the regulation of adaptive immune response...
  2. doi At the crossroad of T cells, adipose tissue, and diabetes
    Giuseppe Matarese
    Dipartimento di Medicina, Facolta di Medicina, Universita di Salerno, Baronissi, Salerno, Italy
    Immunol Rev 249:116-34. 2012
    ....
  3. pmc In vivo veritas, in vitro artificia
    Giuseppe Matarese
    Dipartimento di Medicina e Chirurgia, Universita degli Studi di Salerno, Baronissi Campus, Salerno 84081, Italy
    Trends Mol Med 18:439-42. 2012
    ..In this article, we discuss some of these issues and propose solutions...
  4. ncbi Ob-stopping obesity, metabolic and immune-mediated disorders
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli 80131, Italy
    Structure 20:385-7. 2012
    ..In this issue of Structure, Carpenter et al. report the crystal structure of the leptin-binding domain of human ObR in complex with the Fab fragment of an ObR-blocking monoclonal antibody (9F8 mAb)...
  5. doi Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway
    Mario Galgani
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy
    J Immunol 185:7474-9. 2010
    ..These results may help to explain a link between chronic inflammation and autoimmune T cell reactivity...
  6. ncbi A key role of leptin in the control of regulatory T cell proliferation
    Veronica De Rosa
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, 80131 Napoli, Italy
    Immunity 26:241-55. 2007
    ..Together with the finding of enhanced proliferation of T(reg) cells observed in leptin- and ObR-deficient mice, these results suggest a potential for therapeutic interventions in immune and autoimmune diseases...
  7. pmc An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli 80131, Italy
    Immunity 33:929-41. 2010
    ..These data suggest that energy metabolism, through the leptin-mTOR-axis, sets responsiveness of Treg cells that use this information to control immune tolerance and autoimmunity...
  8. doi Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli 80131, Italy
    J Immunol 189:2941-53. 2012
    ..These results identify a novel link between nutritional status and Teff responses through the leptin-mTOR axis and define a potential target for Teff modulation in normal and pathologic conditions...
  9. pmc Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis
    Anna Maria Malfitano
    Dipartimento di Farmacia, Universita di Salerno, Fisciano, Salerno, Italy
    PLoS ONE 8:e62511. 2013
    ..Our findings suggest potential application of these drugs in neuro-inflammation, supporting further investigations of the effects of compounds in the therapy of MS, particularly on the aspects regarding activation and inflammation...
  10. pmc Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis
    Veronica De Rosa
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Naples, Italy
    J Clin Invest 116:447-55. 2006
    ..Taken together, our data provide what we believe is a new molecular basis for leptin antagonism in EAE and envision novel strategies of leptin-based molecular targeting in the disease...
  11. pmc Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells
    Giuseppe Matarese
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 102:5150-5. 2005
    ..These findings show an inverse relationship between leptin secretion and the frequency of T(Regs) in RRMS and may have implications for the pathogenesis of and therapy for multiple sclerosis...
  12. doi Obesity and susceptibility to autoimmune diseases
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy
    Expert Rev Clin Immunol 7:287-94. 2011
    ....
  13. pmc Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia
    Giuseppe Matarese
    Dipartimento di Medicina e Chirurgia, Universita degli Studi di Salerno, Baronissi Campus, 84081 Baronissi Salerno, Italy
    Proc Natl Acad Sci U S A 110:E818-27. 2013
    ..Thus, metreleptin may prove to be a safe and effective therapy for selective CD4(+) T-cell immune reconstitution in hypoleptinemic states such as tuberculosis and HIV infection in which CD4(+) T cells are reduced...
  14. doi Regulatory T cell proliferative potential is impaired in human autoimmune disease
    Fortunata Carbone
    1 Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli, Italy 2 Dipartimento di Medicina e Chirurgia, Universita di Salerno, Baronissi Campus, Baronissi, Salerno, Italy 3
    Nat Med 20:69-74. 2014
    ..These results suggest a previously unrecognized mechanism that may account for the progressive loss of Treg cells in autoimmune disease. ..
  15. pmc Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
    Veronica Sanna
    Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    J Clin Invest 111:241-50. 2003
    ..Given that leptin appears to regulate EAE susceptibility, inflammatory anorexia, and pathogenic T-cell immune function, we postulate that it may offer a potential target in the treatment of multiple sclerosis...
  16. doi Divergent immunomodulatory effects of recombinant and urinary-derived FSH, LH, and hCG on human CD4+ T cells
    Fortunata Carbone
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy
    J Reprod Immunol 85:172-9. 2010
    ....
  17. doi Cellular and molecular crosstalk between leptin receptor and estrogen receptor-{alpha} in breast cancer: molecular basis for a novel therapeutic setting
    Roberta Fusco
    Dipartimento di Biologia Strutturale e Funzionale, Universita di Napoli Federico II, Naples, Italy
    Endocr Relat Cancer 17:373-82. 2010
    ..In conclusion, this study suggests a crosstalk between LepR and ERalpha, and could envisage novel therapeutic settings aimed at targeting the LepR in breast cancers...
  18. doi The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis?
    Giuseppe Matarese
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Via S Pansini 5, 80131, Napoli, Italy
    J Leukoc Biol 84:893-9. 2008
    ....
  19. pmc Meta-immunological profiling of children with type 1 diabetes identifies new biomarkers to monitor disease progression
    Mario Galgani
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli, Italy
    Diabetes 62:2481-91. 2013
    ..The identification of a specific meta-immunological profile associated with disease status may contribute to our understanding of the basis of diabetes progression. ..
  20. ncbi Leptin in immunology
    Giuseppe Matarese
    Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimenttale, Consiglio Nazionale delle Ricerche, Naples, Italy
    J Immunol 174:3137-42. 2005
    ..We review herein recent advances on the role of leptin in the pathophysiology of immune responses...
  21. ncbi Leptin accelerates autoimmune diabetes in female NOD mice
    Giuseppe Matarese
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    Diabetes 51:1356-61. 2002
    ..These findings indicate that leptin can favor proinflammatory cell responses and directly influence development of autoimmune disease mediated by Th1 responses...
  22. doi Regulatory T cells in obesity: the leptin connection
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli, Italy
    Trends Mol Med 16:247-56. 2010
    ..Here, we provide an update on recent findings relating Treg cells to obesity and discuss how the intricate network of interactions among leptin, Treg cells and adipose tissue might provide new strategies for therapeutic interventions...
  23. ncbi Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, via Ponte Don Melillo 84084 Fisciano Salerno, Italy
    J Neuroimmunol 171:110-9. 2006
    ..Our findings have relevance for the use of arvanil and related compounds as a novel immunotherapeutic approach in the treatment of multiple sclerosis...
  24. doi Leptin as a metabolic link to multiple sclerosis
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Via S Pansini 5, 80131 Napoli, Italy
    Nat Rev Neurol 6:455-61. 2010
    ..We also consider the translational implications of these new findings for improved management of MS...
  25. doi Immunological functions of leptin and adiponectin
    Fortunata Carbone
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli 80131, Italy c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli 80131, Italy
    Biochimie 94:2082-8. 2012
    ..In this review we focus on the main biological activities of leptin and adiponectin on the lipid and carbohydrate metabolism and on their contribute in regulation of innate and adaptive immune responses...
  26. ncbi Leptin: the prototypic adipocytokine and its role in NAFLD
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale, delle Ricerche IEOS CNR, Via S Pansini, 5 80131 Naples, Italy
    Curr Pharm Des 16:1902-12. 2010
    ....
  27. doi The CB1 receptor antagonist rimonabant controls cell viability and ascitic tumour growth in mice
    Anna Maria Malfitano
    Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    Pharmacol Res 65:365-71. 2012
    ....
  28. ncbi Balancing susceptibility to infection and autoimmunity: a role for leptin?
    Giuseppe Matarese
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Trends Immunol 23:182-7. 2002
    ....
  29. doi Leptin as an immunomodulator
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli, Federico II, Via Pansini 5, 80131 Napoli, Italy
    Mol Aspects Med 33:35-45. 2012
    ..Here, we review the advances and controversy for a role of leptin in the pathophysiology of immune responses and discuss novel possible therapeutic implications for leptin modulators...
  30. ncbi Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli 80131, Italy
    Curr Pharm Des 13:3676-80. 2007
    ....
  31. doi Intracellular metabolic pathways control immune tolerance
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli 80131, Italy
    Trends Immunol 33:1-7. 2012
    ..We propose that metabolic changes such as nutritional deprivation or overload could dictate the characteristics of the Treg cell compartment and subsequent downstream immune reactions...
  32. doi Regulatory CD4 T cells: sensing the environment
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Italy
    Trends Immunol 29:12-7. 2008
    ....
  33. ncbi HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway
    Chiara Laezza
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy
    J Mol Med (Berl) 84:967-73. 2006
    ..Our data suggest that lovastatin is an efficient inhibitor of goitrogenesis and provide a rationale for innovative therapeutic strategies employing statins in the treatment of nodular goiter in humans...
  34. ncbi From cannabis to endocannabinoids in multiple sclerosis: a paradigm of central nervous system autoimmune diseases
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano SA, Italy
    Curr Drug Targets CNS Neurol Disord 4:667-75. 2005
    ....
  35. pmc Allelic distribution of human leucocyte antigen in historical and recently diagnosed tuberculosis patients in Southern Italy
    Giuseppina Ruggiero
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via Pansini 5, 80131 Naples, Italy
    Immunology 111:318-22. 2004
    ..00004; Pc = 0.008; and P = 0.0001; and Pc = 0.02, respectively)...
  36. doi Regulatory T cells, leptin and angiogenesis
    Valentina Pucino
    Divisione di Immunologia Clinica ed Allergologia, Centro Interdipartimentale di Ricerca in Scienze Immunologiche di Base e Cliniche, Universita di Napoli Federico II, Napoli, Italy
    Chem Immunol Allergy 99:155-69. 2014
    ..e. vascular endothelial growth factor, leptin). This work aims to discuss some of the most recent advances on the relationship between angiogenesis, leptin and immune tolerance, focusing on the role of Treg cell function in this context...
  37. ncbi Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease?
    Giuseppe Matarese
    Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    Trends Mol Med 9:223-8. 2003
    ..In this review, we focus on the multiple processes underlying the complex pathogenesis of endometriosis, with particular emphasis on the role played by the immune system with the induction of autoimmunity...