Guido Iaccarino


Affiliation: Via Ponte Don Melillo
Country: Italy


  1. Sorriento D, Santulli G, Ciccarelli M, Maione A, Illario M, Trimarco B, et al. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors. Int J Mol Sci. 2018;19: pubmed publisher
  2. Pascale V, Finelli R, Giannotti R, Coscioni E, Izzo R, Rozza F, et al. Cardiac eccentric remodeling in patients with rheumatoid arthritis. Sci Rep. 2018;8:5867 pubmed publisher
    ..02; F = 7,1620) We conclude that unfavorable cardiac remodeling can increase cardiovascular risk in patients with RA. ..
  3. Visco V, Finelli R, Pascale A, Mazzeo P, Ragosa N, Trimarco V, et al. Difficult-to-control hypertension: identification of clinical predictors and use of ICT-based integrated care to facilitate blood pressure control. J Hum Hypertens. 2018;32:467-476 pubmed publisher
    ..16?±?1.67?mm?Hg at 1 month, p?<?0.01). We concluded that DTC hypertension can be predicted based on the clinical characteristics at the first visit. For these patients, ICT-IC is a feasible therapeutic strategy to achieve BP control. ..
  4. Cano A, Dargent G, Carriazo A, López Samaniego L, Apóstolo J, Campos E, et al. Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing. Maturitas. 2018;115:69-73 pubmed publisher
    ..The 2017 meeting in Valencia, Spain, showcased in this paper, provides an up-to-date overview of the current status of A3 activities. ..
  5. Santulli G, Iaccarino G. Adrenergic signaling in heart failure and cardiovascular aging. Maturitas. 2016;93:65-72 pubmed publisher
    ..This article will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiovascular aging. ..
  6. Pecoraro M, Ciccarelli M, Fiordelisi A, Iaccarino G, Pinto A, Popolo A. Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity. Int J Mol Sci. 2018;19: pubmed publisher
    ..In conclusion, our data demonstrate that, in a short-time mouse model of DOXO-induced cardiotoxicity, DZX exerts its cardioprotective effects also by enhancing the amount Cx43. ..
  7. Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G. Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo. Hypertension. 2012;60:129-36 pubmed publisher
    ..In conclusion, our study demonstrates for the first time that ECs are able to synthesize and release catecholamines in response to ischemia...
  8. Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, et al. Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy. J Cardiovasc Transl Res. 2015;8:493-502 pubmed publisher
    ..Our results suggest a previously undisclosed role for GRK2 in the regulation of hypertrophic responses and propose GRK2 as potential therapeutic target for limiting LVH. ..
  9. Cipolletta E, Del Giudice C, Santulli G, Trimarco B, Iaccarino G. Opposite effects of ?2-adrenoceptor gene deletion on insulin signaling in liver and skeletal muscle. Nutr Metab Cardiovasc Dis. 2017;27:615-623 pubmed publisher
    ..Our findings indicate that the cross-talk between ?2-AR and insulin signaling represents a fundamental target towards the development of novel therapeutic approaches to treat type 2 diabetes and metabolic syndrome. ..

More Information


  1. Pecoraro M, Rodriguez Sinovas A, Marzocco S, Ciccarelli M, Iaccarino G, Pinto A, et al. Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our data suggest that DOXO-induced alterations in Ca2+ homeostasis causes in the cells the induction of compensatory mechanisms until a certain threshold, above which cardiac injury is triggered. ..