Fernando Goglia

Summary

Affiliation: Via Port'Arsa
Country: Italy

Publications

  1. doi request reprint Age-related changes in renal and hepatic cellular mechanisms associated with variations in rat serum thyroid hormone levels
    Elena Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Benevento, Italy
    Am J Physiol Endocrinol Metab 294:E1160-8. 2008
  2. doi request reprint Responses of skeletal muscle lipid metabolism in rat gastrocnemius to hypothyroidism and iodothyronine administration: a putative role for FAT/CD36
    Assunta Lombardi
    Dipartimento delle Scienze Biologiche, Universita di Napoli Federico II, Naples, Italy
    Am J Physiol Endocrinol Metab 303:E1222-33. 2012
  3. ncbi request reprint Thyroid hormones and mitochondria
    Fernando Goglia
    Facoltà de Scienze, Universita degli Studi del Sannio, Benevento, Italy
    Biosci Rep 22:17-32. 2002
  4. ncbi request reprint Biological effects of 3,5-diiodothyronine (T(2))
    F Goglia
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Benevento 82100, Italy
    Biochemistry (Mosc) 70:164-72. 2005
  5. pmc Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-L-thyronine in rats
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Caserta, Italy
    Diabetes 60:2730-9. 2011
  6. ncbi request reprint Differential 3,5,3'-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Endocrinology 148:4064-72. 2007
  7. ncbi request reprint Fenofibrate activates the biochemical pathways and the de novo expression of genes related to lipid handling and uncoupling protein-3 functions in liver of normal rats
    Elena Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italia
    Biochim Biophys Acta 1757:486-95. 2006
  8. doi request reprint Rapid activation by 3,5,3'-L-triiodothyronine of adenosine 5'-monophosphate-activated protein kinase/acetyl-coenzyme a carboxylase and akt/protein kinase B signaling pathways: relation to changes in fuel metabolism and myosin heavy-chain protein content i
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Endocrinology 149:6462-70. 2008
  9. ncbi request reprint 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats
    Antonia Lanni
    Dipartimento di Scienze della Vita, Seconda Universita di Napoli, Caserta, Italy
    FASEB J 19:1552-4. 2005
  10. doi request reprint Metabolic effects of the iodothyronine functional analogue TRC150094 on the liver and skeletal muscle of high-fat diet fed overweight rats: an integrated proteomic study
    Elena Silvestri
    Dipartimento di Scienze per la Biologia, la Geologia e l Ambiente, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    Mol Biosyst 8:1987-2000. 2012

Collaborators

Detail Information

Publications40

  1. doi request reprint Age-related changes in renal and hepatic cellular mechanisms associated with variations in rat serum thyroid hormone levels
    Elena Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Benevento, Italy
    Am J Physiol Endocrinol Metab 294:E1160-8. 2008
    ....
  2. doi request reprint Responses of skeletal muscle lipid metabolism in rat gastrocnemius to hypothyroidism and iodothyronine administration: a putative role for FAT/CD36
    Assunta Lombardi
    Dipartimento delle Scienze Biologiche, Universita di Napoli Federico II, Naples, Italy
    Am J Physiol Endocrinol Metab 303:E1222-33. 2012
    ....
  3. ncbi request reprint Thyroid hormones and mitochondria
    Fernando Goglia
    Facoltà de Scienze, Universita degli Studi del Sannio, Benevento, Italy
    Biosci Rep 22:17-32. 2002
    ..In conclusion, it is likely that iodothyronines regulate energy metabolism by both short-term and long-term mechanisms, and that they act in more than one way in affecting mitochondrial functions...
  4. ncbi request reprint Biological effects of 3,5-diiodothyronine (T(2))
    F Goglia
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Benevento 82100, Italy
    Biochemistry (Mosc) 70:164-72. 2005
    ..The accumulated evidence permits the conclusion that the actions of T(2) do not simply mimic those of T(3) but instead are specific actions exerted through mechanisms that are independent of those actuated by T(3) and do not involve THR...
  5. pmc Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-L-thyronine in rats
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Caserta, Italy
    Diabetes 60:2730-9. 2011
    ..Previously, we showed that 3,5-diiodothyronine (T2), concomitantly administered to rats on a 4-week HFD, prevented gain in body weight and adipose mass. Here we investigated whether and how T2 prevented HFD-induced insulin resistance...
  6. ncbi request reprint Differential 3,5,3'-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Endocrinology 148:4064-72. 2007
    ..All promoters share a response element common to TR and PPAR (TRE 1), but the observed species differences may be attributable to different localizations of the MyoD response element, which in the rat maps to exon 1...
  7. ncbi request reprint Fenofibrate activates the biochemical pathways and the de novo expression of genes related to lipid handling and uncoupling protein-3 functions in liver of normal rats
    Elena Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italia
    Biochim Biophys Acta 1757:486-95. 2006
    ....
  8. doi request reprint Rapid activation by 3,5,3'-L-triiodothyronine of adenosine 5'-monophosphate-activated protein kinase/acetyl-coenzyme a carboxylase and akt/protein kinase B signaling pathways: relation to changes in fuel metabolism and myosin heavy-chain protein content i
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Endocrinology 149:6462-70. 2008
    ..These data show that in skeletal muscle, T3 stimulates both fatty acid and glucose metabolism through rapid activations of the associated signaling pathways involving AMPK and Akt/protein kinase B...
  9. ncbi request reprint 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats
    Antonia Lanni
    Dipartimento di Scienze della Vita, Seconda Universita di Napoli, Caserta, Italy
    FASEB J 19:1552-4. 2005
    ..However, the results reported here do not exclude deleterious effects of T2 on a longer time scale as well as do not show that T2 acts in the same way in humans...
  10. doi request reprint Metabolic effects of the iodothyronine functional analogue TRC150094 on the liver and skeletal muscle of high-fat diet fed overweight rats: an integrated proteomic study
    Elena Silvestri
    Dipartimento di Scienze per la Biologia, la Geologia e l Ambiente, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    Mol Biosyst 8:1987-2000. 2012
    ....
  11. doi request reprint TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet
    Federica Cioffi
    Dipartimento di Scienze della Vita, Seconda Universita di Napoli, Caserta, Italy
    FASEB J 24:3451-61. 2010
    ..If reproduced in humans, these results will open interesting possibilities regarding the counteraction of metabolic dysfunction associated with ectopic/visceral fat accumulation...
  12. doi request reprint 3,5-Diiodo-L-thyronine prevents high-fat-diet-induced insulin resistance in rat skeletal muscle through metabolic and structural adaptations
    Maria Moreno
    Dipartimento di Scienze per la Biologia, la Geologia e l Ambiente, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    FASEB J 25:3312-24. 2011
    ..3-fold; P<0.05), supporting the metabolic shift toward a more glycolytic phenotype. These results highlight T2 as a potential therapeutic approach to the treatment of diet-induced metabolic dysfunctions...
  13. doi request reprint Uncoupling protein 3 expression levels influence insulin sensitivity, fatty acid oxidation, and related signaling pathways
    Rosalba Senese
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, Caserta, Italy
    Pflugers Arch 461:153-64. 2011
    ..This is accompanied by decreased fatty acid oxidation and a less intense Akt/PKB and AMPK signaling...
  14. ncbi request reprint Thyroid-state influence on protein-expression profile of rat skeletal muscle
    Elena Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    J Proteome Res 6:3187-96. 2007
    ..This study represents the first systematic identification of thyroid state-induced changes in the skeletal muscle protein-expression profile and reveals new cellular pathways as targets for thyroid hormone action...
  15. ncbi request reprint Sequential changes in the signal transduction responses of skeletal muscle following food deprivation
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100, Caserta, Italy
    FASEB J 20:2579-81. 2006
    ..Accompanying this is a decrease in AMPK phosphorylation, reversible upon nicotinic acid treatment, indicating that fatty acids may modulate this kinase's activity after the metabolic challenges posed by food deprivation...
  16. doi request reprint Pathways affected by 3,5-diiodo-l-thyronine in liver of high fat-fed rats: evidence from two-dimensional electrophoresis, blue-native PAGE, and mass spectrometry
    Elena Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    Mol Biosyst 6:2256-71. 2010
    ..The identified metabolic pathways (mainly at the mitochondrial level) may be responsible for the beneficial effects of T2 on liver adiposity and metabolism...
  17. ncbi request reprint Combined cDNA array/RT-PCR analysis of gene expression profile in rat gastrocnemius muscle: relation to its adaptive function in energy metabolism during fasting
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli studi di Napoli SUN, Caserta
    FASEB J 18:350-2. 2004
    ....
  18. ncbi request reprint Fasting, lipid metabolism, and triiodothyronine in rat gastrocnemius muscle: interrelated roles of uncoupling protein 3, mitochondrial thioesterase, and coenzyme Q
    Maria Moreno
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italia
    FASEB J 17:1112-4. 2003
    ..The data also show that MTE I and UCP3 are likely involved in the same biochemical mechanism and that UCP3 postulated functions, such as lipid handling and uncoupling, are not mutually exclusive but may coexist in vivo...
  19. pmc (Healthy) ageing: focus on iodothyronines
    Pieter de Lange
    Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, Caserta 81100, Italy
    Int J Mol Sci 14:13873-92. 2013
    ....
  20. pmc Studies of complex biological systems with applications to molecular medicine: the need to integrate transcriptomic and proteomic approaches
    Elena Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    J Biomed Biotechnol 2011:810242. 2011
    ..ageing and altered thyroid state) in relevant metabolically active tissues. In addition, we discuss several new applications of proteomic analysis to the investigation of mitochondrial activity...
  21. ncbi request reprint A proteomics approach to identify protein expression changes in rat liver following administration of 3,5,3'-triiodo-L-thyronine
    Elena Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    J Proteome Res 5:2317-27. 2006
    ..This study represents the first systematic identification of T3-induced changes in liver protein expression profile and provides novel information at the molecular, cellular, and tissue level of T3 action...
  22. ncbi request reprint Thyroid: biological actions of 'nonclassical' thyroid hormones
    Rosalba Senese
    Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy Dipartimento di Scienze e Tecnologie, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    J Endocrinol 221:R1-12. 2014
    ....
  23. doi request reprint Thyroid hormones, mitochondrial bioenergetics and lipid handling
    Federica Cioffi
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Caserta, Italy
    Curr Opin Endocrinol Diabetes Obes 17:402-7. 2010
    ..Mitochondria, as a result of their functions, represent the principal objective of scientists investigating the mechanisms underlying the effects of thyroid hormones or their metabolites/derivatives...
  24. doi request reprint Uncoupling proteins: a complex journey to function discovery
    Federica Cioffi
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Caserta, Italy
    Biofactors 35:417-28. 2009
    ..From the above, it is evident that more research will be needed to establish universally accepted functions for UCPs...
  25. doi request reprint Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cells
    Adelaide Del Viscovo
    Dipartimento di Scienze per la Biologia, la Geologia e l Ambiente, Universita del Sannio, Piazza Guerrazzi 1, Benevento, Italy
    Am J Physiol Endocrinol Metab 302:E1419-30. 2012
    ..Collectively, the present results suggest that T2 and T3 exert short-term nongenomic effects on intracellular calcium and NO by modulating plasma membrane and mitochondrial pathways that differ between these iodothyronines...
  26. ncbi request reprint Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    FASEB J 21:3431-41. 2007
    ..It is thus becoming increasingly clear that fatty acids determine the economy of their own usage. We discuss the order of events from the onset of food deprivation and their importance...
  27. doi request reprint Metabolic effects of thyroid hormone derivatives
    Maria Moreno
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa, Benevento, Italy
    Thyroid 18:239-53. 2008
    ..Hopefully, further studies on basic mechanisms of such compounds will be harbingers of more knowledge on the metabolic effects of TH derivatives and on their possible clinical application...
  28. ncbi request reprint Identification of 3,5-diiodo-L-thyronine-binding proteins in rat liver cytosol by photoaffinity labeling
    Maria Moreno
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, I 82100 Benevento, Italy
    Endocrinology 144:2297-303. 2003
    ....
  29. pmc Peroxisome Proliferator-Activated Receptor Delta: A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle
    Pieter de Lange
    Dipartimento di Scienze della Vita, Seconda Universita degli Studi di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    PPAR Res 2008:172676. 2008
    ..The main aim of this review is to highlight the central role for activated PPARdelta in the reversal of any tendency toward the development of insulin resistance...
  30. ncbi request reprint De novo expression of uncoupling protein 3 is associated to enhanced mitochondrial thioesterase-1 expression and fatty acid metabolism in liver of fenofibrate-treated rats
    Antonia Lanni
    Department of Life Sciences, Second University of Naples, Caserta, Italy
    FEBS Lett 525:7-12. 2002
    ..The data demonstrate that UCP3 is involved in fatty acid utilization and support the notion that UCP3 and MTE-1 are linked within the same metabolic pathway...
  31. ncbi request reprint Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself?
    Maria Moreno
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, 82100 Benevento, Italy
    Endocrinology 143:504-10. 2002
    ..Because the effects of T3 and 3,5-T2 are additive, in N rats, the two iodothyronines probably cooperate in vivo to determine the total metabolic rate...
  32. doi request reprint Thyroid hormones and mitochondria: with a brief look at derivatives and analogues
    Federica Cioffi
    Dipartimento di Scienze e Tecnologie, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    Mol Cell Endocrinol 379:51-61. 2013
    ..We summarize data obtained recently and in the past to try to obtain an updated picture of the current research position concerning the metabolic effects of TH, with particular emphasis on those exerted via mitochondria. ..
  33. ncbi request reprint A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
    Fernando Goglia
    Dipartimento di Scienze Biologiche ed Ambientali, 082100, Benevento, Italy
    FASEB J 17:1585-91. 2003
    ..This explains why UCP2, 3, 4, and 5 are present in small amounts usually insufficient to make a large contribution to the H+ conductance of the mitochondrial membrane...
  34. doi request reprint 3,5-Diiodo-L-thyronine modulates the expression of genes of lipid metabolism in a rat model of fatty liver
    Elena Grasselli
    DIPTERIS, Universita di Genova, Genova, Italy
    J Endocrinol 212:149-58. 2012
    ..In conclusion, our findings might give an insight into the mechanisms underlying the anti-steatotic ability of T(2) and help to define the potential therapeutic role of T(2) for preventing or treating liver steatosis...
  35. ncbi request reprint Thyroid hormones as molecular determinants of thermogenesis
    E Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Benevento, Italy
    Acta Physiol Scand 184:265-83. 2005
    ..TH seem to be deeply involved in this modulation, and this article will review some aspects of their possible influence in these conditions...
  36. ncbi request reprint Thyroid-hormone effects on putative biochemical pathways involved in UCP3 activation in rat skeletal muscle mitochondria
    E Silvestri
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    FEBS Lett 579:1639-45. 2005
    ..We suggest that T3 stimulates the UCP3 activity in vivo by affecting the complex network of biochemical pathways underlying the UCP3 activation...
  37. ncbi request reprint Triiodothyronine modulates the expression of aquaporin-8 in rat liver mitochondria
    Giuseppe Calamita
    Department of General and Environmental Physiology, Universita degli Studi di Bari, Via Amendola 165 A, 70126 Bari, Italy
    J Endocrinol 192:111-20. 2007
    ..Overall, our data indicate that the T3 modulation of the AQP8 gene is a rapid downregulation of transcription. Modulation of hepatic AQP8 expression may be relevant to the regulation of mitochondrial metabolism by thyroid hormones...
  38. ncbi request reprint Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats affects bioenergetic parameters in rat skeletal muscle mitochondria
    Assunta Lombardi
    Dipartimento delle Scienze Biologiche, Sezione Fisiologia ed Igiene, Universita degli Studi di Napoli Federico II, Via Mezzocannone, 8 80134 Napoli, Italy
    FEBS Lett 581:5911-6. 2007
    ..As a whole, these results may provide a mechanism by which T2 rapidly affects energy metabolism in hypothyroid rats...
  39. ncbi request reprint Effect of age and cold exposure on morphofunctional characteristics of skeletal muscle in neonatal pigs
    Patrick Herpin
    Unité Mixte de Recherches sur le Veau et le Porc, INRA 35590 St Gilles, France
    Pflugers Arch 444:610-8. 2002
    ..The observed changes reflect the immaturity and remarkable plasticity of piglet skeletal muscle and are likely to underlie its enhanced capacity for shivering thermogenesis after birth...
  40. ncbi request reprint Interrelated influence of superoxides and free fatty acids over mitochondrial uncoupling in skeletal muscle
    Assunta Lombardi
    Dipartimento delle Scienze Biologiche, Sezione Fisiologia, Universita degli Studi di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
    Biochim Biophys Acta 1777:826-33. 2008
    ....