Genomes and Genes


Michele Ciccarelli


Affiliation: Via Ponte Don Melillo
Country: Italy


  1. Cipolletta E, Gambardella J, Fiordelisi A, Del Giudice C, Di Vaia E, Ciccarelli M, et al. Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice. Int J Mol Sci. 2019;20: pubmed publisher
    ..GRK2 inhibition represents a promising therapeutic target for diabetes and its cardiovascular complications. ..
  2. De Angelis E, Pecoraro M, Rusciano M, Ciccarelli M, Popolo A. Cross-Talk between Neurohormonal Pathways and the Immune System in Heart Failure: A Review of the Literature. Int J Mol Sci. 2019;20: pubmed publisher
    ..This review aims to summarize the available knowledge on neurohormonal modulation of immune responses, providing supportive rational background for further research. ..
  3. Pecoraro M, Ciccarelli M, Fiordelisi A, Iaccarino G, Pinto A, Popolo A. Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity. Int J Mol Sci. 2018;19: pubmed publisher
    ..In conclusion, our data demonstrate that, in a short-time mouse model of DOXO-induced cardiotoxicity, DZX exerts its cardioprotective effects also by enhancing the amount Cx43. ..
  4. Sorriento D, Santulli G, Ciccarelli M, Maione A, Illario M, Trimarco B, et al. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors. Int J Mol Sci. 2018;19: pubmed publisher
  5. Ciccarelli M, Rusciano M, Sorriento D, Basilicata M, Santulli G, Campiglia P, et al. CaMKII protects MKP-1 from proteasome degradation in endothelial cells. Cell Signal. 2014;26:2167-74 pubmed publisher
    ..This novel finding opens to a novel scenario in regulation of endothelial cell functions. ..
  6. Pecoraro M, Rodriguez Sinovas A, Marzocco S, Ciccarelli M, Iaccarino G, Pinto A, et al. Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our data suggest that DOXO-induced alterations in Ca2+ homeostasis causes in the cells the induction of compensatory mechanisms until a certain threshold, above which cardiac injury is triggered. ..