Lorella M T Canzoniero
Affiliation: Via Port'Arsa
- Calcium in Alzheimer's disease pathogenesis: too much, too little or in the wrong place?Lorella M T Canzoniero
Department of Biology and Environmental Sciences, University of Sannio, Benevento, Italy
J Alzheimers Dis 8:147-54; discussion 209-15. 2005....
- Intracellular and plasma membrane-initiated pathways involved in the [Ca2+]i elevations induced by iodothyronines (T3 and T2) in pituitary GH3 cellsAdelaide Del Viscovo
Dipartimento di Scienze per la Biologia, la Geologia e l Ambiente, Universita del Sannio, Piazza Guerrazzi 1, Benevento, Italy
Am J Physiol Endocrinol Metab 302:E1419-30. 2012..Collectively, the present results suggest that T2 and T3 exert short-term nongenomic effects on intracellular calcium and NO by modulating plasma membrane and mitochondrial pathways that differ between these iodothyronines...
- MS-275 inhibits aroclor 1254-induced SH-SY5Y neuronal cell toxicity by preventing the formation of the HDAC3/REST complex on the synapsin-1 promoterLuigi Formisano
Division of Pharmacology, Department of Science and Technology, University of Sannio, Benevento, Italy L F, L M T C and Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatologic Sciences, School of Medicine, Federico II University of Naples, Naples, Italy L F, N G, G L, L M, G D R, L M T C
J Pharmacol Exp Ther 352:236-43. 2015..Hence, this study demonstrates that inhibition of HDAC class I attenuates A1254-induced neuronal cell death by preventing HDAC3 binding and histone deacetylation within the synapsin-1 promoter region. ..
- Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cellsLorella M T Canzoniero
Department of Biological and Environmental Sciences, University of Sannio, Benevento, Italy
J Neurosci Res 84:692-7. 2006..These results suggest that PCB-induced cell death in neuroblastoma cells is mediated by an activation of the cGMP/PKG pathway triggered by NO production...
- Raising intracellular calcium attenuates neuronal apoptosis triggered by staurosporine or oxygen-glucose deprivation in the presence of glutamate receptor blockadeLorella M T Canzoniero
Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Neurobiol Dis 15:520-8. 2004..Raising [Ca(2+)](i) either by activating voltage-sensitive Ca(2+) channels with (-) Bay K8644 or by application of low concentrations of kainate attenuated both staurosporine and oxygen-glucose deprivation-induced apoptosis...
- Membrane-permeant chelators can attenuate Zn2+-induced cortical neuronal deathLorella M T Canzoniero
Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Neuropharmacology 45:420-8. 2003..These data point to a potential therapeutic role for membrane-permeant Zn(2+) chelators, perhaps especially possessing low Zn(2+) affinity, in attenuating neuronal death after certain acute insults...
- Mild acidosis enhances AMPA receptor-mediated intracellular zinc mobilization in cortical neuronsValerio Frazzini
Department of Basic and Applied Medical Science, Molecular Neurology Unit, CeSI Center for Excellence on Aging, University G D Annunzio, Chieti, Italy
Mol Med 13:356-61. 2007..Additionally, our results show that selective Ca2+ imaging mandates the use of intracellular heavy metal chelators to avoid confounding effects of endogenous metals such as Zn2+...
- Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's diseaseCarlo Bertoni-Freddari
Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
Rejuvenation Res 11:309-13. 2008....
- Depolarization-induced 65zinc influx into cultured cortical neuronsChristian T Sheline
Center for the Study of Nervous System Injury, Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Neurobiol Dis 10:41-53. 2002..K(+)-induced, Gd(3+)-sensitive (45)Ca(2+) accumulation but not (65)Zn(2+) accumulation was sharply attenuated by lowering extracellular pH to 6.6...
- NMDA antagonists exacerbate neuronal death caused by proteasome inhibition in cultured cortical and striatal neuronsB Joy Snider
Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
Eur J Neurosci 15:419-28. 2002..In particular, concern is raised that glutamate receptor antagonists might exacerbate, rather than attenuate, proteasome inhibition-induced neuronal death...