Maurizio Bifulco

Summary

Affiliation: Via Ponte Don Melillo
Country: Italy

Publications

  1. ncbi request reprint Thyroidology in the medieval Medical School of Salerno
    Maurizio Bifulco
    Department of Pharmaceutical Sciences, University of Salerno, Italy
    Thyroid 17:39-40. 2007
  2. doi request reprint N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation
    Elena Ciaglia
    1 University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, Italy or
    J Leukoc Biol 94:1207-19. 2013
  3. doi request reprint Therapeutic potential of statins in thyroid proliferative disease
    Maurizio Bifulco
    Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano Salerno, Italy
    Nat Clin Pract Endocrinol Metab 4:242-3. 2008
  4. ncbi request reprint Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects
    Maurizio Bifulco
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
    Mol Pharmacol 71:1445-56. 2007
  5. ncbi request reprint Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug
    Maurizio Bifulco
    Dipartmento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano, SA, Italy
    Anticancer Agents Med Chem 8:200-4. 2008
  6. doi request reprint Potential therapeutic role of statins in neurological disorders
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, University di Salerno, Via Ponte Don Melillo 84084 Fisciano, Salerno, Italy
    Expert Rev Neurother 8:827-37. 2008
  7. ncbi request reprint From the gastronomic revolution to the new globesity epidemic
    Maurizio Bifulco
    University of Salerno, Department of Pharmaceutical Sciences, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    J Am Diet Assoc 107:2058-60. 2007
  8. doi request reprint Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon
    Antonietta Santoro
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Italy
    Int J Cancer 125:996-1003. 2009
  9. doi request reprint Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth
    Maria C Proto
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, SA, Italy
    J Cell Physiol 227:250-8. 2012
  10. ncbi request reprint Anandamide inhibits adhesion and migration of breast cancer cells
    Claudia Grimaldi
    Dipartimento di Scienze Farmaceutiche, Endocannabinoid Research Group, , Fisciano SA, Italy
    Exp Cell Res 312:363-73. 2006

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Thyroidology in the medieval Medical School of Salerno
    Maurizio Bifulco
    Department of Pharmaceutical Sciences, University of Salerno, Italy
    Thyroid 17:39-40. 2007
  2. doi request reprint N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation
    Elena Ciaglia
    1 University of Salerno, Via Salvatore Allende, 84081 Baronissi Salerno, Italy or
    J Leukoc Biol 94:1207-19. 2013
    ....
  3. doi request reprint Therapeutic potential of statins in thyroid proliferative disease
    Maurizio Bifulco
    Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano Salerno, Italy
    Nat Clin Pract Endocrinol Metab 4:242-3. 2008
  4. ncbi request reprint Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects
    Maurizio Bifulco
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
    Mol Pharmacol 71:1445-56. 2007
    ..Here we review recent data from the literature and discuss the full pharmacological potential of this drug...
  5. ncbi request reprint Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug
    Maurizio Bifulco
    Dipartmento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano, SA, Italy
    Anticancer Agents Med Chem 8:200-4. 2008
    ..In addition, preliminary clinical observation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug...
  6. doi request reprint Potential therapeutic role of statins in neurological disorders
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, University di Salerno, Via Ponte Don Melillo 84084 Fisciano, Salerno, Italy
    Expert Rev Neurother 8:827-37. 2008
    ..Currently available data suggest that statins are safe and effective in the treatment of these neurological disorders, although further experiments and new data are required...
  7. ncbi request reprint From the gastronomic revolution to the new globesity epidemic
    Maurizio Bifulco
    University of Salerno, Department of Pharmaceutical Sciences, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    J Am Diet Assoc 107:2058-60. 2007
  8. doi request reprint Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon
    Antonietta Santoro
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Italy
    Int J Cancer 125:996-1003. 2009
    ..Our findings suggest that rimonabant is able to inhibit colorectal cancer cell growth at different stages of colon cancer pathogenesis inducing mitotic catastrophe in vitro...
  9. doi request reprint Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growth
    Maria C Proto
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, SA, Italy
    J Cell Physiol 227:250-8. 2012
    ....
  10. ncbi request reprint Anandamide inhibits adhesion and migration of breast cancer cells
    Claudia Grimaldi
    Dipartimento di Scienze Farmaceutiche, Endocannabinoid Research Group, , Fisciano SA, Italy
    Exp Cell Res 312:363-73. 2006
    ....
  11. doi request reprint Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents
    Simona Pisanti
    Department of Pharmaceutical Sciences, University of Salerno, Italy
    Best Pract Res Clin Endocrinol Metab 23:117-31. 2009
    ....
  12. ncbi request reprint The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism
    Daniela Sarnataro
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano Salerno, Italy
    Mol Pharmacol 70:1298-306. 2006
    ..Taken together, our results suggest that SR141716 inhibits human breast cancer cell growth via a CB1R lipid raft/caveolae-mediated mechanism...
  13. doi request reprint Pharmacological actions of statins: a critical appraisal in the management of cancer
    Patrizia Gazzerro
    Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano Salerno, Italy
    Pharmacol Rev 64:102-46. 2012
    ....
  14. ncbi request reprint HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway
    Chiara Laezza
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy
    J Mol Med (Berl) 84:967-73. 2006
    ..Our data suggest that lovastatin is an efficient inhibitor of goitrogenesis and provide a rationale for innovative therapeutic strategies employing statins in the treatment of nodular goiter in humans...
  15. ncbi request reprint Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin
    Patrizia Gazzerro
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano Salerno, Italy
    Oncol Rep 23:171-5. 2010
    ..Our findings suggest that the combined synergic effect of SR141716 and oxaliplatin improves the blocking of colon cancer cell proliferation. Therefore, this combination merits further explorations in preclinical and clinical settings...
  16. doi request reprint The CB1 receptor antagonist rimonabant controls cell viability and ascitic tumour growth in mice
    Anna Maria Malfitano
    Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    Pharmacol Res 65:365-71. 2012
    ....
  17. ncbi request reprint Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy
    Simona Pisanti
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
    J Cell Physiol 211:495-503. 2007
    ..Thus, our results suggest that anandamide could be involved in the control of cancer growth targeting both tumor cell proliferation and the angiogenic stimulation of the vasculature...
  18. ncbi request reprint Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, via Ponte Don Melillo 84084 Fisciano Salerno, Italy
    J Neuroimmunol 171:110-9. 2006
    ..Our findings have relevance for the use of arvanil and related compounds as a novel immunotherapeutic approach in the treatment of multiple sclerosis...
  19. ncbi request reprint Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano SA, Italy
    Immunol Lett 109:145-54. 2007
    ..We showed a transcriptional control of the CD36 gene by arvanil and anandamide associated with an increased protein expression, thus suggesting a possible role of CD36 in anandamide and arvanil anti-inflammatory pattern...
  20. doi request reprint Immune-modulation and properties of absorption and blood brain barrier permeability of 1,8-naphthyridine derivatives
    Anna Maria Malfitano
    Dipartimento di Medicina e Chirurgia, Università di Salerno Facoltà di Medicina, Baronissi Campus, Baronissi, 84081, SA, Italy
    J Neuroimmune Pharmacol 8:1077-86. 2013
    ....
  21. doi request reprint Binding of the hemopressin peptide to the cannabinoid CB1 receptor: structural insights
    Mario Scrima
    Department of Pharmaceutical Sciences, University of Salerno, I 84084 Fisciano, Italy
    Biochemistry 49:10449-57. 2010
    ....
  22. doi request reprint N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A
    Maurizio Bifulco
    Dipartimento di Medicina e Chirurgia, Università of Salerno Facoltà di Medicina, Baronissi, Italy Dipartimento di Farmacia, Universita di Salerno, Fisciano, Italy
    FEBS J 280:6223-32. 2013
    ..These findings establish a paradigm for ameliorating the most obvious cellular pathology in lamin-related progeroid syndromes, and suggest a potential strategy for treating children with Hutchinson-Gilford progeria syndrome...
  23. doi request reprint Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis
    Simona Pisanti
    Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy
    Blood 117:5541-50. 2011
    ....
  24. doi request reprint Update on the endocannabinoid system as an anticancer target
    Anna Maria Malfitano
    University of Salerno, Department of Pharmaceutical Sciences, Fisciano, Salerno, Italy
    Expert Opin Ther Targets 15:297-308. 2011
    ..Numerous findings suggest the involvement of this system (constituted mainly by cannabinoid receptors, endogenous compounds and the enzymes for their synthesis and degradation) in cancer cell growth in vitro and in vivo...
  25. pmc Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis
    Anna Maria Malfitano
    Dipartimento di Farmacia, Universita di Salerno, Fisciano, Salerno, Italy
    PLoS ONE 8:e62511. 2013
    ..Our findings suggest potential application of these drugs in neuro-inflammation, supporting further investigations of the effects of compounds in the therapy of MS, particularly on the aspects regarding activation and inflammation...
  26. ncbi request reprint [The endocannabinoid system as a target for the development of new drugs for cancer therapy]
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli
    Recenti Prog Med 94:194-8. 2003
    ..This evidence is reviewed here and suggests that future anti-cancer therapy might be developed from our knowledge of how the endocannabinoid system controls the growth and metastasis of malignant cells...
  27. doi request reprint Cannabinoid receptor CB1 antagonists state of the art and challenges
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Salerno, Italy
    Vitam Horm 81:159-89. 2009
    ....
  28. doi request reprint The endocannabinoid signaling system in cancer
    Simona Pisanti
    Endocannabinoid Research Group, Department of Pharmacy, University of Salerno, Salerno, Italy
    Trends Pharmacol Sci 34:273-82. 2013
    ..We also discuss the enzyme MAGL, a key player in endocannabinoid metabolism that was recently recognized as a marker of tumor lipogenic phenotype...
  29. pmc Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti-inflammatory activity in mice
    Anna Maria Malfitano
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
    Br J Pharmacol 162:84-93. 2011
    ..Here, we have assessed the effects of rimonabant in vitro in murine immortalized keratinocytes and in vivo by assaying the topical anti-inflammatory activity...
  30. ncbi request reprint Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, 84084 Fisciano SA, Italy
    Oncol Rep 17:813-6. 2007
    ....
  31. pmc Cannabinoids and cancer: pros and cons of an antitumour strategy
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, Fisciano 84084, Salerno, Italy
    Br J Pharmacol 148:123-35. 2006
    ..In this article, we will review the principal molecular pathways modulated by cannabinoids on cancer and summarize pros and cons evidence on the possible future use of endocannabinoid-based drugs in cancer therapy...
  32. doi request reprint PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines
    Giuseppina Gangemi
    Department of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy
    Eur J Pharmacol 714:379-87. 2013
    ..These results showed, for the first time, that PBOX-15 represents a promising compound for the treatment of human CRC and a strong candidate for novel therapeutic options...
  33. doi request reprint Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold
    Clementina Manera
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Eur J Med Chem 52:284-94. 2012
    ..In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels...
  34. doi request reprint Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells
    Lucia Prota
    Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, SA, Italy
    Int J Pharm 412:8-19. 2011
    ..The optimized N-Leu formulation as dry powder is potentially able to reduce hyperinflammatory status associated to CF...
  35. doi request reprint Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways
    Dario Gallotta
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
    Biochem Pharmacol 80:370-80. 2010
    ..Moreover, SR141716 negatively modulated, especially in U937, the PI3K/AKT pathways. In conclusion, our data indicate that SR141716 elicits alternative response and/or cell death pathways depending on the cell type affected...
  36. ncbi request reprint Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, via Ponte Don Melillo 84084, Fisciano, Salerno, Italy
    Life Sci 77:1740-9. 2005
    ....
  37. doi request reprint Endocannabinoids in endocrine and related tumours
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano Salerno, Italy IEOS, CNR Napoli, 80131 Napoli, Italy
    Endocr Relat Cancer 15:391-408. 2008
    ....
  38. doi request reprint Endocannabinoid system modulation in cancer biology and therapy
    Simona Pisanti
    Department of Pharmaceutical Sciences, University of Salerno, Italy
    Pharmacol Res 60:107-16. 2009
    ..The aim of this review is to evidence and update the recent emerging knowledge about the role of the endocannabinoid system in cancer biology and the potentiality of its modulation in cancer therapy...
  39. ncbi request reprint Structures and micelle locations of the nonlipidated and lipidated C-terminal membrane anchor of 2',3'-cyclic nucleotide-3'-phosphodiesterase
    Cinzia Esposito
    Department of Pharmaceutical Sciences, University of Salerno, I 84084 Fisciano, Italy
    Biochemistry 47:308-19. 2008
    ..A general model is proposed in which the post-translational lipidation is an important biomolecular trick to enlarge the hydrophobic surface and to enable the contact of the protein with membrane...
  40. ncbi request reprint From cannabis to endocannabinoids in multiple sclerosis: a paradigm of central nervous system autoimmune diseases
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano SA, Italy
    Curr Drug Targets CNS Neurol Disord 4:667-75. 2005
    ....
  41. doi request reprint Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins
    Antonietta Santoro
    Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    Toxicol Lett 178:71-6. 2008
    ....
  42. doi request reprint Oxylipins from Dracontium loretense
    Angelyne Benavides
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, SA, Italy
    J Nat Prod 72:813-7. 2009
    ..Relative configurations were assigned on the basis of combined analysis of homonuclear and heteronuclear (2,3)J couplings, along with ROE data. Oxylipin 2 exhibited an immunostimulatory effect on human PBMC proliferation...
  43. ncbi request reprint The N-terminal domain of 2',3'-cyclic nucleotide 3'-phosphodiesterase harbors a GTP/ATP binding site
    Stefania Stingo
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, Fisciano SA 84084, Italy
    Chem Biol Drug Des 70:502-10. 2007
    ..Therefore, our findings suggest new functional and structural property of the N-terminal domain of CNPase...
  44. ncbi request reprint Effect of unsaturated fat intake from Mediterranean diet on rat liver mRNA expression profile: selective modulation of genes involved in lipid metabolism
    Davide Eletto
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, I 84084 Fisciano SA, Italy
    Nutr Metab Cardiovasc Dis 15:13-23. 2005
    ..We investigated whether the short term nutritional effect of a fat quota mainly derived from olive and fish oil affects liver mRNA expression profile in rats...
  45. ncbi request reprint Targeting the endocannabinoid system in cancer therapy: a call for further research
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Salerno, Italy
    Nat Med 8:547-50. 2002
  46. ncbi request reprint N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation
    Chiara Laezza
    Istituto di Endocrinologia e Oncologia Sperimentale I E O S, CNR, Bari, Italy
    FASEB J 20:412-8. 2006
    ..Our findings indicate that this isoprenoid end product might be used for antineoplastic therapy, an application emulating that of the lovastatin and/or farnesyl-transferase inhibitors..
  47. ncbi request reprint Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells
    Silvana Libertini
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Endocrinology 148:5186-94. 2007
    ..Lovastatin treatment could be exploited to increase the efficacy of oncolytic adenoviruses, and further studies are warranted to confirm the feasibility of the approach in ATC patients...
  48. ncbi request reprint A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
    Maurizio Bifulco
    Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Italy
    FASEB J 18:1606-8. 2004
    ....
  49. doi request reprint Reply to the letter to the editor "Long-term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer"
    Antonietta Santoro
    Int J Cancer 123:243-4. 2008
  50. doi request reprint In memory of Nino Salvatore: tenth anniversary
    Maurizio Bifulco
    Thyroid 18:91-2. 2008
  51. ncbi request reprint Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis
    Giuseppe Portella
    Endocannabinoid Research Group, Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Italy
    FASEB J 17:1771-3. 2003
    ..Our findings indicate that CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis...
  52. ncbi request reprint Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems
    Luciano De Petrocellis
    Istituto di Cibernetica Eduardo Caianiello, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, Pozzuoli, Napoli, Italy
    Fundam Clin Pharmacol 16:297-302. 2002
    ..These 'entourage' effects of PEA might be attributable to modulation of VR1 activity, and could underlie the enhancement by PEA, described here for the first time, of the antiproliferative effects of VR1 receptor agonists...
  53. ncbi request reprint Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells
    Chiara Laezza
    IEOS CNR, Napoli, Italy
    FEBS Lett 580:6076-82. 2006
    ..The observed mechanism of action, already reported for well-known chemotherapeutic drugs, provides strong evidence for a direct role of anandamide related compounds in the activation of cell cycle checkpoints...
  54. ncbi request reprint Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells
    Daniela Sarnataro
    Dip di Scienze Farmaceutiche, Universita degli Studi di Salerno, Italy
    FEBS Lett 579:6343-9. 2005
    ..Indeed MCD completely blocked the clustering of CB1R at the plasma membrane. On the contrary the lysosomal localization of CB1R was impaired by this treatment only after AEA binding...
  55. ncbi request reprint Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells
    Caterina Messa
    Laboratory of Biochemistry, National Institute for Digestive Diseases, S de Bellis, Bari, Italy
    Scand J Gastroenterol 40:1454-61. 2005
    ..The effect of 17beta-estradiol on both cell growth and apoptosis in this cell line was also investigated...
  56. ncbi request reprint Possible relationship between statin use and decreased prevalence, number, and volume of thyroid nodules: a new indication for these drugs?
    Maurizio Bifulco
    Thyroid 17:903. 2007
  57. ncbi request reprint Helicobacter pylori has stimulatory effects on naive T cells
    Anna Maria Malfitano
    Department of Infectious Diseases and Microbiology, Hammersmith Campus, Imperial College London, London, UK
    Helicobacter 11:21-30. 2006
    ..Unexpectedly, T cells from apparently uninfected individuals respond to H. pylori antigen by proliferating. Also, the T-cell proliferative response appears to be less in infected compared with uninfected individuals...
  58. ncbi request reprint Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
    Maria Notarnicola
    Laboratory of Biochemistry, National Institute for Digestive Diseases S de Bellis, Castellana Grotte, Bari, Italy
    Scand J Gastroenterol 43:66-72. 2008
    ....
  59. ncbi request reprint Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    Alessia Ligresti
    Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche Pozzuoli, Italy
    J Pharmacol Exp Ther 318:1375-87. 2006
    ..Our data support the further testing of cannabidiol and cannabidiol-rich extracts for the potential treatment of cancer...
  60. ncbi request reprint Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors
    Jason W Brooks
    Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
    Eur J Pharmacol 439:83-92. 2002
    ..These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically...