Research Topics
Species | Maurizio BifulcoSummaryAffiliation: Via Ponte Don Melillo Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Potential therapeutic role of statins in neurological disordersMaurizio Bifulco
Dipartimento di Scienze Farmaceutiche, University di Salerno, Via Ponte Don Melillo 84084 Fisciano, Salerno, Italy
Expert Rev Neurother 8:827-37. 2008..Currently available data suggest that statins are safe and effective in the treatment of these neurological disorders, although further experiments and new data are required...
Thyroidology in the medieval Medical School of SalernoMaurizio Bifulco
Department of Pharmaceutical Sciences, University of Salerno, Italy
Thyroid 17:39-40. 2007- Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effectsMaurizio Bifulco
Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
Mol Pharmacol 71:1445-56. 2007..Here we review recent data from the literature and discuss the full pharmacological potential of this drug... - From the gastronomic revolution to the new globesity epidemicMaurizio Bifulco
University of Salerno, Department of Pharmaceutical Sciences, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
J Am Diet Assoc 107:2058-60. 2007 - Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drugMaurizio Bifulco
Dipartmento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano, SA, Italy
Anticancer Agents Med Chem 8:200-4. 2008..In addition, preliminary clinical observation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug... - Therapeutic potential of statins in thyroid proliferative diseaseMaurizio Bifulco
Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano (Salerno, Italy
Nat Clin Pract Endocrinol Metab 4:242-3. 2008 - Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colonAntonietta Santoro
Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Italy
Int J Cancer 125:996-1003. 2009..Our findings suggest that rimonabant is able to inhibit colorectal cancer cell growth at different stages of colon cancer pathogenesis inducing mitotic catastrophe in vitro... - Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agentsSimona Pisanti
Department of Pharmaceutical Sciences, University of Salerno, Italy
Best Pract Res Clin Endocrinol Metab 23:117-31. 2009.... - Pharmacological actions of statins: a critical appraisal in the management of cancerPatrizia Gazzerro
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano Salerno, Italy
Pharmacol Rev 64:102-46. 2012.... - Interaction of endocannabinoid system and steroid hormones in the control of colon cancer cell growthMaria C Proto
Department of Pharmaceutical Sciences, University of Salerno, Fisciano, SA, Italy
J Cell Physiol 227:250-8. 2012.... - Anandamide inhibits adhesion and migration of breast cancer cellsClaudia Grimaldi
Dipartimento di Scienze Farmaceutiche, Endocannabinoid Research Group, , Fisciano SA, Italy
Exp Cell Res 312:363-73. 2006.... - HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathwayChiara Laezza
Dipartimento di Scienze Farmaceutiche, , Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy
J Mol Med 84:967-73. 2006..Our data suggest that lovastatin is an efficient inhibitor of goitrogenesis and provide a rationale for innovative therapeutic strategies employing statins in the treatment of nodular goiter in humans... - Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatinPatrizia Gazzerro
Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano Salerno, Italy
Oncol Rep 23:171-5. 2010..Our findings suggest that the combined synergic effect of SR141716 and oxaliplatin improves the blocking of colon cancer cell proliferation. Therefore, this combination merits further explorations in preclinical and clinical settings... - Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacySimona Pisanti
Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
J Cell Physiol 211:495-503. 2007..Thus, our results suggest that anandamide could be involved in the control of cancer growth targeting both tumor cell proliferation and the angiogenic stimulation of the vasculature... - The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanismDaniela Sarnataro
Dipartimento di Scienze Farmaceutiche, , Via Ponte Don Melillo, 84084 Fisciano (Salerno, Italy
Mol Pharmacol 70:1298-306. 2006..Taken together, our results suggest that SR141716 inhibits human breast cancer cell growth via a CB1R lipid raft/caveolae-mediated mechanism... - The CB1 receptor antagonist rimonabant controls cell viability and ascitic tumour growth in miceAnna Maria Malfitano
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
Pharmacol Res 65:365-71. 2012.... - Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitisAnna Maria Malfitano
Dipartimento di Scienze Farmaceutiche, Universita' di Salerno, Via Ponte don Melillo 84084 Fisciano (Salerno, Italy
J Neuroimmunol 171:110-9. 2006..Our findings have relevance for the use of arvanil and related compounds as a novel immunotherapeutic approach in the treatment of multiple sclerosis... - Binding of the hemopressin peptide to the cannabinoid CB1 receptor: structural insightsMario Scrima
Department of Pharmaceutical Sciences, University of Salerno, I 84084 Fisciano, Italy
Biochemistry 49:10449-57. 2010.... - Cannabinoid receptor CB1 antagonists state of the art and challengesMaurizio Bifulco
Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Salerno, Italy
Vitam Horm 81:159-89. 2009.... - [The endocannabinoid system as a target for the development of new drugs for cancer therapy]Maurizio Bifulco
Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli
Recenti Prog Med 94:194-8. 2003..This evidence is reviewed here and suggests that future anti-cancer therapy might be developed from our knowledge of how the endocannabinoid system controls the growth and metastasis of malignant cells... - Update on the endocannabinoid system as an anticancer targetAnna Maria Malfitano
University of Salerno, Department of Pharmaceutical Sciences, Fisciano, Salerno, Italy
Expert Opin Ther Targets 15:297-308. 2011..Additional studies into the downstream consequences of endocannabinoid treatment are required and may illuminate other potential therapeutic targets... - Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesisSimona Pisanti
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Fisciano, Italy
Blood 117:5541-50. 2011.... - Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cellsAnna Maria Malfitano
Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano SA, Italy
Immunol Lett 109:145-54. 2007..We showed a transcriptional control of the CD36 gene by arvanil and anandamide associated with an increased protein expression, thus suggesting a possible role of CD36 in anandamide and arvanil anti-inflammatory pattern... - Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)Maurizio Bifulco
Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, 84084 Fisciano SA, Italy
Oncol Rep 17:813-6. 2007.... 
Rimonabant reduces keratinocyte viability by induction of apoptosis and exerts topical anti-inflammatory activity in miceAnna Maria Malfitano
Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
Br J Pharmacol 162:84-93. 2011..Here, we have assessed the effects of rimonabant in vitro in murine immortalized keratinocytes and in vivo by assaying the topical anti-inflammatory activity...- Cannabinoids and cancer: pros and cons of an antitumour strategyMaurizio Bifulco
Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, Fisciano 84084, Salerno, Italy
Br J Pharmacol 148:123-35. 2006..In this article, we will review the principal molecular pathways modulated by cannabinoids on cancer and summarize pros and cons evidence on the possible future use of endocannabinoid-based drugs in cancer therapy... - Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffoldClementina Manera
Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
Eur J Med Chem 52:284-94. 2012..In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels... - Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cellsLucia Prota
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, SA, Italy
Int J Pharm 412:8-19. 2011..The optimized N-Leu formulation as dry powder is potentially able to reduce hyperinflammatory status associated to CF... - Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathwaysDario Gallotta
Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
Biochem Pharmacol 80:370-80. 2010..Moreover, SR141716 negatively modulated, especially in U937, the PI3K/AKT pathways. In conclusion, our data indicate that SR141716 elicits alternative response and/or cell death pathways depending on the cell type affected... - Endocannabinoids in endocrine and related tumoursMaurizio Bifulco
Dipartimento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano Salerno, Italy IEOS, CNR Napoli, 80131 Napoli, Italy
Endocr Relat Cancer 15:391-408. 2008.... - Endocannabinoid system modulation in cancer biology and therapySimona Pisanti
Department of Pharmaceutical Sciences, University of Salerno, Italy
Pharmacol Res 60:107-16. 2009..The aim of this review is to evidence and update the recent emerging knowledge about the role of the endocannabinoid system in cancer biology and the potentiality of its modulation in cancer therapy... - Oxylipins from Dracontium loretenseAngelyne Benavides
Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, SA, Italy
J Nat Prod 72:813-7. 2009..Relative configurations were assigned on the basis of combined analysis of homonuclear and heteronuclear (2,3)J couplings, along with ROE data. Oxylipin 2 exhibited an immunostimulatory effect on human PBMC proliferation... - From cannabis to endocannabinoids in multiple sclerosis: a paradigm of central nervous system autoimmune diseasesAnna Maria Malfitano
Dipartimento di Scienze Farmaceutiche, Universita' di Salerno, Fisciano (SA, Italy
Curr Drug Targets CNS Neurol Disord 4:667-75. 2005.... - Structures and micelle locations of the nonlipidated and lipidated C-terminal membrane anchor of 2',3'-cyclic nucleotide-3'-phosphodiesteraseCinzia Esposito
Department of Pharmaceutical Sciences, University of Salerno, I 84084 Fisciano, Italy
Biochemistry 47:308-19. 2008..A general model is proposed in which the post-translational lipidation is an important biomolecular trick to enlarge the hydrophobic surface and to enable the contact of the protein with membrane... - Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteinsAntonietta Santoro
Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
Toxicol Lett 178:71-6. 2008.... - The N-terminal domain of 2',3'-cyclic nucleotide 3'-phosphodiesterase harbors a GTP/ATP binding siteStefania Stingo
Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, Fisciano SA 84084, Italy
Chem Biol Drug Des 70:502-10. 2007..Therefore, our findings suggest new functional and structural property of the N-terminal domain of CNPase... - Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosisMaurizio Bifulco
Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, via Ponte Don Melillo 84084, Fisciano, Salerno, Italy
Life Sci 77:1740-9. 2005.... - Targeting the endocannabinoid system in cancer therapy: a call for further researchMaurizio Bifulco
Dipartimento di Scienze Farmaceutiche, , Fisciano, Salerno, Italy
Nat Med 8:547-50. 2002 - N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylationChiara Laezza
Istituto di Endocrinologia e Oncologia Sperimentale I E O S, CNR, Bari, Italy
FASEB J 20:412-8. 2006..Our findings indicate that this isoprenoid end product might be used for antineoplastic therapy, an application emulating that of the lovastatin and/or farnesyl-transferase inhibitors.. - Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cellsSilvana Libertini
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini 5, 80131, Napoli, Italy
Endocrinology 148:5186-94. 2007..Lovastatin treatment could be exploited to increase the efficacy of oncolytic adenoviruses, and further studies are warranted to confirm the feasibility of the approach in ATC patients... - A new strategy to block tumor growth by inhibiting endocannabinoid inactivationMaurizio Bifulco
Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Italy
FASEB J 18:1606-8. 2004.... - Reply to the letter to the editor "Long-term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer"Antonietta Santoro
Int J Cancer 123:243-4. 2008 - Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systemsLuciano De Petrocellis
Istituto di Cibernetica Eduardo Caianiello, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, Pozzuoli, Napoli, Italy
Fundam Clin Pharmacol 16:297-302. 2002..These 'entourage' effects of PEA might be attributable to modulation of VR1 activity, and could underlie the enhancement by PEA, described here for the first time, of the antiproliferative effects of VR1 receptor agonists... - Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasisGiuseppe Portella
Endocannabinoid Research Group, Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, , Italy
FASEB J 17:1771-3. 2003..Our findings indicate that CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis... - Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cellsDaniela Sarnataro
Dip di Scienze Farmaceutiche, Universita degli Studi di Salerno, Italy
FEBS Lett 579:6343-9. 2005..Indeed MCD completely blocked the clustering of CB1R at the plasma membrane. On the contrary the lysosomal localization of CB1R was impaired by this treatment only after AEA binding... - Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptorsJason W Brooks
Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
Eur J Pharmacol 439:83-92. 2002..These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically... - Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cellsCaterina Messa
Laboratory of Biochemistry, National Institute for Digestive Diseases, S. de Bellis, Bari, Italy
Scand J Gastroenterol 40:1454-61. 2005..CONCLUSIONS: The results of this study suggest that estrogens regulate LDL-R and HMG-CoAR and influence cell growth and apoptosis in colon cancer cells... - Helicobacter pylori has stimulatory effects on naive T cellsAnna Maria Malfitano
Department of Infectious Diseases and Microbiology, Hammersmith Campus, Imperial College London, London, UK
Helicobacter 11:21-30. 2006..pylori antigens identified two that produced a response in naive T cells. CONCLUSIONS: These data suggest that H. pylori possesses molecules that cause higher than expected proliferation of naive T cells... - In memory of Nino Salvatore: tenth anniversaryMaurizio Bifulco
Thyroid 18:91-2. 2008 - Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinomaAlessia Ligresti
Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche Pozzuoli, Italy
J Pharmacol Exp Ther 318:1375-87. 2006..Our data support the further testing of cannabidiol and cannabidiol-rich extracts for the potential treatment of cancer... - Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cellsChiara Laezza
IEOS CNR, Napoli, Italy
FEBS Lett 580:6076-82. 2006..The observed mechanism of action, already reported for well-known chemotherapeutic drugs, provides strong evidence for a direct role of anandamide related compounds in the activation of cell cycle checkpoints... - Possible relationship between statin use and decreased prevalence, number, and volume of thyroid nodules: a new indication for these drugs?Maurizio Bifulco
Thyroid 17:903. 2007 - Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell linesMaria Notarnicola
Laboratory of Biochemistry, National Institute for Digestive Diseases S de Bellis, Castellana Grotte, Bari, Italy
Scand J Gastroenterol 43:66-72. 2008....