P Verdecchia

Summary

Country: Italy

Publications

  1. ncbi request reprint [Obesity and hypertension]
    Paolo Verdecchia
    Unità di Ricerca Clinica Cardiologia Preventiva, SC di Cardiologia, Ospedale S Maria della Misericordia, Perugia
    G Ital Cardiol (Rome) 9:54S-59S. 2008
  2. doi request reprint Tight versus standard blood pressure control in patients with hypertension with and without cardiovascular disease
    Gianpaolo Reboldi
    Hospital of Assisi, Department of Medicine, Via Valentin Muller, 1 06081 Assisi, Italy
    Hypertension 63:475-82. 2014
  3. doi request reprint Antihypertensive drugs and coronary artery disease : evidence from controlled trials
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale R Silvestrini, Località Ponte della Pietra, 06100, Perugia, Italy
    High Blood Press Cardiovasc Prev 12:119-24. 2005
  4. doi request reprint Beyond blood pressure: evidence for cardiovascular, cerebrovascular, and renal protective effects of renin-angiotensin system blockers
    Paolo Verdecchia
    Department of Medicine, Hospital of Assisi, Via Valentin Muller, 106081 Assisi PG, Italy
    Ther Adv Cardiovasc Dis 6:81-91. 2012
  5. doi request reprint Day-night dip and early-morning surge in blood pressure in hypertension: prognostic implications
    Paolo Verdecchia
    Struttura Complessa di Medicina, Ospedale di Assisi, Assisi, Italy
    Hypertension 60:34-42. 2012
  6. doi request reprint Blood pressure and other determinants of new-onset atrial fibrillation in patients at high cardiovascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtoleran
    Paolo Verdecchia
    Department of Medicine, Hospital of Assisi, Assisi, Italy
    J Hypertens 30:1004-14. 2012
  7. ncbi request reprint Regression of left ventricular hypertrophy and prevention of stroke in hypertensive subjects
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 19:493-9. 2006
  8. ncbi request reprint Ambulatory blood pressure monitoring and prognosis in the management of essential hypertension
    Paolo Verdecchia
    Department of Cardiovascular Disease, University of Perugia, Hospital R Silvestrini, Localita S Andrea Delle Fratte, Italy
    Expert Rev Cardiovasc Ther 1:79-89. 2003
  9. ncbi request reprint Adverse prognostic significance of new diabetes in treated hypertensive subjects
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini S Andrea delle Fratte 06122 Perugia, Italy
    Hypertension 43:963-9. 2004
  10. ncbi request reprint Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension
    Paolo Verdecchia
    Department of Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Blood Press 16:381-91. 2007

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint [Obesity and hypertension]
    Paolo Verdecchia
    Unità di Ricerca Clinica Cardiologia Preventiva, SC di Cardiologia, Ospedale S Maria della Misericordia, Perugia
    G Ital Cardiol (Rome) 9:54S-59S. 2008
    ..Thus, weight reduction should be maintained in the long term to elicit a sustained and effective antihypertensive efficacy...
  2. doi request reprint Tight versus standard blood pressure control in patients with hypertension with and without cardiovascular disease
    Gianpaolo Reboldi
    Hospital of Assisi, Department of Medicine, Via Valentin Muller, 1 06081 Assisi, Italy
    Hypertension 63:475-82. 2014
    ....
  3. doi request reprint Antihypertensive drugs and coronary artery disease : evidence from controlled trials
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale R Silvestrini, Località Ponte della Pietra, 06100, Perugia, Italy
    High Blood Press Cardiovasc Prev 12:119-24. 2005
    ....
  4. doi request reprint Beyond blood pressure: evidence for cardiovascular, cerebrovascular, and renal protective effects of renin-angiotensin system blockers
    Paolo Verdecchia
    Department of Medicine, Hospital of Assisi, Via Valentin Muller, 106081 Assisi PG, Italy
    Ther Adv Cardiovasc Dis 6:81-91. 2012
    ..This review considers the rationale and evidence for benefits of RAS blockade beyond BP lowering, and highlights the differences between ARBs and ACEIs, and between agents within these drug classes...
  5. doi request reprint Day-night dip and early-morning surge in blood pressure in hypertension: prognostic implications
    Paolo Verdecchia
    Struttura Complessa di Medicina, Ospedale di Assisi, Assisi, Italy
    Hypertension 60:34-42. 2012
    ..In these subjects, a blunted morning BP surge was an independent predictor of cardiovascular events, whereas an excessive BP surge did not portend an increased risk of events...
  6. doi request reprint Blood pressure and other determinants of new-onset atrial fibrillation in patients at high cardiovascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtoleran
    Paolo Verdecchia
    Department of Medicine, Hospital of Assisi, Assisi, Italy
    J Hypertens 30:1004-14. 2012
    ....
  7. ncbi request reprint Regression of left ventricular hypertrophy and prevention of stroke in hypertensive subjects
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 19:493-9. 2006
    ..The relationship between serial LVH changes and risk of stroke has never been investigated in a mixed population of hypertensive subjects with and without LVH...
  8. ncbi request reprint Ambulatory blood pressure monitoring and prognosis in the management of essential hypertension
    Paolo Verdecchia
    Department of Cardiovascular Disease, University of Perugia, Hospital R Silvestrini, Localita S Andrea Delle Fratte, Italy
    Expert Rev Cardiovasc Ther 1:79-89. 2003
    ..Based on available evidence, an operational flow-chart in order to interpret results of ambulatory blood pressure for a better management of these subjects is suggested...
  9. ncbi request reprint Adverse prognostic significance of new diabetes in treated hypertensive subjects
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini S Andrea delle Fratte 06122 Perugia, Italy
    Hypertension 43:963-9. 2004
    ..In treated hypertensive subjects, occurrence of new diabetes portends a risk for subsequent cardiovascular disease that is not dissimilar from that of previously known diabetes...
  10. ncbi request reprint Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension
    Paolo Verdecchia
    Department of Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Blood Press 16:381-91. 2007
    ..To evaluate the efficacy, safety and tolerability of aliskiren in elderly patients (> or =65 years old) with essential hypertension...
  11. ncbi request reprint Validation of the A&D UA-774 (UA-767Plus) device for self-measurement of blood pressure
    Paolo Verdecchia
    Department of Cardiology, R Silvestrini Hospital, Perugia, Italy
    Blood Press Monit 9:225-9. 2004
    ..To determine the accuracy of the UA-774 (UA-767Plus) blood pressure monitor developed by the A&D Company...
  12. ncbi request reprint [Beta-blockers and arterial hypertension. Evidence-based medicine or excessive perseverance?]
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Ospedale S Maria della Misericordia e Università degli Studi di Perugia, Perugia
    G Ital Cardiol (Rome) 8:552-8. 2007
    ..The present review addresses facts and theories related to the actual concern on the role of beta-blockers in the modern management of hypertensive patients...
  13. doi request reprint The clinical significance of white-coat and masked hypertension
    Paolo Verdecchia
    Hospital S Maria della Misericordia, Clinical Research Unit Preventive Cardiology, Department of Internal Medicine, University of Perugia, Piazzale G Menghini, Perugia, Italy
    Blood Press Monit 12:387-9. 2007
    ..Severity of target organ damage and incidence of major cardiovascular events are greater in patients with MH than in patients whose BP is normal both inside and outside the doctor's office...
  14. ncbi request reprint Clinical usefulness of ambulatory blood pressure monitoring
    Paolo Verdecchia
    Department of Cardiovascular Disease, University of Perugia, Hospital R Silvestrini, Localita S Andrea Delle Fratte, Perugia, Italy
    J Am Soc Nephrol 15:S30-3. 2004
    ..On the basis of available evidence, an operational flowchart is suggested to interpret results of ABP for better treatment of patients with elevated BP...
  15. ncbi request reprint Changes in cardiovascular risk by reduction of left ventricular mass in hypertension: a meta-analysis
    Paolo Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 16:895-9. 2003
    ..The aim of this meta-analysis was to evaluate the prognostic impact of LV hypertrophy regression in hypertension...
  16. ncbi request reprint Left ventricular mass and cardiovascular morbidity in essential hypertension: the MAVI study
    P Verdecchia
    ANMCO Research Center, Via La Marmora, 36, Firenze, Italy
    J Am Coll Cardiol 38:1829-35. 2001
    ..This study investigated the prognostic value of left ventricular (LV) mass at echocardiography in uncomplicated subjects with essential hypertension...
  17. doi request reprint Is the definition of daytime and nighttime blood pressure prognostically relevant?
    Paolo Verdecchia
    Hospital S Maria della Misericordia, Clinical Research Unit Preventive Cardiology, University of Perugia, Piazzale G Menghini, Perugia, Italy
    Blood Press Monit 13:153-5. 2008
    ..In a recent guidelines document of the European Society of Hypertension, there is no clear position in favor of one definition over other...
  18. ncbi request reprint Improved cardiovascular risk stratification by a simple ECG index in hypertension
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale R Silvestrini, S Andrea delle Fratte, 06122 Perugia, Italy
    Am J Hypertens 16:646-52. 2003
    ..0 mV in women or 2.4 mV in men, or both...
  19. ncbi request reprint Should we prefer different drugs to treat hypertension in older and younger adults? Practical implications of clinical trials: European perspective
    Paolo Verdecchia
    Department of Cardiology, Clinical Research Unit Preventive Cardiology Hospital Santa Maria della Misericordia, Perugia, Italy
    Pol Arch Med Wewn 118:513-6. 2008
    ..Antihypertensive treatment should be embedded within the management of global cardiovascular risk, with the use of charts for stratifying risk based on additional risk factors, target organ damage or additional clinical conditions...
  20. ncbi request reprint Regression of left ventricular hypertrophy and cardiovascular risk changes in hypertensive patients
    Paolo Verdecchia
    Department of Cardiovascular Diseases, R Silvestrini Hospital, Perugia, Italy
    Ital Heart J 5:505-10. 2004
    ..According to a recent meta-analysis, effective reversal of LVH is associated with a 59% lesser risk of subsequent adverse events as compared with the persistence or new development of LVH...
  21. ncbi request reprint Prognostic value of lipoprotein fractions in essential hypertension
    Paolo Verdecchia
    Ospedale R Silvestrini, Dipartimento Malattie Cardiovascolari, Italy
    Blood Press 13:295-303. 2004
    ..To evaluate distribution and prognostic value of total cholesterol and lipoprotein fractions in essential hypertension...
  22. ncbi request reprint Reversal of left ventricular hypertrophy: what have recent trials taught us?
    Paolo Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini University of Perugia, Perugia, Italy
    Am J Cardiovasc Drugs 4:369-78. 2004
    ..However, extrapolation of the results of these studies in terms of class effects could be misleading and should be made with caution...
  23. ncbi request reprint Validation of the A&D UA-705 device for self-measurement of blood pressure according to the British Hypertension Society protocol
    Paolo Verdecchia
    Department of Cardiology, Hospital R Silvestrini, Perugia, Italy
    Blood Press Monit 11:223-7. 2006
    ..We tested the accuracy of the UA-705 blood pressure semi-automatic monitor...
  24. ncbi request reprint Is the development of diabetes with antihypertensive therapy a problem?--Pro
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Ospedale R Silvestrini, Perugia, Italy
    J Clin Hypertens (Greenwich) 8:120-6. 2006
    ..The lowest effective dose of these drugs should be used, plasma glucose should be checked periodically, and concomitant lifestyle measures to prevent diabetes should be implemented with resolution...
  25. ncbi request reprint Pre-clinical and clinical experience of telmisartan in cardiac remodelling
    P Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini, University of Perugia, Perugia, Italy
    J Int Med Res 33:12A-20A. 2005
    ....
  26. ncbi request reprint Does brachial pulse pressure predict coronary events?
    Paolo Verdecchia
    Unita di Ricerca Clinica, Cardiologia Preventiva, Struttura Complessa di Cardiologia, Ospedale R Silvestrini, Perugia, Italy
    Adv Cardiol 44:150-9. 2007
    ..Some data suggest that a wide PP could also represent a direct and independent stimulus for progression of atherosclerosis...
  27. ncbi request reprint Ambulatory blood pressure and cardiovascular outcome in relation to perceived sleep deprivation
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva, Ospedale S Maria della Misericordia, Universita di Perugia, Perugia, Italy
    Hypertension 49:777-83. 2007
    ..In conclusion, nighttime BP rises and loses its prognostic significance in the hypertensive subjects who perceive a sleep deprivation by >or=2 hours during overnight monitoring...
  28. ncbi request reprint Do angiotensin II receptor blockers increase the risk of myocardial infarction?
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale R Silvestrini, 06100 Perugia, Italy
    Eur Heart J 26:2381-6. 2005
    ..The uncertainty surrounding safety of angiotensin receptor blockers (ARBs) increased after publication of experimental and clinical studies which suggested an excess risk of myocardial infarction (MI) in people treated with ARBs...
  29. ncbi request reprint Angiotensin-converting enzyme inhibitors and calcium channel blockers for coronary heart disease and stroke prevention
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Hospital R Silvestrini, Localita S Andrea Delle Fratte, 06100, Perugia, Italy
    Hypertension 46:386-92. 2005
    ..However, over and beyond BP reduction, ACEIs appear superior to CCBs for prevention of CHD, whereas CCBs appear superior to ACEIs for prevention of stroke...
  30. ncbi request reprint Echocardiographic left ventricular hypertrophy in hypertension: marker for future events or mediator of events?
    Paolo Verdecchia
    Hospital S Maria della Misericordia, Division of Cardiology, Clinical Research Unit Preventive Cardiology, Perugia, Italy
    Curr Opin Cardiol 22:329-34. 2007
    ..To discuss the most relevant studies on the prognostic impact of echocardiographic left ventricular hypertrophy in hypertension...
  31. ncbi request reprint New-onset diabetes in treated hypertensive patients
    Paolo Verdecchia
    Dipartimento di Malattie Cardiovascolari, Ospedale R Silvestrini, Localita S Andrea Delle Fratte, 06100 Perugia, Italy
    Curr Hypertens Rep 7:174-9. 2005
    ..The lowest effective dose should be used, and plasma glucose should be carefully monitored...
  32. ncbi request reprint [Antihypertensive therapy and cardiovascular prevention. The role of angiotensin II receptor blockers]
    Paolo Verdecchia
    SC di Cardiologia, Ospedale S Maria della Misericordia, Universita degli Studi di Perugia, Perugia
    G Ital Cardiol (Rome) 8:491-7. 2007
    ..Current indications and contraindications to the use of ARBs in patients with hypertension, heart failure, and diabetic nephropathy should be maintained and probably extended to the entire class of these drugs...
  33. ncbi request reprint Asymptomatic left ventricular systolic dysfunction in essential hypertension: prevalence, determinants, and prognostic value
    Paolo Verdecchia
    Department of Cardiovascular Disease, R Silvestrini Hospital, Perugia, Italy
    Hypertension 45:412-8. 2005
    ..62x100 person years) events did not differ (all P=NS) between subjects with and without ALVSD. ALVSD is a potent and early marker of evolution toward severe CHF requiring hospitalization in subjects with essential hypertension...
  34. ncbi request reprint Prognostic value of serial electrocardiographic voltage and repolarization changes in essential hypertension: the HEART Survey study
    Paolo Verdecchia
    Clinical Research Unit in Preventive Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Am J Hypertens 20:997-1004. 2007
    ..The interpretation of serial electrocardiographic (ECG) changes in hypertensive subjects is uncertain. We tested the hypothesis that serial changes in repolarization and voltage are independent determinants of outcome...
  35. ncbi request reprint Does the reduction in systolic blood pressure alone explain the regression of left ventricular hypertrophy?
    P Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini, Perugia, Italy
    J Hum Hypertens 18:S23-8. 2004
    ..These data indicate that SBP is the principal determinant of LVH regression in hypertensive humans...
  36. ncbi request reprint Hypertension and microalbuminuria: the new detrimental duo
    Paolo Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini, Perugia, Italy
    Blood Press 13:198-211. 2004
    ..Determination of MAU is recommended in the initial work-up of subjects with primary hypertension...
  37. doi request reprint Blood pressure reduction and renin-angiotensin system inhibition for prevention of congestive heart failure: a meta-analysis
    Paolo Verdecchia
    Ospedale S Maria della Misericordia, Cardiologia, Perugia, Italy
    Eur Heart J 30:679-88. 2009
    ..It is unclear whether prevention of congestive heart failure (CHF) by drugs that inhibit the renin-angiotensin system (RAS) occurs over and beyond the reduction in blood pressure (BP) achieved by these drugs...
  38. ncbi request reprint Atrial fibrillation in hypertension: predictors and outcome
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale Silvestrini Università di Perugia, Italy
    Hypertension 41:218-23. 2003
    ..Increased left atrial size predisposes to chronicization of atrial fibrillation...
  39. ncbi request reprint Prognostic value of midwall shortening fraction and its relation with left ventricular mass in systemic hypertension
    P Verdecchia
    Ospedale Generale Regionale Raffaello Silvestrini, Dipartimento di Discipline Cardiovascolari, Universita di Perugia, Itlay
    Am J Cardiol 87:479-82, A7. 2001
    ..There were 166 major cardiovascular events during follow-up and the prognostic value of the midwall shortening fraction did not remain significant after controlling for left ventricular mass...
  40. doi request reprint Influence of blood pressure reduction on composite cardiovascular endpoints in clinical trials
    Paolo Verdecchia
    Department of Cardiology, Hospital Santa Maria della Misericordia, Perugia, Italy
    J Hypertens 28:1356-65. 2010
    ..The use of a composite cardiovascular endpoint (CCEP) is frequent in clinical trials. However, the relation between the reduction in blood pressure (BP) and the risk of CCEP is poorly known...
  41. ncbi request reprint Long-term effects of losartan and enalapril, alone or with a diuretic, on ambulatory blood pressure and cardiac performance in hypertension: a case-control study
    P Verdecchia
    Ospedale Raffaello Silvestrini, Unità Operativa di Malattie Cardiovascolari, Perugia, Italy
    Blood Press Monit 5:187-93. 2000
    ..The long-term effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on ambulatory blood pressure and cardiac performance have never been examined comparatively...
  42. pmc Comparative assessment of angiotensin receptor blockers in different clinical settings
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva, Ospedale S Maria della Misericordia, Perugia, Italy
    Vasc Health Risk Manag 5:939-48. 2009
    ..The present review provides a comparative assessment of the different ARBs in their efficacy on major clinical endpoints along the different steps of the cardiovascular disease continuum...
  43. doi request reprint Aliskiren versus ramipril in hypertension
    Paolo Verdecchia
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital Santa Maria della Misericordia, 06156 Perugia, Italy
    Ther Adv Cardiovasc Dis 4:193-200. 2010
    ..These data provide further evidence that aliskiren monotherapy provides a sustained BP reduction over the 24 hours...
  44. ncbi request reprint Angiotensin converting enzyme inhibitors and angiotensin receptor blockers in the treatment of hypertension: should they be used together?
    Paolo Verdecchia
    Dipartimento di Medicina, Ospedale di Assisi, Assisi, Italy
    Curr Vasc Pharmacol 8:742-6. 2010
    ..However, patients with resistant hypertension, particularly if proteinuria coexists, could benefit from this combination, which however requires close monitoring for adverse events, including hyperkalemia and worsening renal function...
  45. ncbi request reprint Calcium antagonists and cardiovascular risk in patients with hypertension and Type 2 diabetes mellitus: evidence from the PIUMA Study. Progetto Ipertensione Umbria Monitoraggio Ambulatoriale
    P Verdecchia
    Unità Operativa di Malattie Cardiovascolari, Ospedale Regionale Raffaello Silvestrini, Perugia, Italy
    Diabetes Nutr Metab 12:292-9. 1999
    ....
  46. ncbi request reprint Prognostic value of ambulatory blood pressure : current evidence and clinical implications
    P Verdecchia
    Ospedale R Silvestrini, Dipartimento di Scienze Cardiologiche, Perugia PG, Italy
    Hypertension 35:844-51. 2000
    ..Intervention studies targeted at ABP are now needed...
  47. ncbi request reprint Blood Pressure Monitoring. Task force III: Target-organ damage, morbidity and mortality
    P Verdecchia
    Dipartimento di Discipline Cardiovascolari, Ospedale R Silvestrini, Perugia, Italy
    Blood Press Monit 4:303-17. 1999
    ..To reach a consensus on ambulatory blood pressure (ABP) as a predictor of target-organ damage (TOD), morbidity and mortality...
  48. ncbi request reprint Value of a simple echocardiographic linear predictor of left ventricular mass in systemic hypertension
    P Verdecchia
    Ospedale Generale Regionale Raffaello Silvestrini, Dipartimento Discipline Cardiovascolari, Perugia, Italy
    Am J Cardiol 84:1209-14. 1999
    ..The prognostic value of this measure does not differ from that of standard LV mass...
  49. ncbi request reprint Circulating insulin and insulin growth factor-1 are independent determinants of left ventricular mass and geometry in essential hypertension
    P Verdecchia
    Ospedale Generale Regionale Raffaello Silvestrini, Unità Operativa di Malattie Cardiovascolari, Perugia, Italy
    Circulation 100:1802-7. 1999
    ..It is unclear whether insulin and insulin-like growth factor-1 (IGF-1) are independent determinants of left ventricular (LV) mass in essential hypertension...
  50. ncbi request reprint White-coat hypertension in adults and children
    P Verdecchia
    General Hospital R Silvestrini, Department of Cardiology, Ponte della Pietra, Perugia, Italy
    Blood Press Monit 4:175-9. 1999
    ..Authors of these longitudinal studies should also compare the response to drug treatment of these subjects with that to life-style-modification measures...
  51. doi request reprint Telmisartan for the reduction of cardiovascular morbidity and mortality
    Paolo Verdecchia
    Unità Operativa Complessa di Medicina, Ospedale di Assisi, Via Valentin Muller, 06081 Assisi, Italy
    Expert Rev Clin Pharmacol 4:151-61. 2011
    ..Telmisartan is, therefore, the only ARB with a broad indication for CV risk reduction in patients with atherothrombotic disease or diabetes with end-organ damage...
  52. ncbi request reprint Prognostic significance of serial changes in left ventricular mass in essential hypertension
    P Verdecchia
    Ospedale Generale Regionale Raffaello Silvestrini, Area Omogenea di Cardiologia e Medicina, Perugia, Italy
    Circulation 97:48-54. 1998
    ..The purpose of this study was to determine the relation between changes in LV mass during antihypertensive treatment and subsequent prognosis...
  53. doi request reprint Angiotensin receptor blockers in hypertension. New insights from Japan
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva, Ospedale S Maria della Misericordia, Perugia, Italy
    Hypertens Res 33:394-7. 2010
    ..002). The protective effect on the dissecting aneurysm of aorta bordered statistical significance. These data reinforce the notion that the protective effect of angiotensin II inhibition is partly independent of BP reduction...
  54. ncbi request reprint Original articles prognostic value of combined echocardiography and ambulatory blood pressure monitoring in hypertensive patients at low or medium cardiovascular risk
    P Verdecchia
    University of Perugia, Italy
    Ital Heart J 2:287-93. 2001
    ..The clinical value of echocardiography and ambulatory blood pressure monitoring (ABPM) in hypertensive patients at low immediate risk of cardiovascular disease is still unknown...
  55. ncbi request reprint When can the practicing physician suspect white coat hypertension? Statement from the Working Group on Blood Pressure Monitoring of the European Society of Hypertension
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale R Silvestrini, Perugia, Italy
    Am J Hypertens 16:87-91. 2003
  56. pmc The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction
    Paolo Verdecchia
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital Santa Maria della Misericordia, and Fondazione Umbra Cuore e Ipertensione AUCI Onlus, Perugia, Italy
    Vasc Health Risk Manag 4:971-81. 2008
    ..Hypertension is an approved indication for this drug, which is also promising for the treatment of heart failure. The efficacy of this drug in reducing major clinical events is being tested in large ongoing clinical trials...
  57. ncbi request reprint [Systolic, diastolic and pulse pressure: prognostic implications]
    P Verdecchia
    Cardiologia e Fisiopatologia Cardiovascolare, Universita degli Studi, Perugia
    Ital Heart J Suppl 2:369-74. 2001
    ..On the other hand, the latter are better predicted by the mean BP. The effects of antihypertensive drugs and drug combinations on the mean BP and pulse pressure, and the potential prognostic implications, deserve further evaluation...
  58. doi request reprint The voltage of R wave in lead aVL improves risk stratification in hypertensive patients without ECG left ventricular hypertrophy
    Paolo Verdecchia
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital S Maria della Misericordia, Cardiologia, PiazzaleG Menghini, Perugia 06132, Italy
    J Hypertens 27:1697-704. 2009
    ..We tested the hypothesis that the voltages of QRS on ECG improve risk stratification in hypertensive patients without left ventricular hypertrophy on ECG...
  59. ncbi request reprint Reference values for ambulatory blood pressure and self-measured blood pressure based on prospective outcome data
    P Verdecchia
    Blood Press Monit 6:323-7. 2001
    ..An average 24 h pulse pressure of over 53 mmHg identifies subjects with a raised cardiovascular risk...
  60. ncbi request reprint Risk of cardiovascular disease in relation to achieved office and ambulatory blood pressure control in treated hypertensive subjects
    Paolo Verdecchia
    Università di Perugia ed Ospedale R Silvestrini, Dipartimento di Malattie Cardiovascolari, Italy
    J Am Coll Cardiol 39:878-85. 2002
    ..We investigated the prognostic impact of 24-h blood pressure control in treated hypertensive subjects...
  61. doi request reprint Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial
    Paolo Verdecchia
    Division of Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Lancet 374:525-33. 2009
    ..We tested the hypothesis that tight control compared with usual control of systolic blood pressure would be beneficial in such patients...
  62. doi request reprint Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial and the Telmisartan Randomized Assessment
    Paolo Verdecchia
    McMaster University, Population Health Research Institute, 237 Barton St E, Hamilton, ON L8L2X2 Canada
    Circulation 120:1380-9. 2009
    ..Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers reduce left ventricular hypertrophy (LVH). The effect of these drugs on LVH in high-risk patients without heart failure is unknown...
  63. ncbi request reprint Left ventricular hypertrophy as an independent predictor of acute cerebrovascular events in essential hypertension
    P Verdecchia
    Dipartimento Malattie Cardiovascolari, Universita di Perugia, Ospedale Silvestrini, Perugia, Italy
    Circulation 104:2039-44. 2001
    ..It is uncertain whether left ventricular hypertrophy (LVH) confers an increased risk for cerebrovascular disease in apparently healthy patients with essential hypertension...
  64. ncbi request reprint Using out of office blood pressure monitoring in the management of hypertension
    P Verdecchia
    Cardiologia e Fisiopatologia Cardiovascolare, Universita di Perugia, Policlinico Monteluce, Via Brunamonti 51, 06122 Perugia PG, Italy
    Curr Hypertens Rep 3:400-5. 2001
    ..ABPM may be valuable for refining cardiovascular risk stratification in untreated subjects with office hypertension, as well as those with resistant hypertension...
  65. ncbi request reprint Independent predictors of isolated clinic ('white-coat') hypertension
    P Verdecchia
    Cardiologia e Fisiopatologia Cardiovascolare and Medicina Interna, Universiá di Perugia, Italy
    J Hypertens 19:1015-20. 2001
    ..However, the pre-test probability of ICH based on the distribution of its independent predictors has not yet been estimated in hypertensive subjects with mildly elevated blood pressure...
  66. ncbi request reprint Different prognostic impact of 24-hour mean blood pressure and pulse pressure on stroke and coronary artery disease in essential hypertension
    P Verdecchia
    Cardiologia e Fisiopatologia Cardiovascolare, Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Dipartimento di Medicina Interna, University of Perugia, Perugia, Italy
    Circulation 103:2579-84. 2001
    ..We tested the hypothesis that the steady and pulsatile components of blood pressure (BP) exert a different influence on coronary artery disease and stroke in subjects with hypertension...
  67. ncbi request reprint [Cardiac failure in hypertensive cardiopathy]
    P Verdecchia
    Dipartimento di Scienze Cardiologiche, Ospedale R Silvestrini, Perugia
    Ital Heart J 1:72-7. 2000
    ..These patients appear to be at increased risk of major cardiovascular events including heart failure...
  68. ncbi request reprint Left ventricular mass and systolic dysfunction in essential hypertension
    G Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Italy
    J Hum Hypertens 16:117-22. 2002
    ..LV hypertrophy is a determinant of subclinical LV dysfunction independently of the concomitant changes in chamber geometry...
  69. pmc Choice of ACE inhibitor combinations in hypertensive patients with type 2 diabetes: update after recent clinical trials
    Gianpaolo Reboldi
    1Department of internal Medicine University of Perugia, Perugia, Italy
    Vasc Health Risk Manag 5:411-27. 2009
    ..The present review will focus on different ACE inhibitor combinations in the treatment of patients with type 2 diabetes mellitus and hypertension, in the light of recent clinical trials, including GUARD and ACCOMPLISH...
  70. ncbi request reprint Prevalent influence of systolic over pulse pressure on left ventricular mass in essential hypertension
    P Verdecchia
    Cardiologia e Fisiopatologia Cardiovascolare, Università de Perugia, Perugia, Italy
    Eur Heart J 23:658-65. 2002
    ..Elevated pulse pressure, an index of increased large artery stiffness, has been associated with increased left ventricular mass. It is unknown whether this relation is independent or mediated by other blood pressure components...
  71. doi request reprint Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  72. doi request reprint Exploring the optimal combination therapy in hypertensive patients with diabetes mellitus
    Gianpaolo Reboldi
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Expert Rev Cardiovasc Ther 7:1349-61. 2009
    ..The present review explores the potential for an 'optimal' combination therapy in patients with diabetes mellitus and hypertension, in view of recent experimental and clinical evidence...
  73. ncbi request reprint Gender, day-night blood pressure changes, and left ventricular mass in essential hypertension. Dippers and peakers
    P Verdecchia
    , Ospedale Generale Regionale R. Silvestrini, Perugia, Italy
    Am J Hypertens 8:193-6. 1995
    ..Daytime hypertension, either associated or not with a blunted nocturnal fall in BP, may be a sufficient determinant of LV wall thickening in men...
  74. doi request reprint Angiotensin II receptor blockers and myocardial infarction: an updated analysis of randomized clinical trials
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 27:941-6. 2009
    ..To evaluate the effects of treatments based on angiotensin II receptor blockers (ARBs) on the risk of myocardial infarction (MI), cardiovascular and all-cause death, as compared with conventional treatment or placebo...
  75. ncbi request reprint Ambulatory pulse pressure: a potent predictor of total cardiovascular risk in hypertension
    P Verdecchia
    Unità Operativa di Malattie Cardiovascolari, Ospedale Regionale Raffaello Silvestrini, Perugia, Italy
    Hypertension 32:983-8. 1998
    ..We conclude that ambulatory PP is a potent risk marker in essential hypertension. CV morbidity is more closely predicted by ambulatory than by office PP even after control for multiple risk factors...
  76. ncbi request reprint High-density lipoprotein cholesterol and left ventricular hypertrophy in essential hypertension
    G Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Hypertens 19:2265-70. 2001
    ..This study examines the possible relation between blood lipids and LV mass in hypertension...
  77. ncbi request reprint Adverse prognostic value of a blunted circadian rhythm of heart rate in essential hypertension
    P Verdecchia
    Area Omogenea di Cardiologia e Medicina, Ospedale Regionale Raffaello Silvestrini, Perugia, Italy
    J Hypertens 16:1335-43. 1998
    ..Previous studies revealed a direct association between resting heart rate and risk of mortality in essential hypertension. However, resting heart rate is a highly variable measure since it is affected by the alerting reaction to the visit...
  78. ncbi request reprint Arterial wall thickening at different sites and its association with left ventricular hypertrophy in newly diagnosed essential hypertension
    G Vaudo
    Sezione di Medicina Interna, Angiologia e Malattie da Arteriosclerosi, University of Perugia, and the Azienda Ospedaliera di Perugia, Italy
    Am J Hypertens 13:324-31. 2000
    ..In summary, in the early stages of hypertension arterial wall thickening appears to be a diffuse process, which occurs in parallel at the carotid and femoral level and shows a positive association with LV hypertrophy...
  79. ncbi request reprint Prognostic value of a new electrocardiographic method for diagnosis of left ventricular hypertrophy in essential hypertension
    P Verdecchia
    Area Omogenea di Cardiologia e Medicina, Ospedale R Silvestrini, Perugia, Italy
    J Am Coll Cardiol 31:383-90. 1998
    ....
  80. ncbi request reprint Hypertrophy at ECG and its regression during treatment survey (HEART survey). Rationale, design and baseline characteristics of patients
    Paolo Verdecchia
    ANMCO Research Center, Florence, Italy
    Ital Heart J 4:479-83. 2003
    ..The aim of this study was to determine the prognostic value of baseline ECG LVH and its serial changes in a large cohort of hypertensive patients...
  81. doi request reprint Methods of measurements: home and ambulatory blood pressure monitoring
    Gianfranco Parati
    Department of Cardiology, S Luca Hospital, Istituto Auxologico Italiano, Milan, Italy
    Blood Press Monit 15:100-5. 2010
    ..This study is aimed at briefly summarizing a few important issues in this context, and at emphasizing the work done by Tom Pickering in this field, as a tribute to his unique contributions to medical science and patient care...
  82. ncbi request reprint Impact of blood pressure variability on cardiac and cerebrovascular complications in hypertension
    Paolo Verdecchia
    Clinical Research Unit Preventive Cardiology, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 20:154-61. 2007
    ..The independent prognostic value of daytime and night-time blood pressure (BP) variability estimated by noninvasive 24-h BP monitoring is unclear...
  83. ncbi request reprint Assessment of the optimal daily dose of valsartan in patients with hypertension, heart failure, or both
    Paolo Verdecchia
    Department of Cardiovascular Disease, Hospital R Silvestrini, University of Perugia, S Andrea delle Fratte, 06122 Perugia, Italy
    Clin Ther 26:460-72. 2004
    ..Therefore, it is necessary to determine the ARB dosages that optimize the efficacy/tolerability ratio...
  84. ncbi request reprint Short- and long-term incidence of stroke in white-coat hypertension
    Paolo Verdecchia
    Dipartimento Malattie Cardiovascolari, Ospedale R Silvestrini, Perugia, Italy
    Hypertension 45:203-8. 2005
    ..In conclusion, WCH was not associated with a definitely increased risk of stroke during the total follow-up period. However, WCH might not be a benign condition for stroke in the long term...
  85. doi request reprint The optimal blood pressure target for patients with coronary artery disease
    Paolo Verdecchia
    Struttura Complessa di Cardiologia, Unità di Ricerca Clinica Cardiologia Preventiva, Ospedale S Maria della Misericordia, Perugia, Italy
    Curr Cardiol Rep 12:302-6. 2010
    ..The optimal BP target for patients with CAD remains undefined. A reasonable target appears to be in the range of 130-140/80-90 mm Hg. Any further reduction may be safe, but not much productive from a prognostic standpoint...
  86. ncbi request reprint White coat hypertension and white coat effect. Similarities and differences
    P Verdecchia
    Ospedale Generale Regionale R. Silvestrini, Area Omogenea di Cardiologia e Medicina, Perugia, Italy
    Am J Hypertens 8:790-8. 1995
    ..001).(abstract truncated at 250 words)..
  87. ncbi request reprint Subclinical left ventricular dysfunction in systemic hypertension and the role of 24-hour blood pressure
    G Schillaci
    Dipartimento di Cardiologia, Ospedale R Silvestrini, Perugia, Italy
    Am J Cardiol 86:509-13. 2000
    ..45 vs -0.16, p <0.001). Thus, an increased 24-hour BP load may chronically lead to depressed myocardial function in systemic hypertension in the absence of clinically overt heart disease...
  88. ncbi request reprint High-normal serum creatinine concentration is a predictor of cardiovascular risk in essential hypertension
    G Schillaci
    Unit of Internal Medicine, Angiology, and Arteriosclerosis, Department of Clinical and Experimental Medicine, University of Perugia Medical School via Brunamonti, 51, 06122 Perugia, Italy
    Arch Intern Med 161:886-91. 2001
    ..However, the possibility that creatinine values within the reference range might contribute to stratification of cardiovascular risk in essential hypertension has never been tested...
  89. ncbi request reprint White-coat hypertension in adults
    Fabio Angeli
    Department of Cardiovascular Disease, Hospital R Silvestrini, Perugia, Italy
    Blood Press Monit 10:301-5. 2005
    ..suggest a treatment based on life-style measures in the low-risk stratum of patients with white-coat hypertension under the conditions of correct definition, absence of comorbid conditions and target-organ damage, and adequate follow-up..
  90. ncbi request reprint Prognostic significance of left ventricular diastolic dysfunction in essential hypertension
    Giuseppe Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Perugia, Italy
    J Am Coll Cardiol 39:2005-11. 2002
    ..We sought to assess the prognostic value of alterations in left ventricular (LV) diastolic function in patients with essential hypertension...
  91. doi request reprint Masked hypertension: evaluation, prognosis, and treatment
    Fabio Angeli
    Department of Cardiology, Clinical Research Unit Preventive Cardiology, Hospital S Maria della Misericordia, Perugia, Italy
    Am J Hypertens 23:941-8. 2010
    ..MH should be searched for in subjects who appear to be more likely to have this condition. Antihypertensive treatment is envisaged in these subjects, although the associated outcome benefits are still undetermined...
  92. ncbi request reprint Meta-Analysis of effectiveness or lack thereof of angiotensin-converting enzyme inhibitors for prevention of heart failure in patients with systemic hypertension
    Fabio Angeli
    Department of Cardiovascular Disease, Hospital R Silvestrini, Perugia, Italy
    Am J Cardiol 93:240-3. 2004
    ..Thus, the hypothesis that ACE inhibitors are superior to other antihypertensive drugs for prevention of CHF in hypertension remains unproven...
  93. doi request reprint Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of myocardial infarction, stroke and death: a meta-analysis
    Gianpaolo Reboldi
    Department of Internal Medicine, University of Perugia, Italy
    J Hypertens 26:1282-9. 2008
    ..To compare the effects of angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors on the risk of myocardial infarction, stroke, cardiovascular mortality and total mortality...
  94. ncbi request reprint Comparison of electrocardiographic criteria for diagnosis of left ventricular hypertrophy in hypertension: the MAVI study
    P Verdecchia
    Department of Cardiology, Hospital R Silvestrini, Perugia, Italy
    Ital Heart J 1:207-15. 2000
    ..In a large population of subjects with hypertension we tested some standard ECG criteria in their sensitivity and specificity for LV hypertrophy. LV mass at echocardiography was the reference standard...
  95. ncbi request reprint Defining normal ambulatory blood pressure in relation to target organ damage and prognosis
    P Verdecchia
    Hypertension Unit, General Hospital R. Silvestrini, Perugia PG, Italy
    Am J Hypertens 6:207S-210S. 1993
    ..abstract truncated at 250 words)..
  96. doi request reprint Neutrophil count for the identification of postmenopausal hypertensive women at increased cardiovascular risk
    Fabio Angeli
    Department of Cardiology and Clinical Research Unit Preventive Cardiology, Hospital S Maria della Misericordia, Perugia, and Department of Cardiovascular Pathophysiology, University of Perugia, Perugia and Department of Internal Medicine, University of Perugia, Perugia, Italy
    Obstet Gynecol 115:695-703. 2010
    ..We tested the independent prognostic value of total white blood cell and neutrophil counts for cardiovascular events in hypertensive postmenopausal women...
  97. ncbi request reprint Change in cardiovascular risk profile by echocardiography in low- or medium-risk hypertension
    Giuseppe Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Perugia, Italy
    J Hypertens 20:1519-25. 2002
    ....
  98. ncbi request reprint Microalbuminuria and hypertension
    G Reboldi
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Minerva Med 96:261-75. 2005
    ....
  99. ncbi request reprint Calcium channel blockade to prevent stroke in hypertension: a meta-analysis of 13 studies with 103,793 subjects
    Fabio Angeli
    Departments of Cardiovascular Disease and Internal Medicine, Hospital R Silvestrini, Perugia, Italy
    Am J Hypertens 17:817-22. 2004
    ..We undertook a meta-analysis to assess whether calcium channel blockers (CCBs) are associated with a lesser risk of stroke as compared with other antihypertensive drugs...
  100. ncbi request reprint Validation of the A&D wrist-cuff UB-511 (UB-512) device for self-measurement of blood pressure
    Fabio Angeli
    Clinic Research Unit, Preventive Cardiology, Department of Cardiology, R Silvestrini Hospital, Perugia, Italy
    Blood Press Monit 11:349-54. 2006
    ..To determine the accuracy of the A&D UB-511 (UB-512) oscillometric wrist-cuff device for self-measurement of blood pressure, the only difference between the two devices being the size of storage memory...
  101. ncbi request reprint Day-to-day variability of electrocardiographic diagnosis of left ventricular hypertrophy in hypertensive patients. Influence of electrode placement
    Fabio Angeli
    Clinical Research Unit Preventive Cardiology, Department of Cardiovascular Diseases, R Silvestrini Hospital, Perugia, Italy
    J Cardiovasc Med (Hagerstown) 7:812-6. 2006
    ....