Cristina Zona

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis
    Cristina Zona
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurophysiol 96:3314-22. 2006
  2. doi request reprint Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture
    Cristina Zona
    Department of Neuroscience, University of Rome Tor Vergata, Italy
    Epilepsy Res 88:46-54. 2010
  3. doi request reprint Substance P receptor activation induces downregulation of the AMPA receptor functionality in cortical neurons from a genetic model of Amyotrophic Lateral Sclerosis
    Silvia Caioli
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1 00133 Rome, Italy
    Neurobiol Dis 44:92-101. 2011
  4. doi request reprint Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis
    Massimo Pieri
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Exp Neurol 215:368-79. 2009
  5. doi request reprint Increased levels of p70S6 phosphorylation in the G93A mouse model of Amyotrophic Lateral Sclerosis and in valine-exposed cortical neurons in culture
    Irene Carunchio
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy
    Exp Neurol 226:218-30. 2010
  6. doi request reprint GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis
    Irene Carunchio
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00173 Rome, Italy
    Eur J Neurosci 28:1275-85. 2008
  7. ncbi request reprint Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam
    Irene Carunchio
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Epilepsia 48:654-62. 2007
  8. ncbi request reprint Altered excitability of motor neurons in a transgenic mouse model of familial amyotrophic lateral sclerosis
    Massimo Pieri
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    Neurosci Lett 351:153-6. 2003
  9. ncbi request reprint Kainate-induced currents in rat cortical neurons in culture are modulated by riluzole
    Cristina Zona
    Fisiologia Umana, Universita degli Studi di Roma Tor Vergata, 00133 Rome, Italy
    Synapse 43:244-51. 2002
  10. doi request reprint Over-expression of N-type calcium channels in cortical neurons from a mouse model of Amyotrophic Lateral Sclerosis
    Massimo Pieri
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy I R C C S Fondazione S Lucia, Via del Fosso di Fiorano, 65, 00143 Rome, Italy
    Exp Neurol 247:349-58. 2013

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis
    Cristina Zona
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurophysiol 96:3314-22. 2006
    ..Clarification of the importance of these changes in membrane ion channel functionality may have diagnostic and therapeutic implications in the pathogenesis of ALS...
  2. doi request reprint Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture
    Cristina Zona
    Department of Neuroscience, University of Rome Tor Vergata, Italy
    Epilepsy Res 88:46-54. 2010
    ..These results indicate that BRV is able to modulate the voltage-activated Na(+) inflow in cortical neurons, which conceivably might contribute to the antiepileptic activity of this drug...
  3. doi request reprint Substance P receptor activation induces downregulation of the AMPA receptor functionality in cortical neurons from a genetic model of Amyotrophic Lateral Sclerosis
    Silvia Caioli
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1 00133 Rome, Italy
    Neurobiol Dis 44:92-101. 2011
    ..These findings provide the first evidence of SP having a physiological and protective role in the G93A mouse model of ALS, and may suggest the possible use of SP as a clinical therapeutic treatment...
  4. doi request reprint Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis
    Massimo Pieri
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Exp Neurol 215:368-79. 2009
    ....
  5. doi request reprint Increased levels of p70S6 phosphorylation in the G93A mouse model of Amyotrophic Lateral Sclerosis and in valine-exposed cortical neurons in culture
    Irene Carunchio
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy
    Exp Neurol 226:218-30. 2010
    ..These findings, besides strongly indicating that BCAAs specifically induce hyperexcitability, seem to suggest the involvement of p70S6 substrate in ALS pathology...
  6. doi request reprint GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis
    Irene Carunchio
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00173 Rome, Italy
    Eur J Neurosci 28:1275-85. 2008
    ..These data show that the functionality and expression of GABA(A) receptors are altered in G93A motor neurons inducing a higher Cl(-) influx into the cell with a possible consequent neuronal excitotoxicity acceleration...
  7. ncbi request reprint Modulation of AMPA receptors in cultured cortical neurons induced by the antiepileptic drug levetiracetam
    Irene Carunchio
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Epilepsia 48:654-62. 2007
    ....
  8. ncbi request reprint Altered excitability of motor neurons in a transgenic mouse model of familial amyotrophic lateral sclerosis
    Massimo Pieri
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    Neurosci Lett 351:153-6. 2003
    ..The passive membrane properties of these neurons were equivalent however. Such results suggest that an altered motor neuron excitability accompanies an ALS associated mutation and that may contribute to the pathogenesis of the disease...
  9. ncbi request reprint Kainate-induced currents in rat cortical neurons in culture are modulated by riluzole
    Cristina Zona
    Fisiologia Umana, Universita degli Studi di Roma Tor Vergata, 00133 Rome, Italy
    Synapse 43:244-51. 2002
    ....
  10. doi request reprint Over-expression of N-type calcium channels in cortical neurons from a mouse model of Amyotrophic Lateral Sclerosis
    Massimo Pieri
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy I R C C S Fondazione S Lucia, Via del Fosso di Fiorano, 65, 00143 Rome, Italy
    Exp Neurol 247:349-58. 2013
    ..These results may be central to the understanding of pathogenic pathways in ALS and provide novel molecular targets for the design of rational therapies for the ALS disorder. ..
  11. ncbi request reprint AMPA receptors are modulated by tachykinins in rat cerebellum neurons
    Massimo Pieri
    Department of Neuroscience, University of Rome Tor Vergata, Italy
    J Neurophysiol 94:2484-90. 2005
    ..This study adds the tachykinins to the list of neuromodulators capable of exerting a excitatory action on cerebellar granule cells...
  12. ncbi request reprint Altered calcium homeostasis in motor neurons following AMPA receptor but not voltage-dependent calcium channels' activation in a genetic model of amyotrophic lateral sclerosis
    Ezia Guatteo
    Fondazione S Lucia, Centro Europeo Ricerca sul Cervello, Via del Fosso di Fiorano, 00173 Roma, Italy
    Neurobiol Dis 28:90-100. 2007
    ....
  13. ncbi request reprint Altered vulnerability to kainate excitotoxicity of transgenic-Cu/Zn SOD1 neurones
    Alida Spalloni
    IRCCS Fondazione Santa Lucia Via Ardeatina 306 00179 Rome, Italy
    Neuroreport 15:2477-80. 2004
    ....
  14. ncbi request reprint Effects of simulated microgravity on the development and maturation of dissociated cortical neurons
    Alessio Crestini
    Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    In Vitro Cell Dev Biol Anim 40:159-65. 2004
    ..Overall, our results indicate that a short time of simulated microgravity preexposure does not affect dramatically the ability of dissociated neural cells to develop and differentiate in an adherent culture system...
  15. ncbi request reprint Modulation of AMPA receptors in spinal motor neurons by the neuroprotective agent riluzole
    Federica Albo
    IRCCS Fondazione S Lucia, Roma, Italy
    J Neurosci Res 78:200-7. 2004
    ..05). These results reveal an interaction of riluzole with glutamatergic neurotransmission in spinal cord motor neurons and can contribute to explain its beneficial effect in the ALS treatment...
  16. ncbi request reprint Cu/Zn-superoxide dismutase (GLY93-->ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture
    Alida Spalloni
    Fondazione Santa Lucia IRCCS, 00179 Rome, Italy
    Neurobiol Dis 15:340-50. 2004
    ..Thus, the SOD1 G93A mutation causes changes in the AMPA-receptor expression and function, as well as a susceptibility to kainate-mediated excitotoxicity, which may promote the motor neuron degeneration seen in ALS...
  17. pmc Enhancement of learning and memory after activation of cerebral Rho GTPases
    Giovanni Diana
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Proc Natl Acad Sci U S A 104:636-41. 2007
    ..The results suggest that learning ability can be improved through pharmacological manipulation of neural connectivity...
  18. ncbi request reprint Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine
    Cristina Zona
    Dipartimento di Neuroscienze, Universita degli Studi di Roma Tor Vergata, Roma, Italy
    Epilepsia 43:685-90. 2002
    ....
  19. ncbi request reprint Tachykinins and excitotoxicity in cerebellar granule cells
    Cinzia Severini
    Institute of Neurobiology and Molecular Medicine, Rome, Italy
    Cerebellum 5:232-7. 2006
    ..This review is an attempt to summarize the diverse evidence suggesting a role for tachykinins in cerebellar granule neurons...