Gianguglielmo Zehender

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Reliable timescale inference of HBV genotype A origin and phylodynamics
    Gianguglielmo Zehender
    L Sacco Department of Biomedical and Clinical Science, University of Milan, 20157 Milan Italy Electronic address
    Infect Genet Evol 32:361-9. 2015
  2. pmc Different evolutionary trends of swine H1N2 influenza viruses in Italy compared to European viruses
    Ana Moreno
    Department of Virology, Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Via Bianchi, 9, 25124 Brescia, Italy
    Vet Res 44:112. 2013
  3. doi request reprint Phylogeography and phylodynamics of European genotype 3 hepatitis E virus
    Gianguglielmo Zehender
    Department of Biomedical and Clinical Sciences L Sacco, University of Milan, Milan, Italy Electronic address
    Infect Genet Evol 25:138-43. 2014
  4. pmc Phylogeny and phylodinamic of Hepatitis C in Italy
    Massimo Ciccozzi
    Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Rome, Italy
    BMC Infect Dis 12:S5. 2012
  5. doi request reprint Reconstruction of the evolutionary dynamics of hepatitis C virus subtypes in Montenegro and the Balkan region
    Gianguglielmo Zehender
    Department of Biomedical and Clinical Sciences L Sacco, Infectious Diseases and Tropical Medicine Chair, University of Milan, Milan, Italy
    Infect Genet Evol 17:223-30. 2013
  6. pmc Reconstruction of the evolutionary dynamics of the A(H1N1)pdm09 influenza virus in Italy during the pandemic and post-pandemic phases
    Gianguglielmo Zehender
    Dipartimento di Scienze Cliniche e Biomediche Luigi Sacco, Sezione di Malattie Infettive, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 7:e47517. 2012
  7. pmc Spatial and temporal dynamics of hepatitis B virus D genotype in Europe and the Mediterranean Basin
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milano, Italy
    PLoS ONE 7:e37198. 2012
  8. doi request reprint Reconstruction of the epidemic history of hepatitis B virus genotype D in Albania
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Chair of Infectious Diseases, University of Milan, Milan, Italy
    Infect Genet Evol 12:291-8. 2012
  9. ncbi request reprint Increased risk of developing peripheral neuropathy in patients coinfected with HIV-1 and HTLV-2
    Gianguglielmo Zehender
    Istituto di Malattie Infettive e Tropicali, Universita degli Studi di Milano, Milan, Italy
    J Acquir Immune Defic Syndr 31:440-7. 2002
  10. doi request reprint Phylogeography and epidemiological history of West Nile virus genotype 1a in Europe and the Mediterranean basin
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, University of Milan, c o Ospedale L Sacco, Via G B Grassi 74, Milan, Italy
    Infect Genet Evol 11:646-53. 2011

Collaborators

Detail Information

Publications32

  1. doi request reprint Reliable timescale inference of HBV genotype A origin and phylodynamics
    Gianguglielmo Zehender
    L Sacco Department of Biomedical and Clinical Science, University of Milan, 20157 Milan Italy Electronic address
    Infect Genet Evol 32:361-9. 2015
    ..In conclusion, the very different epidemiological and evolutionary histories of HBV-A subgenotypes justify the use of different calibration approaches to reconstruct their reciprocal phylodynamics. ..
  2. pmc Different evolutionary trends of swine H1N2 influenza viruses in Italy compared to European viruses
    Ana Moreno
    Department of Virology, Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Via Bianchi, 9, 25124 Brescia, Italy
    Vet Res 44:112. 2013
    ..The data highlight different evolutionary trends between European viruses and currently circulating Italian B strains and show the establishment of reassortant strains involving human viruses in Italian pigs...
  3. doi request reprint Phylogeography and phylodynamics of European genotype 3 hepatitis E virus
    Gianguglielmo Zehender
    Department of Biomedical and Clinical Sciences L Sacco, University of Milan, Milan, Italy Electronic address
    Infect Genet Evol 25:138-43. 2014
    ....
  4. pmc Phylogeny and phylodinamic of Hepatitis C in Italy
    Massimo Ciccozzi
    Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Rome, Italy
    BMC Infect Dis 12:S5. 2012
    ..Monitoring the genetic evolution of HCV is an essential step to control the local as well as global HCV epidemic and to develop efficient preventive and therapeutic strategies...
  5. doi request reprint Reconstruction of the evolutionary dynamics of hepatitis C virus subtypes in Montenegro and the Balkan region
    Gianguglielmo Zehender
    Department of Biomedical and Clinical Sciences L Sacco, Infectious Diseases and Tropical Medicine Chair, University of Milan, Milan, Italy
    Infect Genet Evol 17:223-30. 2013
    ..Our data suggest multiple introduction of HCV subtypes in the area, supported by different causes of dispersion: adverse social conditions and unsafe medical practices for HCV-1b and i.v. drug use for HCV-3a...
  6. pmc Reconstruction of the evolutionary dynamics of the A(H1N1)pdm09 influenza virus in Italy during the pandemic and post-pandemic phases
    Gianguglielmo Zehender
    Dipartimento di Scienze Cliniche e Biomediche Luigi Sacco, Sezione di Malattie Infettive, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 7:e47517. 2012
    ..In conclusion, the A(H1N1)pdm09 virus was introduced into Italy in the spring of 2009 by means of multiple importations. This was followed by repeated founder effects in the post-pandemic period that originated specific Italian clades...
  7. pmc Spatial and temporal dynamics of hepatitis B virus D genotype in Europe and the Mediterranean Basin
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milano, Italy
    PLoS ONE 7:e37198. 2012
    ..We hypothesise that the main route of dispersion of genotype D was the unsafe use of injections and drug addiction...
  8. doi request reprint Reconstruction of the epidemic history of hepatitis B virus genotype D in Albania
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Chair of Infectious Diseases, University of Milan, Milan, Italy
    Infect Genet Evol 12:291-8. 2012
    ..Our data suggest that political and socio-economic factors played an important role in determining the rapid spread of HBV infection in Albania...
  9. ncbi request reprint Increased risk of developing peripheral neuropathy in patients coinfected with HIV-1 and HTLV-2
    Gianguglielmo Zehender
    Istituto di Malattie Infettive e Tropicali, Universita degli Studi di Milano, Milan, Italy
    J Acquir Immune Defic Syndr 31:440-7. 2002
    ....
  10. doi request reprint Phylogeography and epidemiological history of West Nile virus genotype 1a in Europe and the Mediterranean basin
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, University of Milan, c o Ospedale L Sacco, Via G B Grassi 74, Milan, Italy
    Infect Genet Evol 11:646-53. 2011
    ....
  11. doi request reprint Population dynamics of HIV-1 subtype B in a cohort of men-having-sex-with-men in Rome, Italy
    Gianguglielmo Zehender
    Department of Clinical Sciences, L Sacco, University of Milan, Milan, Italy
    J Acquir Immune Defic Syndr 55:156-60. 2010
    ..Epidemiological clusters originating in the early 2000s suggest a recent re-emergence of HIV in Italian MSM...
  12. ncbi request reprint Phylogeny of human T cell lymphotropic virus type 1 in Peru: a high degree of evolutionary relatedness with South African isolates
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, Section of Infectious Diseases, University of Milan, Italy
    AIDS Res Hum Retroviruses 23:1146-9. 2007
    ..These data show a high prevalence of HTLV-1 infection in HIV-1-positive subjects living in Lima and confirm the presence in Latin America of HTLV-1 strains probably arising from South Africa...
  13. doi request reprint Rapid molecular evolution of human bocavirus revealed by Bayesian coalescent inference
    Gianguglielmo Zehender
    Universita degli Studi di Milano, Dipartimento di Scienze Cliniche L Sacco, Sezione di Malattie Infettive, Via G B Grassi, 74 20157 Milano, Italy
    Infect Genet Evol 10:215-20. 2010
    ..The low level of polymorphism is probably due to a relatively recent divergence between the circulating genotypes and strong purifying selection acting on viral antigens...
  14. ncbi request reprint High prevalence of human T-lymphotropic virus type 1 (HTLV-1) in immigrant male-to-female transsexual sex workers with HIV-1 infection
    Gianguglielmo Zehender
    Istituto di Malattie Infettive e Tropicali Università di Milano, Centro Interdisciplinare per gli Studi Biomolecolari e le Applicazioni Industriali CISI, Milan, Italy
    J Med Virol 74:207-15. 2004
    ..These results suggest the independent origin of each infection in the patient's birthplace. The data raise concerns about the further spread of HTLV infections mainly through the sexual route...
  15. doi request reprint Bayesian skyline plot inference of the Toscana virus epidemic: a decline in the effective number of infections over the last 30 years
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, Section of Infectious Diseases, University of Milan, Milan, Italy
    Infect Genet Evol 9:562-6. 2009
    ..In conclusion, our data suggest that continuous and prolonged perturbations of vector/phlebovirus interactions due to the relatively recent climate changes may have contributed to gradually reducing the viral population in endemic areas...
  16. doi request reprint Different evolutionary rates and epidemic growth of hepatitis B virus genotypes A and D
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milan, Italy
    Virology 380:84-90. 2008
    ..These results show the usefulness of phylodynamic studies in reconstructing the history of epidemics due to highly variable DNA viruses, and in evaluating the long-term efficacy of prophylactic measures...
  17. ncbi request reprint Description of a "trans-Saharan" strain of human T-lymphotropic virus type 1 in West Africa
    Gianguglielmo Zehender
    Department of Clinical Sciences L Sacco, Section of Infectious Diseases, University of Milan, Milan, Italy
    J Acquir Immune Defic Syndr 47:269-73. 2008
    ....
  18. pmc Compartmentalization of hepatitis C virus quasispecies in blood mononuclear cells of patients with mixed cryoglobulinemic syndrome
    Gianguglielmo Zehender
    Istituto di Malattie Infettive e Tropicali, Università di Milano c o Ospedale L Sacco, Via G B Grassi 74, 20157 Milan, Italy
    J Virol 79:9145-56. 2005
    ..The frequent HCV quasispecies compartmentalization in patients' PBMC suggests a possible pathogenetic significance...
  19. pmc Within-host dynamics of the hepatitis C virus quasispecies population in HIV-1/HCV coinfected patients
    Flavia Bernini
    Department of Clinical Sciences L Sacco, University of Milan, Milan, Italy
    PLoS ONE 6:e16551. 2011
    ..We hypothesize that an important role is played by the enlargement of the viral replicative space...
  20. ncbi request reprint High level of genetic heterogeneity in S and P genes of genotype D hepatitis B virus
    Chiara De Maddalena
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milan, Italy
    Virology 365:113-24. 2007
    ....
  21. pmc Bayesian phylogeography of Crimean-Congo hemorrhagic fever virus in Europe
    Gianguglielmo Zehender
    Department of Clinical Sciences Luigi Sacco, Section of Infectious Diseases, University of Milan, Milano, Italy
    PLoS ONE 8:e79663. 2013
    ..Given the close proximity of the infected areas, our data suggest that the movement of wild and domestic ungulates from endemic areas was probably the main cause of the dissemination of the virus in eastern Europe. ..
  22. doi request reprint Phylogenetic analysis provides evidence of interactions between Italian heterosexual and South American homosexual males as the main source of national HIV-1 subtype C epidemics
    Alessia Lai
    Department of Biomedical and Clinical Science, Infectious Diseases and Immunopathology Section, L Sacco Hospital, University of Milan, Milan, Italy
    J Med Virol 86:729-36. 2014
    ..Phylogenetic monitoring is warranted to guide public health interventions aimed at controlling HIV infection...
  23. doi request reprint Local and global spatio-temporal dynamics of HIV-1 subtype F1
    Alessia Lai
    Department of Biomedical and Clinical Sciences, Infectious Diseases and Immunopathology Section, L Sacco Hospital, University of Milan, Milan, Italy
    J Med Virol 86:186-92. 2014
    ..Two different pathways from South America and Romania led the F1 variant to Italy in the 1970s...
  24. pmc Enigmatic origin of hepatitis B virus: an ancient travelling companion or a recent encounter?
    Gianguglielmo Zehender
    Gianguglielmo Zehender, Erika Ebranati, Elena Gabanelli, Chiara Sorrentino, Massimo Galli, L Sacco Department of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy
    World J Gastroenterol 20:7622-34. 2014
    ..It is hypothesised that HBV evolutionary rates are time dependent, and that the changes depend on the main transmission routes of the genotypes and the dynamics of the infected populations. ..
  25. doi request reprint Recurrence of another hepatitis B virus escape mutant comes back in a patient infected with HIV and low CD4+ count
    Laura Milazzo
    III Division of Infectious Diseases, Luigi Sacco University Hospital, Milan, Italy
    J Med Virol 86:97-101. 2014
    ....
  26. doi request reprint Genetic drift influenza A(H3N2) virus hemagglutinin (HA) variants originated during the last pandemic turn out to be predominant in the 2011-2012 season in Northern Italy
    Elena Pariani
    Dipartimento di Scienze Biomediche per la Salute, Universita degli Studi di Milano, Italy
    Infect Genet Evol 13:252-60. 2013
    ..Therefore, it should be implemented within the framework of influenza virological surveillance...
  27. pmc HIV-1 subtype F1 epidemiological networks among Italian heterosexual males are associated with introduction events from South America
    Alessia Lai
    Department of Biomedical and Clinical Science, Infectious Diseases and Immunopathology Section, L Sacco Hospital, University of Milan, Milan, Italy
    PLoS ONE 7:e42223. 2012
    ..The contact tracing also revealed an unexpected burden of resistance in epidemiological clusters underlying the need of public interventions to limit the spread of non-B subtypes and transmitted drug resistance...
  28. doi request reprint Phylogeny and population dynamics of respiratory syncytial virus (Rsv) A and B
    Marianna Martinelli
    Department of Biomedical Sciences for Health, University of Milan, Via C Pascal 36, 20133, Milan, Italy Electronic address
    Virus Res 189:293-302. 2014
    ....
  29. pmc Transmission of resistant HIV type 1 variants and epidemiological chains in Italian newly diagnosed individuals
    Alessia Lai
    Department of Clinical Sciences L Sacco Hospital, Section of Infectious Diseases and Immunopathology, University of Milan, Milan, Italy
    AIDS Res Hum Retroviruses 28:857-65. 2012
    ..Intervention strategies of public health are needed to limit HIV-1 transmission and the associated TDR...
  30. doi request reprint Human papillomavirus detection in paraffin-embedded colorectal cancer tissues
    Elisabetta Tanzi
    Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
    J Gen Virol 96:206-9. 2015
    ..3 % of HPV-genotyped specimens had an unclassified β-HPV. Examining additional cases and analysing whole genomes will help to outline the significance of these findings. ..
  31. pmc Extended genetic diversity of bovine viral diarrhea virus and frequency of genotypes and subtypes in cattle in Italy between 1995 and 2013
    Camilla Luzzago
    Department of Veterinary Science and Public Health, University of Milan, Via Celoria 10, 20133 Milan, Italy
    Biomed Res Int 2014:147145. 2014
    ..Northern Italy ranked first for BVDV introduction, prevalence, and dispersion. Nevertheless, the presence of sporadic variants in other restricted areas suggests the risk of different routes of BVDV introduction. ..
  32. ncbi request reprint Hepatitis B virus genotype distribution in HIV-1 coinfected patients
    Gianguglielmo Zehender
    Gastroenterology 125:1559-60; author reply 1660. 2003