Paolo Zatta

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint Accumulation of copper and other metal ions, and metallothionein I/II expression in the bovine brain as a function of aging
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, viale Colombo 3, 35121 Padova, Italy
    J Chem Neuroanat 36:1-5. 2008
  2. ncbi request reprint Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment
    P Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padua, Viale G Colombo, 3, 3512 Padua, Italy
    Cell Mol Life Sci 62:1502-13. 2005
  3. ncbi request reprint The C2 variant of human serum transferrin retains the iron binding properties of the native protein
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Vle G Colombo, 3, 3512 Padova, Italy
    Biochim Biophys Acta 1741:264-70. 2005
  4. ncbi request reprint Metallothionein-I-II expression in young and adult bovine pineal gland
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, University of Padova, Italy
    J Chem Neuroanat 31:124-9. 2006
  5. ncbi request reprint Metallothionein-I-II and GFAP positivity in the brains from frontotemporal dementia patients
    P Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padua, Italy
    J Alzheimers Dis 8:109-16; discussion 209-15. 2005
  6. doi request reprint Alzheimer's disease, metal ions and metal homeostatic therapy
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Padua Metalloproteins Unit, Department of Biology, University of Padua, Viale G Colombo 3 35121 Padua, Italy
    Trends Pharmacol Sci 30:346-55. 2009
  7. ncbi request reprint The role of metals in neurodegenerative processes: aluminum, manganese, and zinc
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, 35121, Padova, Italy
    Brain Res Bull 62:15-28. 2003
  8. ncbi request reprint Binding studies on aluminum(III)-albumin interaction
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Viale G Colombo, 3, 35121, Padua, Italy
    Arch Biochem Biophys 417:59-64. 2003
  9. ncbi request reprint Melatonin prevents free radical formation due to the interaction between beta-amyloid peptides and metal ions [Al(III), Zn(II), Cu(II), Mn(II), Fe(II)]
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Padova Unit Metalloproteins Department of Biology, University of Padova, Padova, Italy
    J Pineal Res 35:98-103. 2003
  10. ncbi request reprint Aluminum and Alzheimer's disease: a Vexata Questio between uncertain data and a lot of imagination
    Paolo Zatta
    CNR Union Metalloproteins, Department of Biology, University of Padova, Padova, Italy
    J Alzheimers Dis 10:33-7. 2006

Collaborators

Detail Information

Publications36

  1. doi request reprint Accumulation of copper and other metal ions, and metallothionein I/II expression in the bovine brain as a function of aging
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, viale Colombo 3, 35121 Padova, Italy
    J Chem Neuroanat 36:1-5. 2008
    ..No age differences were evident between calves and adult. The presence of liquor-contacting metallothionein I/II in cells confirms that their functions in the central nervous system are not yet completely established...
  2. ncbi request reprint Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment
    P Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padua, Viale G Colombo, 3, 3512 Padua, Italy
    Cell Mol Life Sci 62:1502-13. 2005
    ....
  3. ncbi request reprint The C2 variant of human serum transferrin retains the iron binding properties of the native protein
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Vle G Colombo, 3, 3512 Padova, Italy
    Biochim Biophys Acta 1741:264-70. 2005
    ..The implications of these results for the etiopathogenesis of Alzheimer's disease are discussed...
  4. ncbi request reprint Metallothionein-I-II expression in young and adult bovine pineal gland
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, University of Padova, Italy
    J Chem Neuroanat 31:124-9. 2006
    ..In conclusion, our data suggest the presence of a metallothionein-I-II expressing system in the pineal gland and ventricle-adjacent areas of the bovine epithalamus might possibly be related to the anti-aging effects of melatonin...
  5. ncbi request reprint Metallothionein-I-II and GFAP positivity in the brains from frontotemporal dementia patients
    P Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padua, Italy
    J Alzheimers Dis 8:109-16; discussion 209-15. 2005
    ..In addition, the potential use of metallothionein-I-II as a new pharmacological approach to contrast some deleterious aspects of this disease has been also discussed...
  6. doi request reprint Alzheimer's disease, metal ions and metal homeostatic therapy
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Padua Metalloproteins Unit, Department of Biology, University of Padua, Viale G Colombo 3 35121 Padua, Italy
    Trends Pharmacol Sci 30:346-55. 2009
    ..Finally, it is discussed how therapeutic strategies aimed at restoring metal homeostasis can delay and modify the progression of AD-related neurodegeneration...
  7. ncbi request reprint The role of metals in neurodegenerative processes: aluminum, manganese, and zinc
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, 35121, Padova, Italy
    Brain Res Bull 62:15-28. 2003
    ..Also, high concentrations of zinc have been found to kill bacteria, viruses, and cultured cells. Some of the possible mechanisms for cell death are reviewed...
  8. ncbi request reprint Binding studies on aluminum(III)-albumin interaction
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Viale G Colombo, 3, 35121, Padua, Italy
    Arch Biochem Biophys 417:59-64. 2003
    ..Both coordination modes proceed from weak interactions, as shown by the binding energies calculated...
  9. ncbi request reprint Melatonin prevents free radical formation due to the interaction between beta-amyloid peptides and metal ions [Al(III), Zn(II), Cu(II), Mn(II), Fe(II)]
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Padova Unit Metalloproteins Department of Biology, University of Padova, Padova, Italy
    J Pineal Res 35:98-103. 2003
    ..This paper reports the scavenging effect of melatonin of reactants generated by amyloid peptides in combination with some metal ions...
  10. ncbi request reprint Aluminum and Alzheimer's disease: a Vexata Questio between uncertain data and a lot of imagination
    Paolo Zatta
    CNR Union Metalloproteins, Department of Biology, University of Padova, Padova, Italy
    J Alzheimers Dis 10:33-7. 2006
  11. ncbi request reprint Copper deficiency and neurological disorders in man and animals
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Department of Biology, University of Padova, 35100 Padova, Italy
    Brain Res Rev 54:19-33. 2007
    ..The metabolic interaction between copper and other metal ions in some neurological disorders is also discussed in this contribution...
  12. doi request reprint Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals
    Silvia Bolognin
    Department of Biology, Padova Metalloproteins Unit, CNR Institute of Biomedical Technologies, University of Padova, Via Ugo Bassi 58B, 35121, Padova, Italy
    Neuromolecular Med 10:322-32. 2008
    ..Based on the present findings, the literature data on the potential effectiveness of CQ-based chelation therapy in AD should be re-interpreted...
  13. pmc Effects of a copper-deficient diet on the biochemistry, neural morphology and behavior of aged mice
    Silvia Bolognin
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Padova, Italy
    PLoS ONE 7:e47063. 2012
    ....
  14. ncbi request reprint Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis
    Fernanda Ricchelli
    C N R Institute of Biomedical Technologies, Metalloproteins Unit, at the Department of Biology, University of Padova, Viale G Colombo 3 35121 Padova, Italy
    Int J Biochem Cell Biol 39:966-77. 2007
    ..This suggests that cell membranes could be a potential primary target in the ataxin-3 pathogenesis and metals could be a biological factor capable of modulating their interaction with AT3...
  15. doi request reprint Metal ion physiopathology in neurodegenerative disorders
    Silvia Bolognin
    CNR Institute for Biomedical Technologies, Padua Metalloproteins Unit, Department of Biology, University of Padua, Viale G Colombo, 3 35121, Padua, Italy
    Neuromolecular Med 11:223-38. 2009
    ..The opportunities for metal-targeted pharmacological strategies in the major NDs are briefly outlined as well...
  16. doi request reprint Aluminum modulates effects of beta amyloid(1-42) on neuronal calcium homeostasis and mitochondria functioning and is altered in a triple transgenic mouse model of Alzheimer's disease
    Denise Drago
    CNR Institute for Biomedical Technologies, Padua Metalloproteins Unit, Department of Biology, University of Padua, Padua, Italy
    Rejuvenation Res 11:861-71. 2008
    ..Finally, we analyzed the content of the four metals in the brain of a triple transgenic animal model of AD and found that Al is the only one to be increased in the cortex of these mice...
  17. ncbi request reprint Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's disease
    Denise Drago
    Department of Biology, University of Padova, Viale G Colombo, 3 35121 Padova, Italy
    Int J Biochem Cell Biol 40:731-46. 2008
    ....
  18. ncbi request reprint Zn and Cu alteration in connection with astrocyte metallothionein I/II overexpression in the mouse brain upon physical stress
    Mariano Beltramini
    Department of Biology, University of Padova, Padova, Italy
    Glia 47:30-4. 2004
    ..Metallothionein I/II expression was compared with the immunopositivity of glial fibrillary acidic protein (GFAP). It is noteworthy that metallothioneins and GFAP are expressed in different types of astrocytes...
  19. ncbi request reprint The effect of Zn(II) and streptozotocin administration in the mouse brain
    Mariano Beltramini
    Department of Biology, University of Padova, and Pathology Division and the Brain Bank, General Hospital, Dolo Venezia, Italy
    Brain Res 1109:207-18. 2006
    ..All together these results support the efficacy of the Zn treatment in order to prevent streptozotocin effects, including brain tissues...
  20. ncbi request reprint Comparative effects of Abeta(1-42)-Al complex from rat and human amyloid on rat endothelial cell cultures
    Denise Drago
    CNR Institute for Biomedical Technologies, Padova Unit Metalloproteins, Italy
    J Alzheimers Dis 11:33-44. 2007
    ..The data and arguments presented herein clearly demonstrate the involvement of Al(3+) in Abeta aggregation and, consequently, increasing endothelial cell toxicity...
  21. doi request reprint Ontogenesis and migration of metallothionein I/II-containing glial cells in the human telencephalon during the second trimester
    Bruno Cozzi
    Department of Experimental Veterinary Science, University of Padova, Italy
    Brain Res 1327:16-23. 2010
    ....
  22. ncbi request reprint Effects of steroid hormones on the Zn, Cu and MTI/II levels in the mouse brain
    Mariano Beltramini
    Department of Biology, University of Padova, Viale G Colombo, 3 35121, Padova, Italy
    Brain Res 1013:134-41. 2004
    ....
  23. doi request reprint Chelation therapy for neurodegenerative diseases
    Silvia Bolognin
    Department of Biology, CNR Institute for Biomedical Technologies, Padua Metalloproteins Unit, University of Padua, Viale G Colombo 3 35121 Padua, Italy
    Med Res Rev 29:547-70. 2009
    ..The perspectives for the development of new effective agents against ND are critically discussed...
  24. ncbi request reprint Acidic vesicles of the endo-exocytic pathways as targets for some anti-monoamine oxidase drugs
    Paolo Dell'Antone
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Metab Brain Dis 24:713-22. 2009
    ..The effect was not ascribed to an increased proton conductance, but was most likely due to a weak base-like mechanism, in that they exhibit equilibria among species associated with H(+) ions and species lacking this association...
  25. ncbi request reprint Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits
    Paolo Zatta
    CNR Center on Metalloproteins, Department of Biology, University of Padova, Italy
    J Alzheimers Dis 4:1-9. 2002
    ..The relevance on the cholesterol metabolism in Alzheimer's disease pathogenesis is also discussed...
  26. ncbi request reprint Aggregation/fibrillogenesis of recombinant human prion protein and Gerstmann-Sträussler-Scheinker disease peptides in the presence of metal ions
    Fernanda Ricchelli
    Department of Biology, CNR Institute of Biomedical Technologies Metalloproteins Unit, University of Padova, Viale G Colombo 3, 25121 Padova, Italy
    Biochemistry 45:6724-32. 2006
    ....
  27. ncbi request reprint Some biochemical properties of melatonin and the characterization of a relevant metabolite arising from its interaction with H2O2
    Paolo Carampin
    Department of Pharmacological Sciences, University of Padova, Padova, Italy
    J Pineal Res 34:134-42. 2003
    ..The effect of melatonin on catalase, glutathione peroxidase and superoxide dismutase in in vitro and in vivo experiments is also reported...
  28. pmc Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity
    Alberto Granzotto
    Centro Nazionale delle Ricerche, Istituto Tecnologie Biomediche, Metalloproteins Unit, Department of Biology, University of Padova, Padova, Italy
    PLoS ONE 6:e21565. 2011
    ..Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties...
  29. ncbi request reprint Metallothionein I-II immunocytochemical reactivity in Binswanger's encephalopathy
    Pamela Zambenedetti
    Anatomopathology Division, and the Brain Bank, General Hospital, Dolo Venezia, Italy
    J Alzheimers Dis 4:459-66. 2002
    ....
  30. ncbi request reprint Transferrin C2 variant does confer a risk for Alzheimer's disease in caucasians
    Pamela Zambenedetti
    Pathology Division and Brain Bank, General Hospital, Dolo Venice, Italy
    J Alzheimers Dis 5:423-7. 2003
    ..These results suggest that apoE and transferrin may be part of a complex mechanism in the pathogenesis of Alzheimer's disease...
  31. ncbi request reprint The effect of chronic aluminum(III) administration on the nervous system of aged rats: clues to understand its suggested role in Alzheimer's disease
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    J Alzheimers Dis 5:437-44. 2003
    ....
  32. ncbi request reprint Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes
    Massimo Di Vaira
    Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, Florence, Italy
    Inorg Chem 43:3795-7. 2004
    ..A ligand to metal stoichiometry of 2:1 is found in both cases, though in the presence of quite different coordination polyhedra. The present findings are discussed in the frame of modern approaches to AD treatment...
  33. ncbi request reprint Chronic aluminum administration to old rats results in increased levels of brain metal ions and enlarged hippocampal mossy fibers
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:44-7. 2004
    ..This may contribute, as an aggravating factor, to the development of neurodegenerative events, as observed in Alzheimer disease...
  34. ncbi request reprint Ceruloplasmin in neurodegenerative diseases
    Vadim Vassiliev
    Institute for Experimental Medicine, St Petersburg, Russia
    Brain Res Brain Res Rev 49:633-40. 2005
    ..It is essential to further elucidate the mechanism of the neuronal injury associated with these disorders...
  35. ncbi request reprint Aluminum complexing enhances amyloid beta protein penetration of blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 N Grand Blvd, St Louis, MO 63106, USA
    Brain Res 1116:215-21. 2006
    ..Brain-to-blood transport was similar for Al-Abeta42 and Abeta42. In conclusion, complexing with aluminum affects some aspects of blood-to-brain permeability so that Al-Abeta42 would have more ready access to brain cells than Abeta42...
  36. ncbi request reprint Effects of chronic treatment with sodium tetrachloroaurate(III) in mice and membrane models
    Mario Suwalsky
    Faculty of Chemical Sciences, University of Concepcion, Chile
    J Inorg Biochem 98:2080-6. 2004
    ..These results show that toxic effects on animal brain upon treatment with sodium tetrachloroaurate develop with difficulty and may be observed only at high doses...