Alberto Zanchetti

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Cardiac, renal and vascular complications in the diabetic patient
    A Zanchetti
    Centre of Clinical Physiology and Hypertension, University of Milan, Milan, 20122, Italy
    J Renin Angiotensin Aldosterone Syst 1:S21-4. 2000
  2. ncbi Benefits and risks of more intensive blood pressure lowering in hypertensive patients of the HOT study with different risk profiles: does a J-shaped curve exist in smokers?
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore, Istituto Auxologico Italiano, Italy
    J Hypertens 21:797-804. 2003
  3. ncbi Emerging data on calcium-channel blockers: the COHORT study
    Alberto Zanchetti
    Centro Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore e Istituto Auxologico Italiano, Milan, Italy
    Clin Cardiol 26:II17-20. 2003
  4. ncbi Translating worldwide calcium-channel blocker experience into clinical practice
    Alberto Zanchetti
    Centro Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore e Istituto Auxologico Italiano, Milan, Italy
    Clin Cardiol 26:II1-2. 2003
  5. ncbi Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial
    Alberto Zanchetti
    University of Milan, Ospedale Maggiore, Istituto Auxologico Italiano, Milan, Italy
    Circulation 106:2422-7. 2002
  6. ncbi Benefit and harm of low-dose aspirin in well-treated hypertensives at different baseline cardiovascular risk
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore and Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 20:2301-7. 2002
  7. ncbi Efficacy, tolerability, and impact on quality of life of long-term treatment with manidipine or amlodipine in patients with essential hypertension
    A Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore, Milano, Italy
    J Cardiovasc Pharmacol 38:642-50. 2001
  8. ncbi The antiatherogenic effects of antihypertensive treatment: trials completed and ongoing
    A Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Università di Milano Ospedale Maggiore, Via F Sforza 35, 20122 Milano, Italy
    Curr Hypertens Rep 3:350-9. 2001
  9. ncbi Effects of individual risk factors on the incidence of cardiovascular events in the treated hypertensive patients of the Hypertension Optimal Treatment Study. HOT Study Group
    A Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore and Istituto Auxologico Italiano
    J Hypertens 19:1149-59. 2001
  10. ncbi Renal angioplasty: better for treating hypertension or for rescuing renal function?
    A Morganti
    Istituto di Clinica Medica e Terapia Medica Generale, Universita di Milano, Ospedale Maggiore, Milan, Italy
    J Hypertens 17:1659-65. 1999

Collaborators

Detail Information

Publications99

  1. ncbi Cardiac, renal and vascular complications in the diabetic patient
    A Zanchetti
    Centre of Clinical Physiology and Hypertension, University of Milan, Milan, 20122, Italy
    J Renin Angiotensin Aldosterone Syst 1:S21-4. 2000
    ..The VALUE trial will provide the largest body of information yet on the comparative benefits of using an ARB or calcium channel blocker in hypertensive patients with diabetes...
  2. ncbi Benefits and risks of more intensive blood pressure lowering in hypertensive patients of the HOT study with different risk profiles: does a J-shaped curve exist in smokers?
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore, Istituto Auxologico Italiano, Italy
    J Hypertens 21:797-804. 2003
    ..We investigated whether the benefits of intensive DBP lowering could be extended to other subgroups, and whether there are hypertensives in whom the risk of aggressive DBP lowering may outnumber the benefits...
  3. ncbi Emerging data on calcium-channel blockers: the COHORT study
    Alberto Zanchetti
    Centro Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore e Istituto Auxologico Italiano, Milan, Italy
    Clin Cardiol 26:II17-20. 2003
    ..These newest-generation dihydropyridine CCBs offer the potential to reduce side effects, improve patient compliance, and ultimately help patients reach target blood pressures as recommended by the aforementioned guidelines...
  4. ncbi Translating worldwide calcium-channel blocker experience into clinical practice
    Alberto Zanchetti
    Centro Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore e Istituto Auxologico Italiano, Milan, Italy
    Clin Cardiol 26:II1-2. 2003
  5. ncbi Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial
    Alberto Zanchetti
    University of Milan, Ospedale Maggiore, Istituto Auxologico Italiano, Milan, Italy
    Circulation 106:2422-7. 2002
    ..Most cardiovascular events associated with hypertension are complications of atherosclerosis. Some antihypertensive agents influence experimental models of atherosclerosis through mechanisms independent of blood pressure lowering...
  6. ncbi Benefit and harm of low-dose aspirin in well-treated hypertensives at different baseline cardiovascular risk
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore and Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 20:2301-7. 2002
    ..The present analyses of HOT Study data aim at identifying subgroups of hypertensives with different benefit-to-harm ratios from aspirin, in order to provide recommendations about the use of aspirin in hypertension...
  7. ncbi Efficacy, tolerability, and impact on quality of life of long-term treatment with manidipine or amlodipine in patients with essential hypertension
    A Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore, Milano, Italy
    J Cardiovasc Pharmacol 38:642-50. 2001
    ....
  8. ncbi The antiatherogenic effects of antihypertensive treatment: trials completed and ongoing
    A Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Università di Milano Ospedale Maggiore, Via F Sforza 35, 20122 Milano, Italy
    Curr Hypertens Rep 3:350-9. 2001
    ..In hypertensive patients, three studies comparing different antihypertensive agents have been completed, with some evidence favoring calcium antagonists over diuretics. Two studies are ongoing, and should be completed and published soon...
  9. ncbi Effects of individual risk factors on the incidence of cardiovascular events in the treated hypertensive patients of the Hypertension Optimal Treatment Study. HOT Study Group
    A Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore and Istituto Auxologico Italiano
    J Hypertens 19:1149-59. 2001
    ....
  10. ncbi Renal angioplasty: better for treating hypertension or for rescuing renal function?
    A Morganti
    Istituto di Clinica Medica e Terapia Medica Generale, Universita di Milano, Ospedale Maggiore, Milan, Italy
    J Hypertens 17:1659-65. 1999
    ....
  11. ncbi Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol) are associated with alterations in carotid intima-media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lo
    A Zanchetti
    Istituto di Clinica Medica and Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore, Milano, Italy
    J Hypertens 19:79-88. 2001
    ..While the study is in progress, baseline data are here reported to clarify the association of various risk factors with carotid IMT in these medium-high risk hypertensive patients...
  12. ncbi Risk assessment and treatment benefit in intensively treated hypertensive patients of the hypertension Optimal Treatment (HOT) study
    A Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore and Istituto Auxologico Italiano, Italy
    J Hypertens 19:819-25. 2001
    ..The Hypertension Optimal Treatment (HOT) Study provided information about cardiovascular events in 18,790 hypertensives, subjected to pronounced blood pressure lowering for a mean of 3.8 years...
  13. ncbi Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore and Istituto Auxologico Italiano, Milano, Italy
    J Hypertens 20:1015-22. 2002
    ....
  14. ncbi Metabolic syndrome and multiple organ damage in essential hypertension
    Cesare Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    Blood Press 17:195-203. 2008
    ....
  15. ncbi Retinal microvascular changes and target organ damage in untreated essential hypertensives
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Ospedale Maggiore, IRCCS, Milano and Istituto Auxologico Italiano IRCCS, Universita degli Studi di Milano, Milano, Italy
    J Hypertens 22:2095-102. 2004
    ....
  16. ncbi Age and target organ damage in essential hypertension: role of the metabolic syndrome
    Cesare Cuspidi
    Department of Clinical Medicine, Prevention and Applied Biotechnologies, University of Milano Bicocca, Milan, Italy
    Am J Hypertens 20:296-303. 2007
    ..We sought to investigate the association of the metabolic syndrome (MS) with cardiovascular alterations in essential hypertensives in relation to age...
  17. ncbi Body mass index, nocturnal fall in blood pressure and organ damage in untreated essential hypertensive patients
    Cesare Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    Blood Press Monit 13:318-24. 2008
    ..We sought to investigate the relationship between body mass index (BMI) and parameters derived from 48-h ambulatory blood pressure monitoring (ABPM) as well as organ damage in human hypertension...
  18. ncbi Ambulatory blood pressure, target organ damage and left atrial size in never-treated essential hypertensive individuals
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare and Centro Interuniversitario di Fisiologia, Clinica e Ipertensione, Università degli Studi di Milano and Ospedale Maggiore IRCCS, Milan, Italy
    J Hypertens 23:1589-95. 2005
    ..To investigate the relationship between ambulatory blood pressure and different markers of target organ damage with left atrial size in never-treated essential hypertensive individuals...
  19. ncbi Left ventricular hypertrophy and cardiovascular risk stratification: impact and cost-effectiveness of echocardiography in recently diagnosed essential hypertensives
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Università degli Studi di Milano and Ospedale Maggiore IRCCS, Milan, Italy
    J Hypertens 24:1671-7. 2006
    ..However, ultrasound examination of the heart on a routine basis remains a matter of debate...
  20. ncbi Prevalence and clinical correlates of right ventricular hypertrophy in essential hypertension
    Cesare Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    J Hypertens 27:854-60. 2009
    ..Thus, the prevalence and clinical correlates of RVH have been investigated in essential hypertension...
  21. ncbi Impact of carotid intima-media thickening on risk stratification in elderly hypertensives
    Cesare Cuspidi
    Istituto di Clinica, Medica e Terapia Medica and Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore IRCCS, Milano, Italy
    Blood Press 12:25-31. 2003
    ....
  22. ncbi Carotid atherosclerosis and cardiovascular risk stratification: role and cost-effectiveness of echo-Doppler examination in untreated essential hypertensives
    Cesare Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milan, Italy
    Blood Press 15:333-9. 2006
    ..To investigate the impact and cost-effectiveness of carotid ultrasonographic examination on total risk stratification in low-medium risk hypertensive patients in relation to age (< 50 and > 50 years) and gender...
  23. ncbi Statins, antihypertensive treatment, and blood pressure control in clinic and over 24 hours: evidence from PHYLLIS randomised double blind trial
    Giuseppe Mancia
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milan, Italy
    BMJ 340:c1197. 2010
    ..To investigate the possibility that statins reduce blood pressure as well as cholesterol concentrations through clinic and 24 hour ambulatory blood pressure monitoring...
  24. ncbi Short-term reproducibility of a non-dipping pattern in type 2 diabetic hypertensive patients
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore IRCCS, Milan
    J Hypertens 24:647-53. 2006
    ..Little information is available on the reproducibility of nocturnal variations in blood pressure in type 2 diabetic hypertensive patients...
  25. ncbi Carotid wall composition in hypertensive patients after 4-year treatment with lacidipine or atenolol: an echoreflectivity study
    Roberta Paliotti
    Instituto di Medicina Cardiovascolar, University of Milan, Ospedale Maggiore Milan, Italy
    J Hypertens 23:1203-9. 2005
    ..With lacidipine, stable composition is associated with a lower IMT progression than with atenolol...
  26. ncbi Cardiovascular risk stratification according to the 2003 ESH-ESC guidelines in uncomplicated patients with essential hypertension: comparison with the 1999 WHO/ISH guidelines criteria
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro di Fisiologia Clinica e Ipertensione, Universita degli Studi di Milano, Ospedale Maggiore Policlinico, IRCCS, Milano, Italy
    Blood Press 13:144-51. 2004
    ....
  27. ncbi Metabolic syndrome and target organ damage in untreated essential hypertensives
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro di Fisiologia e Ipertensione, Universita degli Studi di Milano, Ospedale Maggiore Policlinico, IRCCS, Milan, Italy
    J Hypertens 22:1991-8. 2004
    ..The prevalence and the relationship between metabolic syndrome, and target organ damage (TOD) in essential hypertensive patients has not been fully explored to date...
  28. ncbi Left ventricular hypertrophy in treated hypertensive patients with good blood pressure control outside the clinic, but poor clinic blood pressure control
    Cesare Cuspidi
    Instituto di Clinica Medica e Terapia Medica and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore IRCCS, Milan, Italy
    J Hypertens 21:1575-81. 2003
    ..These patients were compared with treated hypertensives whose BP was well controlled under the three circumstances...
  29. ncbi Is retinal arteriolar-venular ratio associated with cardiac and extracardiac organ damage in essential hypertension?
    Meilikemu Masaidi
    Istituto di Medicina Cardiovascolare, Fondazione IRCCS Policlinico, Milan, Italy
    J Hypertens 27:1277-83. 2009
    ..We examined the relationship between retinal arteriolar-venular ratio (AVR) and left ventricular hypertrophy, carotid atherosclerosis and microalbuminuria in essential hypertension...
  30. ncbi Prevalence and correlates of left atrial enlargement in essential hypertension: role of ventricular geometry and the metabolic syndrome: the Evaluation of Target Organ Damage in Hypertension study
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore Policlinico IRCCS, and Istituto Auxologico Italiano Milano, Italy
    J Hypertens 23:875-82. 2005
    ..Although data on hypertension-induced left ventricular changes are extensive, relatively little information is available on LA size from large-scale studies...
  31. ncbi Baseline values but not treatment-induced changes in carotid intima-media thickness predict incident cardiovascular events in treated hypertensive patients: findings in the European Lacidipine Study on Atherosclerosis (ELSA)
    Alberto Zanchetti
    Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Universita di Milano, Milan, Italy
    Circulation 120:1084-90. 2009
    ....
  32. ncbi High prevalence of retinal vascular changes in never-treated essential hypertensives: an inter- and intra-observer reproducibility study with non-mydriatic retinography
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro di Fisiologia e Ipertensione, Universita degli Studi di Milano, Ospedale Maggiore Policlinico, IRCCS, Milano, Italy
    Blood Press 13:25-30. 2004
    ..The clinical significance of stratifying cardiovascular risk in hypertensive patients on the basis of retinal changes such as arteriolar narrowing or arterio-venous crossing has been criticized...
  33. ncbi Visit-to-visit blood pressure variability, carotid atherosclerosis, and cardiovascular events in the European Lacidipine Study on Atherosclerosis
    Giuseppe Mancia
    Clinica Medica and Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milan, Italy
    Circulation 126:569-78. 2012
    ....
  34. ncbi Prevalence and incidence of the metabolic syndrome in the European Lacidipine Study on Atherosclerosis (ELSA) and its relation with carotid intima-media thickness
    Alberto Zanchetti
    Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Università di Milano and Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 25:2463-70. 2007
    ..About 35% of subjects in both groups received additional hydrochlorothiazide (12.5-25 mg/day). The patients were followed up for carotid intima-media thickness (IMT) changes for 3.7 years...
  35. ncbi Reproducibility of dipping/nondipping pattern in untreated essential hypertensive patients: impact of sex and age
    Cesare Cuspidi
    Department of Clinical Medicine, Prevention and Applied Biotechnologies, University of Milano Bicocca, Milan, Italy
    Blood Press Monit 12:101-6. 2007
    ..We aimed to evaluate the intrasubject short-term reproducibility of nocturnal blood pressure patterns (dipping/nondipping) in essential hypertensive patients in relation to age (<50 and > or =50 years) and sex...
  36. ncbi Cardiovascular target organ damage in essential hypertensives with or without reproducible nocturnal fall in blood pressure
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare and Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore IRCCS, Milan and Istituto Auxologico Ospedale S Luca, IRCCS, Milan, Italy
    J Hypertens 22:273-80. 2004
    ..The aim of this study was to evaluate the relationship between nocturnal dipping status, defined on the basis of two periods of ABPM, and cardiac and extracardiac target organ damage in essential hypertension...
  37. ncbi Absolute and relative changes in carotid intima-media thickness and atherosclerotic plaques during long-term antihypertensive treatment: further results of the European Lacidipine Study on Atherosclerosis (ELSA)
    Alberto Zanchetti
    Centro Interuniversitario di Fisiologia Clinica e lpertensione, University of Milan, Milan, Italy
    J Hypertens 22:1201-12. 2004
    ....
  38. ncbi Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Universita di Milano, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Ospedale Maggiore Policlinico IRCCS, Italy
    Blood Press 15:107-15. 2006
    ..The 2003 European Society of Hypertension/European Society of Cardiology (ESH/ESC) guidelines recommend angiotensin II receptor antagonists (AIIRAs) as a first-line therapy in hypertensives with left ventricular hypertrophy (LVH)...
  39. ncbi How reliable is isolated clinical hypertension defined by a single 24-h ambulatory blood pressure monitoring?
    Cesare Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milan, Italy
    J Hypertens 25:315-20. 2007
    ..This definition is based on a single ABP monitoring (ABPM) and little attention has been focused on the reproducibility of this condition...
  40. ncbi Different effects of antihypertensive regimens based on fosinopril or hydrochlorothiazide with or without lipid lowering by pravastatin on progression of asymptomatic carotid atherosclerosis: principal results of PHYLLIS--a randomized double-blind trial
    Alberto Zanchetti
    Istituto Auxologico Italiano, Ospedale Maggiore, University of Milan, Italy
    Stroke 35:2807-12. 2004
    ....
  41. ncbi Is the nocturnal fall in blood pressure reduced in essential hypertensive patients with metabolic syndrome?
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro di Fisiologia Clinica e Ipertensione, Universita degli Studi di Milano, Ospedale Maggiore Policlinico, IRCCS, Milano, Italy, Universita degli Studi di Milano, Italy
    Blood Press 13:230-5. 2004
    ....
  42. ncbi Non-dipper treated hypertensive patients do not have increased cardiac structural alterations
    Cesare Cuspidi
    Clinica Medica Generale e Terapia Medica, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    Cardiovasc Ultrasound 1:1. 2003
    ..The aim of our study was to assess whether a reduced nocturnal fall in blood pressure (BP), established on the basis of a single 24-h BP monitoring, in treated essential hypertensives is related to more prominent cardiac alterations...
  43. ncbi Metabolic syndrome score and ambulatory blood pressure in untreated essential hypertension
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Ospedale Maggiore, IRCCS, Milano and Istituto Auxologico Italiano IRCCS, Universita degli Studi di Milano, Milano, Italy
    Blood Press Monit 10:175-80. 2005
    ..The relationship between metabolic syndrome components, as defined by the Adult Treatment Panel III report, and ambulatory blood pressure in hypertensive patients has not been investigated to date...
  44. ncbi Left ventricular diastolic dysfunction in elderly hypertensives: results of the APROS-diadys study
    Alberto Zanchetti
    Centro di Fisiologia Clinica, University of Milan, Ospedale Maggiore Milan, Italy
    J Hypertens 25:2158-67. 2007
    ..This occurs particularly in the elderly and in hypertension, but the prevalence of diastolic dysfunction in elderly hypertensives without CHF has never been investigated systematically...
  45. ncbi Metabolic syndrome in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study: daily life blood pressure, cardiac damage, and prognosis
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica e Prevenzione, Universita Milano Bicocca, Ospedale San Gerardo, Monza, Milan, Italy
    Hypertension 49:40-7. 2007
    ..The contribution of metabolic syndrome components to the risk, however, is unbalanced and mainly related to blood pressure and glucose abnormalities...
  46. ncbi Nocturnal non-dipping pattern in untreated hypertensives at different cardiovascular risk according to the 2003 ESH/ESC guidelines
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Universita di Milano, and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Blood Press 15:37-44. 2006
    ..To evaluate in a large population of untreated, uncomplicated essential hypertensives the relationship between alterations in nocturnal blood pressure (BP) profile, i.e. non-dipping pattern, and total cardiovascular risk...
  47. ncbi Facts and fallacies of blood pressure control in recent trials: implications in the management of patients with hypertension
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, University of Milan, Milan, Italy
    J Hypertens 27:673-9. 2009
    ....
  48. ncbi Role of echocardiography and carotid ultrasonography in stratifying risk in patients with essential hypertension: the Assessment of Prognostic Risk Observational Survey
    Cesare Cuspidi
    Istituto di Clinica Medica e Terapia Medica, , Centro di Fisiologia Clinica e Ipertensione, Ospedale Maggiore and Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 20:1307-14. 2002
    ..CONCLUSIONS : Ultrasound assessment of the heart and carotid wall helps to obtain a more valid assessment of global cardiovascular risk in hypertensive patients without evidence of target-organ damage after routine examination...
  49. ncbi Prevalence of type 2 diabetes among patients with hypertension under the care of 30 Italian clinics of hypertension: results of the (Iper)tensione and (dia)bete study
    Chiara Lonati
    Unità Operativa di Medicina Interna e Centro Ipertensione Arteriosa, Ospedale San Giuseppe Milano Cuore, Via San Vittore 12, Milan, Italy
    J Hypertens 26:1801-8. 2008
    ....
  50. ncbi Trends in hypertension control and left ventricular hypertrophy over three years
    Cesare Cuspidi
    Institute of Internal Medicine, Centro di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
    Ital Heart J 3:514-9. 2002
    ....
  51. ncbi Studies on left ventricular hypertrophy regression in arterial hypertension: a clear message for the clinician?
    Cesare Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    Am J Hypertens 21:458-63. 2008
    ....
  52. ncbi Assessment of long-term antihypertensive treatment by clinic and ambulatory blood pressure: data from the European Lacidipine Study on Atherosclerosis
    Giuseppe Mancia
    Clinica Medica and Department of Clinical Medicine and Prevention, University of Milano Bicocca and Ospedale S Gerardo, Monza, Milan, Italy
    J Hypertens 25:1087-94. 2007
    ..Information on the features of long-term modifications of clinic and 24-h ambulatory blood pressure (ABP) by treatment is limited. The present study aimed to address this issue...
  53. ncbi Findings and implications of the Study on COgnition and Prognosis in the Elderly (SCOPE) - a review
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, University of Milan and Istituto Auxologico Italiano, Milan, Italy
    Blood Press 15:71-9. 2006
    ..Candesartan-based antihypertensive treatment may also have positive effects on cognitive function and quality of life...
  54. ncbi Prevalence and correlates of aortic root dilatation in patients with essential hypertension: relationship with cardiac and extracardiac target organ damage
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Universita di Milano, Ospedale Maggiore Policlinico, IRCCS, Milano, Italy
    J Hypertens 24:573-80. 2006
    ..To assess the prevalence of aortic root dilatation in a large cohort of uncomplicated hypertensive patients and to evaluate the relations of aortic root size to different markers of cardiac and extracardiac target organ damage (TOD)...
  55. ncbi Metabolic syndrome and target organ damage: role of blood pressure
    Cesare Cuspidi
    Clinical Research Unit, Istituto Auxologico Italiano, Via della Resistenza 23, 20036 Meda, MI, Italy
    Expert Rev Cardiovasc Ther 6:731-43. 2008
    ..Thus, target organ damage should be routinely searched for in hypertensives with metabolic syndrome in order to define initial therapeutic strategies and to monitor treatment-induced protection...
  56. ncbi Different effects of antihypertensive therapies based on losartan or atenolol on ultrasound and biochemical markers of myocardial fibrosis: results of a randomized trial
    Michele M Ciulla
    Istituto di Medicina Cardiovascolare and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy
    Circulation 110:552-7. 2004
    ..CONCLUSIONS: In hypertensive patients with LVH, losartan decreases myocardial collagen content, whereas atenolol does not. The difference between the 2 treatments is statistically significant...
  57. ncbi Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives
    Gastone Leonetti
    St. Luca Hospital, Istituto Auxologico Italiano, IRCCS, 20122 Milan, Italy
    Am J Hypertens 15:932-40. 2002
    ..CONCLUSIONS: The two lipophilic dihydropyridine calcium antagonists, lercanidipine and lacidipine, have an antihypertensive effect comparable to that of amlodipine, but a better tolerability profile...
  58. ncbi Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study
    Cesare Cuspidi
    Istituto di Clinica Medica e Terapia Medica and Centro di Fisiologia Clinica e Ipertensione, , Ospedale Maggiore, and Istituto Auxologico Italiano, Milano, Italy
    J Hypertens 20:2293-300. 2002
    ..Candesartan cilexetil was found to be equally effective as enalapril in reducing SBP, DBP and LVMI in hypertensives with LVH, according to both ITT and PP analyses...
  59. ncbi When should antihypertensive drug treatment be initiated and to what levels should systolic blood pressure be lowered? A critical reappraisal
    Alberto Zanchetti
    Istituto Auxologico Italiano, Italy
    J Hypertens 27:923-34. 2009
    ..However, wisdom should not be taken for evidence, and simple trials should be designed to look for more solid evidence in favour of current recommendations...
  60. ncbi Hypertensive myocardial fibrosis
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Via F. Sforza 35, 20122 Milano, Italy
    Nephrol Dial Transplant 21:20-3. 2006
  61. ncbi Aortic coarctation suspected by Doppler echocardiography of renal arteries in hypertensive patients referred to a hospital outpatient hypertension clinic
    Cesare Cuspidi
    Institute of Cardiovascular Medicine, University of Milan, Milan, Italy
    Ital Heart J 6:424-7. 2005
    ....
  62. ncbi Left ventricular hypertrophy regression with antihypertensive treatment: focus on Candesartan
    Cesare Cuspidi
    From Istituto di Medicina Cardiovascolare and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, , Ospedale S Luca, Milano, Italy
    Blood Press Suppl 2:5-15. 2003
  63. ncbi Outcomes in subgroups of hypertensive patients treated with regimens based on valsartan and amlodipine: An analysis of findings from the VALUE trial
    Alberto Zanchetti
    aCentro Interuniversitario di Fisiologia Clinica e Ipertensione, University of Milan, Istituto Auxologico Italiano and Ospedale Maggiore, Milan, Italy
    J Hypertens 24:2163-8. 2006
    ..Stroke incidence was non-significantly, and myocardial infarction was significantly lower in the amlodipine-based regimen, whereas cardiac failure was non-significantly lower on valsartan...
  64. ncbi Angioplasty of the renal artery: antihypertensive and renal effects
    A Morganti
    Clinical Medicine and Medical Therapy Institute, University of Milan, Italy
    J Nephrol 13:S28-33. 2000
    ..Interestingly it appears that this improvement is slower in kidneys of patients with atherosclerotic RAS than in those with fibromuscular RAS...
  65. ncbi Blunted vascular and renal effects of exogenous atrial natriuretic peptide in patients with cushing's disease
    C Sala
    Istituto Clinica Medica, Università di Milano and Ospedale Maggiore Istituto Ricovero e Cura a Carattere Scientifico, Milan, Italy
    J Clin Endocrinol Metab 86:1957-61. 2001
    ..These data are compatible with an impairment of the biological activity of ANP in glucocorticoid hypertension in humans...
  66. ncbi Echocardiography in clinical practice: the burden of arterial hypertension. A multicenter Italian survey
    C Cuspidi
    Department of Clinical Medicine and Prevention, University of Milano Bicocca, Milano, Italy
    J Hum Hypertens 24:395-402. 2010
    ....
  67. ncbi [Hypertension and the progression of organ damage]
    A Morganti
    Istituto di Clinica Medica e Terapia Medica Generale, Centro di Fisiologia Clinica e Ipertensione, Universita degli Studi, Ospedale Maggiore IRCCS, Milano
    Ital Heart J 1:100-3. 2000
    ....
  68. ncbi Closing remarks: current position of calcium channel antagonists in hypertension--the role of manidipine
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Istituto Auxologico Italiano and Ospedale Maggiore di Milano, Via Francesco Sforza 35, 20122 Milan, Italy
    Drugs 65:40-2. 2005
  69. ncbi The Study on COgnition and Prognosis in the Elderly (SCOPE); outcomes in patients not receiving add-on therapy after randomization
    Hans Lithell
    Department of Public Health and Caring Sciences, Section of Geriatrics, University of Uppsala, Sweden
    J Hypertens 22:1605-12. 2004
    ..e. in patients that best reflect the original intention of a placebo-controlled trial...
  70. ncbi Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial
    Michael A Weber
    State University of New York, Brooklyn, NY, USA
    Lancet 363:2049-51. 2004
    ....
  71. ncbi Reduced incidence of new-onset atrial fibrillation with angiotensin II receptor blockade: the VALUE trial
    Roland E Schmieder
    Department of Nephrology and Hypertension, University Erlangen Nuremberg, Erlangen, Germany
    J Hypertens 26:403-11. 2008
    ..Therefore, in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) a prespecified objective was to compare the effects of valsartan and amlodipine on new-onset AF...
  72. ncbi Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial
    Stevo Julius
    University of Michigan, Ann Arbor, USA
    Lancet 363:2022-31. 2004
    ....
  73. ncbi Antihypertensive treatment in patients with type-2 diabetes mellitus: what guidance from recent controlled randomized trials?
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Ospedale Maggiore and Istituto Auxologico Italiano, Milano, Italy
    J Hypertens 20:2099-110. 2002
    ..Patients with type-2 diabetes have a high prevalence of hypertension and show an elevated incidence of cardiovascular events and nephropathy...
  74. ncbi Progressive effects of valsartan compared with amlodipine in prevention of diabetes according to categories of diabetogenic risk in hypertensive patients: the VALUE trial
    Sverre E Kjeldsen
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
    Blood Press 17:170-7. 2008
    ..We conclude that valsartan compared with amlodipine reduces the risk of developing diabetes mellitus, particularly in hypertensive patients with the highest susceptibility for development of diabetes...
  75. ncbi The Study on COgnition and Prognosis in the Elderly (SCOPE) - major CV events and stroke in subgroups of patients
    Peter Trenkwalder
    Department of Internal Medicine, Starnberg Hospital, Ludwig Maximilian University Munich, Osswaldstrasse 1, D 82319 Starnberg, Germany
    Blood Press 14:31-7. 2005
    ..However, the benefit was particularly pronounced in patients who entered the study with a previous stroke...
  76. ncbi Effects of losartan and atenolol on left ventricular mass and neurohormonal profile in patients with essential hypertension and left ventricular hypertrophy
    Bjorn Dahlof
    University of Göteborg Ostra University Hospital, Goteborg, Sweden
    J Hypertens 20:1855-64. 2002
    ..To compare the effects of the angiotensin II antagonist, losartan, with those of atenolol on left ventricular hypertrophy (LVH), blood pressure and neurohormone concentrations in hypertensive patients with LVH...
  77. ncbi Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: the Study on Cognition and Prognosis in the Elderly (SCOPE)
    Vasilios Papademetriou
    Hypertension and Cardiovascular Research, Veterans Administration Medical Center, Washington, DC 20422, USA
    J Am Coll Cardiol 44:1175-80. 2004
    ..The aim of this study was to test the hypothesis that the angiotensin II type 1 receptor blocker (ARB) candesartan can reduce the risk of stroke in elderly patients with isolated systolic hypertension (ISH)...
  78. ncbi The risk functions incorporated in Riscard 2002: a software for the prediction of cardiovascular risk in the general population based on Italian data
    Alessandro Menotti
    Associazione per la Ricerca Cardiologica Via Adda, 87 00198 Roma
    Ital Heart J 3:114-21. 2002
    ..The purpose of this analysis was to produce risk functions for the prediction of cardiovascular diseases based on Italian epidemiological data and suitable for the use in a PC program dedicated to the estimate of risk...
  79. ncbi Targeting hypertension with valsartan: Lessons learned from the Valsartan/HCTZ versus Amlodipine in stage II hypertensive patients (VASt) trial
    Luis M Ruilope
    Internal Medicine, Comlutense University, Madrid, Spain
    J Renin Angiotensin Aldosterone Syst 7:S8-11. 2006
    ..In addition, combination therapy resulted in a trend towards more favourable outcomes with respect to pro-thrombotic and proinflammatory markers than amlodipine alone...
  80. ncbi Different relation between 24-h blood pressure and distensibility at different peripheral arteries. Data from the European Lacidipine Study on Atherosclerosis (ELSA)
    Cristina Giannattasio
    Clinica Medica, University of Milan-Bicocca, San Gerardo Hospital, Monza (Milan, Italy
    J Hypertens 23:557-62. 2005
    ..Alterations of large elastic arteries function is related to structural wall changes. Functional and structural properties of middle-size muscle arteries are independent of BP...
  81. ncbi Blood pressure control in Italy: results of recent surveys on hypertension
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 25:1491-8. 2007
    ..Blood pressure (BP) control is reported to be poor in hypertensive patients worldwide...
  82. ncbi Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE)
    Ingmar Skoog
    Institute of Clinical Neurosciences, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Am J Hypertens 18:1052-9. 2005
    ..We examined whether cognitive function at baseline affected cognitive and cardiovascular outcomes in the Study on COgnition and Prognosis in the Elderly (SCOPE), a blood pressure (BP)-lowering intervention trial...
  83. ncbi Relation of urinary albumin excretion to coronary heart disease and low renal function: role of blood pressure
    Massimo Cirillo
    Nephrology, Medical School of Second University of Naples, Naples, Italy
    Kidney Int 65:2290-7. 2004
    ..The present epidemiologic study investigated if (1) blood pressure status affects the association of urinary albumin excretion with CHD; and (2) urinary albumin excretion is associated with low renal function also...
  84. ncbi New-onset diabetes and antihypertensive drugs
    Giuseppe Mancia
    Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università Milano, Bicocca, Italy
    J Hypertens 24:3-10. 2006
    ..This paper provides new insights into the potential mechanisms responsible for the phenomenon and the clinical significance of antihypertensive drug-induced diabetes...
  85. ncbi Riskard 2005. New tools for prediction of cardiovascular disease risk derived from Italian population studies
    Alessandro Menotti
    V P Associazione per la Ricerca Cardiologica, Via Latina 49, Rome 00179, Italy
    Nutr Metab Cardiovasc Dis 15:426-40. 2005
    ..The need to update tools for the estimate of cardiovascular risk prompted the "Gruppo di Ricerca per la Stima del Rischio Cardiovascolare in Italia" to produce a new chart and new software called Riskard 2005...
  86. ncbi Zofenopril plus hydrochlorothiazide: Combination therapy for the treatment of mild to moderate hypertension
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Istituto Auxologico Italiano, Ospedale Maggiore di Milano, University of Milan, Milan, Italy
    Drugs 66:1107-15. 2006
    ....
  87. ncbi Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: the VALUE trial
    Sverre E Kjeldsen
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Hypertens 24:1405-12. 2006
    ..8%) patients on valsartan and in 586 (11.8%) on amlodipine (OR 0.82, 95% CI 0.72-0.93, P = 0.0015). CONCLUSION: Compared with amlodipine, valsartan reduces the risk of developing diabetes mellitus in high-risk hypertensive patients...
  88. ncbi The Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial: outcomes in patients receiving monotherapy
    Stevo Julius
    University of Michigan, Department of Internal Medicine, Division of Cardiovascular Medicine, 24 Frank Lloyd Wright Dr, PO Box 322, Lobby M, Ann Arbor, MI 48106, USA
    Hypertension 48:385-91. 2006
    ..Moreover, these findings support the feasibility of comparative prospective trials in lower-risk hypertensive patients...
  89. ncbi The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients
    Lisheng Liu
    Division of Hypertension, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, China
    J Hypertens 23:2157-72. 2005
    ....
  90. ncbi Hypertension: which aspects of hypertension should we impact on and how?
    Alberto Zanchetti
    Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Istituto Auxologico Italiano, Ospedale Maggiore, Milan, Italy
    J Hypertens Suppl 24:S2-5. 2006
    ..Fixed-dose antihypertensive combinations have now become a validated option for initiating antihypertensive treatment...
  91. ncbi Clinical pharmacodynamics of nebivolol: new evidence of nitric oxide-mediated vasodilating activity and peculiar haemodynamic properties in hypertensive patients
    Alberto Zanchetti
    Centro di Fisiologia Clinica ed Ipertensione, University of Milan, Ospedale Maggiore, Italy
    Blood Press Suppl 1:17-32. 2004
    ....
  92. ncbi Indexation criteria of ventricular mass and predictive role of blood pressure and body composition
    Liberato Aldo Ferrara
    Department of Clinical and Experimental Medicine, Federico 2nd University of Naples, Naples, Italy
    Am J Hypertens 18:1282-7. 2005
    ..The aims of the present study were to evaluate the prevalence of LVH according to different indexations and different cut-offs and to identify the most useful indexation of LVM to detect hypertension-related LVH...
  93. ncbi VALUE trial: Long-term blood pressure trends in 13,449 patients with hypertension and high cardiovascular risk
    Stevo Julius
    Department of Internal Medicine, Division of Hypertension, University of Michigan Health System, Ann Arbor, Michigan 48109 0356, USA
    Am J Hypertens 16:544-8. 2003
    ..The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) study compares cardiovascular outcomes in 15,314 eligible patients from 31 countries randomized to valsartan or amlodipine-based treatment...
  94. ncbi The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial
    Hans Lithell
    Department of Public Health and Caring Sciences, Sections of Geriatrics Clinical Hypertension Research and Family Medicine, University of Uppsala, Uppsala, Sweden
    J Hypertens 21:875-86. 2003
    ..The prognostic benefits of blood pressure lowering treatment in elderly hypertensive patients were established more than a decade ago, but are less clear in those with mildly to moderately elevated blood pressure...
  95. ncbi Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
    Henry R Black
    Rush Medical College of Rush University, Chicago, IL 60612, USA
    JAMA 289:2073-82. 2003
    ..Hypertensive patients are often given a calcium antagonist to reduce cardiovascular disease risk, but the benefit compared with other drug classes is controversial...
  96. ncbi Assessment of carotid plaque composition in hypertensive patients by ultrasonic tissue characterization: a validation study
    Michele M Ciulla
    Istituto di Clinica Medica Generale e Terapia Medica, Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Milano, Italy
    J Hypertens 20:1589-96. 2002
    ..In the present study, the echoreflectivity (ER) pattern of atherosclerotic plaques in vivo was compared with their histological pattern after surgical removal, and the reproducibility of measurement was tested...
  97. ncbi Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial
    Jan A Staessen
    J Hypertens 22:847-57. 2004
    ..Immediate compared with delayed treatment prevented 17 strokes or 25 major cardiovascular events per 1000 patients followed up for 6 years. These findings underscore the necessity of early treatment of isolated systolic hypertension...
  98. ncbi Prevalence of home blood pressure measurement among selected hypertensive patients: results of a multicenter survey from six hospital outpatient hypertension clinics in Italy
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare and Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Università di Milano e Ospedale Maggiore Policlinico IRCCS, Milano
    Blood Press 14:251-6. 2005
    ..The purpose of this study was to evaluate the prevalence of home blood pressure (BP) measurement, the type of devices and accuracy in a large sample of hypertensive patients referred to hospital outpatient hypertension clinics...
  99. ncbi Evidence-based medicine in hypertension: what type of evidence?
    Alberto Zanchetti
    Centro Interuniversitario di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore and Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 23:1113-20. 2005
    ....