Paolo Zamboni

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. ncbi Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol
    P Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Int Angiol 30:571-97. 2011
  2. ncbi Inflammation in venous disease
    P Zamboni
    Department of Surgery, Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Int Angiol 27:361-9. 2008
  3. doi Venous angioplasty in patients with multiple sclerosis: results of a pilot study
    P Zamboni
    Vascular Diseases Centre, University of Ferrara, C so Giovecca 203, 44100 Ferrara, Italy
    Eur J Vasc Endovasc Surg 43:116-22. 2012
  4. pmc Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara Bellaria Neurosciences, Ferrara and Bologna, Italy
    BMC Med 9:22. 2011
  5. doi The chronic cerebrospinal venous insufficiency syndrome
    P Zamboni
    Vascular Disease Centre, Interventional Radiology Unit, University of Ferrara, 44100 Ferrara, Italy
    Phlebology 25:269-79. 2010
  6. pmc Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave dreams study (brain venous drainage exploited against multiple sclerosis): study protocol for a randomized controlled trial
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, C so Giovecca 203, 44100 Ferrara, Italy
    Trials 13:183. 2012
  7. doi Fusion imaging technology of the intracranial veins
    P Zamboni
    Vascular Disease Center, University of Ferrara, Italy
    Phlebology 27:360-7. 2012
  8. doi Assessment of cerebral venous return by a novel plethysmography method
    Paolo Zamboni
    Vascular Diseases Centre, University of Ferrara, Ferrara, Italy
    J Vasc Surg 56:677-85.e1. 2012
  9. pmc The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, 44100 Ferrara, Italy
    J R Soc Med 99:589-93. 2006
  10. ncbi Intracranial venous haemodynamics in multiple sclerosis
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 4:252-8. 2007

Detail Information

Publications53

  1. ncbi Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol
    P Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Int Angiol 30:571-97. 2011
    ..47 to k=0.80), while within-rater reproducibility in trained operators was k=0.75. Finally, the consensus document proposes a reporting standard of Duplex measurements, and future research to answer areas of uncertainty...
  2. ncbi Inflammation in venous disease
    P Zamboni
    Department of Surgery, Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Int Angiol 27:361-9. 2008
    ....
  3. doi Venous angioplasty in patients with multiple sclerosis: results of a pilot study
    P Zamboni
    Vascular Diseases Centre, University of Ferrara, C so Giovecca 203, 44100 Ferrara, Italy
    Eur J Vasc Endovasc Surg 43:116-22. 2012
    ....
  4. pmc Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara Bellaria Neurosciences, Ferrara and Bologna, Italy
    BMC Med 9:22. 2011
    ..We hypothesized a possible relationship between abnormal perfusion in MS and hampered venous outflow at the extracranial level, a condition possibly associated with MS and known as chronic cerebrospinal venous insufficiency (CCSVI)...
  5. doi The chronic cerebrospinal venous insufficiency syndrome
    P Zamboni
    Vascular Disease Centre, Interventional Radiology Unit, University of Ferrara, 44100 Ferrara, Italy
    Phlebology 25:269-79. 2010
    ..Restenosis rate was found out elevated in the IJVs, but negligible in the AZ. However, PTA seems to positively influence clinical and QoL parameters of the associated MS and warrants further randomized control trials...
  6. pmc Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave dreams study (brain venous drainage exploited against multiple sclerosis): study protocol for a randomized controlled trial
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, C so Giovecca 203, 44100 Ferrara, Italy
    Trials 13:183. 2012
    ..Data from a few small case series suggest possible improvement of the clinical course and quality of life by performing percutaneous balloon angioplasty (PTA) of the stenotic veins...
  7. doi Fusion imaging technology of the intracranial veins
    P Zamboni
    Vascular Disease Center, University of Ferrara, Italy
    Phlebology 27:360-7. 2012
    ..In addition, we investigated the possibility of insonating the veins of the base of the skull through the novel condylar window...
  8. doi Assessment of cerebral venous return by a novel plethysmography method
    Paolo Zamboni
    Vascular Diseases Centre, University of Ferrara, Ferrara, Italy
    J Vasc Surg 56:677-85.e1. 2012
    ..The purpose of this study was to assess the cerebral venous return in relation to the change in position by means of a novel cervical plethysmography method...
  9. pmc The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, 44100 Ferrara, Italy
    J R Soc Med 99:589-93. 2006
  10. ncbi Intracranial venous haemodynamics in multiple sclerosis
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 4:252-8. 2007
    ..Our findings should contribute towards understanding the role of altered venous flow and tissue drainage in the MS inflammatory chain, as well as in the neurodegenerative process...
  11. ncbi CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies: a pilot study
    P Zamboni
    Vascular Diseases Center, University of Ferrara Bellaria Neurosciences, Ferrara and Bologna, Italy
    Int Angiol 29:140-8. 2010
    ..Aim of this study was to investigate the relationship between the VH changes and MRI measures of MS disease severity in a cross sectional survey...
  12. ncbi The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics
    P Zamboni
    Vascular Diseases Center, University of Ferrera, and Bellaria Neurosciences, Ferrara and Bologna, Italy
    Funct Neurol 24:133-8. 2009
    ..027) which was highly associated with the VHISS (r=0.8280, r2=0.6855; p=0.0001). This study demonstrates that venous outflow disturbances in the form of CCSVI significantly impact on CSF pathophysiology in patients with MS...
  13. doi A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Vasc Surg 50:1348-58.e1-3. 2009
    ..CCSVI is strongly associated with multiple sclerosis (MS). This study evaluated the safety of CCSVI endovascular treatment and its influence on the clinical outcome of the associated MS...
  14. pmc Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
    P Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Neurol Neurosurg Psychiatry 80:392-9. 2009
    ..The extracranial venous outflow routes in clinically defined multiple sclerosis (CDMS) have not previously been investigated...
  15. doi The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Neurol Sci 282:21-7. 2009
    ..0001). Moreover, this study demonstrates a significant impairment of cerebral venous drainage in patients affected by MS, a mechanism potentially related to increased iron stores...
  16. ncbi Clinical implications of gene polymorphisms in venous leg ulcer: a model in tissue injury and reparative process
    Paolo Zamboni
    Director of the Vascular Diseases Center, University of Ferrara, 44100 Ferrara, Italy
    Thromb Haemost 98:131-7. 2007
    ....
  17. doi Great saphenous varicose vein surgery without saphenofemoral junction disconnection
    P Zamboni
    Vascular Diseases Centre, Department of Surgery, University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy
    Br J Surg 97:820-5. 2010
    ..The duplex protocol included a reflux elimination test (RET) and assessment of the competence of the terminal valve of the femoral vein...
  18. ncbi The "T" vein of the leg
    P Zamboni
    Department of Surgery, University of Ferrara Day Surgery Unit, Master in Compression Therapy and Wound Healing, St Anna Hospital, Ferrara, Italy
    Dermatol Surg 30:750-2; discussion 753. 2004
    ..Constantly it feeds by reflux varicose veins clinically visible in the paratibial region and/or in the lateral aspect of the leg. For the peculiarity of its anatomical shape as well as duplex appearance, we defined it as the "T" vein...
  19. ncbi Factor XIII contrasts the effects of metalloproteinases in human dermal fibroblast cultured cells
    Paolo Zamboni
    Department of Surgery and Vascular Laboratory, University of Ferrara, Italy
    Vasc Endovascular Surg 38:431-8. 2004
    ..These results support several in vivo reports about the effectiveness of its topical application in order to enhance the venous ulcer healing processes...
  20. ncbi Pathophysiology of perforators in primary chronic venous insufficiency
    Paolo Zamboni
    Department of Surgery, University of Ferrara, Arcispedale S Anna, C so Giovecca 203, 44100 Ferrara, Italy
    World J Surg 29:S115-8. 2005
  21. ncbi Serum iron and matrix metalloproteinase-9 variations in limbs affected by chronic venous disease and venous leg ulcers
    Paolo Zamboni
    Inter Departmental Vascular Disease Center, University of Ferrara, Ferrara, Italy
    Dermatol Surg 31:644-9; discussion 649. 2005
    ..Severe chronic venous disease (CVD) is characterized by both dermal hemosiderin accumulation and matrix metalloproteinase (MMP) hyperactivation. The iron-driven pathway is one of the recognized mechanisms of MMP hyperactivation...
  22. ncbi Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration
    Paolo Zamboni
    Inter Departmental Vascular Disease Center, University of Ferrara, Italy
    J Vasc Surg 42:309-14. 2005
    ..Because CVD leads to local iron overload in the affected legs, we investigated whether two common HFE mutations could increase the risk of chronic venous leg ulceration...
  23. ncbi The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, 44100 Ferrara, Italy
    Free Radic Biol Med 40:1869-73. 2006
    ..We hypothesize that the physiologic iron protective mechanisms are affected by the HFE mutations and should be investigated in all diseases characterized by the combination of iron overload and inflammation...
  24. ncbi Venous collateral circulation of the extracranial cerebrospinal outflow routes
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 6:204-12. 2009
    ....
  25. doi DNA-array of gene variants in venous leg ulcers: detection of prognostic indicators
    Donato Gemmati
    Haemostasis and Thrombosis Center, University of Ferrara, Ferrara, Italy
    J Vasc Surg 50:1444-51. 2009
    ..We selected a number of single nucleotide polymorphisms (SNPs) in candidate genes (HFE, FPN1, MMP12, and FXIII) involved in VLU to identify potentially prognostic markers by means of DNA-array technology...
  26. ncbi Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Center Study Haemostasis and Thrombosis, University of Ferrara, Corso Giovecca 203, I 14400 Ferrara, Italy
    Wound Repair Regen 12:512-7. 2004
    ....
  27. ncbi Influence of gene polymorphisms in ulcer healing process after superficial venous surgery
    Donato Gemmati
    Center Study Hemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    J Vasc Surg 44:554-62. 2006
    ..This study was conducted to investigate the role of HFE-C282Y and FXIII (V34L and P564L) gene variants in ulcer healing time after superficial venous surgery, by assessing the outcome of a cohort of homogeneous CVU patients...
  28. doi Near-infrared spectroscopy assessment following exercise training in patients with intermittent claudication and in untrained healthy participants
    Fabio Manfredini
    Vascular Diseases Center, University of Ferrara, Italy
    Vasc Endovascular Surg 46:315-24. 2012
    ..The assessment of NIRS parameters, that were found stable without training in healthy and modified in PAD only following structured training, might outline the local exercise-induced adaptations...
  29. ncbi Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Mediators Inflamm 2013:423407. 2013
    ..Our data provide new insights into the molecular mechanisms of CVD pathogenesis, highlighting new potential therapeutic targets...
  30. ncbi Prognostic role of factor XIII gene variants in nonhealing venous leg ulcers
    Silvia Tognazzo
    Center Study Haemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    J Vasc Surg 44:815-9. 2006
    ..Because FXIII properties depend upon its genetic variants, we investigated whether intragene polymorphisms may have modulating effects on the CVU area...
  31. pmc Muscle oxygen consumption by NIRS and mobility in multiple sclerosis patients
    Anna Maria Malagoni
    Program Pathophysiology of Vascular Peripheral System, S, Anna Hospital University of Ferrara, Cona, Via A, Moro, 8, Ferrara, 44124, Italy
    BMC Neurol 13:52. 2013
    ..Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocnemius in MS patients and in age-matched healthy controls (HC) measured using NIRS, and to evaluate its possible relationship with patients' mobility...
  32. doi Endothelial PDGF-BB produced ex vivo correlates with relevant hemodynamic parameters in patients affected by chronic venous disease
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy
    Cytokine 63:92-6. 2013
    ..6; p=0.01), while showing a negative correlation with RI (R=-0.5; p=0.03). The potential implications of our findings for the pathophysiology of CVD are discussed...
  33. doi Resting muscle oxygen consumption by near-infrared spectroscopy in peripheral arterial disease: A parameter to be considered in a clinical setting?
    Anna Maria Malagoni
    Vascular Diseases Center, University of Ferrara, Italy
    Angiology 61:530-6. 2010
    ..003). The determination of rmVO(2)ven by NIRS is suitable for the clinical setting and allows noninvasive quantification of a compensatory peripheral adaptation in patients with PAD...
  34. pmc Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis
    Donato Gemmati
    Department of Biomedical Sciences and Advanced Therapies, Hematology Unit Center Hemostasis and Thrombosis, University of Ferrara, Ferrara, Italy
    BMC Med Genet 13:70. 2012
    ..Conversely, systemic iron overload is not always observed. We explored the role of common single nucleotide polymorphisms (SNPs) in the main iron homeostasis genes in MS patients...
  35. pmc Custom CGH array profiling of copy number variations (CNVs) on chromosome 6p21.32 (HLA locus) in patients with venous malformations associated with multiple sclerosis
    Alessandra Ferlini
    Section of Medical Genetics, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    BMC Med Genet 11:64. 2010
    ....
  36. ncbi Evaluation of patient compliance, quality of life impact and cost-effectiveness of a "test in-train out" exercise-based rehabilitation program for patients with intermittent claudication
    Anna Maria Malagoni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Circ J 75:2128-34. 2011
    ..This retrospective study evaluates compliance, impact on Quality of Life (QoL) and cost-effectiveness of a hospital prescribed, at-home performed (Test-in/Train-out) rehabilitative program for patients with IC...
  37. doi Time- and dose-dependent effects of chronic wound fluid on human adult dermal fibroblasts
    Monica De Mattei
    Department of Morphology and Embryology, Ferrara, Italy
    Dermatol Surg 34:347-56. 2008
    ..Wound healing is a biologic process that is altered in patients affected by chronic venous ulcers. The wound microenvironment is reflected in the chronic wound fluid (CWF), an exudate containing serum components and tissue-derived proteins...
  38. pmc GM-CSF exhibits anti-inflammatory activity on endothelial cells derived from chronic venous disease patients
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 70, 44100 Ferrara, Italy
    Mediators Inflamm 2013:561689. 2013
    ..Since in vitro recombinant GM-CSF induced VEC proliferation and counteracted the induction of ICAM-1, VCAM-1 and OPG upon exposure to TNF-α, our data suggest an anti-inflammatory activity of GM-CSF on venous endothelial cells...
  39. pmc An ultrasound model to calculate the brain blood outflow through collateral vessels: a pilot study
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Cona, FE, Italy
    BMC Neurol 13:81. 2013
    ..We developed a novel model to calculate the cerebral venous return, normalized to the arterial inflow, in the different segments of the IJV...
  40. ncbi Acute and long-term effects of an exercise program for dialysis patients prescribed in hospital and performed at home
    Anna Maria Malagoni
    Vascular Diseases Center, University of Ferrara, Ferrara Italy
    J Nephrol 21:871-8. 2008
    ..We evaluated the effects of an original 6-month walking program on physical capacity, health-related quality of life (HRQL) and postdialysis fatigue (PDF)...
  41. ncbi Acute oxygenation changes on ischemic foot of a novel intermittent pneumatic compression device and of an existing sequential device in severe peripheral arterial disease
    Fabio Manfredini
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    BMC Cardiovasc Disord 14:40. 2014
    ..In severe PAD patients we measured the foot oxygenation changes evoked by a novel intermittent IPC device (GP), haemodynamics and compliance to the treatment. Reference values were obtained by a sequential foot-calf device (SFC)...
  42. doi Modulation of circulating cytokine-chemokine profile in patients affected by chronic venous insufficiency undergoing surgical hemodynamic correction
    Veronica Tisato
    Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, Via Fossato di Mortara 66, 44121 Ferrara, Italy
    J Immunol Res 2014:473765. 2014
    ....
  43. doi CCSVI is associated with multiple sclerosis
    Sandra Morovic
    Vascular Diseases Center, University of Ferrara, Italy
    Neurol Res 34:770-9. 2012
    ....
  44. doi Does thoracic pump influence the cerebral venous return?
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    J Appl Physiol (1985) 112:904-10. 2012
    ....
  45. doi Sport therapy for hypertension: why, how, and how much?
    Fabio Manfredini
    Vascular Diseases Center, University of Ferrara, S Anna Hospital, Ferrara, Italy
    Angiology 60:207-16. 2009
    ..Supervised or home-based exercise programs allow a nonpharmacological reduction of hypertension and reduce risk factors, with possible beneficial effects on cardiovascular morbidity...
  46. ncbi Urine hemosiderin: a novel marker to assess the severity of chronic venous disease
    Paolo Zamboni
    Department of Surgery and Vascular Laboratory, University of Ferrara, Italy
    J Vasc Surg 37:132-6. 2003
    ..We hypothesized that hemosiderin, normally absent, could be present in the urine in CVI...
  47. pmc Endothelial cells obtained from patients affected by chronic venous disease exhibit a pro-inflammatory phenotype
    Veronica Tisato
    Department of Morphology and Embryology and LTTA Centre, University of Ferrara, Ferrara, Italy
    PLoS ONE 7:e39543. 2012
    ..Therefore, new insights on the characteristics of large vein endothelium would increase our knowledge of large vessel physiopathology...
  48. ncbi Training rather than walking: the test in -train out program for home-based rehabilitation in peripheral arteriopathy
    Fabio Manfredini
    Center of Biomedical Studies Applied to Sport, University of Ferrara, Ferrara, Italy
    Circ J 72:946-52. 2008
    ....
  49. ncbi Diffuse acute abdominal pain and palpation of the lower limb pulses: what kind of link?
    Roberto Galeotti
    Department of Radiolog, University of Ferrara, Ferrara, Italy
    Intern Emerg Med 1:216-7. 2006
  50. ncbi Doppler haemodynamics of cerebral venous return
    Erica Menegatti
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 5:260-5. 2008
    ..In future, the development of this diagnostic technique could be of singular interest in iron-related inflammatory and neurodegenerative disorders like multiple sclerosis...
  51. ncbi Early oral feeding after colorectal resection: a randomized controlled study
    Carlo V Feo
    Section of General Surgery, Department of Surgery, School of Medicine, University of Ferrara, Ferrara, Italy
    ANZ J Surg 74:298-301. 2004
    ..The present study is a randomised controlled trial on the effect of early oral feeding without NG decompression following elective colorectal resection for cancer...
  52. doi Interplay of iron metallobiology, metalloproteinases, and FXIII, and role of their gene variants in venous leg ulcer
    Ajay V Singh
    European School of Molecular Medicine, Milan, Italy
    Int J Low Extrem Wounds 9:166-79. 2010
    ....
  53. ncbi Regarding "Treatment of superficial and perforator venous incompetence without deep venous insufficiency: is routine perforator ligation necessary?"
    Paolo Zamboni
    J Vasc Surg 39:1144-5; author reply 1145. 2004