M Volpe

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi request reprint Markers of inflammation and fibrosis are related to cardiovascular damage in hypertensive patients with metabolic syndrome
    Sebastiano Sciarretta
    Cardiology Department, II School of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    Am J Hypertens 20:784-91. 2007
  2. ncbi request reprint Microalbuminuria screening in patients with hypertension: recommendations for clinical practice
    M Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Int J Clin Pract 62:97-108. 2008
  3. ncbi request reprint ARB-Based Single-Pill Platform to Guide a Practical Therapeutic Approach to Hypertensive Patients
    Massimo Volpe
    Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035 39, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 21:137-47. 2014
  4. pmc Multivariate risk assessment and risk score cards in hypertension
    Giuliano Tocci
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Vasc Health Risk Manag 3:313-20. 2007
  5. ncbi request reprint Open-label study assessing the long-term efficacy and safety of triple olmesartan/amlodipine/hydrochlorothiazide combination therapy for hypertension
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa 1035, 00189, Rome, Italy
    Adv Ther 31:561-74. 2014
  6. pmc New treatment options in the management of hypertension: appraising the potential role of azilsartan medoxomil
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Sant Andrea Hospital, Sapienza University of Rome, Rome Italy
    Integr Blood Press Control 5:19-25. 2012
  7. pmc Olmesartan medoxomil for the treatment of hypertension in children and adolescents
    Giuliano Tocci
    Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    Vasc Health Risk Manag 7:177-81. 2011
  8. ncbi request reprint Olmesartan in the treatment of hypertension in elderly patients: a review of the primary evidence
    Massimo Volpe
    Chair and Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant Andrea Hospital, University of Rome Sapienza, Via di Grottarossa 1035 39, 00189, Rome, Italy
    Drugs Aging 30:987-98. 2013
  9. doi request reprint Follow-up, study design and outcome parameters
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    EuroIntervention 9:R96-100. 2013
  10. doi request reprint Plasma renin and cardiovascular risk: what is the evidence for an association?
    Massimo Volpe
    Cardiology Division, Department of Clinical and Molecular Medicine, Second School of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    Cardiology 125:50-9. 2013

Collaborators

Detail Information

Publications143 found, 100 shown here

  1. ncbi request reprint Markers of inflammation and fibrosis are related to cardiovascular damage in hypertensive patients with metabolic syndrome
    Sebastiano Sciarretta
    Cardiology Department, II School of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    Am J Hypertens 20:784-91. 2007
    ..This issue has not been clarified yet in patients with MS. The aim of our study was to investigate the relationship between markers of inflammation and fibrosis with CD in hypertensive patients with and without MS...
  2. ncbi request reprint Microalbuminuria screening in patients with hypertension: recommendations for clinical practice
    M Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Int J Clin Pract 62:97-108. 2008
    ..Microalbuminuria, in addition to being an early sign of kidney damage, is often found in patients with essential hypertension, suggesting that it may reflect early vascular abnormalities...
  3. ncbi request reprint ARB-Based Single-Pill Platform to Guide a Practical Therapeutic Approach to Hypertensive Patients
    Massimo Volpe
    Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035 39, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 21:137-47. 2014
    ..We believe it will increase the percentage of hypertensive patients who achieve blood pressure control when applied as part of an integrative approach that includes regular follow-up and instruction on lifestyle changes. ..
  4. pmc Multivariate risk assessment and risk score cards in hypertension
    Giuliano Tocci
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Vasc Health Risk Manag 3:313-20. 2007
    ....
  5. ncbi request reprint Open-label study assessing the long-term efficacy and safety of triple olmesartan/amlodipine/hydrochlorothiazide combination therapy for hypertension
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa 1035, 00189, Rome, Italy
    Adv Ther 31:561-74. 2014
    ..To reduce cardiovascular risk associated with hypertension, the majority of patients require at least two drugs to control their blood pressure (BP), and many require three or more...
  6. pmc New treatment options in the management of hypertension: appraising the potential role of azilsartan medoxomil
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Sant Andrea Hospital, Sapienza University of Rome, Rome Italy
    Integr Blood Press Control 5:19-25. 2012
    ..This ARB induces a potent and long-lasting antihypertensive effect and may have cardioprotective properties. This article reviews the current evidence on the clinical effectiveness of azilsartan in hypertension...
  7. pmc Olmesartan medoxomil for the treatment of hypertension in children and adolescents
    Giuliano Tocci
    Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    Vasc Health Risk Manag 7:177-81. 2011
    ....
  8. ncbi request reprint Olmesartan in the treatment of hypertension in elderly patients: a review of the primary evidence
    Massimo Volpe
    Chair and Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant Andrea Hospital, University of Rome Sapienza, Via di Grottarossa 1035 39, 00189, Rome, Italy
    Drugs Aging 30:987-98. 2013
    ..This article provides an overview of the main recent clinical evidence supporting the use of OM-based therapy in elderly patients with hypertension...
  9. doi request reprint Follow-up, study design and outcome parameters
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    EuroIntervention 9:R96-100. 2013
    ..To assess this, patients who have undergone this procedure should be submitted to a specific follow-up in centres of excellence in treating resistant hypertension...
  10. doi request reprint Plasma renin and cardiovascular risk: what is the evidence for an association?
    Massimo Volpe
    Cardiology Division, Department of Clinical and Molecular Medicine, Second School of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    Cardiology 125:50-9. 2013
    ..Currently, however, the link between plasma renin and CV risk in treated patients is inconsistent between different populations and in various clinical conditions, calling for further investigation...
  11. doi request reprint 2012 consensus document of the Italian Society of Hypertension (SIIA): strategies to improve blood pressure control in Italy: from global cardiovascular risk stratification to combination therapy
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant Andrea Hospital, University of Rome Sapienza, Via di Grottarossa 1035 39, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 20:45-52. 2013
    ....
  12. doi request reprint [Renal denervation for the treatment of resistant hypertension: definition, patient selection and description of the procedure. 2012 Position paper of the Italian Society of Hypertension]
    Massimo Volpe
    Cattedra e Struttura Complessa di Cardiologia, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Azienda Ospedaliera Sant Andrea, Roma
    G Ital Cardiol (Rome) 13:846-52. 2012
    ....
  13. doi request reprint [Strategies for improving blood pressure control in Italy: from global cardiovascular risk stratification to combination therapy. 2012 Position paper of the Italian Society of Hypertension]
    Massimo Volpe
    Cattedra e Struttura Complessa di Cardiologia, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Azienda Ospedaliera Sant Andrea, Roma
    G Ital Cardiol (Rome) 13:853-60. 2012
    ..The present document of the Italian Society of Hypertension aims to provide main indications for implementing combination therapy in the clinical management of hypertension in order to improve blood pressure control in Italy...
  14. doi request reprint A New Option for Therapeutic Management of Patients with Cardiovascular Disease : A Closer Look at the ONTARGET Study
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, Rome, 1035 39, 00189, Italy
    High Blood Press Cardiovasc Prev 15:47-51. 2008
    ....
  15. doi request reprint Cardiovascular risk in hypertension - can we ask for more? : focus on aliskiren
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, Rome, 00189, Italy
    High Blood Press Cardiovasc Prev 15:255-68. 2008
    ....
  16. doi request reprint A New Option for Therapeutic Management of Patients with Cerebrovascular Disease : A Closer Look at the PRoFESS Trial
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 15:105-7. 2008
    ....
  17. doi request reprint β-Blockers and Diuretics in the Treatment of Hypertension : 'A Friendly Fire?'
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 39, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 15:109-11. 2008
    ....
  18. doi request reprint Renal artery denervation for treating resistant hypertension : definition of the disease, patient selection and description of the procedure
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant Andrea Hospital, and IRCCS Neuromed, Rome, Via di Grottarossa 1035 39, 00189, Pozzilli, Isernia, Rome, Italy
    High Blood Press Cardiovasc Prev 19:237-44. 2012
    ....
  19. doi request reprint 2008 white paper for implementing strategies and interventions for cardiovascular prevention in Italy
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, Rome, 1035 39, 00189, Italy
    High Blood Press Cardiovasc Prev 15:63-73. 2008
    ..These proposals are listed, and briefly discussed, leading to the development of a 'call-to-action', aimed at reducing the incidence of cardiovascular diseases and their impact on the healthcare system, even in the short to medium term...
  20. ncbi request reprint Global cardiovascular risk management in primary prevention
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Via di Grottarossa 1035 39, 00189 Rome, Italy
    Curr Vasc Pharmacol 10:709-11. 2012
    ....
  21. doi request reprint Preventing cardiovascular events with angiotensin II receptor blockers: a closer look at telmisartan and valsartan
    Massimo Volpe
    Department of Clinical and Molecular Science, Division of Cardiology, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    Expert Rev Cardiovasc Ther 10:1061-72. 2012
    ..Few head-to-head comparisons between telmisartan and valsartan have been performed. However, some blood pressure-independent properties of these two ARBs can be scrutinized from separate studies in the available literature...
  22. doi request reprint [Polytherapy in cardiovascular prevention: open issues]
    Massimo Volpe
    Divisione di Cardiologia, Departimento di Medicina Clinica e Molecolare, Universita di Roma Sapienza, Ospedale Sant Andrea, Roma
    G Ital Cardiol (Rome) 13:503-10. 2012
    ..This present article proposes a critical analysis of some open issues related to polytherapy in cardiovascular prevention...
  23. pmc Rationale for triple fixed-dose combination therapy with an angiotensin II receptor blocker, a calcium channel blocker, and a thiazide diuretic
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, University of Rome, Sapienza, Sant Andrea Hospital, Rome, Italy
    Vasc Health Risk Manag 8:371-80. 2012
    ..The availability of these fixed-dose combinations should lead to improvement in blood pressure control and aid compliance with long-term therapy, optimizing the management of this chronic condition...
  24. doi request reprint Cardiovascular risk assessment beyond Systemic Coronary Risk Estimation: a role for organ damage markers
    Massimo Volpe
    Cardiology Department of Clinical and Molecular Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 30:1056-64. 2012
    ..Inclusion of organ damage markers in the assessment may thus contribute to improve this process...
  25. doi request reprint Renin as a biomarker of cardiovascular disease in clinical practice
    M Volpe
    Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome Sapienza, S Andrea Hospital, Rome, Italy
    Nutr Metab Cardiovasc Dis 22:312-7. 2012
    ..With the new advances of pharmacological treatment acting on the RAAS, the effect of elevated levels of renin on the prognosis of these patients becomes even more intriguing...
  26. doi request reprint Inhibition of the renin-angiotensin-aldosterone system: is there room for dual blockade in the cardiorenal continuum?
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome La Sapienza, Rome, Italy
    J Hypertens 30:647-54. 2012
    ..In this review, we revisited potential advantages of dual blockade of renin-angiotensin-aldosterone system in arterial hypertension and diabetes...
  27. pmc Effort angina in a patient with advanced coronary artery disease. Role played by coronary angiography, Ivus and cardiac CT: case report
    Domenico M Zardi
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Cardiovasc Ultrasound 6:48. 2008
    ..This additional diagnosis promptly resulted in a therapeutic approach with percutaneous transluminal coronary angioplasty (PTCA)...
  28. doi request reprint Efficacy and safety of a stepped-care regimen using olmesartan medoxomil, amlodipine and hydrochlorothiazide in patients with moderate-to-severe hypertension: an open-label, long-term study
    Massimo Volpe
    Specialty School of Cardiology, University of Rome La Sapienza, Rome, Italy
    Clin Drug Investig 29:381-91. 2009
    ..This long-term open-label study assessed a treatment algorithm based on olmesartan medoxomil (hereafter olmesartan), amlodipine and hydrochlorothiazide (HCTZ)...
  29. ncbi request reprint Integrated cardiovascular risk management for the future: lessons learned from the ASCOT trial
    Massimo Volpe
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Aging Clin Exp Res 17:46-53. 2005
    ....
  30. doi request reprint Efficacy and tolerability of olmesartan medoxomil combined with amlodipine in patients with moderate to severe hypertension after amlodipine monotherapy: a randomized, double-blind, parallel-group, multicentre study
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Clin Drug Investig 29:11-25. 2009
    ....
  31. ncbi request reprint Blood pressure control in Italy: results of recent surveys on hypertension
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 25:1491-8. 2007
    ..Blood pressure (BP) control is reported to be poor in hypertensive patients worldwide...
  32. doi request reprint Angiotensin II receptor blockers and myocardial infarction: an updated analysis of randomized clinical trials
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 27:941-6. 2009
    ..To evaluate the effects of treatments based on angiotensin II receptor blockers (ARBs) on the risk of myocardial infarction (MI), cardiovascular and all-cause death, as compared with conventional treatment or placebo...
  33. doi request reprint Managing hypertension in cardiology practice according to risk profile
    M Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Pozzilli, IS, Italy
    Int J Clin Pract 62:1403-12. 2008
    ....
  34. ncbi request reprint Antihypertensive therapy and cerebrovascular protection
    Massimo Volpe
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Curr Opin Nephrol Hypertens 15:498-504. 2006
    ..High blood pressure is the most relevant modifiable risk factor for developing stroke...
  35. ncbi request reprint Therapeutic implications of recent megatrials in hypertension: in favor of new drugs
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome and IRCCS Neuromed, Pozzilli, Isernia Italy
    J Nephrol 20:S12-8. 2007
    ....
  36. ncbi request reprint Reduction in estimated stroke risk associated with practice-based stroke-risk assessment and awareness in a large, representative population of hypertensive patients: results from the ForLife study in Italy
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 25:2390-7. 2007
    ..Data from a subsequent visit within 6 months, to evaluate the impact of systematic stroke risk assessment, are reported...
  37. ncbi request reprint Managing cardiovascular risk: the need for change
    M Volpe
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital and IRCCS Neuromed Pozzilli, IS, Italy
    J Hum Hypertens 22:154-7. 2008
  38. ncbi request reprint Angiotensin II receptor blockers and myocardial infarction: deeds and misdeeds
    Massimo Volpe
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza Sant Andrea Hospital, Rome
    J Hypertens 23:2113-8. 2005
    ....
  39. doi request reprint 2007 ESH/ESC Guidelines for the management of hypertension, from theory to practice: global cardiovascular risk concept
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens Suppl 27:S3-11. 2009
    ..This synergistic approach holds the best promise for treating total cardiovascular risk and reducing the mounting global burden of cardiovascular disease associated with hypertension...
  40. doi request reprint 2010 position paper of the Italian Society of Hypertension (SIIA): angiotensin receptor blockers and risk of cancer
    Massimo Volpe
    Hypertension Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    High Blood Press Cardiovasc Prev 18:37-40. 2011
    ....
  41. doi request reprint Direct renin inhibition: from pharmacological innovation to novel therapeutic opportunities
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Italy
    High Blood Press Cardiovasc Prev 18:93-105. 2011
    ....
  42. doi request reprint Should all patients at high cardiovascular risk receive renin-angiotensin system blockers?
    M Volpe
    Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant Andrea Hospital, Via di Grottarossa 1035 9, 00189 Rome, Italy
    QJM 105:11-27. 2012
    ..This extensive clinical trial evidence suggests that ACE inhibitors or ARBs should be part of the standard treatment for patients at risk of CV events. ARBs may represent a preferred option due to their unsurpassed tolerability...
  43. doi request reprint Antihypertensive therapy in diabetes: the legacy effect and RAAS blockade
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, 00189 Rome, Italy
    Curr Hypertens Rep 13:318-24. 2011
    ..This review article critically discusses current evidence and explores the rationale for a legacy effect of RAAS blockade in hypertensive patients with diabetes...
  44. doi request reprint Prediction of long-term survival in chronic heart failure by multiple biomarker assessment: a 15-year prospective follow-up study
    Massimo Volpe
    Cardiology, Department of Clinical and Molecular Medicine, 2nd Faculty of Medicine, Sapienza University, Rome, Italy
    Clin Cardiol 33:700-7. 2010
    ..However, their long-term predictive value in the context of other candidate predictors has never been assessed. This information may prove valuable in the management of a chronic disease with a long natural history, as CHF is today...
  45. ncbi request reprint Challenging hypertension: how to diagnose and treat resistant hypertension in daily clinical practice
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, 00189 Rome, Italy
    Expert Rev Cardiovasc Ther 8:811-20. 2010
    ..In this article, we will review and discuss the definition, pathophysiological mechanisms, diagnostic algorithms and potential new therapeutic options for treating resistant hypertension...
  46. doi request reprint Hypertension as an underlying factor in heart failure with preserved ejection fraction
    Massimo Volpe
    Faculty of Medicine, University of Roma La Sapienza, Rome, Italy
    J Clin Hypertens (Greenwich) 12:277-83. 2010
    ..The deleterious effects of hypertension on mechanisms underlying the development of HF-PEF underscore the importance of effective and early control of hypertension for the prevention of HF-PEF...
  47. doi request reprint The challenge of polypharmacy in cardiovascular medicine
    Massimo Volpe
    Cardiology Department, IInd School of Medicine, University of Rome Sapienza, S Andrea Hospital, Rome, Italy
    Fundam Clin Pharmacol 24:9-17. 2010
    ..However, large randomized trials are required to define its impact on clinical outcomes. This review will focus on challenges of polypharmacy in CV medicine, illustrating potential options to face this emerging crisis...
  48. doi request reprint Redefining blood pressure targets in high-risk patients?: lessons from coronary endpoints in recent randomized clinical trials
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    Am J Hypertens 24:1060-8. 2011
    ..Our conclusions highlight the importance of a closer scrutiny for coronary artery disease and suggest caution in lowering BP levels aggressively in patients with high-risk profile or diabetes...
  49. doi request reprint Global cardiovascular risk management in different Italian regions: an analysis of the Evaluation of Final Feasible Effect of Control Training and Ultra Sensitisation (EFFECTUS) educational program
    G Tocci
    Chair and Division of Cardiology, II Faculty of Medicine, University Sapienza, Sant Andrea Hospital, Rome, Italy
    Nutr Metab Cardiovasc Dis 22:635-42. 2012
    ..The present study evaluates differences on clinical approach to global CV risk among physicians involved in the EFFECTUS program and stratified in three geographical macro-areas (North, Center, South) of our Country...
  50. doi request reprint Management of hypertension and stroke prevention: results of the Italian cardiologist survey
    G Tocci
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Int J Clin Pract 63:207-16. 2009
    ..To provide an overview of current habits, priorities, perceptions and knowledge of cardiologists with regard to hypertension and stroke prevention in outpatient practice...
  51. ncbi request reprint Differential brain atrial natriuretic peptide expression co-segregates with occurrence of early stroke in the stroke-prone phenotype of the spontaneously hypertensive rat
    S Rubattu
    Istituto Neurologico Mediterraneo Neuromed, Pozzilli Is, Department of Pathology and Experimental Medicine, University La Sapienza, Rome, Italy
    J Hypertens 17:1849-52. 1999
    ....
  52. ncbi request reprint Pulmonary embolism in pregnancy
    E Conti
    Department of Cardiology, School of Medicine and Psychology, Sapienza University of Rome, Sant Andrea Hospital, Rome, Italy
    J Thromb Thrombolysis 37:251-70. 2014
    ....
  53. doi request reprint Bridging science and health policy in cardiovascular disease: focus on lipid management: A Report from a Session held during the 7th International Symposium on Multiple Risk Factors in Cardiovascular Diseases: Prevention and Intervention--Health Policy, i
    V Atella
    Department of Economics, University of Rome Tor Vergata, Rome, Italy
    Atheroscler Suppl 10:3-21. 2009
    ..Failure to bridge the gap between science and health policy, particularly in relation to lipid management, could result in missed opportunities to reverse the burgeoning epidemic of CVD in Europe...
  54. ncbi request reprint Hypertension therapy: mixing, matching, and meeting targets
    Massimo Volpe
    Faculty of Medicine, University of Rome La Sapienza, Osp Sant Andrea IRCCS Neuromed Pozzilli IS, Rome, Italy
    Adv Ther 21:107-22. 2004
    ..In addition, angiotensin-receptor blocker/diuretic combinations may have cardiovascular benefits beyond those from blood pressure lowering itself...
  55. doi request reprint Impact of physicians' age on the clinical management of global cardiovascular risk: analysis of the results of the Evaluation of Final Feasible Effect of Control Training and Ultra Sensitisation Educational Programme
    G Tocci
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University Sapienza, Sant Andrea Hospital, Rome, Italy
    Int J Clin Pract 65:649-57. 2011
    ..To evaluate the potential impact of physicians' age on global cardiovascular (CV) risk management in the population of the Evaluation of Final Feasible Effect of Ultra Control Training and Sensitisation (EFFECTUS) study...
  56. ncbi request reprint Reduced levels of N-terminal-proatrial natriuretic peptide in hypertensive patients with metabolic syndrome and their relationship with left ventricular mass
    Speranza Rubattu
    U O Cardiologia, IInd School of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    J Hypertens 25:833-9. 2007
    ..We aimed to assess the ANP levels and their relationship with left ventricular mass (LVM) in patients affected by MS...
  57. ncbi request reprint Genetic susceptibility to cerebrovascular accidents
    S Rubattu
    Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Isernia, Italy
    J Cardiovasc Pharmacol 38:S71-4. 2001
    ....
  58. ncbi request reprint Treatment of systolic hypertension: spotlight on recent studies with angiotensin II antagonists
    M Volpe
    Cattedra di Cardiologia, II Facolta di Medicina e Chirurgia, Universita di Roma La Sapienza, Rome, Italy
    J Hum Hypertens 19:93-102. 2005
    ..This, in patients with ISH, AII antagonists more facilitate systolic BP control, providing cardiovascular protection and offering an excellent risk-benefit profile...
  59. doi request reprint Fixed-combination therapies in hypertension management: focus on enalapril/lercanidipine
    Giuliano Tocci
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 1039, 00189 Rome, Italy
    Expert Rev Cardiovasc Ther 7:115-23. 2009
    ....
  60. ncbi request reprint Cerebrovascular disease in women
    Massimo Volpe
    Dipartimento di Medicina Sperimentale e Patologia, Universita degli Studi di Roma La Sapienza, Rome, Italy
    J Hypertens Suppl 20:S39-43. 2002
    ..In addition, emerging pathophysiological, clinical and therapeutic issues confer specific characteristics to stroke in women. This article briefly covers some of the most important of these aspects...
  61. ncbi request reprint [Activation of the renin-angiotensin-aldosterone system in heart failure]
    Massimo Volpe
    Divisione di Cardiologia, II Facolta di Medicina, Universita degli Studi La Sapienza, Ospedale S Andrea, Roma
    Ital Heart J 6:16S-23S. 2005
    ..This article reviews the current knowledge on the biochemical and functional organization of the RAAS, its pathophysiological role in CHF, and the potential therapeutic implications...
  62. doi request reprint Coronary artery fistula from the circumflex artery to the left atrium: invasive and non-invasive imaging techniques
    Luciano De Biase
    Universita degli Studi La Sapienza, Rome, Italy
    J Cardiovasc Med (Hagerstown) 9:320-2. 2008
  63. ncbi request reprint Development of heart failure in recent hypertension trials
    Giuliano Tocci
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 26:1477-86. 2008
    ..Heart failure represents a major cause of disease burden worldwide and is expected to further rise in the coming decades. Hypertension is the clinical condition most frequently associated to heart failure...
  64. ncbi request reprint Is it time to measure microalbuminuria in hypertension?
    Massimo Volpe
    Division of Cardiology, 2nd Faculty of Medicine, University of Rome La Sapienza, Italy
    J Hypertens 21:1213-20. 2003
    ..Upcoming new guidelines and diagnostic algorithms in hypertension need to underscore the clinical positioning of microalbuminuria for stratification of risk and follow-up purposes...
  65. ncbi request reprint Comparison of the blood pressure-lowering effects and tolerability of Losartan- and Amlodipine-based regimens in patients with isolated systolic hypertension
    Massimo Volpe
    Universita degli Studi di Roma La Sapienza, Rome, Italy
    Clin Ther 25:1469-89. 2003
    ..Isolated systolic hypertension (ISH) is the predominant form of hypertension in the elderly. Effects of angiotensin II on the vascular wall and endothelium may contribute to development of ISH...
  66. ncbi request reprint Fewer mega-trials and more clinically oriented studies in hypertension research? The case of blocking the renin-angiotensin-aldosterone system
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa 1035 9, 00189 Rome, Italy
    J Am Soc Nephrol 17:S36-43. 2006
    ....
  67. ncbi request reprint Treatment priorities and current prescribing patterns in hypertension: results of GRASP, an international physician survey
    Massimo Volpe
    Second Faculty of Medicine and Sant Andrea Hospital, University of Rome La Sapienza, Rome, Italy
    Curr Med Res Opin 20:1151-60. 2004
    ..The results of GRASP confirm the desirability of research to identify methods and strategies that will facilitate the integration of clinical trial results into general practice treatment of hypertension...
  68. ncbi request reprint Angiotensin II-receptor antagonist in the treatment of hypertension
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Ospedale Sant Andrea, Via di Grottarossa, 1035 39, 00189 Rome, Italy
    Curr Hypertens Rep 7:287-93. 2005
    ..In this article, we provide some evidence derived from these trials, supporting a role for ARBs in primary and secondary prevention of cardiovascular and renal disease, beyond blood pressure control...
  69. ncbi request reprint Beyond hypertension toward guidelines for cardiovascular risk reduction
    Massimo Volpe
    Department of Cardiology, II Faculty of Medicine, University of Rome La Sapienza Rome, Rome, Italy
    Am J Hypertens 17:1068-74. 2004
    ..We propose that global risk should be used as the main determinant of whom to treat, how to treat, and how much to treat...
  70. ncbi request reprint Angiotensin II: an amplifier of cardiovascular risk
    Massimo Volpe
    Division of Cardiology, 2nd Faculty of Medicine, University of Rome La Sapienza, S Andrea Hospital, Via di Grottarossa, 1035 00159 Rome, Italy
    Curr Hypertens Rep 6:247-8. 2004
  71. ncbi request reprint Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant
    Speranza Rubattu
    IRCCS Neuromed, Pozzilli Is, Department of Cardiology, IInd School of Medicine, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
    J Hypertens 22:2129-34. 2004
    ..In the present study we characterized the contributory role of RAAS genes in the susceptibility to develop ischemic stroke in humans...
  72. ncbi request reprint Antihypertensive strategy based on angiotensin II receptor blockers: a new gateway to reduce risk in hypertension
    Giuliano Tocci
    University La Sapienza of Rome, Cardiology, II Faculty of Medicine, Sant Andrea Hospital, Rome, Italy
    Expert Rev Cardiovasc Ther 5:767-76. 2007
    ..This review highlights the evidence derived from recent clinical trials, supporting a role for pharmacological strategies based on ARBs in primary and secondary prevention of cardiovascular and renal disease...
  73. doi request reprint The cardiovascular continuum refined: A hypothesis
    Massimo Volpe
    University of Roma La Sapienza Sant Andrea Hospital, Italy
    Blood Press 19:273-7. 2010
    ..The combination of proteomic biomarkers with clinical phenotypes and genetic haplotype information may also aid prognosis of individual cardiovascular risk in a near future...
  74. ncbi request reprint Hypertension and heart failure: role of neurohormonal mechanisms
    Massimo Volpe
    2nd Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Clin Exp Hypertens 26:603-10. 2004
    ..This article synthetically reviews this aspect together with a specific analysis of the significance of measurements of neurohormones for diagnosis and prognostic stratification in heart failure...
  75. ncbi request reprint Angiotensin II AT2 receptor subtype: an uprising frontier in cardiovascular disease?
    Massimo Volpe
    Cattedra di Cardiologia, II Facolta di Medicina, Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    J Hypertens 21:1429-43. 2003
    ....
  76. doi request reprint IGF-1 and atherothrombosis: relevance to pathophysiology and therapy
    Elena Conti
    Cardiology Division, Department of Clinical and Molecular Medicine, II Faculty of Medicine of Rome Sapienza, Rome, Italy
    Clin Sci (Lond) 120:377-402. 2011
    ..Perhaps the time has come for the regenerative properties of IGF-1 to be assessed as a new pharmacological tool in cardiovascular medicine...
  77. ncbi request reprint Recombinant human insulin-like growth factor-1: a new cardiovascular disease treatment option?
    E Conti
    Cardiology Department, II Faculty of Medicine, University of Rome La Sapienza, Rome, Ospedale Sant Andrea, Italy
    Cardiovasc Hematol Agents Med Chem 6:258-71. 2008
    ..In view of its ability to improve flow-metabolism coupling, IGF-1 could indeed represent a new cardiovascular disease treatment option for many cardiac disorders such as ischemic heart disease and heart failure...
  78. doi request reprint Growth factors in preeclampsia: a vascular disease model. A failed vasodilation and angiogenic challenge from pregnancy onwards?
    E Conti
    Cardiology, Clinical and Molecular Medicine Department, Sapienza University of Rome, Italy Electronic address
    Cytokine Growth Factor Rev 24:411-25. 2013
    ....
  79. ncbi request reprint Plasma NT-proBNP levels and the risk of atrial fibrillation after major lung resection
    A M Gurgo
    Division of Cardiology Sant Andrea Policlinic, II Faculty od Medicine La Sapienza University, Rome, Italy
    Minerva Cardioangiol 56:581-5. 2008
    ..The authors tested the hypothesis that elevated preoperative plasma levels of N-terminal brain-type natriuretic peptide (NT-pro-BNP) may predict the occurrence of postoperative AF...
  80. ncbi request reprint Angiotensin-II receptor blockers: benefits beyond blood pressure reduction?
    M Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, and IRCCS Neuromed Pozzilli IS, Italy
    J Hum Hypertens 19:331-9. 2005
    ....
  81. ncbi request reprint Angiotensin II AT2 subtype receptors: an emerging target for cardiovascular therapy
    M Volpe
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Ital Heart J 1:96-103. 2000
    ....
  82. doi request reprint Role of the renin-angiotensin-aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction
    Sebastiano Sciarretta
    Department of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, S Andrea Hospital, Via di Grottarossa 1035 1039, 00100 Rome, Italy
    Clin Sci (Lond) 116:467-77. 2009
    ....
  83. ncbi request reprint Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists
    Francesco Cosentino
    Division of Cardiology, 2nd Faculty of Medicine, University La Sapienza, Rome, Italy
    Am J Hypertens 18:493-9. 2005
    ..Growing evidence shows the existence of cross-talk between the Ang II receptor subtypes, which is revealed by AT1R blockade. Hence, under certain conditions, AT2R may act as an antagonistic system with respect to the AT1R...
  84. doi request reprint Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure
    Angelo Scuteri
    UO Geriatria, INRCA IRCCS, Via Cassia 1167, Rome, Italy
    Eur Heart J 30:1525-9. 2009
    ..This study was designed to explore whether left ventricular mass index (LVMI) is associated with cognitive decline and dementia in elderly subjects, independently of blood pressure (BP) levels...
  85. doi request reprint Association of renal damage with cardiovascular diseases is independent of individual cardiovascular risk profile in hypertension: data from the Italy - Developing Education and awareness on MicroAlbuminuria in patients with hypertensive Disease study
    Sebastiano Sciarretta
    II Faculty of Medicine, University of Rome Sapienza, Division of Cardiology, S Andrea Hospital, Rome, Italy
    J Hypertens 28:251-8. 2010
    ..The aim of the present study was to evaluate whether preclinical renal damage is associated with cardiovascular diseases independently of individual risk profile assessed by risk charts...
  86. pmc Lack of Influence of the Androgen Receptor Gene CAG-Repeat Polymorphism on Clinical and Electrocardiographic Manifestations of the Brugada Syndrome in Man
    S Mariani
    Department of Experimental Medicine, Section of Medical Physiopathology and Endocrinology, Sapienza University of Rome, Italy
    Clin Med Insights Cardiol 6:145-52. 2012
    ..We investigated whether the hormonal pattern and the variation within CAG repeat polymorphism in exon 1 of the androgen receptor (AR) gene, affecting androgen sensitivity, are associated with the Brugada ECG phenotype in males...
  87. doi request reprint Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage
    S Mennuni
    Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S Andrea, Rome, Italy
    J Hum Hypertens 28:74-9. 2014
    ....
  88. ncbi request reprint A protective role of a cholesteryl ester transfer protein gene variant towards ischaemic stroke in Sardinians
    G Quarta
    Department of Cardiology, IInd School of Medicine, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
    J Intern Med 262:555-61. 2007
    ..This population has been previously shown to be a highly conservative sample...
  89. ncbi request reprint Etiology and pathophysiology of stroke as a complex trait
    S Rubattu
    IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli Isernia, Rome, Italy
    Am J Hypertens 13:1139-48. 2000
    ....
  90. ncbi request reprint Beta2-adrenergic receptor gene polymorphisms and risk of ischemic stroke
    Rosita Stanzione
    Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, University La Sapienza, Rome, Italy
    Am J Hypertens 20:657-62. 2007
    ..Beta2-adrenergic receptors (beta2-AR) mediate vasorelaxation in response to adrenergic agents. Genetic polymorphisms of beta2-AR were implicated in various cardiovascular and noncardiovascular traits...
  91. doi request reprint p66(Shc) protein, oxidative stress, and cardiovascular complications of diabetes: the missing link
    Pietro Francia
    Cardiology, 2nd Faculty of Medicine, Sapienza University of Rome, Sant Andrea Hospital, Via di Grottarossa, 1035 39, 00189, Rome, Italy
    J Mol Med (Berl) 87:885-91. 2009
    ..The present review focuses on the reported evidence linking p66(Shc) signaling pathway to high glucose-associated endothelial dysfunction, atherogenesis, nephropathy, and cardiomyopathy...
  92. ncbi request reprint Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin
    Pietro Francia
    Division of Cardiology, 2nd Faculty of Medicine, University La Sapienza, Sant Andrea Hospital, Rome, Italy
    Eur J Heart Fail 9:306-9. 2007
    ..Apelin, the endogenous ligand of the APJ receptor, is under evaluation for its potential role in human CHF pathophysiology. This study aims to assess whether biventricular pacing affects plasma apelin levels in patients with severe CHF...
  93. doi request reprint Update on phase II studies of erythropoietin in acute myocardial infarction. Rationale and design of Exogenous erythroPoietin in Acute Myocardial Infarction: New Outlook aNd Dose Association Study (EPAMINONDAS)
    Felicita Andreotti
    Institute of Cardiology, Department of Cardiovascular Medicine, A Gemelli University Hospital, Largo Gemelli 8, 00168, Rome, Italy
    J Thromb Thrombolysis 28:489-95. 2009
    ..The results of current phase II studies will help define the safety/efficacy profile of Epo for patients with STEMI...
  94. ncbi request reprint Physicians, patients, and public knowledge and perception regarding hypertension and stroke: a review of survey studies
    Massimo Volpe
    University of Rome La Sapienza, Rome and IRCCS Neuromed, Pozzilli, Italy
    Curr Med Res Opin 22:1319-30. 2006
    ..There is a lack of clear understanding of the current state of knowledge, attitudes, and perceptions about hypertension and stroke among patients, the public, and physicians...
  95. doi request reprint Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases
    Speranza Rubattu
    Department of Cardiology, II School of Medicine, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
    Am J Hypertens 21:733-41. 2008
    ..This review deals with the major relevant findings related to the cardiovascular and metabolic effects of natriuretic peptides, to their potential therapeutic use, and to their role in mediating cardiovascular diseases...
  96. ncbi request reprint Independent association of ECG abnormalities with microalbuminuria and renal damage in hypertensive patients without overt cardiovascular disease: data from Italy-Developing Education and awareness on MicroAlbuminuria in patients with hypertensive
    Sebastiano Sciarretta
    Second School of Medicine, University of Rome Sapienza, S Andrea Hospital, Rome, Italy
    J Hypertens 27:410-7. 2009
    ..This study investigated the relationship between ECG abnormalities and microalbuminuria (MAU) in hypertensive patients without overt cardiovascular disease. This relationship, in fact, has never been extensively studied...
  97. ncbi request reprint The renin-angiotensin system as a risk factor and therapeutic target for cardiovascular and renal disease
    Massimo Volpe
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Italy
    J Am Soc Nephrol 13:S173-8. 2002
    ....
  98. doi request reprint Evaluation of systolic properties in hypertensive patients with different degrees of diastolic dysfunction and normal ejection fraction
    Sebastiano Sciarretta
    Cardiology Department, II School of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    Am J Hypertens 22:437-43. 2009
    ..We performed a multiparametric echocardiographic assessment of LV systolic properties in patients without cardiovascular diseases, with preserved EF and different degrees of DD...
  99. doi request reprint Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results
    Alessandro Boccanelli
    Department of Cardiovascular Diseases, San Giovanni Addolorata Hospital, Roma, Italy
    Eur J Heart Fail 11:68-76. 2009
    ..Aldosterone receptor antagonists improve outcome in severe HF, but no information is available in NYHA class II...