M Volpe

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi Markers of inflammation and fibrosis are related to cardiovascular damage in hypertensive patients with metabolic syndrome
    Sebastiano Sciarretta
    Cardiology Department, II School of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    Am J Hypertens 20:784-91. 2007
  2. ncbi Microalbuminuria screening in patients with hypertension: recommendations for clinical practice
    M Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Int J Clin Pract 62:97-108. 2008
  3. ncbi [Strategies for improving blood pressure control in Italy: from global cardiovascular risk stratification to combination therapy. 2012 Position paper of the Italian Society of Hypertension]
    Massimo Volpe
    Cattedra e Struttura Complessa di Cardiologia, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Azienda Ospedaliera Sant Andrea, Roma
    G Ital Cardiol (Rome) 13:853-60. 2012
  4. ncbi [Renal denervation for the treatment of resistant hypertension: definition, patient selection and description of the procedure. 2012 Position paper of the Italian Society of Hypertension]
    Massimo Volpe
    Cattedra e Struttura Complessa di Cardiologia, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Azienda Ospedaliera Sant Andrea, Roma
    G Ital Cardiol (Rome) 13:846-52. 2012
  5. ncbi A New Option for Therapeutic Management of Patients with Cardiovascular Disease : A Closer Look at the ONTARGET Study
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, Rome, 1035 39, 00189, Italy
    High Blood Press Cardiovasc Prev 15:47-51. 2008
  6. ncbi 2008 white paper for implementing strategies and interventions for cardiovascular prevention in Italy
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, Rome, 1035 39, 00189, Italy
    High Blood Press Cardiovasc Prev 15:63-73. 2008
  7. ncbi Cardiovascular risk in hypertension - can we ask for more? : focus on aliskiren
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, Rome, 00189, Italy
    High Blood Press Cardiovasc Prev 15:255-68. 2008
  8. ncbi A New Option for Therapeutic Management of Patients with Cerebrovascular Disease : A Closer Look at the PRoFESS Trial
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 15:105-7. 2008
  9. ncbi Renal artery denervation for treating resistant hypertension : definition of the disease, patient selection and description of the procedure
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant Andrea Hospital, and IRCCS Neuromed, Rome, Via di Grottarossa 1035 39, 00189, Pozzilli, Isernia, Rome, Italy
    High Blood Press Cardiovasc Prev 19:237-44. 2012
  10. ncbi β-Blockers and Diuretics in the Treatment of Hypertension : 'A Friendly Fire?'
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 39, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 15:109-11. 2008

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi Markers of inflammation and fibrosis are related to cardiovascular damage in hypertensive patients with metabolic syndrome
    Sebastiano Sciarretta
    Cardiology Department, II School of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    Am J Hypertens 20:784-91. 2007
    ..This issue has not been clarified yet in patients with MS. The aim of our study was to investigate the relationship between markers of inflammation and fibrosis with CD in hypertensive patients with and without MS...
  2. ncbi Microalbuminuria screening in patients with hypertension: recommendations for clinical practice
    M Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Int J Clin Pract 62:97-108. 2008
    ..In addition, pharmacoeconomic studies have shown that these long-term benefits translate into a substantially reduced burden on healthcare resources...
  3. ncbi [Strategies for improving blood pressure control in Italy: from global cardiovascular risk stratification to combination therapy. 2012 Position paper of the Italian Society of Hypertension]
    Massimo Volpe
    Cattedra e Struttura Complessa di Cardiologia, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Azienda Ospedaliera Sant Andrea, Roma
    G Ital Cardiol (Rome) 13:853-60. 2012
    ..The present document of the Italian Society of Hypertension aims to provide main indications for implementing combination therapy in the clinical management of hypertension in order to improve blood pressure control in Italy...
  4. ncbi [Renal denervation for the treatment of resistant hypertension: definition, patient selection and description of the procedure. 2012 Position paper of the Italian Society of Hypertension]
    Massimo Volpe
    Cattedra e Struttura Complessa di Cardiologia, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Azienda Ospedaliera Sant Andrea, Roma
    G Ital Cardiol (Rome) 13:846-52. 2012
    ....
  5. ncbi A New Option for Therapeutic Management of Patients with Cardiovascular Disease : A Closer Look at the ONTARGET Study
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, Rome, 1035 39, 00189, Italy
    High Blood Press Cardiovasc Prev 15:47-51. 2008
    ....
  6. ncbi 2008 white paper for implementing strategies and interventions for cardiovascular prevention in Italy
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, Rome, 1035 39, 00189, Italy
    High Blood Press Cardiovasc Prev 15:63-73. 2008
    ..These proposals are listed, and briefly discussed, leading to the development of a 'call-to-action', aimed at reducing the incidence of cardiovascular diseases and their impact on the healthcare system, even in the short to medium term...
  7. ncbi Cardiovascular risk in hypertension - can we ask for more? : focus on aliskiren
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, Rome, 00189, Italy
    High Blood Press Cardiovasc Prev 15:255-68. 2008
    ....
  8. ncbi A New Option for Therapeutic Management of Patients with Cerebrovascular Disease : A Closer Look at the PRoFESS Trial
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 15:105-7. 2008
    ....
  9. ncbi Renal artery denervation for treating resistant hypertension : definition of the disease, patient selection and description of the procedure
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant Andrea Hospital, and IRCCS Neuromed, Rome, Via di Grottarossa 1035 39, 00189, Pozzilli, Isernia, Rome, Italy
    High Blood Press Cardiovasc Prev 19:237-44. 2012
    ....
  10. ncbi β-Blockers and Diuretics in the Treatment of Hypertension : 'A Friendly Fire?'
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 39, 00189, Rome, Italy
    High Blood Press Cardiovasc Prev 15:109-11. 2008
    ....
  11. ncbi Global cardiovascular risk management in primary prevention
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Via di Grottarossa 1035 39, 00189 Rome, Italy
    Curr Vasc Pharmacol 10:709-11. 2012
    ....
  12. ncbi Preventing cardiovascular events with angiotensin II receptor blockers: a closer look at telmisartan and valsartan
    Massimo Volpe
    Department of Clinical and Molecular Science, Division of Cardiology, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    Expert Rev Cardiovasc Ther 10:1061-72. 2012
    ..Few head-to-head comparisons between telmisartan and valsartan have been performed. However, some blood pressure-independent properties of these two ARBs can be scrutinized from separate studies in the available literature...
  13. ncbi [Polytherapy in cardiovascular prevention: open issues]
    Massimo Volpe
    Divisione di Cardiologia, Departimento di Medicina Clinica e Molecolare, Universita di Roma Sapienza, Ospedale Sant Andrea, Roma
    G Ital Cardiol (Rome) 13:503-10. 2012
    ..This present article proposes a critical analysis of some open issues related to polytherapy in cardiovascular prevention...
  14. ncbi Rationale for triple fixed-dose combination therapy with an angiotensin II receptor blocker, a calcium channel blocker, and a thiazide diuretic
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, University of Rome, Sapienza, Sant Andrea Hospital, Rome, Italy
    Vasc Health Risk Manag 8:371-80. 2012
    ..The availability of these fixed-dose combinations should lead to improvement in blood pressure control and aid compliance with long-term therapy, optimizing the management of this chronic condition...
  15. ncbi Cardiovascular risk assessment beyond Systemic Coronary Risk Estimation: a role for organ damage markers
    Massimo Volpe
    Cardiology Department of Clinical and Molecular Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 30:1056-64. 2012
    ..Inclusion of organ damage markers in the assessment may thus contribute to improve this process...
  16. ncbi Renin as a biomarker of cardiovascular disease in clinical practice
    M Volpe
    Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome Sapienza, S Andrea Hospital, Rome, Italy
    Nutr Metab Cardiovasc Dis 22:312-7. 2012
    ..With the new advances of pharmacological treatment acting on the RAAS, the effect of elevated levels of renin on the prognosis of these patients becomes even more intriguing...
  17. ncbi Inhibition of the renin-angiotensin-aldosterone system: is there room for dual blockade in the cardiorenal continuum?
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome La Sapienza, Rome, Italy
    J Hypertens 30:647-54. 2012
    ..In this review, we revisited potential advantages of dual blockade of renin-angiotensin-aldosterone system in arterial hypertension and diabetes...
  18. ncbi Effort angina in a patient with advanced coronary artery disease. Role played by coronary angiography, Ivus and cardiac CT: case report
    Domenico M Zardi
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Cardiovasc Ultrasound 6:48. 2008
    ..This additional diagnosis promptly resulted in a therapeutic approach with percutaneous transluminal coronary angioplasty (PTCA)...
  19. ncbi Antihypertensive therapy in diabetes: the legacy effect and RAAS blockade
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, 00189 Rome, Italy
    Curr Hypertens Rep 13:318-24. 2011
    ..This review article critically discusses current evidence and explores the rationale for a legacy effect of RAAS blockade in hypertensive patients with diabetes...
  20. ncbi 2010 position paper of the Italian Society of Hypertension (SIIA): angiotensin receptor blockers and risk of cancer
    Massimo Volpe
    Hypertension Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    High Blood Press Cardiovasc Prev 18:37-40. 2011
    ....
  21. ncbi Efficacy and safety of a stepped-care regimen using olmesartan medoxomil, amlodipine and hydrochlorothiazide in patients with moderate-to-severe hypertension: an open-label, long-term study
    Massimo Volpe
    Specialty School of Cardiology, University of Rome La Sapienza, Rome, Italy
    Clin Drug Investig 29:381-91. 2009
    ..This long-term open-label study assessed a treatment algorithm based on olmesartan medoxomil (hereafter olmesartan), amlodipine and hydrochlorothiazide (HCTZ)...
  22. ncbi 2007 ESH/ESC Guidelines for the management of hypertension, from theory to practice: global cardiovascular risk concept
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens Suppl 27:S3-11. 2009
    ..This synergistic approach holds the best promise for treating total cardiovascular risk and reducing the mounting global burden of cardiovascular disease associated with hypertension...
  23. ncbi Prediction of long-term survival in chronic heart failure by multiple biomarker assessment: a 15-year prospective follow-up study
    Massimo Volpe
    Cardiology, Department of Clinical and Molecular Medicine, 2nd Faculty of Medicine, Sapienza University, Rome, Italy
    Clin Cardiol 33:700-7. 2010
    ..However, their long-term predictive value in the context of other candidate predictors has never been assessed. This information may prove valuable in the management of a chronic disease with a long natural history, as CHF is today...
  24. ncbi Antihypertensive therapy and cerebrovascular protection
    Massimo Volpe
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Curr Opin Nephrol Hypertens 15:498-504. 2006
    ..High blood pressure is the most relevant modifiable risk factor for developing stroke...
  25. ncbi Challenging hypertension: how to diagnose and treat resistant hypertension in daily clinical practice
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 9, 00189 Rome, Italy
    Expert Rev Cardiovasc Ther 8:811-20. 2010
    ..In this article, we will review and discuss the definition, pathophysiological mechanisms, diagnostic algorithms and potential new therapeutic options for treating resistant hypertension...
  26. ncbi Angiotensin II receptor blockers and myocardial infarction: deeds and misdeeds
    Massimo Volpe
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza Sant Andrea Hospital, Rome
    J Hypertens 23:2113-8. 2005
    ....
  27. ncbi Efficacy and tolerability of olmesartan medoxomil combined with amlodipine in patients with moderate to severe hypertension after amlodipine monotherapy: a randomized, double-blind, parallel-group, multicentre study
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Clin Drug Investig 29:11-25. 2009
    ....
  28. ncbi Integrated cardiovascular risk management for the future: lessons learned from the ASCOT trial
    Massimo Volpe
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Aging Clin Exp Res 17:46-53. 2005
    ....
  29. ncbi The challenge of polypharmacy in cardiovascular medicine
    Massimo Volpe
    Cardiology Department, IInd School of Medicine, University of Rome Sapienza, S Andrea Hospital, Rome, Italy
    Fundam Clin Pharmacol 24:9-17. 2010
    ..However, large randomized trials are required to define its impact on clinical outcomes. This review will focus on challenges of polypharmacy in CV medicine, illustrating potential options to face this emerging crisis...
  30. ncbi Redefining blood pressure targets in high-risk patients?: lessons from coronary endpoints in recent randomized clinical trials
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Rome, Italy
    Am J Hypertens 24:1060-8. 2011
    ..Our conclusions highlight the importance of a closer scrutiny for coronary artery disease and suggest caution in lowering BP levels aggressively in patients with high-risk profile or diabetes...
  31. ncbi Managing cardiovascular risk: the need for change
    M Volpe
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant'Andrea Hospital and IRCCS Neuromed-Pozzilli, IS, Italy
    J Hum Hypertens 22:154-7. 2008
  32. ncbi Direct renin inhibition: from pharmacological innovation to novel therapeutic opportunities
    Massimo Volpe
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University of Rome Sapienza, Sant Andrea Hospital, Italy
    High Blood Press Cardiovasc Prev 18:93-105. 2011
    ....
  33. ncbi Should all patients at high cardiovascular risk receive renin-angiotensin system blockers?
    M Volpe
    Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant Andrea Hospital, Via di Grottarossa 1035 9, 00189 Rome, Italy
    QJM 105:11-27. 2012
    ..This extensive clinical trial evidence suggests that ACE inhibitors or ARBs should be part of the standard treatment for patients at risk of CV events. ARBs may represent a preferred option due to their unsurpassed tolerability...
  34. ncbi Reduction in estimated stroke risk associated with practice-based stroke-risk assessment and awareness in a large, representative population of hypertensive patients: results from the ForLife study in Italy
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 25:2390-7. 2007
    ..Data from a subsequent visit within 6 months, to evaluate the impact of systematic stroke risk assessment, are reported...
  35. ncbi Therapeutic implications of recent megatrials in hypertension: in favor of new drugs
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome and IRCCS Neuromed, Pozzilli, Isernia Italy
    J Nephrol 20:S12-8. 2007
    ....
  36. ncbi Hypertension as an underlying factor in heart failure with preserved ejection fraction
    Massimo Volpe
    Faculty of Medicine, University of Roma La Sapienza, Rome, Italy
    J Clin Hypertens (Greenwich) 12:277-83. 2010
    ..The deleterious effects of hypertension on mechanisms underlying the development of HF-PEF underscore the importance of effective and early control of hypertension for the prevention of HF-PEF...
  37. ncbi Blood pressure control in Italy: results of recent surveys on hypertension
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 25:1491-8. 2007
    ..Blood pressure (BP) control is reported to be poor in hypertensive patients worldwide...
  38. ncbi Managing hypertension in cardiology practice according to risk profile
    M Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Pozzilli, IS, Italy
    Int J Clin Pract 62:1403-12. 2008
    ....
  39. ncbi Angiotensin II receptor blockers and myocardial infarction: an updated analysis of randomized clinical trials
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 27:941-6. 2009
    ..To evaluate the effects of treatments based on angiotensin II receptor blockers (ARBs) on the risk of myocardial infarction (MI), cardiovascular and all-cause death, as compared with conventional treatment or placebo...
  40. ncbi Global cardiovascular risk management in different Italian regions: an analysis of the Evaluation of Final Feasible Effect of Control Training and Ultra Sensitisation (EFFECTUS) educational program
    G Tocci
    Chair and Division of Cardiology, II Faculty of Medicine, University Sapienza, Sant Andrea Hospital, Rome, Italy
    Nutr Metab Cardiovasc Dis 22:635-42. 2012
    ..The present study evaluates differences on clinical approach to global CV risk among physicians involved in the EFFECTUS program and stratified in three geographical macro-areas (North, Center, South) of our Country...
  41. ncbi Management of hypertension and stroke prevention: results of the Italian cardiologist survey
    G Tocci
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Int J Clin Pract 63:207-16. 2009
    ..To provide an overview of current habits, priorities, perceptions and knowledge of cardiologists with regard to hypertension and stroke prevention in outpatient practice...
  42. ncbi Differential brain atrial natriuretic peptide expression co-segregates with occurrence of early stroke in the stroke-prone phenotype of the spontaneously hypertensive rat
    S Rubattu
    Istituto Neurologico Mediterraneo Neuromed, Pozzilli Is, Department of Pathology and Experimental Medicine, University La Sapienza, Rome, Italy
    J Hypertens 17:1849-52. 1999
    ....
  43. ncbi Hypertension therapy: mixing, matching, and meeting targets
    Massimo Volpe
    Faculty of Medicine, University of Rome La Sapienza, Osp. Sant'Andrea-IRCCS Neuromed-Pozzilli (IS, Rome, Italy
    Adv Ther 21:107-22. 2004
    ..In addition, angiotensin-receptor blocker/diuretic combinations may have cardiovascular benefits beyond those from blood pressure lowering itself...
  44. ncbi Impact of physicians' age on the clinical management of global cardiovascular risk: analysis of the results of the Evaluation of Final Feasible Effect of Control Training and Ultra Sensitisation Educational Programme
    G Tocci
    Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine, University Sapienza, Sant Andrea Hospital, Rome, Italy
    Int J Clin Pract 65:649-57. 2011
    ..To evaluate the potential impact of physicians' age on global cardiovascular (CV) risk management in the population of the Evaluation of Final Feasible Effect of Ultra Control Training and Sensitisation (EFFECTUS) study...
  45. ncbi Bridging science and health policy in cardiovascular disease: focus on lipid management: A Report from a Session held during the 7th International Symposium on Multiple Risk Factors in Cardiovascular Diseases: Prevention and Intervention--Health Policy, i
    V Atella
    Department of Economics, University of Rome Tor Vergata, Rome, Italy
    Atheroscler Suppl 10:3-21. 2009
    ..Failure to bridge the gap between science and health policy, particularly in relation to lipid management, could result in missed opportunities to reverse the burgeoning epidemic of CVD in Europe...
  46. ncbi Reduced levels of N-terminal-proatrial natriuretic peptide in hypertensive patients with metabolic syndrome and their relationship with left ventricular mass
    Speranza Rubattu
    U O Cardiologia, IInd School of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    J Hypertens 25:833-9. 2007
    ..We aimed to assess the ANP levels and their relationship with left ventricular mass (LVM) in patients affected by MS...
  47. ncbi Treatment of systolic hypertension: spotlight on recent studies with angiotensin II antagonists
    M Volpe
    Cattedra di Cardiologia, II Facolta di Medicina e Chirurgia, Universita di Roma La Sapienza, Rome, Italy
    J Hum Hypertens 19:93-102. 2005
    ..This, in patients with ISH, AII antagonists more facilitate systolic BP control, providing cardiovascular protection and offering an excellent risk-benefit profile...
  48. ncbi Genetic susceptibility to cerebrovascular accidents
    S Rubattu
    Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Isernia, Italy
    J Cardiovasc Pharmacol 38:S71-4. 2001
    ....
  49. ncbi Treatment priorities and current prescribing patterns in hypertension: results of GRASP, an international physician survey
    Massimo Volpe
    Second Faculty of Medicine and Sant'Andrea Hospital, University of Rome La Sapienza, Rome, Italy
    Curr Med Res Opin 20:1151-60. 2004
    ..The results of GRASP confirm the desirability of research to identify methods and strategies that will facilitate the integration of clinical trial results into general practice treatment of hypertension...
  50. ncbi Antihypertensive strategy based on angiotensin II receptor blockers: a new gateway to reduce risk in hypertension
    Giuliano Tocci
    University La Sapienza of Rome, Cardiology, II Faculty of Medicine, Sant Andrea Hospital, Rome, Italy
    Expert Rev Cardiovasc Ther 5:767-76. 2007
    ..This review highlights the evidence derived from recent clinical trials, supporting a role for pharmacological strategies based on ARBs in primary and secondary prevention of cardiovascular and renal disease...
  51. ncbi Multivariate risk assessment and risk score cards in hypertension
    Giuliano Tocci
    Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Vasc Health Risk Manag 3:313-20. 2007
    ....
  52. ncbi Cerebrovascular disease in women
    Massimo Volpe
    Dipartimento di Medicina Sperimentale e Patologia, Universita degli Studi di Roma La Sapienza, Rome, Italy
    J Hypertens Suppl 20:S39-43. 2002
    ..In addition, emerging pathophysiological, clinical and therapeutic issues confer specific characteristics to stroke in women. This article briefly covers some of the most important of these aspects...
  53. ncbi Angiotensin II: an amplifier of cardiovascular risk
    Massimo Volpe
    Division of Cardiology, 2nd Faculty of Medicine, University of Rome--La Sapienza, S. Andrea Hospital, Via di Grottarossa, 1035-00159 Rome, Italy
    Curr Hypertens Rep 6:247-8. 2004
  54. ncbi Angiotensin II AT2 receptor subtype: an uprising frontier in cardiovascular disease?
    Massimo Volpe
    Cattedra di Cardiologia, II Facolta di Medicina, Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    J Hypertens 21:1429-43. 2003
    ....
  55. ncbi Comparison of the blood pressure-lowering effects and tolerability of Losartan- and Amlodipine-based regimens in patients with isolated systolic hypertension
    Massimo Volpe
    Universita degli Studi di Roma La Sapienza, Rome, Italy
    Clin Ther 25:1469-89. 2003
    ..Isolated systolic hypertension (ISH) is the predominant form of hypertension in the elderly. Effects of angiotensin II on the vascular wall and endothelium may contribute to development of ISH...
  56. ncbi Is it time to measure microalbuminuria in hypertension?
    Massimo Volpe
    Division of Cardiology, 2nd Faculty of Medicine, University of Rome La Sapienza, Italy
    J Hypertens 21:1213-20. 2003
    ..Upcoming new guidelines and diagnostic algorithms in hypertension need to underscore the clinical positioning of microalbuminuria for stratification of risk and follow-up purposes...
  57. ncbi Development of heart failure in recent hypertension trials
    Giuliano Tocci
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 26:1477-86. 2008
    ..Heart failure represents a major cause of disease burden worldwide and is expected to further rise in the coming decades. Hypertension is the clinical condition most frequently associated to heart failure...
  58. ncbi Coronary artery fistula from the circumflex artery to the left atrium: invasive and non-invasive imaging techniques
    Luciano De Biase
    , Rome, Italy
    J Cardiovasc Med (Hagerstown) 9:320-2. 2008
  59. ncbi Fixed-combination therapies in hypertension management: focus on enalapril/lercanidipine
    Giuliano Tocci
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa, 1035 1039, 00189 Rome, Italy
    Expert Rev Cardiovasc Ther 7:115-23. 2009
    ....
  60. ncbi Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant
    Speranza Rubattu
    IRCCS Neuromed, Pozzilli Is, Department of Cardiology, IInd School of Medicine, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
    J Hypertens 22:2129-34. 2004
    ..In the present study we characterized the contributory role of RAAS genes in the susceptibility to develop ischemic stroke in humans...
  61. ncbi The cardiovascular continuum refined: A hypothesis
    Massimo Volpe
    University of Roma La Sapienza Sant Andrea Hospital, Italy
    Blood Press 19:273-7. 2010
    ..The combination of proteomic biomarkers with clinical phenotypes and genetic haplotype information may also aid prognosis of individual cardiovascular risk in a near future...
  62. ncbi Beyond hypertension toward guidelines for cardiovascular risk reduction
    Massimo Volpe
    Department of Cardiology, II Faculty of Medicine, University of Rome La Sapienza Rome, Rome, Italy
    Am J Hypertens 17:1068-74. 2004
    ..We propose that global risk should be used as the main determinant of whom to treat, how to treat, and how much to treat...
  63. ncbi Hypertension and heart failure: role of neurohormonal mechanisms
    Massimo Volpe
    2nd Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    Clin Exp Hypertens 26:603-10. 2004
    ..This article synthetically reviews this aspect together with a specific analysis of the significance of measurements of neurohormones for diagnosis and prognostic stratification in heart failure...
  64. ncbi Fewer mega-trials and more clinically oriented studies in hypertension research? The case of blocking the renin-angiotensin-aldosterone system
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Via di Grottarossa 1035 9, 00189 Rome, Italy
    J Am Soc Nephrol 17:S36-43. 2006
    ....
  65. ncbi Angiotensin II-receptor antagonist in the treatment of hypertension
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Ospedale Sant Andrea, Via di Grottarossa, 1035 39, 00189 Rome, Italy
    Curr Hypertens Rep 7:287-93. 2005
    ..In this article, we provide some evidence derived from these trials, supporting a role for ARBs in primary and secondary prevention of cardiovascular and renal disease, beyond blood pressure control...
  66. ncbi [Activation of the renin-angiotensin-aldosterone system in heart failure]
    Massimo Volpe
    Divisione di Cardiologia, II Facolta di Medicina, Universita degli Studi La Sapienza, Ospedale S Andrea, Roma
    Ital Heart J 6:16S-23S. 2005
    ..This article reviews the current knowledge on the biochemical and functional organization of the RAAS, its pathophysiological role in CHF, and the potential therapeutic implications...
  67. ncbi IGF-1 and atherothrombosis: relevance to pathophysiology and therapy
    Elena Conti
    Cardiology Division, Department of Clinical and Molecular Medicine, II Faculty of Medicine of Rome Sapienza, Rome, Italy
    Clin Sci (Lond) 120:377-402. 2011
    ..Perhaps the time has come for the regenerative properties of IGF-1 to be assessed as a new pharmacological tool in cardiovascular medicine...
  68. ncbi Plasma NT-proBNP levels and the risk of atrial fibrillation after major lung resection
    A M Gurgo
    Division of Cardiology Sant Andrea Policlinic, II Faculty od Medicine La Sapienza University, Rome, Italy
    Minerva Cardioangiol 56:581-5. 2008
    ..The authors tested the hypothesis that elevated preoperative plasma levels of N-terminal brain-type natriuretic peptide (NT-pro-BNP) may predict the occurrence of postoperative AF...
  69. ncbi Angiotensin-II receptor blockers: benefits beyond blood pressure reduction?
    M Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, and IRCCS Neuromed Pozzilli IS, Italy
    J Hum Hypertens 19:331-9. 2005
    ....
  70. ncbi Angiotensin II AT2 subtype receptors: an emerging target for cardiovascular therapy
    M Volpe
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Ital Heart J 1:96-103. 2000
    ....
  71. ncbi Association of renal damage with cardiovascular diseases is independent of individual cardiovascular risk profile in hypertension: data from the Italy - Developing Education and awareness on MicroAlbuminuria in patients with hypertensive Disease study
    Sebastiano Sciarretta
    II Faculty of Medicine, University of Rome Sapienza, Division of Cardiology, S Andrea Hospital, Rome, Italy
    J Hypertens 28:251-8. 2010
    ..The aim of the present study was to evaluate whether preclinical renal damage is associated with cardiovascular diseases independently of individual risk profile assessed by risk charts...
  72. ncbi Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure
    Angelo Scuteri
    UO Geriatria, INRCA IRCCS, Via Cassia 1167, Rome, Italy
    Eur Heart J 30:1525-9. 2009
    ..This study was designed to explore whether left ventricular mass index (LVMI) is associated with cognitive decline and dementia in elderly subjects, independently of blood pressure (BP) levels...
  73. ncbi Role of the renin-angiotensin-aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction
    Sebastiano Sciarretta
    Department of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, S Andrea Hospital, Via di Grottarossa 1035 1039, 00100 Rome, Italy
    Clin Sci (Lond) 116:467-77. 2009
    ....
  74. ncbi Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists
    Francesco Cosentino
    Division of Cardiology, 2nd Faculty of Medicine, University La Sapienza, Rome, Italy
    Am J Hypertens 18:493-9. 2005
    ..In view of this, our study highlights the importance of the integrated Ang II receptor network, which may help to define further the mechanisms of the well-established vascular protective effects of AT1R blockers...
  75. ncbi A protective role of a cholesteryl ester transfer protein gene variant towards ischaemic stroke in Sardinians
    G Quarta
    Department of Cardiology, IInd School of Medicine, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
    J Intern Med 262:555-61. 2007
    ..This population has been previously shown to be a highly conservative sample...
  76. ncbi Recombinant human insulin-like growth factor-1: a new cardiovascular disease treatment option?
    E Conti
    Cardiology Department, II Faculty of Medicine, University of Rome La Sapienza, Rome, Ospedale Sant Andrea, Italy
    Cardiovasc Hematol Agents Med Chem 6:258-71. 2008
    ..In view of its ability to improve flow-metabolism coupling, IGF-1 could indeed represent a new cardiovascular disease treatment option for many cardiac disorders such as ischemic heart disease and heart failure...
  77. ncbi Etiology and pathophysiology of stroke as a complex trait
    S Rubattu
    IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli Isernia, Rome, Italy
    Am J Hypertens 13:1139-48. 2000
    ....
  78. ncbi p66(Shc) protein, oxidative stress, and cardiovascular complications of diabetes: the missing link
    Pietro Francia
    Cardiology, 2nd Faculty of Medicine, Sapienza University of Rome, Sant Andrea Hospital, Via di Grottarossa, 1035 39, 00189, Rome, Italy
    J Mol Med (Berl) 87:885-91. 2009
    ..The present review focuses on the reported evidence linking p66(Shc) signaling pathway to high glucose-associated endothelial dysfunction, atherogenesis, nephropathy, and cardiomyopathy...
  79. ncbi Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin
    Pietro Francia
    Division of Cardiology, 2nd Faculty of Medicine, University La Sapienza, Sant Andrea Hospital, Rome, Italy
    Eur J Heart Fail 9:306-9. 2007
    ..Apelin, the endogenous ligand of the APJ receptor, is under evaluation for its potential role in human CHF pathophysiology. This study aims to assess whether biventricular pacing affects plasma apelin levels in patients with severe CHF...
  80. ncbi Physicians, patients, and public knowledge and perception regarding hypertension and stroke: a review of survey studies
    Massimo Volpe
    University of Rome 'La Sapienza, Rome and IRCCS Neuromed, Pozzilli, Italy
    Curr Med Res Opin 22:1319-30. 2006
    ..Physicians worldwide need to engage in patient communication regarding hypertension, stroke, and the dangers of uncontrolled hypertension, and need to implement guideline recommendations for hypertension diagnosis and management...
  81. ncbi The renin-angiotensin system as a risk factor and therapeutic target for cardiovascular and renal disease
    Massimo Volpe
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Italy
    J Am Soc Nephrol 13:S173-8. 2002
    ....
  82. ncbi Update on phase II studies of erythropoietin in acute myocardial infarction. Rationale and design of Exogenous erythroPoietin in Acute Myocardial Infarction: New Outlook aNd Dose Association Study (EPAMINONDAS)
    Felicita Andreotti
    Institute of Cardiology, Department of Cardiovascular Medicine, A Gemelli University Hospital, Largo Gemelli 8, 00168, Rome, Italy
    J Thromb Thrombolysis 28:489-95. 2009
    ..The results of current phase II studies will help define the safety/efficacy profile of Epo for patients with STEMI...
  83. ncbi Beta2-adrenergic receptor gene polymorphisms and risk of ischemic stroke
    Rosita Stanzione
    Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, University La Sapienza, Rome, Italy
    Am J Hypertens 20:657-62. 2007
    ..Beta2-adrenergic receptors (beta2-AR) mediate vasorelaxation in response to adrenergic agents. Genetic polymorphisms of beta2-AR were implicated in various cardiovascular and noncardiovascular traits...
  84. ncbi Evaluation of systolic properties in hypertensive patients with different degrees of diastolic dysfunction and normal ejection fraction
    Sebastiano Sciarretta
    Cardiology Department, II School of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    Am J Hypertens 22:437-43. 2009
    ..We performed a multiparametric echocardiographic assessment of LV systolic properties in patients without cardiovascular diseases, with preserved EF and different degrees of DD...
  85. ncbi Independent association of ECG abnormalities with microalbuminuria and renal damage in hypertensive patients without overt cardiovascular disease: data from Italy-Developing Education and awareness on MicroAlbuminuria in patients with hypertensive
    Sebastiano Sciarretta
    Second School of Medicine, University of Rome Sapienza, S Andrea Hospital, Rome, Italy
    J Hypertens 27:410-7. 2009
    ..This study investigated the relationship between ECG abnormalities and microalbuminuria (MAU) in hypertensive patients without overt cardiovascular disease. This relationship, in fact, has never been extensively studied...
  86. ncbi Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases
    Speranza Rubattu
    Department of Cardiology, II School of Medicine, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
    Am J Hypertens 21:733-41. 2008
    ..This review deals with the major relevant findings related to the cardiovascular and metabolic effects of natriuretic peptides, to their potential therapeutic use, and to their role in mediating cardiovascular diseases...
  87. ncbi Anti-remodelling effect of canrenone in patients with mild chronic heart failure (AREA IN-CHF study): final results
    Alessandro Boccanelli
    Department of Cardiovascular Diseases, San Giovanni Addolorata Hospital, Roma, Italy
    Eur J Heart Fail 11:68-76. 2009
    ..Aldosterone receptor antagonists improve outcome in severe HF, but no information is available in NYHA class II...
  88. ncbi Endothelial dysfunction and stroke
    F Cosentino
    Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy
    J Cardiovasc Pharmacol 38:S75-8. 2001
    ..In this paper, we analyse current evidence suggesting that endothelial dysfunction can play a role in the pathogenesis of ischaemic stroke...
  89. ncbi Can primary care professionals' adherence to Evidence Based Medicine tools improve quality of care in type 2 diabetes mellitus? A systematic review
    A G de Belvis
    Department of Public Health and Preventive Medicine, Catholic University, Rome, Italy
    Diabetes Res Clin Pract 85:119-31. 2009
    ..Our aim is to review the effectiveness of EBM tools available to primary care professionals to improve the quality of Type 2 diabetes disease management...
  90. ncbi Long-term reduction of peripheral resistance with celiprolol and effects on left ventricular mass
    B Trimarco
    First Clinica Medica, Second Faculty of Medicine, University of Naples, Italy
    J Int Med Res 16:62A-72A. 1988
    ..It is generally accepted, however, that the ability of beta-blockers to reverse left ventricular hypertrophy is unrelated to the individual pharmacological characteristics of each agent...
  91. ncbi Hypertension, stroke, and endothelium
    Francesco Cosentino
    Division of Cardiology, University La Sapienza, Ospedale Sant'Andrea, Via di Grottarossa, 1035, 00189 Rome, Italy
    Curr Hypertens Rep 7:68-71. 2005
    ..In this brief review, we analyze current evidence suggesting that endothelial dysfunction can play a role in the pathogenesis of ischemic stroke...
  92. ncbi Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension
    Speranza Rubattu
    IRCCS Neuromed, Polo Molisano University of Rome La Sapienza, Pozzilli, Italy
    J Am Coll Cardiol 48:499-505. 2006
    ....
  93. ncbi Tumor necrosis factor-alpha as trigger of platelet activation in patients with heart failure
    Pasquale Pignatelli
    University of Rome La Sapienza, Divisione IV Clinica Medica, Policlinico Umberto I, Viale del Policlinico, 00185, Rome, Italy
    Blood 106:1992-4. 2005
    ..This study showed that TNF-alpha behaves as a trigger of platelet activation through stimulation of the arachidonic acid pathway...
  94. ncbi Nitric oxide release is impaired in hypertensive individuals with familial history of stroke
    Francesco Cosentino
    Division of Cardiology, 2(nd) Faculty of Medicine, University La Sapienza, Rome, Italy
    Am J Hypertens 19:1213-6. 2006
    ..Such a phenotype may represent an early marker of susceptibility to cerebrovascular events in this population...
  95. ncbi Contribution of genetic factors to renal lesions in the stroke-prone spontaneously hypertensive rat
    Bruna Gigante
    Istituto Neurologico Mediterraneo Neuromed, 86077 Pozzilli, IS, Italy
    Hypertension 42:702-6. 2003
    ..Our results demonstrate that in this intercross, susceptibility to renal damage is influenced by several genetic loci acting independently from high blood pressure levels and also shows a sexual dimorphism...
  96. ncbi Phosphodiesterase 4D and 5-lipoxygenase activating protein genes and risk of ischemic stroke in Sardinians
    Giovanni Quarta
    Department of Cardiology, University La Sapienza, Ospedale Sant Andrea, Rome
    Eur J Hum Genet 17:1448-53. 2009
    ..In conclusion, we found no evidence of association between PDE4D and ALOX5AP genes and the risk of IS in a genetically homogenous population from Sardinia...
  97. ncbi Acute anti-ischemic effect of testosterone in men with coronary artery disease
    G M Rosano
    Department of Cardiology, Istituto H San Raffaele, Roma and Milano, Italy
    Circulation 99:1666-70. 1999
    ..Accordingly, the aim of the present study was to evaluate the effect of acute administration of testosterone on exercise-induced myocardial ischemia in men...
  98. ncbi Antihypertensive treatment and development of heart failure in hypertension: a Bayesian network meta-analysis of studies in patients with hypertension and high cardiovascular risk
    Sebastiano Sciarretta
    Department of Cardiology, Second Faculty of Medicine, University of Rome La Sapienza, S Andrea Hospital, Rome, Italy
    Arch Intern Med 171:384-94. 2011
    ..It is still debated whether there are differences among the various antihypertensive strategies in heart failure prevention. We performed a network meta-analysis of recent trials in hypertension aimed at investigating this issue...
  99. ncbi Left bundle-branch block--pathophysiology, prognosis, and clinical management
    Pietro Francia
    Division of Cardiology, II Faculty of Medicine, Sant Andrea Hospital, University La Sapienza, Rome, Italy
    Clin Cardiol 30:110-5. 2007
    ..This paper reviews historical landmarks, pathophysiologic features, prognostic implications, and clinical management of LBBB in apparently healthy subjects and those with heart disease...
  100. ncbi Role of a molecular variant of rat atrial natriuretic Peptide gene in vascular remodeling
    Paola De Paolis
    Research Center, San Pietro Hospital, Rome, Italy
    Ann Clin Lab Sci 37:135-40. 2007
    ....
  101. ncbi Natriuretic peptides and cardiovascular damage in the metabolic syndrome: molecular mechanisms and clinical implications
    Carmine Savoia
    Cardiology Unit, Second Faculty of Medicine, Sant Andrea Hospital, Sapienza University of Rome, Rome, Italy
    Clin Sci (Lond) 118:231-40. 2010
    ....