Marco Volante

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Regione Gonzole10, 10043, Orbassano, Torino, Italy
    Virchows Arch 451:S61-9. 2007
  2. ncbi request reprint Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Orbassano, Turin, Italy
    Mod Pathol 20:1172-82. 2007
  3. doi request reprint Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Turin, Italy
    Am J Surg Pathol 37:606-12. 2013
  4. ncbi request reprint Extrapulmonary neuroendocrine small and large cell carcinomas: a review of controversial diagnostic and therapeutic issues
    Marco Volante
    Department of Oncology, University of Turin at San Luigi Hospital, 10043 Torino, Italy Electronic address
    Hum Pathol 45:665-73. 2014
  5. pmc DNA copy number alterations and PPARG amplification in a patient with multifocal bladder urothelial carcinoma
    Donatella Conconi
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    BMC Res Notes 5:607. 2012
  6. pmc Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte oncology network
    Maria P Brizzi
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Azienda Ospedaliera San Luigi, Regione Gonzole, 10, 10043 Orbassano TO, Italy
    BMC Cancer 9:388. 2009
  7. ncbi request reprint RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, 10043 Orbassano, Italy
    J Clin Endocrinol Metab 94:4735-41. 2009
  8. doi request reprint Increased neuroendocrine cells in resected metastases compared to primary colorectal adenocarcinomas
    Marco Volante
    University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    Virchows Arch 457:521-7. 2010
  9. doi request reprint The Weiss score and beyond--histopathology for adrenocortical carcinoma
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Horm Cancer 2:333-40. 2011
  10. doi request reprint Poorly differentiated thyroid carcinoma: diagnostic features and controversial issues
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Endocr Pathol 19:150-5. 2008

Detail Information

Publications91

  1. ncbi request reprint Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Regione Gonzole10, 10043, Orbassano, Torino, Italy
    Virchows Arch 451:S61-9. 2007
    ..Moreover, molecular and clinical aspects, which might help to understand their possible histogenesis and biological behavior, will be reviewed...
  2. ncbi request reprint Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Orbassano, Turin, Italy
    Mod Pathol 20:1172-82. 2007
    ....
  3. doi request reprint Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Turin, Italy
    Am J Surg Pathol 37:606-12. 2013
    ....
  4. ncbi request reprint Extrapulmonary neuroendocrine small and large cell carcinomas: a review of controversial diagnostic and therapeutic issues
    Marco Volante
    Department of Oncology, University of Turin at San Luigi Hospital, 10043 Torino, Italy Electronic address
    Hum Pathol 45:665-73. 2014
    ..This overview highlights controversial pathological and clinical issues and summarizes possible solutions to most of such EPNEC-related problems. ..
  5. pmc DNA copy number alterations and PPARG amplification in a patient with multifocal bladder urothelial carcinoma
    Donatella Conconi
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    BMC Res Notes 5:607. 2012
    ..Because the clinical outcome of superficial bladder tumors is relatively unpredictable, there is a pressing need to identify markers that may predict tumor recurrence and progression and new treatment strategies...
  6. pmc Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte oncology network
    Maria P Brizzi
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Azienda Ospedaliera San Luigi, Regione Gonzole, 10, 10043 Orbassano TO, Italy
    BMC Cancer 9:388. 2009
    ..A phase II study was designed to test the activity of protracted 5-fluorouracil (5FU) infusion plus long-acting release (LAR) octreotide in patients with neuroendocrine carcinoma...
  7. ncbi request reprint RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, 10043 Orbassano, Italy
    J Clin Endocrinol Metab 94:4735-41. 2009
    ..Recently homogeneous diagnostic criteria have been proposed by our group (Turin proposal) that need to be complemented by detailed molecular characterization...
  8. doi request reprint Increased neuroendocrine cells in resected metastases compared to primary colorectal adenocarcinomas
    Marco Volante
    University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    Virchows Arch 457:521-7. 2010
    ....
  9. doi request reprint The Weiss score and beyond--histopathology for adrenocortical carcinoma
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Horm Cancer 2:333-40. 2011
    ..As a complement to the morphological approach, some immunohistochemical markers (such as steroidogenic factor 1) have been proposed as diagnostic and prognostic adjuncts but still lack wide clinical validation...
  10. doi request reprint Poorly differentiated thyroid carcinoma: diagnostic features and controversial issues
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Endocr Pathol 19:150-5. 2008
    ..The present paper aims to review the various aspects of this tumor type, from morphology to immunohistochemistry and molecular abnormalities from a practical and daily practice-oriented point of view...
  11. ncbi request reprint Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas
    Marco Volante
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Orbassano, Torino, Italy
    Mod Pathol 19:1563-9. 2006
    ..In addition, a strong metalloproteinase type 2 expression in adrenocortical carcinoma was for the first time recognized as an unfavorable prognostic factor...
  12. ncbi request reprint A practical diagnostic approach to solid/trabecular nodules in the thyroid
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Regione Gonzole 10, Turin, Orbassano, Italy
    Endocr Pathol 19:75-81. 2008
    ..A schematic algorithm is presented, which takes into consideration the diagnostic hallmarks of the most relevant entities that enter in the differential diagnosis in solid/trabecular nodules within the thyroid...
  13. ncbi request reprint Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Turin, Italy
    Am J Surg Pathol 31:1256-64. 2007
    ..An algorithmic approach was devised for practical use in the diagnosis of this tumor...
  14. doi request reprint Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Endocr Pathol 21:1-6. 2010
    ....
  15. doi request reprint Clinicopathological study of a series of 92 adrenocortical carcinomas: from a proposal of simplified diagnostic algorithm to prognostic stratification
    Marco Volante
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Turin, Italy
    Histopathology 55:535-43. 2009
    ..The aim was to investigate the impact of individual pathological parameters in the diagnosis and prognosis of adrenocortical carcinoma...
  16. doi request reprint Caveolin-1 expression in lung carcinoma varies according to tumour histotype and is acquired de novo in brain metastases
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Histopathology 55:20-7. 2009
    ..To study caveolin-1 (Cav-1) expression in metastatic lung carcinomas...
  17. doi request reprint Epidermal growth factor receptor gene in primary tumor and metastatic sites from non-small cell lung cancer
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Thorac Oncol 4:684-8. 2009
    ..Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are capable of reducing brain and adrenal metastases. However, the EGFR status may be discordant between primary NSCLC and the corresponding metastases...
  18. pmc Detection and characterization of classical and "uncommon" exon 19 Epidermal Growth Factor Receptor mutations in lung cancer by pyrosequencing
    Luisella Righi
    Divisions of Pathology, University of Torino, Regione Gonzole 10, Torino, Orbassano 10043, Italy
    BMC Cancer 13:114. 2013
    ....
  19. ncbi request reprint Galectin-3 and Ki-67 expression in multiglandular parathyroid lesions
    Enrico Saggiorato
    Section of Endocrinology, University of Turin, Italy
    Am J Clin Pathol 126:59-66. 2006
    ....
  20. pmc Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth
    Marco Volante
    Departments of Pathology, Endocrinology, and Pharmacology, University of Turin, Turin
    Am J Pathol 162:645-54. 2003
    ....
  21. doi request reprint Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors
    Paolo Ceppi
    Thoracic Oncology Unit, Pathology Division, Department of Clinical and Biological Sciences, University of Torino, San Luigi Hospital, Torino, Italy
    Clin Cancer Res 14:1059-64. 2008
    ..Neuroendocrine tumors (NET) represent potential targets of antifolate agents, but no data on TS expression level in these tumors are currently available...
  22. ncbi request reprint Epidermal growth factor ligand/receptor loop and downstream signaling activation pattern in completely resected nonsmall cell lung cancer
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    Cancer 110:1321-8. 2007
    ....
  23. doi request reprint Effects of Src kinase inhibition induced by dasatinib in non-small cell lung cancer cell lines treated with cisplatin
    Paolo Ceppi
    University of Turin, Department of Clinical and Biological Sciences, San Luigi Hospital, Regione Gonzole 10, Orbassano, Italy
    Mol Cancer Ther 8:3066-74. 2009
    ..The data of this study support further clinical studies aimed to evaluate the efficacy of Src-inhibiting agents in combination with cisplatin in the treatment of NSCLC...
  24. ncbi request reprint Bone sialoprotein is predictive of bone metastases in resectable non-small-cell lung cancer: a retrospective case-control study
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
    J Clin Oncol 24:4818-24. 2006
    ..Currently, there are no predictive or diagnostic markers to identify high-risk patients for metastatic bone dissemination...
  25. doi request reprint The prognostic role of immunohistochemical chromogranin a expression in prostate cancer patients is significantly modified by androgen-deprivation therapy
    Alfredo Berruti
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Torino, Italy
    Prostate 70:718-26. 2010
    ..This study was undertaken to assess the prognostic role of tissue chromogranin A (CgA) expression in patients addressed to ADT as opposed to those who did not...
  26. doi request reprint Human ASH1 expression in prostate cancer with neuroendocrine differentiation
    Ida Rapa
    Division of Pathology, Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Turin, Italy
    Mod Pathol 21:700-7. 2008
    ....
  27. doi request reprint Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung
    Valentina Monica
    Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Torino, Italy
    Mod Pathol 22:709-17. 2009
    ....
  28. doi request reprint Obestatin in human neuroendocrine tissues and tumours: expression and effect on tumour growth
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Orbassano, Turin, Italy
    J Pathol 218:458-66. 2009
    ....
  29. doi request reprint Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation
    Riccarda Granata
    Laboratory of Molecular and Cellular Endocrinology, Department of Internal Medicine, University of Turin, Corso Dogliotti 14 10126 Turin, Italy
    FASEB J 26:3393-411. 2012
    ..These results provide evidence of a novel role for obestatin in adipocyte function and glucose metabolism and suggest potential therapeutic perspectives in insulin resistance and metabolic dysfunctions...
  30. doi request reprint Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility
    Marta Annunziata
    Laboratory of Molecular and Cellular Endocrinology, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
    Hum Reprod 27:2117-29. 2012
    ....
  31. doi request reprint Phase II study of weekly paclitaxel and sorafenib as second/third-line therapy in patients with adrenocortical carcinoma
    Alfredo Berruti
    Department of Clinical and Biological Science, University of Turin, Azienda Ospedaliero Universitaria San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy
    Eur J Endocrinol 166:451-8. 2012
    ..There is a strong rationale in the use of antiangiogenic therapy in the management of adrenocortical carcinoma (ACC). Metronomic administration of chemotherapy and antiangiogenic drugs can be synergistic in targeting endothelial cells...
  32. doi request reprint Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy
    Paolo Ceppi
    Thoracic Oncology Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano Torino, Italy
    Clin Cancer Res 15:1039-45. 2009
    ..The aim of the present study was to investigate the role of Pol eta mRNA expression levels in non-small cell lung cancer (NSCLC)...
  33. doi request reprint Non-small cell lung cancer exhibits transcript overexpression of genes associated with homologous recombination and DNA replication pathways
    Silvia Saviozzi
    Genomics and Informatics Unit, University of Torino, Turin, Italy
    Cancer Res 69:3390-6. 2009
    ..In conclusion, genes belonging to DNA repair/replication pathways are overexpressed in NSCLC and are associated with a more aggressive phenotype...
  34. ncbi request reprint Galectin-3 and HBME-1 expression in oncocytic cell tumors of the thyroid
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Virchows Arch 445:183-8. 2004
    ....
  35. ncbi request reprint Co-expression of EGF receptor, TGFalpha and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis
    Marco Tampellini
    Division of Medical Oncology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy
    Virchows Arch 450:321-8. 2007
    ..4% vs 38.7%; p = 0.02). In agreement with in vitro data, EGFR, TGFalpha and S6K co-expression in human CRC was significantly higher in patients with advanced stage at diagnosis...
  36. doi request reprint Mammalian target of rapamycin signaling activation patterns in neuroendocrine tumors of the lung
    Luisella Righi
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, Orbassano, Turin, Italy
    Endocr Relat Cancer 17:977-87. 2010
    ....
  37. doi request reprint Functional role and prognostic significance of CD157 in ovarian carcinoma
    Erika Ortolan
    Department of Genetics, Biology and Biochemistry, University of Turin Medical School, Turin, Italy
    J Natl Cancer Inst 102:1160-77. 2010
    ..Because CD157 is expressed in mesothelial cells and diapedesis resembles tumor cell migration, we investigated the role of CD157 in ovarian carcinoma...
  38. ncbi request reprint Cathepsin K is selectively expressed in the stroma of lung adenocarcinoma but not in bronchioloalveolar carcinoma. A useful marker of invasive growth
    Ida Rapa
    Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Orbassano, Torino, Italy
    Am J Clin Pathol 125:847-54. 2006
    ....
  39. ncbi request reprint Basaloid adenocarcinoma. A new variant of pulmonary adenocarcinoma
    Valerio Marci
    Department of Pathology, University of Turin at San Luigi Hospital, Orbassano, Turin, Italy
    Virchows Arch 451:729-36. 2007
    ..These findings indicate that a basaloid variant of adenocarcinoma is also existing in the spectrum of basaloid carcinomas of the lung...
  40. ncbi request reprint Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart
    Riccarda Granata
    Laboratory of Molecular and Cellular Endocrinology, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
    Cardiovasc Res 83:303-12. 2009
    ..We investigated GHRH effects on cardiac myocyte cell survival and the underlying signalling mechanisms...
  41. ncbi request reprint Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases
    Nicoletta Bergero
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Prbassano, Italy
    Hum Pathol 36:908-14. 2005
    ..We conclude that Gal-3 immunostaining is a valuable tool to support a diagnosis of PC in highly proliferating (Ki67 >6%) tumors affecting a single parathyroid gland...
  42. ncbi request reprint Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours
    Elena Allia
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    J Pathol 207:336-45. 2005
    ....
  43. doi request reprint Mammalian target of rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma
    Ida Rapa
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Orbassano, Turin, Italy
    J Clin Endocrinol Metab 96:2146-53. 2011
    ..The genetic pathways involved in medullary thyroid carcinomas (MTC), except for RET mutations, are largely unknown, as is the detailed mapping of proteins activated as a consequence of RET tyrosine kinase phosphorylation...
  44. doi request reprint Adrenocortical tumors with myxoid features: a distinct morphologic and phenotypical variant exhibiting malignant behavior
    Mauro Papotti
    Department of Clinical and Biological Sciences, University of Turin at St Luigi Hospital, Orbassano, Torino, Italy
    Am J Surg Pathol 34:973-83. 2010
    ....
  45. doi request reprint Gemcitabine plus metronomic 5-fluorouracil or capecitabine as a second-/third-line chemotherapy in advanced adrenocortical carcinoma: a multicenter phase II study
    Paola Sperone
    Dipartimento di Scienze Cliniche e Biologiche Università di Torino, Orbassano, Italy
    Endocr Relat Cancer 17:445-53. 2010
    ..3 (range: 1-43) and 9.8 months (range: 3-73) respectively. Gemcitabine plus metronomic fluoropyrimidines is a well-tolerated and moderately active regimen in heavily pretreated ACC patients...
  46. ncbi request reprint Impact of pregnancy on prognosis of differentiated thyroid cancer: clinical and molecular features
    Ilaria Messuti
    Endocrine Unit, Department of Oncology, Presidio Sanitario Gradenigo, University of Turin, Corso Regina Margherita 10, Turin, Italy
    Eur J Endocrinol 170:659-66. 2014
    ..It is possible that associated physiological changes could favor tumor development and growth. However, few data are available about the outcome of DTC related to pregnancy, leading to conflicting results...
  47. ncbi request reprint RFamide peptides 43RFa and 26RFa both promote survival of pancreatic β-cells and human pancreatic islets but exert opposite effects on insulin secretion
    Riccarda Granata
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medical Sciences, University of Torino, Torino, Italy
    Diabetes 63:2380-93. 2014
    ..In conclusion, because of their survival effects along with the effects on insulin secretion, these findings suggest potential for 43RFa and 26RFa as therapeutic targets in the treatment of diabetes. ..
  48. doi request reprint The reticulin algorithm for adrenocortical tumor diagnosis: a multicentric validation study on 245 unpublished cases
    Eleonora Duregon
    Departments of Oncology Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Torino Department of Medicine DIMED, Pathology and Cytopathology Unit Department of Medicine DIMED, Endocrinology Unit Department of Statistics, University of Padua, Padova Divisions of Pathology Endocrinology, University of Florence at Careggi Hospital, Firenze Divisions of Endocrinology Pathology, Niguarda Ca Granda Hospital, Milano Department of Pathology and Molecular Genetics, General Hospital, Treviso Department of Medical Oncology, University of Brescia, Italy
    Am J Surg Pathol 37:1433-40. 2013
    ....
  49. doi request reprint Ribonucleotide reductase large subunit (RRM1) gene expression may predict efficacy of adjuvant mitotane in adrenocortical cancer
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
    Clin Cancer Res 18:3452-61. 2012
    ..Our aim was to evaluate the gene expression of ribonucleotide reductase large subunit 1 (RRM1) and excision repair cross-complementation group 1 (ERCC1) in ACC as potential biomarkers for clinical outcome and response to mitotane...
  50. doi request reprint Oncocytic adrenocortical tumors: diagnostic algorithm and mitochondrial DNA profile in 27 cases
    Eleonora Duregon
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    Am J Surg Pathol 35:1882-93. 2011
    ....
  51. doi request reprint Retrospective evaluation of the outcome of open versus laparoscopic adrenalectomy for stage I and II adrenocortical cancer
    Francesco Porpiglia
    S C D U Urologia, University of Turin San Luigi Hospital, Turin, Italy
    Eur Urol 57:873-8. 2010
    ..Although there is consensus that laparoscopy is the standard of care for the resection of benign adrenal tumours, there is controversy regarding the role of laparoscopy for the resection of adrenocortical cancer (ACC)...
  52. ncbi request reprint Ghrelin expression in fetal, infant, and adult human lung
    Marco Volante
    Department of Pathology, University of Turin, Turin, Italy
    J Histochem Cytochem 50:1013-21. 2002
    ..We conclude that the fetal lung is an additional source of circulating ghrelin, whose functions at the respiratory tract level remain to be clarified...
  53. pmc Absence of RET gene point mutations in sporadic thyroid C-cell hyperplasia
    Enrico Saggiorato
    Section of Endocrinology, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Italy
    J Mol Diagn 9:214-9. 2007
    ....
  54. ncbi request reprint MicroRNA expression patterns in adrenocortical carcinoma variants and clinical pathologic correlations
    Eleonora Duregon
    Department of Oncology, University of Turin at San Luigi Hospital, Orbassano, 10043, Torino, Italy
    Hum Pathol 45:1555-62. 2014
    ..017). In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis. ..
  55. ncbi request reprint Differential expression of HER2, STAT3, SOX2, IFI16 and cell cycle markers during HPV-related head and neck carcinogenesis
    Jasenka Mazibrada
    Department of Oncology, University of Turin at San Luigi Hospital, Turin, Italy
    New Microbiol 37:129-43. 2014
    ..The presence of HPV may induce upregulation of HER2/neu, pStat3 and IFI16. High levels and a strong positive correlation between pStat3 and IFI16 suggest their synergistic pro-apoptotic effects in HPV-positive lesions. ..
  56. ncbi request reprint Human ASH-1 promotes neuroendocrine differentiation in androgen deprivation conditions and interferes with androgen responsiveness in prostate cancer cells
    Ida Rapa
    Department of Oncology at San Luigi Hospital, University of Turin, Orbassano, Turin, Italy
    Prostate 73:1241-9. 2013
    ..Our study aimed at testing in vitro the role of hASH-1, a transcription factor implicated in neuroendocrine differentiation, in the onset of neuroendocrine phenotype in prostate cancer cells...
  57. doi request reprint Prospective evaluation of mitotane toxicity in adrenocortical cancer patients treated adjuvantly
    Fulvia Daffara
    Medicina Interna I, A S O San Luigi, Regione Gonzole, 10, 10043 Orbassano, Italy
    Endocr Relat Cancer 15:1043-53. 2008
    ..A low-dose monitored regimen of mitotane is tolerable and able to maintain elevated drug concentrations in the long term. Mitotane exerts a complex effect on the endocrine system that may require multiple hormone replacement therapy...
  58. ncbi request reprint Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats
    Riccarda Granata
    Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    J Mol Endocrinol 45:9-17. 2010
    ..Taken together, our results suggest that in STZ-treated newborn rats, UAG and Ob improve glucose metabolism and preserve islet cell mass, granting a therapeutic potential in medical conditions associated with impaired beta-cell function...
  59. ncbi request reprint Potential applications of molecular biology in neuroendocrine tumors
    Tommaso Emmer
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Endocr Pathol 14:319-28. 2003
    ..g., oxytocin and somatostatin receptors) and the development of potent synthetic analogs of such peptides, are opening promising applications in the diagnosis and therapy of endocrine tumors...
  60. ncbi request reprint p63 expression as a new prognostic marker in Merkel cell carcinoma
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Cancer 110:640-7. 2007
    ..Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor, mostly affecting elderly individuals. The histogenesis of this rare tumor as well as its prognostic criteria are a matter of dispute...
  61. ncbi request reprint Neuro-endocrine tumours of the lung. A review of relevant pathological and molecular data
    Luisella Righi
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Turin, Italy
    Virchows Arch 451:S51-9. 2007
    ..The "molecular classification" of NE tumours should be integrated to morphology, for a better definition of the different histological types and a more appropriate selection of the therapeutic strategy...
  62. ncbi request reprint Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas
    Marco Volante
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, and Department of Pathology, Ospedale di Circolo, Varese, Italy
    Virchows Arch 448:545-51. 2006
    ....
  63. doi request reprint Influence of the CYP2B6 polymorphism on the pharmacokinetics of mitotane
    Antonio D'Avolio
    Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, Turin, Italy
    Pharmacogenet Genomics 23:293-300. 2013
    ..The aim of this study was to assess the potential impact of the pharmacogenetic variability of CYP2B6 and ABCB1 genes on the pharmacokinetics of mitotane...
  64. ncbi request reprint Ghrelin and the endocrine pancreas
    Fabio Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Ospedale Molinette, Corso Dogliotti 14, 10126 Turin, Italy
    Endocrine 22:19-24. 2003
    ..This evidence indicates that the endocrine pancreas plays a role in directly or indirectly modulating ghrelin secretion...
  65. ncbi request reprint Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns: a clinicopathologic study of 183 patients
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Cancer 100:950-7. 2004
    ..Conversely, some authors pointed out that PD carcinomas are characterized by unequivocal, high-grade histology with atypias, high mitotic counts, and necrosis rather than by a specific growth pattern...
  66. doi request reprint Anti-angiogenic effect of tamoxifen combined with epirubicin in breast cancer patients
    Teresa Mele
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche Università di Torino, Azienda Ospedaliera Universitaria San Luigi di Orbassano, Regione Gonzole 10, 10043, Orbassano, Italy
    Breast Cancer Res Treat 123:795-804. 2010
    ..02). The addition of tamoxifen to epirubicin resulted in a suppression of a key angiogenic pathway. These data suggest a potential synergism of these two drugs...
  67. doi request reprint The pathological diagnosis of neuroendocrine tumors: common questions and tentative answers
    Marco Volante
    Divisions of Pathology, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    Virchows Arch 458:393-402. 2011
    ..The present paper is an overview of the most frequently asked questions and an attempt to provide practical answers related to NEN diagnosis in the daily pathology work...
  68. doi request reprint Diagnostic controversies in vascular proliferations of the thyroid gland
    Mauro Papotti
    Department of Pathology, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
    Endocr Pathol 19:175-83. 2008
    ....
  69. ncbi request reprint 99mTc-MIBI Imaging in the presurgical characterization of thyroid follicular neoplasms: relationship to multidrug resistance protein expression
    Enrico Saggiorato
    Section of Endocrinology, Division of Internal Medicine, Department of Clinical and Biological Sciences, Gradenigo Hospital, University of Turin, Turin, Italy
    J Nucl Med 50:1785-93. 2009
    ..This study also aimed to analyze the relationship between (99m)Tc-MIBI images and P-glycoprotein (P-gp)/multidrug resistance-associated protein-1 (MRP1) immunohistochemical expression...
  70. ncbi request reprint Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case
    Donatella Pacchioni
    Department of Biomedical Science, University of Turin, Italy
    Am J Surg Pathol 31:632-6. 2007
    ..A definitive classification and histogenetic interpretation of this previously unreported tumor type awaits description of further cases showing similar features which, perhaps, as it may happen, went so far unnoticed...
  71. ncbi request reprint Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?
    Eugenio Leonardo
    Division of Pathology, San Luigi Hospital, Orbassano, Torino, Italy
    Appl Immunohistochem Mol Morphol 15:220-3. 2007
    ..We conclude that when Ki67 immunohistochemistry is used for diagnostic purposes in a suspected HTT, only MIB-1 clone at room temperature should be employed...
  72. doi request reprint Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: a validation study focusing on clinical and pathologic correlates
    Eleonora Duregon
    Division of Pathology, University of Turin at San Luigi Hospital, 10043 Orbassano, Torino, Italy
    Hum Pathol 44:822-8. 2013
    ....
  73. ncbi request reprint Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
    Paolo Ceppi
    Thoracic Oncology Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Torino, Italy
    Cancer 107:1589-96. 2006
    ..In patients with cancer, one of the main mechanism of resistance to antimetabolite drugs is related to higher levels of thymidylate synthase (TS) activity...
  74. ncbi request reprint Immunohistochemical study of neuroendocrine differentiation in primary glandular lesions and tumors of the urinary bladder
    Enrico R Bollito
    Division of Pathology, San Luigi Gonzaga Hospital, Orbassano, Italy
    Anal Quant Cytol Histol 27:218-24. 2005
    ..Neuroendocrine (NE) cells are uncommon in primary adenocarcinoma (AC) and other glandular lesions of the bladder, with no recent study series concerning its significance in differential diagnosis, prognosis or biologic significance...
  75. ncbi request reprint The grey zone between pure (neuro)endocrine and non-(neuro)endocrine tumours: a comment on concepts and classification of mixed exocrine-endocrine neoplasms
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Regione Gonzole10, 10043 Orbassano Torino, Italy
    Virchows Arch 449:499-506. 2006
    ..The recognition of MEECs may be of relevance for a targeted therapeutic strategy, foreseeing the use of biotherapies similar to those proposed for pure NE tumours...
  76. ncbi request reprint E2F-1 transcription factor is overexpressed in oxyphilic thyroid tumors
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Mod Pathol 15:1038-43. 2002
    ..In addition, in oxyphilic tumors, more than two thirds of tumor cells express E2F-1, an event possibly linked to proapoptotic rather than proliferative signals in such neoplasms...
  77. ncbi request reprint Somatostatin receptors and their interest in diagnostic pathology
    Marco Volante
    Department of Biomedical Sciences, San Luigi Hospital, Orbassano, University of Turin, Turin, Italy
    Endocr Pathol 15:275-91. 2004
    ..This is particularly, but not exclusively, the case in the field of neuroendocrine oncology, where sst typing may affect the clinical management of patients with sst-positive tumors...
  78. ncbi request reprint Prognostic factors of clinical interest in poorly differentiated carcinomas of the thyroid
    Marco Volante
    Department of Biomedical Sciences, San Luigi Hospital, Orbassano, University of Turin, Italy
    Endocr Pathol 15:313-7. 2004
    ..Therefore, as also proposed for other thyroid carcinomas (e.g., papillary carcinoma) grading of PD carcinomas on the basis of these latter parameters is encouraged to select those cases with a high risk of poor outcome...
  79. ncbi request reprint Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, I 10126 Torino, Italy
    J Clin Endocrinol Metab 87:1300-8. 2002
    ..Expression of GHS-R in some of the endocrine tumors studied indicates that autocrine/paracrine circuits may be active in neoplastic conditions...
  80. ncbi request reprint Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression
    Sofia Asioli
    Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Mod Pathol 23:1269-78. 2010
    ..Expression of IMP3 appears to be an adverse prognostic factor for poorly differentiated thyroid carcinoma...
  81. ncbi request reprint Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function
    Riccarda Granata
    Laboratory of Molecular and Cellular Endocrinology, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti, 14 10126 Turin, Italy
    Diabetes 57:967-79. 2008
    ..We investigated obestatin effect on survival of beta-cells and human pancreatic islets and the underlying signaling pathways...
  82. ncbi request reprint Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma
    Mauro Papotti
    Department of Pathology, University of Turin, Italy
    Eur J Endocrinol 147:515-21. 2002
    ..The aim of this study was to assess the role of galectin-3 immunodetection in a series of FNA cytological samples of benign and malignant thyroid cystic nodules...
  83. ncbi request reprint Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Cancer Res 62:2406-13. 2002
    ....
  84. ncbi request reprint RET activation and clinicopathologic features in poorly differentiated thyroid tumors
    Massimo Santoro
    Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:370-9. 2002
    ....
  85. doi request reprint Excision repair cross complementing-1 and topoisomerase IIalpha gene expression in small-cell lung cancer patients treated with platinum and etoposide: a retrospective study
    Paolo Ceppi
    Thoracic Oncology Unit, University of Torino, S Luigi Hospital, Orbassano Torino, Italy
    J Thorac Oncol 3:583-9. 2008
    ..Aim of the study was to quantify ERCC1, RRM1, and TopoIIalpha mRNA expression profile as predictive factors for response and survival in SCLC patients treated with platinum/etoposide...
  86. doi request reprint Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study
    Armando Bartolazzi
    Department of Pathology, St Andrea University Hospital, Rome, Italy
    Lancet Oncol 9:543-9. 2008
    ..We aimed to assess the diagnostic effect of galectin-3 expression analysis in distinguishing preoperatively benign from malignant follicular thyroid nodules when FNA findings were indeterminate...
  87. ncbi request reprint Merkel cell carcinomas: expression of S-phase kinase-associated protein 2 (Skp2), p27, and proliferation markers
    Lori A Erickson
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Endocr Pathol 14:221-29. 2003
    ....
  88. ncbi request reprint Diagnostic role of galectin-3 in follicular thyroid tumors
    Marco Volante
    Virchows Arch 444:309-12. 2004
  89. ncbi request reprint GSTT1 and M1 polymorphisms in Hürthle thyroid cancer patients
    Karmen Stankov
    Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Unita Operativa di Genetica Medica, Policlinico S Orsola Malpighi, Pad 11, Via Massarenti 9, 40138 Bologna, Italy
    Cancer Lett 240:76-82. 2006
    ..6% in controls (OR 1.24; 95% CI, 0.62-2.48), indicating that the GSTT1 and M1 null genotypes do not increase the risk of development of oxyphilic tumors...
  90. ncbi request reprint Allelic loss on chromosomes 2q21 and 19p 13.2 in oxyphilic thyroid tumors
    Karmen Stankov
    Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Unita Operativa di Genetica Medica, Policlinico S Orsola Malpighi, Bologna, Italy
    Int J Cancer 111:463-7. 2004
    ..This led to the exclusion of linkage with the NMTC1 locus and to the refutation of the digenic inheritance hypothesis at least in this family...
  91. ncbi request reprint Galectin-3 expression in hyalinizing trabecular tumors of the thyroid gland
    Robyn L Gaffney
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Surg Pathol 27:494-8. 2003
    ..Our study suggests that the variable pattern of galectin-3 expression may reflect a difference in biologic behavior between HTT and papillary thyroid carcinoma...