B Viviani

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Perspectives on neuroinflammation and excitotoxicity: A neurotoxic conspiracy?
    Barbara Viviani
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy Electronic address
    Neurotoxicology 43:10-20. 2014
  2. doi request reprint Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner
    Barbara Viviani
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit Degli Studi di Milano, Milan, Italy Electronic address
    Brain Behav Immun . 2013
  3. pmc CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation
    Saula Ravasi
    Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Respir Res 7:42. 2006
  4. pmc Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation
    Fabrizio Gardoni
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Neuroinflammation 8:14. 2011
  5. ncbi request reprint Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases
    B Viviani
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 23:8692-700. 2003
  6. ncbi request reprint Cytokines role in neurodegenerative events
    Barbara Viviani
    Laboratory of Toxicology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Lett 149:85-9. 2004
  7. ncbi request reprint The anti-inflammatory activity of estrogen in glial cells is regulated by the PKC-anchoring protein RACK-1
    Barbara Viviani
    Centre of Excellence on Neurodegenerative Diseases and Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 83:1180-7. 2002
  8. ncbi request reprint Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor
    Barbara Viviani
    Laboratory of Toxicology and Centre of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 93:412-21. 2005
  9. ncbi request reprint Dithiocarbamate propineb induces acetylcholine release through cytoskeletal actin depolymerization in PC12 cells
    Barbara Viviani
    Department of Pharmacological Sciences, Laboratory of Toxicology, University of Milan, Italy
    Toxicol Lett 182:63-8. 2008
  10. doi request reprint Cytokines and neuronal channels: a molecular basis for age-related decline of neuronal function?
    Barbara Viviani
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Exp Gerontol 46:199-206. 2011

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Perspectives on neuroinflammation and excitotoxicity: A neurotoxic conspiracy?
    Barbara Viviani
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy Electronic address
    Neurotoxicology 43:10-20. 2014
    ....
  2. doi request reprint Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner
    Barbara Viviani
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universit Degli Studi di Milano, Milan, Italy Electronic address
    Brain Behav Immun . 2013
    ..These data reveal a long-term, sex-dependent modification in receptor organisation at the hippocampal post-synapses following MD. We suggest that this effect might contribute to priming hippocampal synapses to the action of IL-1β...
  3. pmc CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation
    Saula Ravasi
    Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Respir Res 7:42. 2006
    ..We used human ASMC (HASMC) to identify the signal transduction pathway(s) of the leukotriene D4 (LTD4)-induced DNA synthesis...
  4. pmc Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation
    Fabrizio Gardoni
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Neuroinflammation 8:14. 2011
    ....
  5. ncbi request reprint Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases
    B Viviani
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 23:8692-700. 2003
    ..These data suggest that IL-1beta increases NMDA receptor function through activation of tyrosine kinases and subsequent NR2A/B subunit phosphorylation. These effects may contribute to glutamate-mediated neurodegeneration...
  6. ncbi request reprint Cytokines role in neurodegenerative events
    Barbara Viviani
    Laboratory of Toxicology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Lett 149:85-9. 2004
    ..Here, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) contribute to neurodegeneration and the molecular mechanisms involved will be shortly reviewed...
  7. ncbi request reprint The anti-inflammatory activity of estrogen in glial cells is regulated by the PKC-anchoring protein RACK-1
    Barbara Viviani
    Centre of Excellence on Neurodegenerative Diseases and Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 83:1180-7. 2002
    ..These results demonstrate that estrogen reduction of the RACK-1 expression, leading to a defective protein kinase-C activation counteracts the inflammatory response in astrocytes...
  8. ncbi request reprint Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor
    Barbara Viviani
    Laboratory of Toxicology and Centre of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 93:412-21. 2005
    ..These data demonstrate that erythropoietin activates the CREB transcription pathway and increases BDNF expression and production, which contributes to erythropoietin mediated neuroprotection...
  9. ncbi request reprint Dithiocarbamate propineb induces acetylcholine release through cytoskeletal actin depolymerization in PC12 cells
    Barbara Viviani
    Department of Pharmacological Sciences, Laboratory of Toxicology, University of Milan, Italy
    Toxicol Lett 182:63-8. 2008
    ..These data suggest that dithiocarbamates, through the activation of intracellular cascade(s), impair cytoskeletal actin. This effect may contribute to affect synaptic vesicles processing resulting in an impaired cholinergic transmission...
  10. doi request reprint Cytokines and neuronal channels: a molecular basis for age-related decline of neuronal function?
    Barbara Viviani
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Exp Gerontol 46:199-206. 2011
    ..By reviewing literature and data obtained in our laboratory, we discuss the hypothesis that cytokines modulation of neuronal channels might occur during the aging process and play a role in aged related decline of neuronal functions...
  11. ncbi request reprint Dying neural cells activate glia through the release of a protease product
    B Viviani
    Institute of Pharmacological Sciences, University of Milan, Milan, Italy
    Glia 32:84-90. 2000
    ..We conclude that a primary neurodegenerative event may induce glial response by releasing a neurospecific protein factor via activation of a caspase...
  12. ncbi request reprint Ontogenesis of protein kinase C betaII and its anchoring protein RACK1 in the maturation of alveolar macrophage functional responses
    E Corsini
    Laboratory of Toxicology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Immunol Lett 76:89-93. 2001
    ..Our results show an age-associated increase in the expression of PKC betaII and RACK1, which correlated with a maturation of alveolar macrophage functional responses...
  13. ncbi request reprint Reactive oxygen species generated by glia are responsible for neuron death induced by human immunodeficiency virus-glycoprotein 120 in vitro
    B Viviani
    Department of Pharmacological Sciences, , Via Balzaretti 9, 20133, Milan, Italy
    Neuroscience 107:51-8. 2001
    ..Our results indicate that reactive oxygen species produced in glial cells by gp120 exposure cause neurodegeneration by inducing the synthesis of interleukin-1beta...
  14. ncbi request reprint Cloricromene, a semi-synthetic coumarin derivative, inhibits tumor necrosis factor-alpha production at a pre-transcriptional level
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Eur J Pharmacol 418:231-7. 2001
    ..Our results show that cloricromene interferes with the early signal transduction pathway triggered by lipopolysaccharide...
  15. ncbi request reprint Sodium arsenate induces overproduction of interleukin-1alpha in murine keratinocytes: role of mitochondria
    E Corsini
    Laboratory of Toxicology, Institute of Pharmological Sciences, University of Milan, Italy
    J Invest Dermatol 113:760-5. 1999
    ....
  16. ncbi request reprint Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia
    E Vegeto
    Milano Molecular Pharmacology Lab, and Institute of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 21:1809-18. 2001
    ..Our study proposes a novel explanation for the protective effects of estrogen in neurodegenerative and inflammatory diseases and provides new molecular and cellular targets for the screening of ER ligands acting in the CNS...
  17. ncbi request reprint Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling
    F Gilardi
    Laboratory of Biochemistry and Molecular Biology of Lipids Mass spectrometry Giovanni Galli, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Neuroscience 164:530-40. 2009
    ....
  18. ncbi request reprint Trimethyltin-activated cyclooxygenase stimulates tumor necrosis factor-alpha release from glial cells through reactive oxygen species
    B Viviani
    Laboratory of Toxicology, Institute of Pharmacological Sciences, University of Milan, Milan, Italy
    Toxicol Appl Pharmacol 172:93-7. 2001
    ..These results suggest that activation of arachidonic acid metabolism causes TNF-alpha release through the production of ROS rather than PGE(2). Indeed, PGE(2) may exert negative feedback on the release of TNF-alpha...
  19. ncbi request reprint Cyclosporin A exacerbates skin irritation induced by tributyltin by increasing nuclear factor kappa B activation
    E Corsini
    Center for Cosmetic Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Milan, Italy
    J Invest Dermatol 117:1627-34. 2001
    ..Cyclophilin D suppression prevented cyclosporine A potentiation of tributyltin-induced cellular oxidative activity, indicating the key role of the binding of cyclosporine A to mitochondrial cyclophilin D in mediating this effect...
  20. doi request reprint Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    Br J Dermatol 160:16-25. 2009
    ..We have recently shown in immune cells that decreased expression of the receptor for activated C kinase (RACK)-1 underlies defective protein kinase C (PKC) activation and functional immune impairment with ageing...
  21. doi request reprint Further development of the NCTC 2544 IL-18 assay to identify in vitro contact allergens
    V Galbiati
    Laboratory of Toxicology, Department of Pharmacological Science, Università degli Studi di, Milano, Italy
    Toxicol In Vitro 25:724-32. 2011
    ..The assay can be performed in a 96-well plate format, different keratinocyte cell lines can be used, and a role for oxidative stress in contact allergen-induced IL-18 was demonstrated...
  22. pmc Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    Pia Villa
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Exp Med 198:971-5. 2003
    ..These findings suggest that rhEPO attenuates ischemia-induced inflammation by reducing neuronal death rather than by direct effects upon EPO-R-expressing inflammatory cells...
  23. ncbi request reprint Identification by DNA macroarray of nur77 as a gene induced by di-n-butyltin dichloride: its role in organotin-induced apoptosis
    Alessandra Gennari
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Italy
    Toxicol Appl Pharmacol 181:27-31. 2002
    ..Antisense oligonucleotide inhibition of nur77 expression prevented apoptosis induced by DBTC, supporting a role for nur77 in organotin-induced apoptotic cell death...
  24. ncbi request reprint Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII transduction pathway
    Fabrizio Gardoni
    Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Eur J Neurosci 16:777-86. 2002
    ..Thus, our data provide clues that PSD-95 reduced expression in neurons is responsible for neuronal vulnerability mediated by direct activation of alpha CaMKII transduction pathway in the postsynaptic compartment...
  25. ncbi request reprint In vivo dehydroepiandrosterone restores age-associated defects in the protein kinase C signal transduction pathway and related functional responses
    Emanuela Corsini
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Immunol 168:1753-8. 2002
    ..These findings suggest that the age-related loss in immunological responses, linked to defective pathways of signal transduction, are partially under hormonal control and can be restored by appropriate replacement therapy...
  26. ncbi request reprint Facilitation of acetylcholine signaling by the dithiocarbamate fungicide propineb
    Marina Marinovich
    Laboratory of Toxicology and Section of Theoretical Pharmacology and Receptor Modeling, Department Pharmacological Sciences, University of Milan, Italy
    Chem Res Toxicol 15:26-32. 2002
    ..In LMMPs, the potentiation of cholinergic transmission is partly dependent on the activation of ganglionic nicotinic receptors. Other targets relevant to cholinergic transmission seem not to be affected by propineb...
  27. ncbi request reprint Immunomodulatory effects of the herbicide propanil on cytokine production in humans: In vivo and in vitro exposure
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Appl Pharmacol 222:202-10. 2007
    ..These findings improve our understanding of the mechanism underlying propanil-induced immunotoxicity...
  28. pmc Increased carrageenan-induced acute lung inflammation in old rats
    Emanuela Corsini
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Immunology 115:253-61. 2005
    ..Indeed, we found decreased cAMP-responsive element binding protein (CREB) and phosphorous-CREB (P-CREB) expression in old rats, which may account for reduced IL-10 production in old rats...
  29. ncbi request reprint High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, Milan, Italy
    J Leukoc Biol 80:376-82. 2006
    ....
  30. ncbi request reprint Molecular mechanisms underlying mancozeb-induced inhibition of TNF-alpha production
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Appl Pharmacol 212:89-98. 2006
    ..Overall, this study contributes to our understanding of the mechanism underlying mancozeb-induced immunotoxicity...
  31. ncbi request reprint Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone
    Emanuela Corsini
    Laboratories of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Leukoc Biol 77:247-56. 2005
    ..Overall, our findings contribute to the understanding of the complex process of immunosenescence and identify age-related loss in immunological responses as partially associated with decreased RACK-1 expression...
  32. ncbi request reprint Induction of adipose differentiation related protein and neutral lipid droplet accumulation in keratinocytes by skin irritants
    Emmanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Italy
    J Invest Dermatol 121:337-44. 2003
    ..ADRP expression was also induced in vivo following treatment with sodium dodecyl sulfate in an experimental model of skin irritation, indicating that the in vitro model represents irritation...
  33. ncbi request reprint Resistance to acute silicosis in senescent rats: role of alveolar macrophages
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Chem Res Toxicol 16:1520-7. 2003
    ....
  34. doi request reprint Neuroprotective effects of progesterone in chronic experimental autoimmune encephalomyelitis
    S Giatti
    Department of Endocrinology, Pathophysiology and Applied Biology, Center of Excellence on Neurodegenerative Diseases, Universita degli Studi di Milano, Milano, Italy
    J Neuroendocrinol 24:851-61. 2012
    ..Taken together, these results indicate that PROG is effective in reducing the severity of chronic EAE and, consequently, may have potential with respect to MS treatment...
  35. pmc Endogenous erythropoietin as part of the cytokine network in the pathogenesis of experimental autoimmune encephalomyelitis
    Manuela Mengozzi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 14:682-8. 2008
    ..Given the known inhibitory effect of EPO on neuroinflammation, our study indicates that EPO should be viewed as part of the inflammatory/anti-inflammatory network in MS...
  36. ncbi request reprint Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors
    Barbara Viviani
    Laboratory of Toxicology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Biol Chem 281:30212-22. 2006
    ..Thus, tyrosine phosphorylation may contribute to the sensitization of the receptor increasing its function and synaptic localization. Both of these effects are relevant for neurodegeneration...
  37. doi request reprint Preparation and coculture of neurons and glial cells
    Barbara Viviani
    University of Milan, Milan, Italy
    Curr Protoc Cell Biol . 2006
    ..This system has the advantage that the two cell populations can be separated at any point in the exposure without disrupting the cells integrity and organization...
  38. ncbi request reprint Cytokines and neuronal ion channels in health and disease
    Barbara Viviani
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Italy
    Int Rev Neurobiol 82:247-63. 2007
    ..Consequently, cytokines are now regarded as novel neuromodulators, opening important perspectives in the current view of brain behavior...
  39. ncbi request reprint Erythropoietin: a novel neuroprotective cytokine
    Stefano Bartesaghi
    Laboratory of Toxicology and Centre of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neurotoxicology 26:923-8. 2005
    ....
  40. pmc Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo
    Tiziana Mennini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 12:153-60. 2006
    ..Thus CEPO, which does not bind to the classical homodimeric EPO receptor and is devoid of hematopoietic activity, could be effective in chronic treatment aimed at reducing motoneuron degeneration...
  41. ncbi request reprint Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naive THp-1 cells
    Montserrat Mitjans
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Toxicol In Vitro 22:386-95. 2008
    ..Our data suggests that production of IL-8 by naïve THP-1 cells may represent a promising in vitro model for the screening of potential chemical allergens and activation of p38 MAPK represents a common pathway triggered by allergens...