A Virdis

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. doi request reprint Endothelial aging and gender
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Maturitas 71:326-30. 2012
  2. doi request reprint Endothelial dysfunction and vascular disease in later life
    A Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Maturitas 67:20-4. 2010
  3. doi request reprint The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:920-7. 2010
  4. doi request reprint Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 53:1008-16. 2009
  5. ncbi request reprint Obesity in the childhood: a link to adult hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 15:1063-71. 2009
  6. ncbi request reprint Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 21:2275-80. 2003
  7. doi request reprint Inducible nitric oxide synthase is involved in endothelial dysfunction of mesenteric small arteries from hypothyroid rats
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Endocrinology 150:1033-42. 2009
  8. ncbi request reprint Endothelial function assessment in complicated hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 14:1761-70. 2008
  9. ncbi request reprint C-reactive protein and hypertension: is there a causal relationship?
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 13:1693-8. 2007
  10. ncbi request reprint Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 49:679-86. 2007

Detail Information

Publications78

  1. doi request reprint Endothelial aging and gender
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Maturitas 71:326-30. 2012
    ..Whether endogenous androgen may modulate endothelial function and the mechanisms involved are still unsolved issues, since data concerning the effect of testosterone on endothelium are scanty and contradictory...
  2. doi request reprint Endothelial dysfunction and vascular disease in later life
    A Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Maturitas 67:20-4. 2010
    ..Regular physical training is an important non-pharmacological intervention which protects the vascular endothelium from ageing-related alterations and ameliorates the cardiovascular risk profile among the elderly population...
  3. doi request reprint The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:920-7. 2010
    ..A compensatory CYP 2C9-derived EDHF pathway is activated to sustain endothelium-dependent vasodilation. This PHPT-related endothelial dysfunction is reversed after PTx...
  4. doi request reprint Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 53:1008-16. 2009
    ....
  5. ncbi request reprint Obesity in the childhood: a link to adult hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 15:1063-71. 2009
    ....
  6. ncbi request reprint Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 21:2275-80. 2003
    ..We assessed whether third-generation oral contraceptive (OC) treatment (30 microg ethinylestradiol + 75 microg gestodene daily) could affect the endothelial function of healthy women...
  7. doi request reprint Inducible nitric oxide synthase is involved in endothelial dysfunction of mesenteric small arteries from hypothyroid rats
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Endocrinology 150:1033-42. 2009
    ..It is suggested that in this animal model, characterized by TSH elevation and low-grade inflammation, an increased expression and function of iNOS, resulting in superoxide generation, accounts for an impaired NO availability...
  8. ncbi request reprint Endothelial function assessment in complicated hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 14:1761-70. 2008
    ....
  9. ncbi request reprint C-reactive protein and hypertension: is there a causal relationship?
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 13:1693-8. 2007
    ..Without such crucial information, at the present time the causal connection between inflammation and blood pressure, although regarded as an intriguing possibility, remains undiscovered...
  10. ncbi request reprint Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 49:679-86. 2007
    ....
  11. ncbi request reprint Cigarette smoking and hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 6756100 Pisa, Italy
    Curr Pharm Des 16:2518-25. 2010
    ..Hypertensive smokers are more likely to develop severe forms of hypertension, including malignant and renovascular hypertension, an effect likely due to an accelerated atherosclerosis...
  12. ncbi request reprint Is Hyperhomocyst(e)inemia a humoral predictor of coronary heart disease?
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 11:2187-97. 2005
    ....
  13. ncbi request reprint Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Circulation 101:2896-901. 2000
    ..Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related endothelial dysfunction...
  14. ncbi request reprint Mechanisms responsible for endothelial dysfunction induced by fasting hyperhomocystinemia in normotensive subjects and patients with essential hypertension
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 38:1106-15. 2001
    ..We sought to evaluate whether fasting hyperhomocystinemia reduces endothelial function by oxidative stress in normotensive subjects and hypertensive patients...
  15. ncbi request reprint Age-related reduction of NO availability and oxidative stress in humans
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 38:274-9. 2001
    ..These alterations are similar but anticipated in hypertensive patients compared with normotensive subjects...
  16. ncbi request reprint Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Circulation 100:1400-5. 1999
    ..The present study was designed to identify the mechanism(s) responsible for NO-independent vasodilation to bradykinin in patients with essential hypertension...
  17. doi request reprint Effect of verapamil, trandolapril and their combination on vascular function and structure in essential hypertensive patients
    D Versari
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Atherosclerosis 205:214-20. 2009
    ..The aim of the present study is to evaluate the effect of treatment with verapamil, trandolapril and their combination on peripheral microcirculation vasoreactivity...
  18. ncbi request reprint Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients
    S Taddei
    I Clinica Medica, University of Pisa, Italy
    J Hypertens 16:447-56. 1998
    ..Essential hypertension is characterized by an impairment of endothelium-dependent vasodilatation...
  19. ncbi request reprint Exclusion of the ACE D/I gene polymorphism as a determinant of endothelial dysfunction
    G P Rossi
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Hypertension 37:293-300. 2001
    ....
  20. ncbi request reprint Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 19:1379-86. 2001
    ..Since calcium antagonists can improve endothelial function in hypertensive patients, we tested whether this beneficial effect could be related to restoration of NO availability by antioxidant activity...
  21. ncbi request reprint Endothelial dysfunction in hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Cardiovasc Pharmacol 38:S11-4. 2001
    ..This alteration in the NO pathway could be the main mechanism through which a dysfunctional endothelium could be a promoter of atherosclerosis and thrombosis and therefore lead to cardiovascular events in essential hypertensive patients...
  22. ncbi request reprint Role of endothelin in the control of peripheral vascular tone in human hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Heart Fail Rev 6:277-85. 2001
    ..Therefore endothelin-1 could potentially be involved in the pathogenesis of essential hypertension or of its complications, and blockade of this system is a fascinating new target for therapeutic intervention in this disease...
  23. ncbi request reprint Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitric-oxide synthase and oxidative stress
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Pharmacol Exp Ther 312:945-53. 2005
    ..Oxidative stress is the main mechanism responsible for reduced NO availability, and COX-2 might act as a source of ROS...
  24. ncbi request reprint High serum levels of CXC (CXCL10) and CC (CCL2) chemokines in untreated essential hypertension
    A Antonelli
    Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Pisa, Italy
    Int J Immunopathol Pharmacol 25:387-95. 2012
    ..In conclusion, this study demonstrates increased circulating levels of the prototype chemokines CXCL10 and CCL2 in patients with hypertension...
  25. ncbi request reprint Soluble E-selectin in essential hypertension: a correlate of vascular structural changes
    R De Caterina
    CNR Institute of Clinical Physiology, University of Pisa, Italy
    Am J Hypertens 14:259-66. 2001
    ..We evaluated plasma soluble (s) E-selectin to assess its relationship with endothelium-dependent and endothelium-independent vasodilation in patients with hypertension...
  26. ncbi request reprint Mechanisms of endothelial dysfunction: clinical significance and preventive non-pharmacological therapeutic strategies
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Curr Pharm Des 9:2385-402. 2003
    ..It is worth noting that most of non-pharmacological measures act by preventing or reducing oxidative stress...
  27. doi request reprint Vascular reactivity in patients with undifferentiated connective tissue diseases
    Marta Mosca
    Rheumatology Unit, Department of Internal Medicine, University of Pisa, Italy
    Atherosclerosis 203:185-91. 2009
    ..We investigated endothelial function in the peripheral circulation of patients with undifferentiated connective tissue diseases (UCTDs), in comparison to healthy controls...
  28. doi request reprint Human endothelial dysfunction: EDCFs
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    Pflugers Arch 459:1015-23. 2010
    ..The mechanisms that regulate the balance between NO and EDCFs and the processes transforming the endothelium from a protective organ to a source of vasoconstrictor, proaggregatory and promitogenic mediators, remain to be determined...
  29. ncbi request reprint Hypertension in the elderly: an evidence-based review
    A Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Pharm Des 17:3020-31. 2011
    ..However the HYVET study suggests that a goal of 150/90 mmHg can be reasonable in patients aged 80 years or more. Drug treatment should be titrated with particular caution to adverse responses and excessive blood pressure lowering...
  30. ncbi request reprint Clinical and methodological aspects of endothelial function in patients with systemic autoimmune diseases
    L Ghiadoni
    Hypertension Unit, Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 26:680-7. 2008
    ..No single test currently available is specific for the vascular district tested or the risk factor/diseases considered, and a panel of several tests is therefore needed to characterize the multiple aspects of endothelial biology...
  31. ncbi request reprint Presence of cardiovascular structural changes in essential hypertensive patients with coronary microvascular disease and effects of long-term treatment
    A Virdis
    I Clinica Medica, University of Pisa, Italy
    Am J Hypertens 9:361-9. 1996
    ..Our results also indicate that both cardiac and forearm vascular abnormalities can be reversed by antihypertensive treatment with an ACE inhibitor...
  32. ncbi request reprint Endothelial dysfunction in hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    J Nephrol 13:205-10. 2000
    ..This alteration in the NO pathway could be the main mechanism through which a dysfunctional endothelium could be a promoter of atherosclerosis and thrombosis in essential hypertension...
  33. ncbi request reprint The role of endothelium in human hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa, Italy
    Curr Opin Nephrol Hypertens 7:203-9. 1998
    ..Available evidence indicates that different classes of antihypertensive compounds have different effects on endothelial dysfunction...
  34. ncbi request reprint Effect of acute and chronic vitamin D administration on systemic renin angiotensin system in essential hypertensives and controls
    G Bernini
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Endocrinol Invest 36:216-20. 2013
    ..To investigate the systemic renin-angiotensin system (RAS) in essential hypertensives (EH) and controls (C) after short- and long-term vitamin D receptor activation...
  35. ncbi request reprint Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension
    S Taddei
    Department of Internal Medicine, University of Pisa Italy
    Hypertension 37:943-8. 2001
    ..These results indicate that nifedipine increases endothelium-dependent vasodilation by restoring NO availability, an effect probably determined by antioxidant activity...
  36. ncbi request reprint [Clinical significance of the assessment of endothelial function]
    Stefano Taddei
    Dipartimento di Medicina Interna, Universita degli Studi, Pisa
    Ital Heart J Suppl 5:357-65. 2004
    ....
  37. ncbi request reprint Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:5076-82. 2006
    ..The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis...
  38. ncbi request reprint Endothelial function in hypertension: role of gender
    Agostino Virdis
    Department of Internal Medicine, Hypertension Unit, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Hypertens Suppl 20:S11-6. 2002
    ..Finally, whether endogenous androgen can impair endothelial function is still an unsolved issue since data concerning the effect of testosterone on endothelial function are scanty and contradictory...
  39. ncbi request reprint [Obesity and endothelial dysfunction]
    Stefano Taddei
    Prof Stefano Taddei Dipartimento di Medicina Interna, Universita degli Studi, Via Roma, 67 56100 Pisa
    G Ital Cardiol (Rome) 7:715-23. 2006
    ..At present, whether an improvement of endothelial dysfunction secondary to weight loss is significantly associated with a better cardiovascular prognosis is still unknown. (G Ital Cardiol 2006; 7 (11): 715-723)..
  40. ncbi request reprint Nitric oxide modulates tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 49:878-84. 2007
    ....
  41. pmc Endothelium-dependent contractions and endothelial dysfunction in human hypertension
    Daniele Versari
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Br J Pharmacol 157:527-36. 2009
    ..The mechanisms that regulate the balance between NO and EDCF, and the processes transforming the endothelium from a protective organ to a source of vasoconstrictor, proaggregatory and promitogenic mediators remain to be determined...
  42. ncbi request reprint Therapeutic implications of recent megatrials: in favor of old drugs
    Antonio Salvetti
    Department of Internal Medicine, University of Pisa, Pisa Italy
    J Nephrol 20:S4-S11. 2007
    ....
  43. doi request reprint Tissue-type plasminogen activator release in healthy subjects and hypertensive patients: relationship with beta-adrenergic receptors and the nitric oxide pathway
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 52:314-21. 2008
    ..This impaired fibrinolytic activity might contribute to the increased cardiovascular risk associated with hypertension...
  44. ncbi request reprint Calcium antagonist treatment by lercanidipine prevents hyperpolarization in essential hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Hypertension 41:950-5. 2003
    ..These results indicate that in essential hypertension, lercanidipine increases endothelium-dependent vasodilation by restoring NO availability and preventing hyperpolarization, an effect probably determined by antioxidant activity...
  45. ncbi request reprint Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 48:508-15. 2006
    ....
  46. doi request reprint Effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients
    Chiara Giannarelli
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Circulation 119:1625-33. 2009
    ..We aimed to assess the effect of sulfaphenazole, a specific CYP 2C9 inhibitor, on tPA release in normotensive subjects and patients with essential hypertension...
  47. ncbi request reprint Effects of antihypertensive drugs on endothelial dysfunction: clinical implications
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs 62:265-84. 2002
    ..In the near future, large scale clinical trials are required to demonstrate that treatment of endothelial dysfunction can lead to better prognosis in patients with essential hypertension...
  48. ncbi request reprint Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
    ..Patients with sHT are characterized by endothelial dysfunction resulting from a reduction in NO availability, an alteration partially independent of dyslipidemia and reversed by levothyroxine supplementation...
  49. doi request reprint The blockade of adenosine deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors
    Luca Antonioli
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    J Pharmacol Exp Ther 335:434-42. 2010
    ....
  50. ncbi request reprint Endothelium-dependent vasodilation and carotid artery wall remodeling in athletes and sedentary subjects
    Fabio Galetta
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56126, Pisa, Italy
    Atherosclerosis 186:184-92. 2006
    ..56, p<0.0001). In conclusion, regular physical training can attenuate the age-related impairment of endothelium-dependent vasodilation, which is related to an attenuation of the age-induced remodeling of the carotid wall...
  51. pmc Lack of pharmacokinetic bioequivalence between generic and branded amoxicillin formulations. A post-marketing clinical study on healthy volunteers
    Mario Del Tacca
    Clinical Pharmacology Centre for Drug Experimentation, Pisa University Hospital, Pisa, Italy
    Br J Clin Pharmacol 68:34-42. 2009
    ..The aim was to establish whether two generic formulations of amoxicillin, available on the Italian market, fulfil the criteria for clinical pharmacokinetic bioequivalence vs. the branded drug...
  52. ncbi request reprint Vascular reactivity in congenital hypogonadal men before and after testosterone replacement therapy
    Giampaolo Bernini
    Department of Internal Medicine, Pisa University, Italy
    J Clin Endocrinol Metab 91:1691-7. 2006
    ..The contribution of endogenous testosterone (TS) in the functional integrity of peripheral circulation in men was studied...
  53. ncbi request reprint Which endothelium-derived factors are really important in humans?
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    Biol Chem 387:151-7. 2006
    ..Further studies are needed in the future to assess the specific impact of different endothelial responses on the clinical outcome in patients with cardiovascular risk factors and disease...
  54. ncbi request reprint Endothelium, aging, and hypertension
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Curr Hypertens Rep 8:84-9. 2006
    ..Currently, dynamic physical activity represents the only effective intervention in preventing age-related impaired endothelium-dependent vasodilation in aged healthy individuals...
  55. ncbi request reprint Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study
    F Monzani
    Department of Internal Medicine and National Research Council Institute of Clinical Physiology, University of Pisa, Pisa 56126, Italy
    J Clin Endocrinol Metab 89:2099-106. 2004
    ....
  56. ncbi request reprint Central blood pressure, arterial stiffness, and wave reflection: new targets of treatment in essential hypertension
    Lorenzo Ghiadoni
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Curr Hypertens Rep 11:190-6. 2009
    ..Thus, whether these measurements should be routinely performed as a diagnostic or therapeutic indicator remains debatable...
  57. doi request reprint The ageing endothelium, cardiovascular risk and disease in man
    Daniele Versari
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Exp Physiol 94:317-21. 2009
    ..Therefore, it is conceivable that endothelial dysfunction plays a major role in predisposing to age-related increased cardiovascular risk in the elderly...
  58. ncbi request reprint Inhibition of adenosine deaminase attenuates inflammation in experimental colitis
    Luca Antonioli
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Pisa, Italy
    J Pharmacol Exp Ther 322:435-42. 2007
    ....
  59. ncbi request reprint Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment
    Dierk H Endemann
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Hypertension 43:399-404. 2004
    ....
  60. ncbi request reprint Hyperhomocyst(e)inemia: is this a novel risk factor in hypertension?
    Agostino Virdis
    Department of Internal Medicine University of Pisa, Italy
    J Nephrol 15:414-21. 2002
    ....
  61. ncbi request reprint Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang II-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats
    Rhian M Touyz
    Laboratory of Experimental Hypertension, bLaboratory of Experimental Cardiovascular Biology, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 20:1127-34. 2002
    ..In the present in vivo study, we investigated whether short-term inhibition of ERK1/2-dependent signaling pathways influences vascular function and blood pressure (BP) in spontaneously hypertensive rats (SHR)...
  62. ncbi request reprint Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma
    Quy N Diep
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Montreal, Quebec, Canada
    Circulation 105:2296-302. 2002
    ..We tested the hypothesis that pioglitazone or rosiglitazone would prevent BP elevation and vascular dysfunction in angiotensin (Ang) II-infused rats by direct vascular effects...
  63. ncbi request reprint Spironolactone improves angiotensin-induced vascular changes and oxidative stress
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Hypertension 40:504-10. 2002
    ..Our findings suggest that aldosterone may mediate some of angiotensin II-induced vascular effects in hypertension, in part via increased oxidative stress...
  64. ncbi request reprint Resistance artery mechanics and composition in angiotensin II-infused rats: effects of aldosterone antagonism
    Mario Fritsch Neves
    Multidisciplinary Research Group on Hypertension, Canadian Institutes of Health Research, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    J Hypertens 21:189-98. 2003
    ..Angiotensin (Ang) II stimulates aldosterone production, which may mediate some of the effects of Ang II...
  65. ncbi request reprint Small artery mechanics in hyperhomocysteinemic mice: effects of angiotensin II
    Mario F Neves
    Canadian Institutes of Health Research, Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    J Hypertens 22:959-66. 2004
    ..The purpose of this study was to evaluate whether mild hyperhomocysteinemia (H-Hcy) may increase vascular stiffness of small arteries...
  66. ncbi request reprint Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction
    Farhad Amiri
    Experimental Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Circulation 110:2233-40. 2004
    ..To directly test the role of endothelium-derived ET-1 in cardiovascular pathophysiology, we specifically targeted expression of the human preproET-1 gene to the endothelium by using the Tie-2 promoter in C57BL/6 mice...
  67. ncbi request reprint Attenuated responses to angiotensin II in follitropin receptor knockout mice, a model of menopause-associated hypertension
    Danesh Javeshghani
    Experimental Hypertension, Clinical Research Institute of Montreal, Quebec, 110 Pine Ave West, Montreal, H2W 1R7, Canada
    Hypertension 42:761-7. 2003
    ..Our findings suggest that vascular Ang II signaling is downregulated in female FORKO mice and that Ang II may not play an important role in blood pressure elevation in this model of menopause-associated hypertension...
  68. ncbi request reprint Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy
    Mario Fritsch Neves
    Clinical Research Institute of Montreal, QC, Canada
    Can J Physiol Pharmacol 83:999-1006. 2005
    ....
  69. ncbi request reprint Aging and hypertension: what about the endothelium?
    Lorenzo Ghiadoni
    J Hypertens 24:1243-4. 2006
  70. ncbi request reprint Tissue kallikrein gene polymorphisms induce no change in endothelium-dependent or independent vasodilation in hypertensive and normotensive subjects
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University of Padova, Padova, Italy
    J Hypertens 24:1955-63. 2006
    ....
  71. ncbi request reprint Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 23:1352-7. 2003
    ..We evaluated the effect of hyperhomocystinemia and angiotensin (Ang) II on vascular function and structure in methylenetetrahydrofolate reductase knockout mice (Mthfr+/-)...
  72. ncbi request reprint Chronic treatment with long-acting nifedipine reduces vasoconstriction to endothelin-1 in essential hypertension
    Isabella Sudano
    Cardiovascular Center, Cardiology, University Hospital of Zurich, Zurich, Switzerland
    Hypertension 49:285-90. 2007
    ..Those vasculoprotective effects may importantly contribute to a reduction in major clinical events seen during treatment with these compounds...
  73. ncbi request reprint Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling
    Qian Pu
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Hypertension 42:49-55. 2003
    ..Endothelin blockade may exert beneficial effects on vascular remodeling, fibrosis, oxidative stress, and adhesion molecule expression in aldosterone-induced hypertension...
  74. ncbi request reprint The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Am Coll Cardiol 41:938-45. 2003
    ..We sought to investigate whether two polymorphisms located in the promoter (T(-786)C) and exon 7 (Glu298Asp) of the endothelial nitric oxide (NO) synthase (eNOS) gene affected agonists-mediated NO release...
  75. ncbi request reprint Vascular inflammation: a role in vascular disease in hypertension?
    Agostino Virdis
    Multidisciplinary Research Group on Hypertension, Quebec, Canada
    Curr Opin Nephrol Hypertens 12:181-7. 2003
    ....
  76. ncbi request reprint Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice
    Agostino Virdis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:535-42. 2004
    ..Angiotensin (Ang) II stimulates vascular reactive oxygen species generation via NAD(P)H oxidase activation. We investigated whether vascular NAD(P)H oxidase influences structure and function of resistance arteries from Ang II-infused mice...
  77. ncbi request reprint A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke
    Francesco Cipollone
    G d Annunzio University of Chieti and G d Annunzio University Foundation, Chieti, Italy
    JAMA 291:2221-8. 2004
    ..Although COX-2 expression may be genetically determined, the relation between COX-2 polymorphisms and the risk of MI and stroke is unclear...
  78. ncbi request reprint Low birth weight and insulin resistance: can capillary recruitment predict hypertension development?
    Agostino Virdis
    J Hypertens 20:1933-5. 2002