Paolo Vineis

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint History of bias
    Paolo Vineis
    University of Torino, ISI Foundation, Torino
    Soz Praventivmed 47:156-61. 2002
  2. ncbi request reprint Tobacco and cancer: recent epidemiological evidence
    P Vineis
    Unit of Cancer Epidemiology, University of Torino, CPO Piemonte, via Santena 7 10126 Torino, Torino, Italy
    J Natl Cancer Inst 96:99-106. 2004
  3. ncbi request reprint Cancer as an evolutionary process at the cell level: an epidemiological perspective
    Paolo Vineis
    Department of Biomedical Sciences and Human Oncology, University of Torino, Via Santena 7, 10126 Torino, Italy and ISI Foundation, Torino, Italy
    Carcinogenesis 24:1-6. 2003
  4. ncbi request reprint The randomized controlled trial in studies using biomarkers
    Paolo Vineis
    Dipartimento di Scienze Biomediche e Oncologia Umana, Via Santena 7, University of Torino, Torino, Italy
    Biomarkers 8:13-32. 2003
  5. ncbi request reprint The relationship between polymorphisms of xenobiotic metabolizing enzymes and susceptibility to cancer
    Paolo Vineis
    Dipartimento di Scienze Biomediche e Oncologia Umana, Unit of Cancer Epidemiology, University of Torino and ISI Foundation, Via Santena 7, 10126 Torino, Italy
    Toxicology 181:457-62. 2002
  6. ncbi request reprint CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls
    Paolo Vineis
    Universita degli Studi di Torino, Torino, Italy
    Int J Cancer 104:650-7. 2003
  7. ncbi request reprint Diet, genetic susceptibility and carcinogenesis
    P Vineis
    Unit of Cancer Epidemiology, University of Torino and CPO Piemonte, Torino, Italy
    Public Health Nutr 4:485-91. 2001
  8. ncbi request reprint Causality in epidemiology
    Paolo Vineis
    Unit of Clinical Epidemiology, Ospedale S Giovanni Battista, Torino
    Soz Praventivmed 48:80-7. 2003
  9. pmc Evidence-based medicine and ethics: a practical approach
    P Vineis
    University of Torino and ISI Foundation, Torino
    J Med Ethics 30:126-30. 2004
  10. pmc Delayed infection, late tonsillectomy or adenoidectomy and adult leukaemia: a case-control study
    P Vineis
    Servizio di Epidemiologia dei Tumori, Ospedale S Giovanni Battista e Università di Torino, Italy
    Br J Cancer 88:47-9. 2003

Detail Information

Publications100

  1. ncbi request reprint History of bias
    Paolo Vineis
    University of Torino, ISI Foundation, Torino
    Soz Praventivmed 47:156-61. 2002
    ..The subsequent period--until now--has been characterised by more formal and systematic definitions...
  2. ncbi request reprint Tobacco and cancer: recent epidemiological evidence
    P Vineis
    Unit of Cancer Epidemiology, University of Torino, CPO Piemonte, via Santena 7 10126 Torino, Torino, Italy
    J Natl Cancer Inst 96:99-106. 2004
  3. ncbi request reprint Cancer as an evolutionary process at the cell level: an epidemiological perspective
    Paolo Vineis
    Department of Biomedical Sciences and Human Oncology, University of Torino, Via Santena 7, 10126 Torino, Italy and ISI Foundation, Torino, Italy
    Carcinogenesis 24:1-6. 2003
    ....
  4. ncbi request reprint The randomized controlled trial in studies using biomarkers
    Paolo Vineis
    Dipartimento di Scienze Biomediche e Oncologia Umana, Via Santena 7, University of Torino, Torino, Italy
    Biomarkers 8:13-32. 2003
    ..This review summarizes the main issues that should be addressed in a protocol, and illustrates these with an example...
  5. ncbi request reprint The relationship between polymorphisms of xenobiotic metabolizing enzymes and susceptibility to cancer
    Paolo Vineis
    Dipartimento di Scienze Biomediche e Oncologia Umana, Unit of Cancer Epidemiology, University of Torino and ISI Foundation, Via Santena 7, 10126 Torino, Italy
    Toxicology 181:457-62. 2002
    ..In addition, a theoretical approach to the problem of gene-environment interactions at low levels of exposure is offered...
  6. ncbi request reprint CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls
    Paolo Vineis
    Universita degli Studi di Torino, Torino, Italy
    Int J Cancer 104:650-7. 2003
    ..The analyses were more inconsistent and failed to reach statistical significance in Asians. This observation might be due to design specificities or unknown effect modifiers in the Asian studies...
  7. ncbi request reprint Diet, genetic susceptibility and carcinogenesis
    P Vineis
    Unit of Cancer Epidemiology, University of Torino and CPO Piemonte, Torino, Italy
    Public Health Nutr 4:485-91. 2001
    ..The present contribution is a short review of the relevant literature, with particular emphasis on some polymorphisms involved in dietary exposures. In addition, the practical implications of genetic testing in this field are discussed...
  8. ncbi request reprint Causality in epidemiology
    Paolo Vineis
    Unit of Clinical Epidemiology, Ospedale S Giovanni Battista, Torino
    Soz Praventivmed 48:80-7. 2003
    ..Epidemiology makes use more often of study designs that simulate experimentation, than of surveys in the general population...
  9. pmc Evidence-based medicine and ethics: a practical approach
    P Vineis
    University of Torino and ISI Foundation, Torino
    J Med Ethics 30:126-30. 2004
    ..Physicians and patients should accept the irreducible fuzziness of many of the concepts they use when dealing with health and disease...
  10. pmc Delayed infection, late tonsillectomy or adenoidectomy and adult leukaemia: a case-control study
    P Vineis
    Servizio di Epidemiologia dei Tumori, Ospedale S Giovanni Battista e Università di Torino, Italy
    Br J Cancer 88:47-9. 2003
    ..2, 95% confidence interval 1.1-16.2). We propose that late infection is a proliferative stimulus for B-cells...
  11. ncbi request reprint Dose-response relationship in tobacco-related cancers of bladder and lung: a biochemical interpretation
    Paolo Vineis
    Department of Biomedical Sciences and Human Oncology, University of Torino and ISI Foundation, Torino, Italy
    Int J Cancer 108:2-7. 2004
  12. ncbi request reprint Outdoor air pollution and lung cancer: recent epidemiologic evidence
    Paolo Vineis
    Department of Biomedical Sciences and Human Oncology, University of Turin and CPO Piemonte, Turin, Italy
    Int J Cancer 111:647-52. 2004
  13. pmc Haematopoietic cancer and medical history: a multicentre case control study
    P Vineis
    Unit of Cancer Epidemiology, Ospedale S Giovanni, Torino, Italy
    J Epidemiol Community Health 54:431-6. 2000
    ..Other associations (diabetes, tonsillectomy, autoimmune diseases) have been inconsistently reported...
  14. pmc Delayed infection, family size and malignant lymphomas
    P Vineis
    Servizio di Epidemiologia dei Tumori, Ospedale S Giovanni Battista e Università di Torino, Via Santena 7, I 10123 Torino, Italy
    J Epidemiol Community Health 54:907-11. 2000
    ..It is suggested that delayed infection could explain NHL trends, through an impairment of the Th1/Th2 lymphocyte patterns...
  15. ncbi request reprint Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer
    Carlotta Sacerdote
    Unità di epidemiologia dei tumori, Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino and CPO Piemonte, Torino, Italy
    Mutagenesis 22:281-5. 2007
    ..This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms...
  16. doi request reprint DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis
    Fabrizio Veglia
    Life Sciences and Epidemiology Unit, ISI Foundation, Torino 10133, Italy
    Carcinogenesis 29:932-6. 2008
    ..The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years...
  17. pmc Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy
    Carlotta Sacerdote
    HuGeF Human Genetics Foundation, Torino, Italy
    Int J Cancer 133:2004-9. 2013
    ..This finding may have clinical implications for the choice of therapy. ..
  18. doi request reprint Association between total number of deaths, diabetes mellitus, incident cancers, and haplotypes in chromosomal region 8q24 in a prospective study
    Simonetta Guarrera
    Department of Genetics, Biology and Biochemistry, Universityof Torino, Torino, Italy
    Am J Epidemiol 175:479-87. 2012
    ..This observation can shed light on the mechanisms underlying reported associations between 8q24 variants and disparate chronic diseases...
  19. doi request reprint ERCC1 haplotypes modify bladder cancer risk: a case-control study
    Fulvio Ricceri
    Unit of Epidemiology and Life Sciences, ISI Foundation, Turin, Italy
    DNA Repair (Amst) 9:191-200. 2010
    ..A detailed characterization of DNA repair genetic variation is warranted and might ultimately help to identify multiple susceptibility variants that could be responsible for joint effects on the risk...
  20. ncbi request reprint Expression of DNA repair and metabolic genes in response to a flavonoid-rich diet
    Simonetta Guarrera
    Institute for Scientific Interchange Foundation, Section of Life Sciences, Viale Settimio Severo 65, Torino, Italy
    Br J Nutr 98:525-33. 2007
    ..Larger studies are needed to clarify the possible effects of flavonoids in vivo; our preliminary results could help to better plan new studies on gene expression and diet...
  21. doi request reprint Persistent infection by HCV and EBV in peripheral blood mononuclear cells and risk of non-Hodgkin's lymphoma
    Lorenzo Richiardi
    Cancer Epidemiology Unit, CeRMS and CPO Piemonte, University of Turin, Via Santena 7, 10129 Turin, Italy
    Cancer Epidemiol 34:709-12. 2010
    ..These null results, although based on a relatively small sample size, suggest that persistent EBV and HCV infection in the PBMC is not a stronger predictor of NHL risk than serological evidence of infection...
  22. ncbi request reprint Lactase persistence and bitter taste response: instrumental variables and mendelian randomization in epidemiologic studies of dietary factors and cancer risk
    Carlotta Sacerdote
    Centre for cancer Epidemiology and Prevention CPO Piemonte, Turin, Italy
    Am J Epidemiol 166:576-81. 2007
    ..These results suggest that the LCT and TAS2R38 variants are good candidates for Mendelian randomization studies of cancer and other health outcomes...
  23. ncbi request reprint Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis
    Paolo Vineis
    Epidemiology Department, Univerisitá degli Studi di Torino, 10126 Torino, Italy
    Carcinogenesis 28:1902-5. 2007
    ..People with rare combinations of common gene variants have a high risk of cancer and can be assimilated to subjects with highly penetrant mutations...
  24. ncbi request reprint Occupational exposures, environmental tobacco smoke, and lung cancer
    Fabrizio Veglia
    Institute for Scientific Interchange ISI Foundation, Turin, Italy
    Epidemiology 18:769-75. 2007
    ..We have studied the association between 52 high-risk job titles and lung cancer incidence in a large prospective study, with more than 200,000 participants followed for more than 6 years and 809 incident cases of lung cancer...
  25. pmc Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects
    Fulvio Ricceri
    Human Genetics Foundation previously at ISI Foundation, Turin, Italy
    Cancer Epidemiol Biomarkers Prev 19:3174-81. 2010
    ..Factors that have been reported to be related to DNA adduct levels include smoking, diet, body mass index (BMI), genetic polymorphisms, the season of collection of biologic material, and air pollutants...
  26. doi request reprint Is there evidence of involvement of DNA repair polymorphisms in human cancer?
    Fulvio Ricceri
    Human Genetics Foundation, Torino, Italy
    Mutat Res 736:117-21. 2012
    ....
  27. ncbi request reprint Bulky DNA adducts and risk of cancer: a meta-analysis
    Fabrizio Veglia
    Section of Life Sciences, ISI Foundation, 10133 Torino, Italy
    Cancer Epidemiol Biomarkers Prev 12:157-60. 2003
    ..This conclusion also suggests that similar (aromatic) compounds may be involved in the etiology of both types of cancer...
  28. ncbi request reprint Lower educational level is a predictor of incident type 2 diabetes in European countries: the EPIC-InterAct study
    Carlotta Sacerdote
    Center for Cancer Prevention, CPO Piemonte, Torino, Italy
    Int J Epidemiol 41:1162-73. 2012
    ..Age-, gender- and country-specific relative indices of inequality (RII) were used as the measure of educational level and RII tertiles were analysed...
  29. ncbi request reprint Randomized controlled trial: effect of nutritional counselling in general practice
    Carlotta Sacerdote
    CPO Piemonte, Torino, Italy
    Int J Epidemiol 35:409-15. 2006
    ..To investigate the effectiveness of a non-structured 15-min educational intervention by general practitioners (GPs) on modifications of daily diet among healthy adults...
  30. ncbi request reprint Exposure to solvents and risk of non-Hodgkin lymphoma: clues on putative mechanisms
    Paolo Vineis
    University of Turin, Turin, Italy
    Cancer Epidemiol Biomarkers Prev 16:381-4. 2007
    ..Both hypotheses (i.e., the interaction with autoimmune diseases and with familial predisposition) indirectly suggest that an immunologic mechanism could be involved in lymphomagenesis from solvents...
  31. ncbi request reprint XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review
    Maurizio Manuguerra
    Section of Epidemiology, ISI Foundation, Torino, Italy
    Am J Epidemiol 164:297-302. 2006
    ....
  32. ncbi request reprint Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells
    Federica Saletta
    Section of Life Sciences, ISI Foundation, Turin, Italy
    Cancer Res 67:7088-94. 2007
    ....
  33. pmc Occult HCV infection: an unexpected finding in a population unselected for hepatic disease
    Laura De Marco
    Unit of Cancer Epidemiology, C E R M S, University of Turin, Turin, Italy
    PLoS ONE 4:e8128. 2009
    ..Abnormal values of liver enzymes and presence of replicative HCV-RNA in peripheral blood mononuclear cells are also observed. Aim of the study was to evaluate occult HCV occurrence in a population unselected for hepatic disease...
  34. ncbi request reprint Aromatic amines and cancer
    P Vineis
    Unit of Cancer Epidemiology, Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
    Cancer Causes Control 8:346-55. 1997
    ..The consistent observation of a difference between men and women in bladder cancer risk, after allowing for known risk factors, suggests consideration of gender-related biological determinants for future investigation...
  35. ncbi request reprint DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
    G Matullo
    ISI Foundation and Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    Carcinogenesis 27:997-1007. 2006
    ..Further investigations of the combined effects of polymorphisms within these DNA repair genes, smoking and other risk factors may help to clarify the influence of genetic variation in the carcinogenic process...
  36. ncbi request reprint DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study
    G Matullo
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Turin, Italy
    Int J Cancer 92:562-7. 2001
    ..Our results suggest that bladder-cancer risk can be genetically modulated by XRCC3, which may repair DNA cross-link lesions produced by aromatic amines and other environmental chemicals...
  37. ncbi request reprint Current smoking, occupation, N-acetyltransferase-2 and bladder cancer: a pooled analysis of genotype-based studies
    P Vineis
    CPO Piemonte at the University of Torino, Torino, Italy
    Cancer Epidemiol Biomarkers Prev 10:1249-52. 2001
    ..Our observation suggests that NAT2 is not a risk factors per se but modulates the effect of carcinogens contained in tobacco smoke (probably arylamines) or associated with occupational exposures...
  38. doi request reprint Appropriateness of early breast cancer management in relation to patient and hospital characteristics: a population based study in Northern Italy
    R Rosato
    Department of Psychology, University of Torino, Torino, Italy
    Breast Cancer Res Treat 117:349-56. 2009
    ..Social and geographical factors, in addition to hospital specialization, should be considered to reduce inappropriateness of care for breast cancer...
  39. ncbi request reprint [The physicians' view on the utility and impact of oncological guidelines in clinical practice. A survey of Piedmont physicians]
    Carlotta Sacerdote
    SCDU Epidemiologia dei Tumori, AO S G Battista, CPO Piemonte, Torino
    Epidemiol Prev 31:34-8. 2007
    ..To determine whether the guidelines (LGR) prepared in Piedmont for the treatment of colorectal and breast cancer reached the targetphysician population and how they were been perceived by physicians...
  40. ncbi request reprint Individual susceptibility to carcinogens
    Paolo Vineis
    Unit of Cancer Epidemiology, Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
    Oncogene 23:6477-83. 2004
    ..Such susceptibility genes are of considerable scientific interest, but do not confer high enough risks to be clinically relevant...
  41. ncbi request reprint Environment, population, and biology: a short history of modern epidemiology
    Alessandra Parodi
    History of Medicine, University of Torino, Italy
    Perspect Biol Med 49:357-68. 2006
    ..The tension between mechanistic and population-based studies is still present within epidemiology and is in fact essential for the success of the discipline...
  42. ncbi request reprint Determinants of exposure to environmental tobacco smoke in 21,588 Italian non-smokers
    Fabrizio Veglia
    Institute for Scientific Interchange Foundation, Turin, Italy
    Tumori 89:665-8. 2003
    ..Exposure is likely to be uneven in the population. Knowledge of its distribution is important for a better planning of preventive activities...
  43. pmc Compliance with clinical practice guidelines for breast cancer treatment: a population-based study of quality-of-care indicators in Italy
    Carlotta Sacerdote
    Cancer Epidemiology Unit, San Giovanni Battista Hospital, CPO Piemonte and University of Turin, Turin, Italy
    BMC Health Serv Res 13:28. 2013
    ..The aim of this population-based study was to evaluate the impact of regional guidelines (Piedmont guidelines, PGL) for breast cancer diagnosis and treatment on quality-of-care indicators in the Northwestern Italian region of Piedmont...
  44. ncbi request reprint Dietary habits, internal migration and social class in a sample of a northern Italian population
    P Vineis
    Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
    Tumori 78:235-8. 1992
    ..47 in men and 0.56 in women. Important gradients by social class were also suggested for several nutrients...
  45. doi request reprint Modelling patterns of clearance of HPV-16 infection and vaccination efficacy
    Iacopo Baussano
    SCDU di Epidemiologia dei Tumori, Servizio di Statistica Medica, CPO Piemonte, Novara, Italy
    Vaccine 29:1270-7. 2011
    ....
  46. ncbi request reprint Genetic testing for sale
    Paolo Vineis
    University of Torino, Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
    Epidemiology 15:3-5. 2004
  47. ncbi request reprint Selection and validation of biomarkers for chemoprevention: the contribution of epidemiology
    P Vineis
    University of Torino, Italy
    IARC Sci Publ 154:57-68. 2001
    ..Finally, we suggest a theory of causality based on the work of Wesley Salmon and the concept of 'propagating mark', which is particularly attractive for molecular epidemiologists...
  48. ncbi request reprint Quality of systematic reviews used in guidelines for oncology practice
    F Vigna-Taglianti
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    Ann Oncol 17:691-701. 2006
    ..Systematic reviews are an important tool for developing clinical recommendations. Those of high quality assure a good level of confidence on the strength of the recommendations...
  49. ncbi request reprint XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects
    G Matullo
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126, Torino, ISI Foundation, Institute for Scientific Interchange, Villa Gualino, 10133, Torino, Italy
    Carcinogenesis 22:1437-45. 2001
    ..These data show that all the analysed polymorphisms could result in deficient DNA repair and suggest a need for further investigation into the possible interactions between these polymorphisms, smoking and other risk factors...
  50. ncbi request reprint Prevention of exposure of young children to parental tobacco smoke: effectiveness of an educational program
    P Vineis
    Unit of Cancer Epidemiology, Ospedale Maggiore di S. Giovanni Battista, Torino, Italy
    Tumori 79:183-6. 1993
    ..CONCLUSIONS: Educational interventions against smoking should be planned taking into account the difference in efficacy according to social class...
  51. ncbi request reprint EPO or not-EPO? An evidence based informed consent
    E Mezza
    Department of Internal Medicine, University of Torino, Torino, Italy
    Int J Artif Organs 27:320-9. 2004
    ..Informed consent is crucial in therapeutic choices; however, the forms presented to patients are often locally developed and information may not be homogeneous...
  52. ncbi request reprint DNA adducts and the protective role of fruits and vegetables
    P Vineis
    University of Torino, Italy
    IARC Sci Publ 156:469-74. 2002
  53. ncbi request reprint Asbestos exposure, physical activity and colon cancer: a case-control study
    P Vineis
    Dipartimento di Scienze Biomediche e Oncologia Umana, Main Hospital and University of Torino, Italy
    Tumori 79:301-3. 1993
    ..8, 95% c.i. 1.05-21.5), in particular pipe fitters and boilermakers (3 cases and 1 control; OR = 10.7; 1.07-103)...
  54. ncbi request reprint Inter-observer variability in the interpretation of mammograms
    P Vineis
    Servizio di Epidemiologia dei Tumori, , Torino, Italia
    Tumori 74:275-9. 1988
    ..82 (median 0.60) for parenchymal patterns; 0.33-0.67 (0.48) for diagnosis in five categories; and 0.22-0.57 (0.38) for indications for further diagnostic tests. These values are comparable with those reported from other investigations...
  55. pmc Haemoglobin adducts formed by aromatic amines in smokers: sources of inter-individual variability
    G Ronco
    Unit of Epidemiology, Local Health Administration TO I, Torino, Italy
    Br J Cancer 61:534-7. 1990
    ..This interpretation is consistent with recent animal experiments suggesting that there are different enzyme systems for the two classes of compounds...
  56. pmc Disease proportions attributable to environment
    Rodolfo Saracci
    Imperial College London, St, Mary s Campus, Norfolk Place W2 1PG, London, UK
    Environ Health 6:38. 2007
    ..The latter aspect is not just a semantic question but carries implications for the focus of preventive actions, whether centred on the material and social environment or on single individuals...
  57. ncbi request reprint The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition
    Stein Emil Vollset
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 16:2416-24. 2007
    ..However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer...
  58. ncbi request reprint Assessment of cumulative evidence on genetic associations: interim guidelines
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Int J Epidemiol 37:120-32. 2008
    ..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...
  59. ncbi request reprint Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study
    Timothy J Key
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:672-81. 2007
    ..Previous studies suggest that high plasma concentrations of carotenoids, retinol, or tocopherols may reduce the risk of prostate cancer...
  60. ncbi request reprint The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects
    Domenico Palli
    Molecular and Nutritional Epidemiology Unit and Cancer Risk Factor Branch, Molecular Biology Laboratory CSPO, Scientific Institute of Tuscany, Florence, Italy
    Carcinogenesis 25:577-84. 2004
    ..Our results suggest that the role of a diet rich in antioxidants in preventing or reducing DNA adduct formation is restricted to subjects lacking the detoxifying activity of GSTM1 isoenzyme (approximately 50% of the general population)...
  61. doi request reprint Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
    Hubert W Vesper
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Agric Food Chem 56:6046-53. 2008
    ..In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered...
  62. ncbi request reprint Occupation and bladder cancer among men in Western Europe
    Manolis Kogevinas
    Respiratory and Environmental Health Research Unit, IMIM, Barcelona, Spain
    Cancer Causes Control 14:907-14. 2003
    ..We examined which occupations and industries are currently at high risk for bladder cancer in men...
  63. ncbi request reprint Non-Hodgkin's lymphoma, leukemia, and exposures in agriculture: results from the Italian multicenter case-control study
    Lucia Miligi
    Environmental and Occupational Epidemiology Unit, Center for Study and Prevention of Cancer, Florence, Italy
    Am J Ind Med 44:627-36. 2003
    ..The etiology of non-Hodgkin's lymphoma (NHL) and leukemia is still largely unknown, but exposure to chemicals, in particular pesticides, has been suggested to be a risk factor...
  64. doi request reprint CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
    Mazda Jenab
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Eur J Cancer 44:774-80. 2008
    ..However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. These findings should be confirmed in larger independent studies...
  65. doi request reprint A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
    ..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
  66. ncbi request reprint Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review
    Lawrence S Engel
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Am J Epidemiol 156:95-109. 2002
    ..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer...
  67. ncbi request reprint Biomarkers of dietary intake of micronutrients modulate DNA adduct levels in healthy adults
    Domenico Palli
    Molecular and Nutritional Epidemiology Unit and Cancer Risk Factor Branch, Molecular Biology Laboratory CSPO, Scientific Institute of Tuscany, Florence, Italy
    Carcinogenesis 24:739-46. 2003
    ....
  68. doi request reprint Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Julie A Britton
    Department of Epidemiology and Public Health, Imperial College London, Room 151, St Mary s Campus, Norfolk Place W2 1PG, London, UK
    Haematologica 93:1666-77. 2008
    ..It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma...
  69. ncbi request reprint 4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European Prospective Investigation into Cancer and Nutrition prospective study
    Luisa Airoldi
    Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Epidemiol Biomarkers Prev 14:2118-24. 2005
    ..The most important finding of this prospective study is that, at least in women, 4-ABP-Hb adducts may help identify subjects at high risk of cancers related to environmental tobacco smoke exposure...
  70. doi request reprint The microenvironments of multistage carcinogenesis
    Ezio Laconi
    Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Patologia Sperimentale, Universita di Cagliari, 09125 Cagliari, Italy
    Semin Cancer Biol 18:322-9. 2008
    ..A deeper understanding of the role(s) of tissue and tumor microenvironments in the pathogenesis of cancer is essential to design more effective strategies for the management of this disease...
  71. ncbi request reprint Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population
    Ute Nöthlings
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, 14558 Germany
    J Nutr 138:775-81. 2008
    ....
  72. ncbi request reprint Combination of DNA repair gene single nucleotide polymorphisms and increased levels of DNA adducts in a population-based study
    Giuseppe Matullo
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Italy
    Cancer Epidemiol Biomarkers Prev 12:674-7. 2003
    ..18-21.45; five alleles, adjusted OR = 7.65, 95% CI = 0.94-62.2]. Our study suggests that the combined effect of multiple variant alleles may be more important than the investigation of single SNP in modulating DNA repair capacity...
  73. ncbi request reprint A molecular epidemiology project on diet and cancer: the EPIC-Italy Prospective Study. Design and baseline characteristics of participants
    Domenico Palli
    UO Epidemiologia Molecolare e Nutrizionale, Centro per lo Studio e la Prevenzione Oncologica CSPO, Istituto scientifico della Regione Toscana, Florence, Italy
    Tumori 89:586-93. 2003
    ..Baseline characteristics of participants are briefly described...
  74. ncbi request reprint Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition
    Ruth C Travis
    Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    Int J Cancer 121:1331-8. 2007
    ....
  75. ncbi request reprint Air pollution and risk of lung cancer in a prospective study in Europe
    Paolo Vineis
    Imperial College London, London, UK
    Int J Cancer 119:169-74. 2006
    ..The association with NO(2) did not change after adjustment by cotinine and additional potential confounders, including occupational exposures. No clear association was found with other pollutants...
  76. ncbi request reprint A pooled analysis of bladder cancer case-control studies evaluating smoking in men and women
    Diana Puente
    Respiratory and Environmental Health Research Unit, Municipal Institute of Medical Research IMIM, 80 Dr Aiguader Rd, Barcelona, 08003, Spain
    Cancer Causes Control 17:71-9. 2006
    ..We pooled primary data from 14 case-control studies of bladder cancer from Europe and North America and evaluated differences in risk of smoking by gender...
  77. ncbi request reprint Amount of DNA in plasma and cancer risk: a prospective study
    Emmanuelle Gormally
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:746-9. 2004
    ..e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPD deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% CI = 1.20-4.67)...
  78. ncbi request reprint Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study
    Giuseppe Matullo
    Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2569-78. 2005
    ..03-0.81). Our results suggest that polymorphisms and/or haplotypes in XRCC3, XRCC1, and PCNA genes and spanning XPD-ERCC1 region may modulate bladder cancer risk and that some of these effects may preferentially affect current smokers...
  79. ncbi request reprint Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nu
    Federico Canzian
    Hormones and Cancer Team, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:2316-25. 2005
    ....
  80. ncbi request reprint A self-fulfilling prophecy: are we underestimating the role of the environment in gene-environment interaction research?
    Paolo Vineis
    Department of Epidemiology and Public Health, Imperial College London, UK
    Int J Epidemiol 33:945-6. 2004
  81. ncbi request reprint Measuring DNA repair capacity: small steps
    Marianne Berwick
    J Natl Cancer Inst 97:84-5. 2005
  82. ncbi request reprint DNA adducts and lung cancer risk: a prospective study
    Marco Peluso
    Cancer Risk Factor Branch, CSPO Scientific Institute of Tuscany Region, Florence, Italy
    Cancer Res 65:8042-8. 2005
    ..Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O3 indicates a possible role for photochemical smog in determining DNA damage...
  83. ncbi request reprint Air pollution and cancer: biomarker studies in human populations
    Paolo Vineis
    Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, Norfolk Place, London, UK
    Carcinogenesis 26:1846-55. 2005
    ....
  84. ncbi request reprint Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Rudolf Kaaks
    Nutrition and Hormones Group, International Agency for Research on Cancer IARC WHO, Lyon, France
    J Natl Cancer Inst 97:755-65. 2005
    ..We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort to examine associations among premenopausal serum concentrations of sex steroids and subsequent breast cancer risk...
  85. ncbi request reprint Gene-environment interactions: how many false positives?
    Giuseppe Matullo
    J Natl Cancer Inst 97:550-1. 2005
  86. ncbi request reprint Randomized controlled trial: effects of diet on DNA damage in heavy smokers
    Glenn Talaska
    Department of Environmental Health, University of Cincinnati, OH, USA
    Mutagenesis 21:179-83. 2006
    ..Smoking is the most important single preventable cause of cancer; at the present stage of knowledge it is totally unlikely that certain dietary habits can seriously counteract the effects of tobacco smoking...
  87. ncbi request reprint Randomized controlled trial of dietary intervention: association between level of urinary phenolics and anti-mutagenicity
    Christian Malaveille
    International Agency for Research on Cancer, Lyon, France
    Mutat Res 561:83-90. 2004
    ..A strong correlation was found between urinary phenolics and anti-mutagenicity in all the groups involved in the trial. Such correlation was not explained by dietary variables...
  88. ncbi request reprint TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study
    Emmanuelle Gormally
    IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Res 66:6871-6. 2006
    ..TP53 mutation may be associated with environmental exposures. These observations have implications for monitoring early steps of carcinogenesis...
  89. ncbi request reprint Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Jakob Linseisen
    Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Int J Cancer 121:1103-14. 2007
    ..In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers...
  90. ncbi request reprint Non-Hodgkin's lymphoma and type of tobacco smoke
    Emanuele Stagnaro
    Department of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy
    Cancer Epidemiol Biomarkers Prev 13:431-7. 2004
    ..This investigation sought to evaluate the association between NHL and type of tobacco smoked (blond, black, or mixed), focusing on the Working Formulation (WF) subgroups...
  91. ncbi request reprint Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition
    Olga M Sinilnikova
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 16:409-15. 2007
    ..However, they suggest a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis...
  92. pmc Applying new biotechnologies to the study of occupational cancer--a workshop summary
    Mark Toraason
    National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Environ Health Perspect 112:413-6. 2004
    ..The workshop focused on identifying and interpreting markers for early biologic effect and inherited modifiers of risk...
  93. ncbi request reprint Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
    Kim M Smits
    University Maastricht, Maastricht, The Netherlands
    Int J Cancer 110:266-70. 2004
    ..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected...
  94. pmc Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study
    Paolo Vineis
    Imperial College London, London UK
    Environ Health 6:7. 2007
    ..It is therefore useful to estimate the burden of disease associated with indoor and outdoor air pollution...
  95. ncbi request reprint Immunotoxic effects of chemicals: A matrix for occupational and environmental epidemiological studies
    Angela Veraldi
    Centre for Study and Cancer Prevention, Unit of Environmental and Occupational Epidemiology, Florence, Italy
    Am J Ind Med 49:1046-55. 2006
    ..Many biological and chemical agents have the capacity to alter the way the immune system functions in human and animals. This study evaluates the immunotoxicity of 20 substances used widely in work environments...
  96. ncbi request reprint Alcohol consumption and risk of leukemia: A multicenter case-control study
    Giuseppe Gorini
    Istituto Toscano Tumori, Environmental and Occupational Epidemiology Unit, Centre for Study and Prevention of Cancer CSPO, Via di S Salvi, 12 50135 Florence, Italy
    Leuk Res 31:379-86. 2007
    ....
  97. ncbi request reprint Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort
    Karen Steindorf
    Unit of Environmental Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 119:2389-97. 2006
    ..It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors...
  98. ncbi request reprint Tobacco smoke and bladder cancer--in the European Prospective Investigation into Cancer and Nutrition
    Bine Kjøller Bjerregaard
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 119:2412-6. 2006
    ....
  99. pmc Causal models in epidemiology: past inheritance and genetic future
    Paolo Vineis
    Division of Epidemiology, Public Health and Primary Care, Imperial College London, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Environ Health 5:21. 2006
    ..4. At the population level, there is additional uncertainty in quantifying interaction and assigning etiologic fractions to different necessary causes because of ignorance about the components of the sufficient cause...
  100. ncbi request reprint CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions
    Paolo Vineis
    Imperial College London, London, UK
    Biomarkers 9:298-305. 2004
    ..7 (95% CI = 0.5-15.3). An association between lung cancer and the homozygous CYP1A1*2A genotype is confirmed. An apparent and biologically plausible interaction is suggested between this genotype and GSTM1...