R Vigneri

Summary

Affiliation: University of Catania
Country: Italy

Publications

  1. pmc Insulin analogs and cancer
    Laura Sciacca
    Endocrinology Section, Department of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Nesima Hospital Catania, Italy
    Front Endocrinol (Lausanne) 3:21. 2012
  2. doi request reprint Insulin has multiple antiamyloidogenic effects on human neuronal cells
    Giuseppe Pandini
    Department of Clinical and Molecular Biomedicine, Endocrinology Unit, University of Catania, Garibaldi Nesima Hospital, Via Palermo 636, Catania 95122, Italy
    Endocrinology 154:375-87. 2013
  3. doi request reprint Insulin and its analogs: actions via insulin and IGF receptors
    R Vigneri
    Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Nesima Hospital, Italy
    Acta Diabetol 47:271-8. 2010
  4. ncbi request reprint Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
    L Frittitta
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Garibaldi Hospital, Italy
    Diabetes 47:1095-100. 1998
  5. pmc Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
    F Frasca
    Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    Mol Cell Biol 19:3278-88. 1999
  6. doi request reprint Clinical and molecular mechanisms favoring cancer initiation and progression in diabetic patients
    L Sciacca
    Endocrinology, Department of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Nesima Medical Center, 95122 Catania, Italy
    Nutr Metab Cardiovasc Dis 23:808-15. 2013
  7. ncbi request reprint Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation
    D Spampinato
    Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Hospital, Italy
    Metabolism 52:1092-5. 2003
  8. doi request reprint Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
    L Sciacca
    Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Nesima Hospital, Via Palermo 636, 95122 Catania, Italy
    Diabetologia 53:1743-53. 2010
  9. ncbi request reprint The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
    B V Costanzo
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Ospedale Garibaldi, Italy
    Diabetes 50:831-6. 2001
  10. ncbi request reprint Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms
    R Baratta
    Department of Internal and Specialist Medicine, University of Catania, Garibaldi Hospital, P zza S M di Gesù, 95123 Catania, Italy
    J Mol Med (Berl) 81:718-23. 2003

Collaborators

Detail Information

Publications27

  1. pmc Insulin analogs and cancer
    Laura Sciacca
    Endocrinology Section, Department of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Nesima Hospital Catania, Italy
    Front Endocrinol (Lausanne) 3:21. 2012
    ..Results are controversial and methodologically weak. Therefore prospective clinical studies are needed to evaluate the possible tumor growth-promoting effects of these insulin analogs...
  2. doi request reprint Insulin has multiple antiamyloidogenic effects on human neuronal cells
    Giuseppe Pandini
    Department of Clinical and Molecular Biomedicine, Endocrinology Unit, University of Catania, Garibaldi Nesima Hospital, Via Palermo 636, Catania 95122, Italy
    Endocrinology 154:375-87. 2013
    ..In human neuronal cells, therefore, insulin may prevent Aβ formation and accumulation by multiple mechanisms, both Gsk-3β dependent and independent...
  3. doi request reprint Insulin and its analogs: actions via insulin and IGF receptors
    R Vigneri
    Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Nesima Hospital, Italy
    Acta Diabetol 47:271-8. 2010
    ..Prospective clinical studies, however, may add further useful information on the issue of the insulin analogs' possible differences with respect to native insulin...
  4. ncbi request reprint Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
    L Frittitta
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Garibaldi Hospital, Italy
    Diabetes 47:1095-100. 1998
    ..These studies indicate, therefore, that the elevation of PC-1 content may be a primary factor in the cause of insulin resistance...
  5. pmc Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
    F Frasca
    Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    Mol Cell Biol 19:3278-88. 1999
    ..These data indicate, therefore, that there are two receptors for IGF-II, both IGF-I-R and IR-A. Further, they suggest that interaction of IGF-II with IR-A may play a role both in fetal growth and cancer biology...
  6. doi request reprint Clinical and molecular mechanisms favoring cancer initiation and progression in diabetic patients
    L Sciacca
    Endocrinology, Department of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Nesima Medical Center, 95122 Catania, Italy
    Nutr Metab Cardiovasc Dis 23:808-15. 2013
    ..25), but the pandemic nature of the disease means that a considerable number of lives could be spared through a better understanding of the factors associating diabetes and cancer...
  7. ncbi request reprint Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation
    D Spampinato
    Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Hospital, Italy
    Metabolism 52:1092-5. 2003
    ..8 +/- 10.7 v 55.7 +/- 5.8 nmol x mg(-1) x min(-1)) was not different in the 2 groups. Our data show that GlcN-induced insulin resistance is mediated, at least in part, by impaired skeletal muscle IR autophosphorylation...
  8. doi request reprint Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
    L Sciacca
    Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Nesima Hospital, Via Palermo 636, 95122 Catania, Italy
    Diabetologia 53:1743-53. 2010
    ..The characterisation of these effects was the aim of the present study...
  9. ncbi request reprint The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
    B V Costanzo
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Ospedale Garibaldi, Italy
    Diabetes 50:831-6. 2001
    ....
  10. ncbi request reprint Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms
    R Baratta
    Department of Internal and Specialist Medicine, University of Catania, Garibaldi Hospital, P zza S M di Gesù, 95123 Catania, Italy
    J Mol Med (Berl) 81:718-23. 2003
    ..e., insulin sensitivity index and M value) and insulin secretion (i.e., HOMA-B%) indexes...
  11. doi request reprint The tall cell variant of papillary thyroid carcinoma: clinical and pathological features and outcomes
    C Regalbuto
    Endocrinology, Department of Clinical and Molecular Bio Medicine, University of Catania, Garibaldi Nesima Hospital, Via Palermo 636, 95122 Catania, Italy
    J Endocrinol Invest 36:249-54. 2013
    ....
  12. ncbi request reprint Immunostaining for Met/HGF receptor may be useful to identify malignancies in thyroid lesions classified suspicious at fine-needle aspiration biopsy
    A Ippolito
    Istituto di Medicina Interna e di Malattie Endocrine e del Metabolismo, University of Catania, Italy
    Thyroid 11:783-7. 2001
    ..These data suggest that Met immunostaining of suspicious cytological smears are useful for identifying malignant lesions, especially those with a papillary histotype...
  13. ncbi request reprint A soluble PC-1 circulates in human plasma: relationship with insulin resistance and associated abnormalities
    L Frittitta
    Istituto di Medicina Interna, Malattie Endocrine e Metaboliche, Universita di Catania, Ospedale Garibaldi
    J Clin Endocrinol Metab 84:3620-5. 1999
    ..In conclusion, PC-1 circulates in human plasma, and its concentration is related to insulin sensitivity. This may help to plan studies aimed at understanding the role of PC-1 in insulin resistance...
  14. ncbi request reprint Healing of chronic necrobiosis lipoidica lesions in a type 1 diabetic patient after pancreas-kidney transplantation: a case report
    D Gullo
    University of Catania, Catania, Italy
    J Endocrinol Invest 30:259-62. 2007
    ....
  15. ncbi request reprint Aggressive fibromatosis of the neck initiated after thyroidectomy
    S Arena
    Division of Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Catania, Italy
    J Endocrinol Invest 29:78-81. 2006
    ..Therefore, the patient received external radiation therapy (total dose 60 Gy) with clinical benefit. The patient is without symptoms 1 yr after surgery...
  16. ncbi request reprint Acute changes in clinical parameters and thyroid function peripheral markers following L-T4 withdrawal in patients totally thyroidectomized for thyroid cancer
    C Regalbuto
    Division of Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Italy
    J Endocrinol Invest 29:32-40. 2006
    ..Alternative procedures, such as the use of recombinant human TSH, should be used whenever possible...
  17. ncbi request reprint Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio
    M Anello
    Institute of Internal Medicine, Endocrinology, and Metabolism and S Signorelli Diabetes Center, Ospedale Garibaldi, Italy
    Am J Physiol Endocrinol Metab 281:E1082-7. 2001
    ..The abnormal plasma amino acid levels often present in obesity and diabetes may, therefore, affect pancreatic islet insulin secretion in these patients...
  18. ncbi request reprint The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance
    L Frittitta
    Istituto di Medicina Interna, Endocrinologia e Malattie del Metabolismo, Ospedale Garibaldi, Universita di Catania, 95123 Catania, Italy
    J Clin Endocrinol Metab 86:5888-91. 2001
    ..05) of BMI, gender, age, and waist circumference. In conclusion, the Q121 PC-1 variant and obesity have independent and additive effects in causing insulin resistance...
  19. ncbi request reprint Usefulness of recombinant human thyrotropin in the radiometabolic treatment of selected patients with thyroid cancer
    G Pellegriti
    Istituto di Medicina Interna e Malattie Endocrine e del Metabolismo, University of Catania Medical School, Ospedale Garibaldi, Catania, Italy
    Thyroid 11:1025-30. 2001
    ..Its efficacy to treat advanced metastatic disease should be further investigated...
  20. ncbi request reprint A ten-year (1989-1998) perspective study of the incidence of Type 1 diabetes in the district of Catania (Sicily) in a 0-14 year age group
    M L Arpi
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Ospedale Garibaldi, Italy
    J Endocrinol Invest 25:414-9. 2002
    ..The study revealed a non-random spatial distribution of T1DM incidence in children not accounted for by known demographic factors. A significant seasonal pattern and temporal trend of incidence were also detected...
  21. ncbi request reprint Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor
    F Frasca
    Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Universita di Catania, Ospedale Garibaldi, Piazza S Maria di Gesù, 95123 Catania, Italy
    Oncogene 20:3845-56. 2001
    ..These data suggests that c-Abl and/or STI571-inhibited tyrosine kinases can negatively regulate the Met receptor to restrain the motile response in thyroid cancer cells...
  22. ncbi request reprint High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells
    L Frittitta
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Garibaldi Hospital, Catania, Italy
    Diabetes Metab Res Rev 16:26-32. 2000
    ..Data were compared with those obtained in matched insulin sensitive or resistant healthy subjects. In addition, the effect of high insulin concentration on PC-1 protein content was studied in HepG2 cells...
  23. ncbi request reprint Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases
    A Belfiore
    Cattedra di Endocrinologia, University of Catania, Italy
    J Clin Endocrinol Metab 82:2322-8. 1997
    ..99; P = 0.0099), and vascular invasion (hazard ratio = 3.19; P = 0.0358). These findings suggest a role for Met/HGF-R in papillary thyroid cancer and its clinical use to select patients with a high risk of distant metastases...
  24. doi request reprint BRAF(V600E) mutation and the biology of papillary thyroid cancer
    F Frasca
    Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, Catania, Italy
    Endocr Relat Cancer 15:191-205. 2008
    ..These results indicate that BRAF((V600E)) mutation is a marker of aggressive disease in both micro- and macro-PTCs. Moreover, for the first time, a possible link between BRAF((V600E)) mutation and environmental carcinogens is suggested...
  25. doi request reprint Adiponectin increases glucose-induced insulin secretion through the activation of lipid oxidation
    G Patanè
    Unit of Endocrinology, Department of Clinical and Molecular Biomedicine, Garibaldi Nesima Hospital, University of Catania Medical School, Via Palermo 636, 95122, Catania, Italy
    Acta Diabetol 50:851-7. 2013
    ..Adiponectin, therefore, in addition to its well-known effect on insulin sensitivity, has important effects at the pancreatic level...
  26. pmc The IGF system in thyroid cancer: new concepts
    V Vella
    Cattedra di Endocrinologia, Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, Catania, Italy
    Mol Pathol 54:121-4. 2001
    ..These data indicate that both IR/IGF-I-R hybrids and IR-A play an important role in the overactivation of the IGF system in thyroid cancer and in IGF-I mitogenic signalling in these tumours. J Clin PATHOL: Mol Pathol..