Affiliation: University of Trieste
- Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiencyAnnalisa Marcuzzi
Department of Reproductive and Developmental Sciences, University of Trieste, Trieste, Italy
Pediatr Res 64:177-82. 2008..All these compounds were effective in preventing the inflammation induced by alendronate-muramyldipeptide, suggesting a possible role for these compounds in the treatment of MKD in humans...
- IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac diseaseElisabet Einarsdottir
Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
BMC Med Genet 10:8. 2009..IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases...
- Acute abdomen: the presenting sign of systemic lupus erythematosus in childhoodLoredana Lepore
Clinica Pediatrica, IRCCS Burlo Garofolo, , Italy
J Pediatr Gastroenterol Nutr 35:570-2. 2002
- Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac DiseaseA Ventura
Department of Pediatrics, University of Trieste, IRCCS Burlo Garofolo, Trieste, Italy
Gastroenterology 117:297-303. 1999..In a multicenter national study, we examined the relationship between the prevalence of autoimmune disorders in celiac disease and the duration of exposure to gluten...
- Screening for coeliac disease in healthy blood donors at two immuno-transfusion centres in north-east ItalyC Trevisiol
Department of Paediatrics, IRCCS Burlo Garofolo, Trieste, Italy
Ital J Gastroenterol Hepatol 31:584-6. 1999..The aim of this study was to investigate the prevalence of coeliac disease in healthy blood donors in a North-eastern region of Italy...
- Diagnosed child, treated child: food challenge as the first step toward tolerance induction in cow's milk protein allergyG Longo
Allergology Department, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
Eur Ann Allergy Clin Immunol 44:54-60. 2012..Food challenge is required to assess tolerance in cow milk (CM) allergy. A positive challenge contraindicates the reintroduction of CM. Specific oral tolerance induction (SOTI) is a promising treatment...
- Adverse effects during specific oral tolerance induction: in-hospital "rush" phaseE Barbi
Pediatric Emergency Department, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, University of Trieste, Italy
Eur Ann Allergy Clin Immunol 44:18-25. 2012..Different protocols have demonstrated its efficacy. Nevertheless, SOTI is still considered an experimental method and should be limited to highly controlled settings...
- Serologic response to Bartonella henselae in patients with cat scratch disease and in sick and healthy childrenT Not
Clinica Pediatrica and Istituto d Igiene, Trieste, Italy
Acta Paediatr 88:284-9. 1999..The high specificity of ELISA in patients with non-Hodgkin's lymphoma will help the clinician to exclude a potentially life-threatening disease associated with lymphadenopathy...
- IBD and IBD mimicking enterocolitis in children younger than 2 years of ageZ Cannioto
Department of Reproduction and Development Sciences, University of Trieste IRCCS Burlo Garofolo, Trieste, Italy
Eur J Pediatr 168:149-55. 2009..Some severe immunodeficiencies, such as WAS and CGD, may represent a problem in terms of differential diagnosis and might be wrongly diagnosed as very early onset IBD...
- Coeliac disease in primary care: evaluation of a case-finding strategyI Berti
Department of Paediatrics, IRCCS Burlo Garofolo, University of Trieste, Italy
Dig Liver Dis 38:461-7. 2006....
- Molecular dissection of the tissue transglutaminase autoantibody response in celiac diseaseR Marzari
Dipartimento di Biologia, Universita di Trieste, Trieste, Italy
J Immunol 166:4170-6. 2001..The possible role of these anti-transglutaminase Abs in the onset of CD and associated autoimmune pathologies is discussed...
- Efficacy of long-term treatment with thalidomide in children and young adults with Crohn disease: preliminary resultsS Facchini
Dipartimento di Scienza della Riproduzione e dello Sviluppo, IRCCS Burlo Garofolo, , Italia
J Pediatr Gastroenterol Nutr 32:178-81. 2001..CONCLUSION: Thalidomide seems to be an effective and safe treatment in patients with refractory Crohn disease. This is the first report of long-term use of thalidomide in refractory Crohn disease in pediatric patients...
- Anti-transglutaminase antibodies in non-coeliac children suffering from infectious diseasesF Ferrara
Department of Reproductive and Development Science, University of Trieste, and Children Hospital IRCCS Burlo Garofolo Trieste, Italy
Clin Exp Immunol 159:217-23. 2010..The infection-triggered anti-transglutaminase antibodies have the same biological properties as that of the coeliacs, with the same in-vivo potential for damage...
- Speeding up coeliac disease diagnosis in the developing countriesS Crovella
Department of Reproductive and Developmental Sciences, University of Trieste, Institute of Child Health I R C C S Burlo Garofolo, Italy
Dig Liver Dis 39:900-2. 2007....
- Videogame playing as distraction technique in course of venipunctureM Minute
Department of Pediatrics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, University of Trieste, Italy
Pediatr Med Chir 34:77-83. 2012..The aim of the present open randomized controlled trial was to investigate the efficacy of adding an active distraction strategy (videogame) to EMLA premedication in needle-related pain in children...
- Adverse effects during specific oral tolerance induction: in home phaseE Barbi
Emergency Department, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, University of Trieste, Italy
Allergol Immunopathol (Madr) 40:41-50. 2012..There are little data in the literature regarding the home-phase of SOTI, not only with regard to type and frequency of adverse reactions but also regarding the most suitable treatment and protocol...
- Efficacy and safety of thalidomide in children and young adults with intractable inflammatory bowel disease: long-term resultsM Lazzerini
Department of Pediatrics, Institute of Child Health, IRCCS Burlo Garofolo, Trieste, Italy
Aliment Pharmacol Ther 25:419-27. 2007..Anti-tumour necrosis factor-alpha antibodies are useful for the treatment of refractory Crohn's disease and ulcerative colitis. Thalidomide is another agent with tumour necrosis factor-alpha suppressive properties...
- Proton pump inhibitors in children: a reviewF Marchetti
Department of Pediatrics, IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
Dig Liver Dis 35:738-46. 2003..Multicentre randomised controlled studies are needed to better define the efficacy profile, the optimal dosage with respect to the different indications and the safety profile for chronic therapy of proton pump inhibitors in children...
- A reliable screening procedure for coeliac disease in clinical practiceC Trevisiol
Dept of Reproductive and Development Science, IRCCS Burlo Garofolo, University of Trieste, Italy
Scand J Gastroenterol 37:679-84. 2002..CONCLUSIONS: These results prove that human tTG-based ELISA is an excellent diagnostic tool for CD, for mass screening by both the specialist and the general clinic...
- Human tissue transglutaminase ELISA and an old study: a revision of the blood donor screening study for coeliac disease in the USAE Neri
Center for Celiac Research, University of Maryland at Baltimore, USA
Scand J Gastroenterol 39:195-7. 2004
- Regulatory T-cell function is impaired in celiac diseaseMarilena Granzotto
Laboratory of Immunology, IRCCS Burlo Garofolo, Via dell Istria 65 1, 34137, Trieste, Italy
Dig Dis Sci 54:1513-9. 2009..However, the suppressor activity of Tregs was significantly impaired in CD patients. These results suggest that a defect in Tregs function could play a role in the pathogenesis of CD and in CD-associated autoimmunity...
- Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiencyAnnalisa Marcuzzi
Paediatric Division, Institute of Child Health, IRCCS Burlo Garofolo, Via dell Istria 65 1, 34137, Trieste, Italy
Inflamm Res 59:335-8. 2010..The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels...
- Heterozygous nucleotide-binding oligomerization domain-2 mutations affect monocyte maturation in Crohn's diseaseMarilena Granzotto
Laboratory of Immunology, Institute of Child Health IRCCS Burlo Garofolo, Via dell Istria 65 1, Trieste 34137, Italy
World J Gastroenterol 13:6191-6. 2007..To investigate the function of monocytes in Crohn's disease (CD) patients and to correlate this with disease-associated nucleotide-binding oligomerization domain-2 (NOD2) gene variants...
- Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trialMarco Pennesi
Clinica Pediatrica, Istituto per l Infanzia IRCCS Burlo Garofolo, Via dell Istria 65 1, 34100 Trieste, Italy
Pediatrics 121:e1489-94. 2008....
- The universe of immune deficiencies in Crohn's disease: a new viewpoint for an old disease?Alberto Tommasini
Institute for Maternal and Child Health, IRCCS Burlo Garofolo and University of Trieste, Trieste, Italy
Scand J Gastroenterol 45:1141-9. 2010..We review such evidences starting from selected cases and discuss the clinical implications of these findings...
- A new mutation in two siblings with cystinosis presenting with Bartter syndromeMarco Pennesi
Department of Pediatrics, IRCCS Burlo Garofalo, University of Trieste, Via dell Istria 65 1, Trieste, Italy
Pediatr Nephrol 20:217-9. 2005..We describe two siblings with nephropathic cystinosis presenting with features of Bartter syndrome and their genetic pattern...
- Intestinal plexiform neurofibromasL Calligaris
Department of Pediatrics, Children's Hospital IRCCS Burlo Garofolo, Trieste, Italy
Dig Liver Dis 40:578. 2008
- Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiencyA Lenhardt
Department of Paediatrics, IRCCS Burlo Garofolo, University of Trieste, Via dell'Istria 65/1, 34100 Trieste, Italy
Dig Liver Dis 36:730-4. 2004..7%). CONCLUSIONS: The prevalence of coeliac disease in subjects with total IgA deficiency was 8.7%. Assay of IgG anti-human-tissue-transglutaminase can be recommended for screening coeliac disease in IgA-deficient subjects...
- Respiratory training with a specific device in cystic fibrosis: a prospective studyR Sartori
Clinica Pediatrica, IRCCS Burlo Garofolo, University of Trieste, Via dell Istria 65 1, 34100, Trieste, Italy
J Cyst Fibros 7:313-9. 2008..Patients where instructed and trained by a physiotherapist with individualized settings of training parameters...
- Treatment with pamidronate for osteoporosis complicating long-term intestinal failureS Pastore
Institute for Maternal and Child Health IRCCS Burlo Garofolo, University of Trieste, Italy
J Pediatr Gastroenterol Nutr 55:615-8. 2012..The patients did not have any prominent adverse effect. Finally, in our experience, pamidronate is effective for improving bone mineral density and safe in patients with intestinal failure-associated bone disease...
- Deep sedation with propofol for upper gastrointestinal endoscopy in children, administered by specially trained pediatricians: a prospective case series with emphasis on side effectsE Barbi
Dept of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
Endoscopy 38:368-75. 2006..The aim of the present study was to assess the safety and efficacy of procedural sedation with propofol for gastroscopy in a pediatric ward with trained personnel and monitoring facilities...
- Glomerular permeability after surgical trauma in children: relationship between microalbuminuria and surgical stress scoreA Sarti
Department of Anesthesia and Intensive Care, Research and Care Children Hospital, IRCCS Burlo Garofolo, Via dell Istria 65 1, 34 137 Trieste, Italy
Crit Care Med 29:1626-9. 2001..To determine whether there is an increase of urinary albumin during and after surgical trauma and investigate a possible relationship between microalbuminuria and the severity of surgical stress...
- Anti-brain but not celiac disease antibodies in Landau-Kleffner syndrome and related epilepsiesS Boscolo
BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via L. Giorgieri 10-34127, Trieste, Italy
J Neuroimmunol 160:228-32. 2005..We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac...
- Two novel POLG mutations causing hepatic mitochondrial DNA depletion with recurrent hypoketotic hypoglycaemia and fatal liver dysfunctionB Bortot
Children s Neurology and Psychiatry Unit, Institute of Child Health IRCCS, Burlo Garofolo, Via dell Istria, Trieste, Italy
Dig Liver Dis 41:494-9. 2009..Inherited mtDNA depletion syndromes (MDS) are a group of severe mitochondrial disorders resulting from defects in nucleus-encoded factors and often associated with severe or fatal liver failure...
- Clinical quiz: cat scratch diseaseRiccardo Troncone
Clinica Pediatrica, Serviuzio di Radiologia, UCO di Igiene e Medicina Preventiva IRCCS Burlo Garafalo, Universita' di Trieste, Trieste, Italy
J Pediatr Gastroenterol Nutr 36:227, 265. 2003
- Diagnostic challenge of hyper-IgD syndrome in four children with inflammatory gastrointestinal complaintsChiara Oretti
Children's Hospital IRCCS Burlo Garofolo, Department of Sciences of Reproduction and Development, University of Trieste, Trieste, Italy
Scand J Gastroenterol 41:430-6. 2006..CONCLUSIONS: Gastrointestinal complaints associated with recurrent fever and mesenteric adenopathy warrant genetic investigation for HIDS, in order to avoid unnecessary invasive investigations and treatment...
- TPMT genotype and the use of thiopurines in paediatric inflammatory bowel diseaseG Stocco
Department of Biomedical Sciences, University of Trieste, via L Giorgieri 7, 9, Italy
Dig Liver Dis 37:940-5. 2005..Subjects with reduced TPMT activity have a higher concentration of active thiopurine metabolites and may be at increased risk of bone-marrow suppression...
- The treatment of internal anal sphincter achalasia with botulinum toxinA Messineo
Department of Pediatric Surgery, IRCCS, Burlo Garofolo, Trieste, Italy
Pediatr Surg Int 17:521-3. 2001..Double-blind studies and longer follow-up periods are needed to better evaluate these preliminary results and define the limits of this promising therapy...
- Antigranulocyte monoclonal antibody immunoscintigraphy in inflammatory bowel disease in children and young adolescentsI Bruno
Clinica Pediatrica, Dipartimento Clinico di Scienza della Riproduzione e dello Sviluppo, , IRCCS Burlo Garofolo, Italy
Acta Paediatr 91:1050-5. 2002..However, its specificity is low and all positive cases must be confirmed histologically...
- Prevalence of autoimmune disorders in relatives of patients with celiac diseaseP Petaros
Department of Pediatrics, IRCCS Burlo Garofolo, Trieste, Italy
Dig Dis Sci 47:1427-31. 2002..Relatives of CD patients had an increased prevalence of AD compared to control groups, and relatives of CD patients with ADs, have a risk as high as 25% of being silent celiacs: they should thus be screened for CD...
- Vertebral osteomyelitis in 2 childrenM Del Santo
Department of Pediatrics, IRCCS Burlo Garofolo, University of Trieste, Italy
Clin Pediatr (Phila) 41:711-3. 2002
- Prognostic impact of atypical presentation in pediatric systemic lupus erythematosus: results from a multicenter studyAndrea Taddio
Department of Sciences of Reproduction and Development, Institute of Child Health IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
J Pediatr 156:972-7. 2010..The aim of the study is to assess the rate of atypical manifestations at onset in pediatric systemic lupus erythematosus (SLE) and to evaluate their effect on disease outcome...
- Fasting increases tobramycin oral absorption in miceLuigina De Leo
Department of Reproductive and Developmental Sciences, University of Trieste, and Institute of Child Health IRCCS Burlo Garofolo, Trieste, Italy
Antimicrob Agents Chemother 54:1644-6. 2010..When experiments aimed at increasing the oral bioavailability of hydrophilic compounds are performed, timing of fasting should be extremely accurate...
- Anti-idiotypic response in mice expressing human autoantibodiesRoberto Di Niro
Department of Biology, University of Trieste, Trieste, Italy
Mol Immunol 45:1782-91. 2008..This finding raises the question of whether an anti-idiotypic response to anti-TG2 antibodies is a factor associated with celiac disease...
- Detection of anti-brain serum antibodies using a semi-quantitative immunohistological methodSabrina Boscolo
BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via L. Giorgieri, 10, 34127 Trieste, Italy
J Immunol Methods 309:139-49. 2006..In conclusion, this standardised semi-quantitative procedure makes immunohistochemistry a reliable diagnostic test for autoimmune neuropathologies and represents an excellent exclusion test for anti-neural autoimmunity...
- Selective resistance to different glucocorticoids in severe autoimmune disordersIlenia Drigo
Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
Clin Immunol 134:313-9. 2010....
- Evidence of a correlation between mannose binding lectin and celiac disease: a model for other autoimmune diseasesMichele Boniotto
Department of Sciences of Reproduction and Development, University of Trieste, Via dell Istria 65 1, 34100 Trieste, Italy
J Mol Med (Berl) 83:308-15. 2005..Here we propose a role for MBL in the disease which could be easily applied to other autoimmune disorders...
- Genome search in celiac diseaseL Greco
Department of Pediatrics, University of Federico II, Naples, Italy
Am J Hum Genet 62:669-75. 1998..Furthermore, a factor on 11qter possibly differentiates the two forms. In contrast, none of the regions recently published was confirmed by the present screening...
- Elective bone marrow transplantation in a child with X-linked hyper-IgM syndrome presenting with acute respiratory distress syndromeV Leone
Department of Pediatrics IRCCS Burlo Garofolo, University of Trieste, Trieste, Italy
Bone Marrow Transplant 30:49-52. 2002..We describe how correct diagnosis and successful treatment were made possible thanks to the involvement of a network of specialists...
- Specific oral tolerance induction in children with very severe cow's milk-induced reactionsGiorgio Longo
Pediatric Department, D S R S, I R C C S Burlo Garofolo, University of Trieste, Trieste, Italy
J Allergy Clin Immunol 121:343-7. 2008..Avoiding the food and carrying self-injectable epinephrine are the current strategies for their management...
- The analysis of the fine specificity of celiac disease antibodies using tissue transglutaminase fragmentsDaniele Sblattero
Dipartimento di Biologia, University of Trieste, Trieste, Italy
Eur J Biochem 269:5175-81. 2002..This is identical to the region recognized by anti-transglutaminase Igs found in the serum of celiac disease patients...
- Celiac disease in patients with sporadic and inherited cardiomyopathies and in their relativesTarcisio Not
Department of Pediatrics, I.R.C.C.S. Burlo Garofolo, Trieste, Italy
Eur Heart J 24:1455-61. 2003..However, gluten intolerance cannot be considered causative since CD seems to be associated but not co-segregated with DCM in familial cases...
- One-step cloning of anti tissue transglutaminase scFv from subjects with celiac diseaseDaniele Sblattero
Department of Biology, University of Trieste, Via L Giorgieri 10, 34127 Trieste, Italy
J Autoimmun 22:65-72. 2004..This method can be used for the rapid characterization of the anti-transglutaminase response in a potentially large number of subjects including asymptomatic patients whose serum antibodies may be undetectable...
- Testing for anti-human transglutaminase antibodies in saliva is not useful for diagnosis of celiac diseaseValentina Baldas
Department of Reproductive and Development Science and Service of Dentistry, I.R.C.C.S. Burlo Garofolo, Trieste, Italy
Clin Chem 50:216-9. 2004
- Tremors and chorea induced by trimethoprim-sulfamethoxazole in a child with Pneumocystis pneumoniaJenny Bua
Department of Pediatrics, Institute of Child Health, IRCCS Burlo Garofolo, Trieste, Italy
Pediatr Infect Dis J 24:934-5. 2005..These symptoms disappeared 3 days after TMP-SMX was discontinued. Pediatricians should be aware of tremors and chorea among the potential adverse effects of high doses of TMP-SMX...
- The gut as site of production of autoimmune antibodiesDaniele Sblattero
Department of Biology, University of Trieste, Via L. Giorgieri 10, 34127 Trieste, Italy
J Pediatr Gastroenterol Nutr 39:S730-1. 2004
- Anti-transglutaminase antibodies and ageValentina Baldas
Clinica Pediatrica, Istituto d'Igiene, Dipartimento di Biologia, , Italy
Clin Chem 50:1856-60. 2004
- Dual sugar gut-permeability testing on blood drop in animal modelsFourogh Katouzian
Department of Reproductive and Development Science and IRCCS, Instituto per I'Infanzia Burlo Garofolo Clinica Pediatrica University of Trieste, Via dell'Istria 65/1, IT-34100, Trieste, Italy
Clin Chim Acta 352:191-7. 2005..This cheap simple method allows us to measure in vivo the biological activity of other molecules which modulate the paracellular pathway...
- Medium-term survival without haematopoietic stem cell transplantation in a case of IPEX: insights into nutritional and immunosuppressive therapyAndrea Taddio
Department of Sciences of Reproduction and Development, University of Trieste, Via dell'Istria 65/1, 34137, Trieste, Italy
Eur J Pediatr 166:1195-7. 2007
- Bone metabolism in celiac diseaseChiara Zanchi
Department of Reproductive and Development Science, University of Trieste and Institute of Child Health IRCCS, Burlo Garofolo, Trieste, Italy
J Pediatr 153:262-5. 2008..To investigate the prevalence of both calcium metabolism alterations and bone defects in children with celiac disease (CD)...
- Prevalence of methylenetetrahydrofolate reductase polymorphisms in young patients with inflammatory bowel diseaseGabriele Stocco
Department of Biomedical Sciences, University of Trieste, Trieste, Italy
Dig Dis Sci 51:474-9. 2006..The incidence of mutations in the MTHFR gene was not different between patients with IBD and control subjects; the mutated genotype was not associated with an increased risk of toxicity during thiopurine treatment...
- Characterization of the anti-tissue transglutaminase antibody response in nonobese diabetic miceDaniele Sblattero
Department of Biology, University of Trieste, Trieste, Italy
J Immunol 174:5830-6. 2005..Data from NOD mice on a gluten-free diet suggest that the anti-tTG response is not gluten-dependent. The intestinal Ab response to tTG is a feature of NOD mice, but the underlying mechanisms remain obscure...
- Amantadine in chronic granulomatous diseaseMarilena Granzotto
Laboratory of Immunology, IRCCS Burlo Garofolo, Trieste, Italy
Pediatr Hematol Oncol 22:147-51. 2005..Since the drug has been employed, the patients have not developed new infections, suggesting a role of amantadine as a part of CGD prophylactic regimen. These results suggest the opportunity of testing the drug in larger studies...
- Early combined immunosuppression in Crohn's diseaseLaura Badina
Lancet 371:1995; author reply 1996-7. 2008
- Inflammatory bowel diseaseFederico Marchetti
N Engl J Med 347:1982-4; author reply 1982-4. 2002
- Cerebro-fronto-facial syndrome (Dandy-Walker Variant and frontofacial dysmorphisms): report of the first case identified by increased nuchal translucency beyond 13(+6) weeksGabriele Tonni
Division of Obstetrics and Gynecology, Guastalla Provincial Hospital, AUSL Reggio Emilia, Italy
Congenit Anom (Kyoto) 47:68-71. 2007..Careful ultrasonographic follow-up is mandatory in all cases of increased first trimester nuchal translucency with normal karyotype in order to identify associated anomalies...
- Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter studyAlessio Fasano
Center for Celiac Research, University of Maryland School of Medicine, 22 S Greene St, N5W70, PO Box 140, Baltimore, MD 21201 1595, USA
Arch Intern Med 163:286-92. 2003..The aim of this study was to determine the prevalence of CD in at-risk and not-at-risk groups in the United States...