Research Topics
Genomes and Genes | Andrea VelardiSummaryAffiliation: University of Perugia Country: Italy Publications
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Publications
Role of KIRs and KIR ligands in hematopoietic transplantationAndrea Velardi
Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, 06129 Perugia, Italy
Curr Opin Immunol 20:581-7. 2008..It is hoped the dramatic improvements afforded by the discovery of the role of NK cell alloreactivity will extend the use of haploidentical transplants, as the donors are, unlike the unrelated, immediately available family members...- Killer-cell immunoglobulin-like receptors reactivity and outcome of stem cell transplantAndrea Velardi
Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Curr Opin Hematol 19:319-23. 2012..This review focuses on advances in the field of natural killer (NK) cell alloreactivity as a form of immunotherapy in the setting of allogeneic haematopoietic transplantation... - An overview of methods required to evaluate donor NK cell alloreactivity for haploidentical haemopoietic stem cell transplantationAndrea Velardi
Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
Methods Mol Biol 882:469-76. 2012..Donor-vs.-recipient NK cell alloreactivity is evaluated by integrating genetic, phenotypic, and functional features... - Clinical impact of natural killer cell reconstitution after allogeneic hematopoietic transplantationAndrea Velardi
Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
Semin Immunopathol 30:489-503. 2008..Here, we review the translation of NK cell allorecognition into the clinical practice of allogeneic hematopoietic transplantation and discuss how it has opened innovative perspectives in the cure of leukemia... - Natural killer cell allorecognition of missing self in allogeneic hematopoietic transplantation: a tool for immunotherapy of leukemiaAndrea Velardi
Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, 06132 Perugia, Italy
Curr Opin Immunol 21:525-30. 2009..Studies have been performed to infuse NK cells for immunotherapy outside the fields of transplantation and/or harness the function of endogenous NK cells in patients with hematological malignancies... 
Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantationKatia Perruccio
Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51-06122 Perugia, Italy
Blood 106:4397-406. 2005..This study opens new perspectives for reducing infectious mortality after haploidentical transplantations...- Thymosin alpha1 to harness immunity to pathogens after haploidentical hematopoietic transplantationKatia Perruccio
Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
Ann N Y Acad Sci 1194:153-61. 2010..Larger numbers of patients and longer follow-up are, of course, needed to assess its impact on survival... 
Natural killer cell recognition of missing self and haploidentical hematopoietic transplantationLoredana Ruggeri
Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51, Perugia, Italy
Semin Cancer Biol 16:404-11. 2006..In clinical trials, donor versus recipient NK alloreactions are highly beneficial as they reduce the risk of leukemia relapse, do not cause GvHD and markedly improve event-free survival...- A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantationSilvia Bozza
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
Blood 102:3807-14. 2003.... - Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive valueLoredana Ruggeri
Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Istituto di Ricovero e Cura a Carattere Scientifico, Foundation on Transplantation Biotechnologies, Perugia, Italy
Blood 110:433-40. 2007..Only transplantation from NK-alloreactive donors is associated with a survival advantage... - Immunotherapy with alloreactive natural killer cells in haploidentical haematopoietic transplantationAndrea Velardi
Division of Hematology and Clinical Immunology, Perugia, Italy
Hematol J 5:S87-90. 2004 - Alloreactive natural killer cells in mismatched hematopoietic stem cell transplantationLoredana Ruggeri
Department of Clinical and Experimental Medicine, Haematology and Clinical Immunology, University of Perugia, Italy
Blood Cells Mol Dis 33:216-21. 2004..recipient NK alloreactions... - TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patientsAgostinho Carvalho
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, Perugia, Italy
Blood 119:967-77. 2012..Therefore, TLR3 essentially promotes antifungal memory CD8⁺ T-cell responses and its deficiency is a novel susceptibility factor for aspergillosis in high-risk patients... - Thymosin alpha1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and toleranceLuigina Romani
Dept of Experimental Medicine, Section of Microbiology, University of Perugia, Via del Giochetto, Perugia 06126, Italy
Blood 108:2265-74. 2006..Thus, instructive immunotherapy with Talpha1 targeting IDO-competent DCs could allow for a balanced control of inflammation and tolerance... - Photodynamic purging of alloreactive T cells for adoptive immunotherapy after haploidentical stem cell transplantationKatia Perruccio
Department of Clinical and Experimental Medicine, IRCCS Foundation on Transplantation Biotechnologies, University of Perugia, Via Brunamonti 51, 06123, Italy
Blood Cells Mol Dis 40:76-83. 2008..Consequently, a clinical trial is planned to incorporate infusion of photo-allodepleted donor T cells after haploidentical stem cell transplantation with the aim of decreasing infection-related mortality... - Hematopoietic stem cell transplantation from alternative donors for high-risk acute leukemia: the haploidentical optionFranco Aversa
Hematopoietic Stem Cell Transplant Unit, Section of Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06100, Italy
Curr Stem Cell Res Ther 2:105-12. 2007.... - Natural killer cell alloreactivity in allogeneic hematopoietic transplantationLoredana Ruggeri
Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Curr Opin Oncol 19:142-7. 2007..SUMMARY: Given the benefits of natural killer cell alloreactivity, it is expected that it will encourage greater use of haploidentical transplants for the large numbers of leukemia patients without matched donors... - Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signalingLuigina Romani
Department of Experimental Medicine and Biochemical Sciences Microbiology Section, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
Blood 103:4232-9. 2004.... - Microparticles derived from endothelial progenitor cells in patients at different cardiovascular riskMatteo Pirro
Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Atherosclerosis 197:757-67. 2008..We also investigated the relationship of EPCs-derived microparticles to cardiovascular risk factors and aortic stiffness, a marker of cardiovascular risk and impaired vascular repair by EPCs... - Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantationMauro Di Ianni
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Blood 117:3921-8. 2011..This study provides evidence that Tregs are a conserved mechanism in humans... - Prospects for dendritic cell vaccination against fungal infections in hematopoietic transplantationKatia Perruccio
Division of Hematology, Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Blood Cells Mol Dis 33:248-55. 2004..Thus, the remarkable functional plasticity of DCs in response to fungi can be exploited for the deliberate targeting of cells and pathways of cell-mediated immunity in response to fungal vaccines... - NK cell alloreactivity and allogeneic hematopoietic stem cell transplantationLoredana Ruggeri
Department of Clinical and Experimental Medicine, IRCCS Foundation on Transplantation Biotechnologies, University of Perugia, Italy
Blood Cells Mol Dis 40:84-90. 2008..We are designing a clinical haploidentical transplant trial using alloreactive NK cells in the conditioning regimen, with the aim of reducing TRM and improving outcomes and overall survival... - Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplantsLoredana Ruggeri
Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
Science 295:2097-100. 2002..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation... - Natural killer cells as a therapeutic tool in mismatched transplantationLoredana Ruggeri
Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 06100, Perugia, Italy
Best Pract Res Clin Haematol 17:427-38. 2004.... - Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantationMauro Di Ianni
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Best Pract Res Clin Haematol 24:459-66. 2011.... - Jack of all trades: thymosin α1 and its pleiotropyLuigina Romani
Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy Istituto Superiore di Sanità, Roma, Italy Department of Experimental Medicine and Biochemical Science, University of Tor Vergata, Rome, Italy
Ann N Y Acad Sci 1269:1-6. 2012..Thus, Tα1 continues to live up to its promises... - Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapseFranco Aversa
HSCT Unit, Hematology Section, Department of Clinical and Experimental Medicine, University of Perugia, 06100 Perugia, Italy
J Clin Oncol 23:3447-54. 2005..As our original method of graft processing was unsuitable for large-scale clinical studies, we use automated devices for CD34+ cell purification... - Protection of killer antiidiotypic antibodies against early invasive aspergillosis in a murine model of allogeneic T-cell-depleted bone marrow transplantationElio Cenci
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Infect Immun 70:2375-82. 2002..These results indicate that mimicking the action of neutrophils could be a strategy through which KT MAbs exert therapeutic efficacy in A. fumigatus infections... - Provision of antifungal immunity and concomitant alloantigen tolerization by conditioned dendritic cells in experimental hematopoietic transplantationClaudia Montagnoli
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Blood Cells Mol Dis 40:55-62. 2008..Thus, transplantation tolerance and concomitant pathogen clearance could be achieved through the therapeutic induction of antigen-specific Treg cells via instructive immunotherapy with pathogen- or TLR-conditioned donor DC... - Toward the identification of a tolerogenic signature in IDO-competent dendritic cellsCiriana Orabona
Section of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
Blood 107:2846-54. 2006..Overall, these studies reveal the occurrence of a simple and evolutionarily conserved code in the control of tolerance by an ancestral metabolic enzyme... - The impact of donor natural killer cell alloreactivity on allogeneic hematopoietic transplantationLoredana Ruggeri
Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Transpl Immunol 14:203-6. 2005..Pre-transplant molecular high-resolution HLA of recipient and donor, KIR genotyping of the donor and direct assessment of the donor NK repertoire identify donors with the potential for donor-vs-recipient NK cell alloreactivity... - Natural killer cell alloreactivity for leukemia therapyLoredana Ruggeri
Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, 06122 Perugia, Italy
J Immunother (1997) 28:175-82. 2005..Transplantation from NK alloreactive haploidentical donors controls acute myeloid leukemia relapse and improves engraftment without causing graft-versus-host disease... - Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipientsCristina Cunha
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
PLoS ONE 6:e27962. 2011.... - Expansion of CD56-negative, CD16-positive, KIR-expressing natural killer cells after T cell-depleted haploidentical hematopoietic stem cell transplantationClaudia de Angelis
Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Acta Haematol 126:13-20. 2011..These results demonstrate that CD56- NK cells are functional, recognize missing self and, like their CD56+ counterparts, may contribute to graft-versus-leukemia reactions... - Natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantationLoredana Ruggeri
Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Int J Hematol 81:13-7. 2005.... - Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunityCristina Cunha
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Blood 116:5394-402. 2010.... - Exploitation of alloreactive NK cells in adoptive immunotherapy of cancerLoredana Ruggeri
Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, 06122 Perugia, Italy
Curr Opin Immunol 17:211-7. 2005.... - Allogeneic hematopoietic transplantation and natural killer cell recognition of missing selfLoredana Ruggeri
Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Immunol Rev 214:202-18. 2006..We review the translation of NK cell recognition of missing self into the clinical practice of allogeneic hematopoietic transplantation and discuss how it has opened innovative perspectives in the cure of leukemia... - Fourth International Workshop on Haploidentical Transplants, Naples, Italy, July 8-10, 2004Franco Aversa
Department of Clinical and Experimental Medicine, University of Perugia, Italy
Blood Cells Mol Dis 33:159-75. 2004..The Workshop closed with presentations on tolerance induction that was followed by the results of ongoing registration studies being performed by the Italian GIMEMA group and the European Bone Marrow Transplant group... - Transplants across human leukocyte antigen barriersMassimo F Martelli
Department of Hematology, University of Perugia, Perugia, Italy
Semin Hematol 39:48-56. 2002..T-cell-depleted megadose stem cell transplant from a mismatched family member, who is immediately available, can now be offered as a viable option to candidates with high-risk acute leukemias... - CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-IgCarmine Vacca
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
Microbes Infect 7:1040-8. 2005..However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4... - Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantationAngela Bacci
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
J Immunol 168:2904-13. 2002.... - Increased ratio of CD31+/CD42- microparticles to endothelial progenitors as a novel marker of atherosclerosis in hypercholesterolemiaMatteo Pirro
Department of Clinical and Experimental Medicine, University of Perugia, Italy
Arterioscler Thromb Vasc Biol 26:2530-5. 2006..We also studied the in vitro effect of microparticles from hypercholesterolemic patients on endothelial progenitor survival...