Andrea Velardi

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. doi request reprint Role of KIRs and KIR ligands in hematopoietic transplantation
    Andrea Velardi
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, 06129 Perugia, Italy
    Curr Opin Immunol 20:581-7. 2008
  2. doi request reprint Natural killer cell alloreactivity 10 years later
    Andrea Velardi
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Opin Hematol 19:421-6. 2012
  3. doi request reprint Killer-cell immunoglobulin-like receptors reactivity and outcome of stem cell transplant
    Andrea Velardi
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Opin Hematol 19:319-23. 2012
  4. doi request reprint An overview of methods required to evaluate donor NK cell alloreactivity for haploidentical haemopoietic stem cell transplantation
    Andrea Velardi
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
    Methods Mol Biol 882:469-76. 2012
  5. doi request reprint Natural killer cell allorecognition of missing self in allogeneic hematopoietic transplantation: a tool for immunotherapy of leukemia
    Andrea Velardi
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, 06132 Perugia, Italy
    Curr Opin Immunol 21:525-30. 2009
  6. doi request reprint Clinical impact of natural killer cell reconstitution after allogeneic hematopoietic transplantation
    Andrea Velardi
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
    Semin Immunopathol 30:489-503. 2008
  7. pmc Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation
    Katia Perruccio
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51 06122 Perugia, Italy
    Blood 106:4397-406. 2005
  8. ncbi request reprint A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation
    Silvia Bozza
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Blood 102:3807-14. 2003
  9. ncbi request reprint Natural killer cell recognition of missing self and haploidentical hematopoietic transplantation
    Loredana Ruggeri
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51, Perugia, Italy
    Semin Cancer Biol 16:404-11. 2006
  10. doi request reprint Thymosin alpha1 to harness immunity to pathogens after haploidentical hematopoietic transplantation
    Katia Perruccio
    Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 1194:153-61. 2010

Collaborators

Detail Information

Publications44

  1. doi request reprint Role of KIRs and KIR ligands in hematopoietic transplantation
    Andrea Velardi
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, 06129 Perugia, Italy
    Curr Opin Immunol 20:581-7. 2008
    ..It is hoped the dramatic improvements afforded by the discovery of the role of NK cell alloreactivity will extend the use of haploidentical transplants, as the donors are, unlike the unrelated, immediately available family members...
  2. doi request reprint Natural killer cell alloreactivity 10 years later
    Andrea Velardi
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Opin Hematol 19:421-6. 2012
    ..This article reviews the impact of natural killer (NK) cell alloreactivity on hematopoietic cell transplantation since it was first observed in haploidentical transplant recipients 10 years ago...
  3. doi request reprint Killer-cell immunoglobulin-like receptors reactivity and outcome of stem cell transplant
    Andrea Velardi
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Opin Hematol 19:319-23. 2012
    ..This review focuses on advances in the field of natural killer (NK) cell alloreactivity as a form of immunotherapy in the setting of allogeneic haematopoietic transplantation...
  4. doi request reprint An overview of methods required to evaluate donor NK cell alloreactivity for haploidentical haemopoietic stem cell transplantation
    Andrea Velardi
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
    Methods Mol Biol 882:469-76. 2012
    ..Donor-vs.-recipient NK cell alloreactivity is evaluated by integrating genetic, phenotypic, and functional features...
  5. doi request reprint Natural killer cell allorecognition of missing self in allogeneic hematopoietic transplantation: a tool for immunotherapy of leukemia
    Andrea Velardi
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, 06132 Perugia, Italy
    Curr Opin Immunol 21:525-30. 2009
    ..Studies have been performed to infuse NK cells for immunotherapy outside the fields of transplantation and/or harness the function of endogenous NK cells in patients with hematological malignancies...
  6. doi request reprint Clinical impact of natural killer cell reconstitution after allogeneic hematopoietic transplantation
    Andrea Velardi
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
    Semin Immunopathol 30:489-503. 2008
    ..Here, we review the translation of NK cell allorecognition into the clinical practice of allogeneic hematopoietic transplantation and discuss how it has opened innovative perspectives in the cure of leukemia...
  7. pmc Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation
    Katia Perruccio
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51 06122 Perugia, Italy
    Blood 106:4397-406. 2005
    ..This study opens new perspectives for reducing infectious mortality after haploidentical transplantations...
  8. ncbi request reprint A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation
    Silvia Bozza
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Blood 102:3807-14. 2003
    ....
  9. ncbi request reprint Natural killer cell recognition of missing self and haploidentical hematopoietic transplantation
    Loredana Ruggeri
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 51, Perugia, Italy
    Semin Cancer Biol 16:404-11. 2006
    ..In clinical trials, donor versus recipient NK alloreactions are highly beneficial as they reduce the risk of leukemia relapse, do not cause GvHD and markedly improve event-free survival...
  10. doi request reprint Thymosin alpha1 to harness immunity to pathogens after haploidentical hematopoietic transplantation
    Katia Perruccio
    Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 1194:153-61. 2010
    ..Larger numbers of patients and longer follow-up are, of course, needed to assess its impact on survival...
  11. pmc Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value
    Loredana Ruggeri
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Istituto di Ricovero e Cura a Carattere Scientifico, Foundation on Transplantation Biotechnologies, Perugia, Italy
    Blood 110:433-40. 2007
    ..Only transplantation from NK-alloreactive donors is associated with a survival advantage...
  12. ncbi request reprint Immunotherapy with alloreactive natural killer cells in haploidentical haematopoietic transplantation
    Andrea Velardi
    Division of Hematology and Clinical Immunology, Perugia, Italy
    Hematol J 5:S87-90. 2004
  13. ncbi request reprint Alloreactive natural killer cells in mismatched hematopoietic stem cell transplantation
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Haematology and Clinical Immunology, University of Perugia, Italy
    Blood Cells Mol Dis 33:216-21. 2004
    ..recipient NK alloreactions...
  14. doi request reprint TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients
    Agostinho Carvalho
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, Perugia, Italy
    Blood 119:967-77. 2012
    ..Therefore, TLR3 essentially promotes antifungal memory CD8⁺ T-cell responses and its deficiency is a novel susceptibility factor for aspergillosis in high-risk patients...
  15. ncbi request reprint Thymosin alpha1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance
    Luigina Romani
    Dept of Experimental Medicine, Section of Microbiology, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Blood 108:2265-74. 2006
    ..Thus, instructive immunotherapy with Talpha1 targeting IDO-competent DCs could allow for a balanced control of inflammation and tolerance...
  16. ncbi request reprint Hematopoietic stem cell transplantation from alternative donors for high-risk acute leukemia: the haploidentical option
    Franco Aversa
    Hematopoietic Stem Cell Transplant Unit, Section of Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06100, Italy
    Curr Stem Cell Res Ther 2:105-12. 2007
    ....
  17. ncbi request reprint Photodynamic purging of alloreactive T cells for adoptive immunotherapy after haploidentical stem cell transplantation
    Katia Perruccio
    Department of Clinical and Experimental Medicine, IRCCS Foundation on Transplantation Biotechnologies, University of Perugia, Via Brunamonti 51, 06123, Italy
    Blood Cells Mol Dis 40:76-83. 2008
    ..Consequently, a clinical trial is planned to incorporate infusion of photo-allodepleted donor T cells after haploidentical stem cell transplantation with the aim of decreasing infection-related mortality...
  18. ncbi request reprint Natural killer cell alloreactivity in allogeneic hematopoietic transplantation
    Loredana Ruggeri
    Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Opin Oncol 19:142-7. 2007
    ..Mismatched transplantation, however, triggers alloreactivity mediated by natural killer cells which is based upon 'missing self recognition'...
  19. ncbi request reprint Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling
    Luigina Romani
    Department of Experimental Medicine and Biochemical Sciences Microbiology Section, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Blood 103:4232-9. 2004
    ....
  20. ncbi request reprint Microparticles derived from endothelial progenitor cells in patients at different cardiovascular risk
    Matteo Pirro
    Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Atherosclerosis 197:757-67. 2008
    ..We also investigated the relationship of EPCs-derived microparticles to cardiovascular risk factors and aortic stiffness, a marker of cardiovascular risk and impaired vascular repair by EPCs...
  21. ncbi request reprint Prospects for dendritic cell vaccination against fungal infections in hematopoietic transplantation
    Katia Perruccio
    Division of Hematology, Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Blood Cells Mol Dis 33:248-55. 2004
    ..Thus, the remarkable functional plasticity of DCs in response to fungi can be exploited for the deliberate targeting of cells and pathways of cell-mediated immunity in response to fungal vaccines...
  22. ncbi request reprint NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, IRCCS Foundation on Transplantation Biotechnologies, University of Perugia, Italy
    Blood Cells Mol Dis 40:84-90. 2008
    ..We are designing a clinical haploidentical transplant trial using alloreactive NK cells in the conditioning regimen, with the aim of reducing TRM and improving outcomes and overall survival...
  23. doi request reprint Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Blood 117:3921-8. 2011
    ..This study provides evidence that Tregs are a conserved mechanism in humans...
  24. doi request reprint Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Best Pract Res Clin Haematol 24:459-66. 2011
    ....
  25. ncbi request reprint Natural killer cells as a therapeutic tool in mismatched transplantation
    Loredana Ruggeri
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via Brunamonti 06100, Perugia, Italy
    Best Pract Res Clin Haematol 17:427-38. 2004
    ....
  26. ncbi request reprint Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    Loredana Ruggeri
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, Perugia University School of Medicine, Perugia, Italy
    Science 295:2097-100. 2002
    ..NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation...
  27. doi request reprint Jack of all trades: thymosin α1 and its pleiotropy
    Luigina Romani
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy Istituto Superiore di Sanità, Roma, Italy Department of Experimental Medicine and Biochemical Science, University of Tor Vergata, Rome, Italy
    Ann N Y Acad Sci 1269:1-6. 2012
    ..Thus, Tα1 continues to live up to its promises...
  28. ncbi request reprint Provision of antifungal immunity and concomitant alloantigen tolerization by conditioned dendritic cells in experimental hematopoietic transplantation
    Claudia Montagnoli
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Blood Cells Mol Dis 40:55-62. 2008
    ..Thus, transplantation tolerance and concomitant pathogen clearance could be achieved through the therapeutic induction of antigen-specific Treg cells via instructive immunotherapy with pathogen- or TLR-conditioned donor DC...
  29. ncbi request reprint Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse
    Franco Aversa
    HSCT Unit, Hematology Section, Department of Clinical and Experimental Medicine, University of Perugia, 06100 Perugia, Italy
    J Clin Oncol 23:3447-54. 2005
    ..As our original method of graft processing was unsuitable for large-scale clinical studies, we use automated devices for CD34+ cell purification...
  30. ncbi request reprint Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
    Ciriana Orabona
    Section of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood 107:2846-54. 2006
    ..Overall, these studies reveal the occurrence of a simple and evolutionarily conserved code in the control of tolerance by an ancestral metabolic enzyme...
  31. ncbi request reprint The impact of donor natural killer cell alloreactivity on allogeneic hematopoietic transplantation
    Loredana Ruggeri
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Transpl Immunol 14:203-6. 2005
    ..Pre-transplant molecular high-resolution HLA of recipient and donor, KIR genotyping of the donor and direct assessment of the donor NK repertoire identify donors with the potential for donor-vs-recipient NK cell alloreactivity...
  32. ncbi request reprint Natural killer cell alloreactivity for leukemia therapy
    Loredana Ruggeri
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, 06122 Perugia, Italy
    J Immunother 28:175-82. 2005
    ..Transplantation from NK alloreactive haploidentical donors controls acute myeloid leukemia relapse and improves engraftment without causing graft-versus-host disease...
  33. pmc Protection of killer antiidiotypic antibodies against early invasive aspergillosis in a murine model of allogeneic T-cell-depleted bone marrow transplantation
    Elio Cenci
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Infect Immun 70:2375-82. 2002
    ..These results indicate that mimicking the action of neutrophils could be a strategy through which KT MAbs exert therapeutic efficacy in A. fumigatus infections...
  34. pmc Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients
    Cristina Cunha
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS ONE 6:e27962. 2011
    ....
  35. ncbi request reprint Natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation
    Loredana Ruggeri
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Int J Hematol 81:13-7. 2005
    ....
  36. doi request reprint Expansion of CD56-negative, CD16-positive, KIR-expressing natural killer cells after T cell-depleted haploidentical hematopoietic stem cell transplantation
    Claudia de Angelis
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Acta Haematol 126:13-20. 2011
    ..These results demonstrate that CD56- NK cells are functional, recognize missing self and, like their CD56+ counterparts, may contribute to graft-versus-leukemia reactions...
  37. doi request reprint Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity
    Cristina Cunha
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Blood 116:5394-402. 2010
    ....
  38. ncbi request reprint Exploitation of alloreactive NK cells in adoptive immunotherapy of cancer
    Loredana Ruggeri
    Division of Haematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, 06122 Perugia, Italy
    Curr Opin Immunol 17:211-7. 2005
    ....
  39. ncbi request reprint Allogeneic hematopoietic transplantation and natural killer cell recognition of missing self
    Loredana Ruggeri
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Immunol Rev 214:202-18. 2006
    ..We review the translation of NK cell recognition of missing self into the clinical practice of allogeneic hematopoietic transplantation and discuss how it has opened innovative perspectives in the cure of leukemia...
  40. ncbi request reprint Fourth International Workshop on Haploidentical Transplants, Naples, Italy, July 8-10, 2004
    Franco Aversa
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Blood Cells Mol Dis 33:159-75. 2004
    ..The Workshop closed with presentations on tolerance induction that was followed by the results of ongoing registration studies being performed by the Italian GIMEMA group and the European Bone Marrow Transplant group...
  41. ncbi request reprint Transplants across human leukocyte antigen barriers
    Massimo F Martelli
    Department of Hematology, University of Perugia, Perugia, Italy
    Semin Hematol 39:48-56. 2002
    ..T-cell-depleted megadose stem cell transplant from a mismatched family member, who is immediately available, can now be offered as a viable option to candidates with high-risk acute leukemias...
  42. ncbi request reprint CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig
    Carmine Vacca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Microbes Infect 7:1040-8. 2005
    ..However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4...
  43. ncbi request reprint Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantation
    Angela Bacci
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 168:2904-13. 2002
    ....
  44. ncbi request reprint Increased ratio of CD31+/CD42- microparticles to endothelial progenitors as a novel marker of atherosclerosis in hypercholesterolemia
    Matteo Pirro
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Arterioscler Thromb Vasc Biol 26:2530-5. 2006
    ..We also studied the in vitro effect of microparticles from hypercholesterolemic patients on endothelial progenitor survival...