Giuseppe Valacchi

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. pmc Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients
    Alessandra Pecorelli
    Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy
    Mediators Inflamm 2013:137629. 2013
  2. pmc Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation
    Claudia Sticozzi
    Department of Mechanical and Structural Engineering, University of Trento, Trento, Italy
    PLoS ONE 7:e33592. 2012
  3. ncbi request reprint Ozonated oils as functional dermatological matrices: effects on the wound healing process using SKH1 mice
    G Valacchi
    Dipartimento di Scienze della Vita e Biotecnologie, Universita degli Studi di Ferrara, Italy Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea Electronic address
    Int J Pharm 458:65-73. 2013
  4. ncbi request reprint Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases?
    V Bocci
    Department of Life Science and Biotechnologie, University of Ferrara, Italy
    Curr Med Chem 20:3397-415. 2013
  5. pmc Cutaneous responses to environmental stressors
    Giuseppe Valacchi
    Department of Evolutionary Biology, University of Ferrara, Ferrara, Italy
    Ann N Y Acad Sci 1271:75-81. 2012
  6. doi request reprint Scavenger receptor class B type I: a multifunctional receptor
    Giuseppe Valacchi
    Department of Evolutionary Biology, University of Ferrara, Ferrara, Italy
    Ann N Y Acad Sci 1229:E1-7. 2011
  7. doi request reprint Rottlerin exhibits antiangiogenic effects in vitro
    Giuseppe Valacchi
    Department of Biomedical Sciences, University of Siena, Italy
    Chem Biol Drug Des 77:460-70. 2011
  8. doi request reprint Scavenger receptor B1 post-translational modifications in Rett syndrome
    Claudia Sticozzi
    Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
    FEBS Lett 587:2199-204. 2013
  9. pmc Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder
    Cinzia Signorini
    Department of Molecular and Developmental Medicine, University of Siena, I 53100 Siena, Italy
    Oxid Med Cell Longev 2013:343824. 2013
  10. doi request reprint Morphological changes and oxidative damage in Rett Syndrome erythrocytes
    Lucia Ciccoli
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Biochim Biophys Acta 1820:511-20. 2012

Collaborators

Detail Information

Publications43

  1. pmc Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients
    Alessandra Pecorelli
    Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy
    Mediators Inflamm 2013:137629. 2013
    ..In conclusion, these findings suggest that mitochondrial-ATP-proteasome functions are likely to be involved in RTT clinical features. ..
  2. pmc Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation
    Claudia Sticozzi
    Department of Mechanical and Structural Engineering, University of Trento, Trento, Italy
    PLoS ONE 7:e33592. 2012
    ....
  3. ncbi request reprint Ozonated oils as functional dermatological matrices: effects on the wound healing process using SKH1 mice
    G Valacchi
    Dipartimento di Scienze della Vita e Biotecnologie, Universita degli Studi di Ferrara, Italy Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea Electronic address
    Int J Pharm 458:65-73. 2013
    ..The present study shows that not only the ozonation grade is of importance for the improvement of wound healing process but also the typical composition of the oil. ..
  4. ncbi request reprint Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases?
    V Bocci
    Department of Life Science and Biotechnologie, University of Ferrara, Italy
    Curr Med Chem 20:3397-415. 2013
    ..It is hoped to evaluate this integrated medical approach because it represents a sheet anchor for many patients. ..
  5. pmc Cutaneous responses to environmental stressors
    Giuseppe Valacchi
    Department of Evolutionary Biology, University of Ferrara, Ferrara, Italy
    Ann N Y Acad Sci 1271:75-81. 2012
    ..This short review provides an overview of the effects and mechanisms of action of CS, O₃, and UV on cutanous tissues...
  6. doi request reprint Scavenger receptor class B type I: a multifunctional receptor
    Giuseppe Valacchi
    Department of Evolutionary Biology, University of Ferrara, Ferrara, Italy
    Ann N Y Acad Sci 1229:E1-7. 2011
    ..In this short review, we have summarized the biological aspects to which SR-B1 has been thus far associated...
  7. doi request reprint Rottlerin exhibits antiangiogenic effects in vitro
    Giuseppe Valacchi
    Department of Biomedical Sciences, University of Siena, Italy
    Chem Biol Drug Des 77:460-70. 2011
    ..These results suggest that Rottlerin may prove useful in the development of therapeutic agents against angiogenesis...
  8. doi request reprint Scavenger receptor B1 post-translational modifications in Rett syndrome
    Claudia Sticozzi
    Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
    FEBS Lett 587:2199-204. 2013
    ..Our findings show for the first time a loss of SRB1 in RTT cells and its relationship with a chronic oxidative stress status...
  9. pmc Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder
    Cinzia Signorini
    Department of Molecular and Developmental Medicine, University of Siena, I 53100 Siena, Italy
    Oxid Med Cell Longev 2013:343824. 2013
    ..In our experience, Rett syndrome offers a unique setting for physicians, biologists, and chemists to explore the borders of the lipid mediators concept. ..
  10. doi request reprint Morphological changes and oxidative damage in Rett Syndrome erythrocytes
    Lucia Ciccoli
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Biochim Biophys Acta 1820:511-20. 2012
    ..Here, RBCs shape was evaluated in RTT patients and healthy subjects as a function of OS markers, blood oxygenation, pulmonary gas exchange, and cardio-respiratory parameters...
  11. doi request reprint Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism
    Alessandra Pecorelli
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Viale M Bracci 16, Siena, Italy
    Brain Dev 35:146-54. 2013
    ..Increased levels of NPBI could contribute to lipid peroxidation and, consequently, to increased plasma and erythrocyte membranes 4-HNE PAs thus amplifying the oxidative damage, potentially contributing to the autistic phenotype...
  12. doi request reprint F₄-neuroprostanes mediate neurological severity in Rett syndrome
    Cinzia Signorini
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Clin Chim Acta 412:1399-406. 2011
    ..In addition, we investigate on the impact of ω-3 polyunsaturated fatty acids (ω-3 PUFAs) supplementation on F₄-NeuroPs levels...
  13. doi request reprint Oxidative stress in Rett syndrome: natural history, genotype, and variants
    Silvia Leoncini
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, and Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Senese, Siena, Italy
    Redox Rep 16:145-53. 2011
    ....
  14. pmc Subclinical inflammatory status in rett syndrome
    Alessio Cortelazzo
    Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy Department of Medical Biotechnologies, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2014:480980. 2014
    ..Our findings reveal for the first time the presence of a subclinical chronic inflammatory status related to the "pseudo-autistic" phase of RTT, which is related to the severity carried by the MECP2 gene mutation. ..
  15. doi request reprint Subclinical myocardial dysfunction in Rett syndrome
    Claudio De Felice
    Neonatal Intensive Care Unit, University General Hospital, Azienda Ospedaliera Universitaria Senese, Viale M Bracci 16, Siena, Italy
    Eur Heart J Cardiovasc Imaging 13:339-45. 2012
    ..Besides, increased oxidative stress markers (OS) have been found in RTT. We hypothesized that (i) RTT patients present a subclinical biventricular dysfunction and (ii) the myocardial dysfunction correlate with OS...
  16. pmc F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    J Lipid Res 52:2287-97. 2011
    ....
  17. pmc Erythrocyte shape abnormalities, membrane oxidative damage, and β-actin alterations: an unrecognized triad in classical autism
    Lucia Ciccoli
    Department of Molecular and Developmental Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2013:432616. 2013
    ....
  18. pmc Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells
    Emanuela Maioli
    Dipartimento di Fisiologia, University of Siena, Italy
    J Biomed Biotechnol 2009:742936. 2009
    ....
  19. ncbi request reprint Rottlerin: bases for a possible usage in psoriasis
    Emanuela Maioli
    Department of Physiology, University of Siena, Via Aldo Moro, 7 53100 Siena, Italy
    Curr Drug Metab 11:425-30. 2010
    ..Herein, we will review the multiple activities of Rottlerin (antioxidant, antiproliferative, antiangiogenic and anti-inflammatory) that give to the drug the potential to be used as a new therapeutic approach against psoriasis...
  20. doi request reprint Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes
    Claudia Sticozzi
    Dipartimento di Scienze della Vita e Biotecnologie, Universita degli Studi di Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
    Eur J Pharm Sci 49:133-41. 2013
    ..These data suggest that compounds VA441 and VA428, along with their role in inhibiting COX-2 and inflammation, could have a possible therapeutic (topical and systemic) use against skin proliferative disorders, such as psoriasis...
  21. doi request reprint Increased levels of 4HNE-protein plasma adducts in Rett syndrome
    Alessandra Pecorelli
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Clin Biochem 44:368-71. 2011
    ..Increased oxidative stress (OS) has been documented in MeCP2-RTT patients. Here, we evaluated the levels of 4-hydroxynonenal plasma protein adducts (4HNE-PAs) in MeCP2-, CDKL5-, and FOXG1-RTT and in their clinical variants...
  22. pmc Beta-actin deficiency with oxidative posttranslational modifications in Rett syndrome erythrocytes: insights into an altered cytoskeletal organization
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Siena, Italy Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese AOUS, Siena, Italy
    PLoS ONE 9:e93181. 2014
    ..Our findings demonstrate, for the first time, a beta-actin down-regulation and oxidative PTMs for RBCs of RTT patients, thus indicating an altered cytoskeletal organization. ..
  23. pmc Effects of ω -3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy
    Mediators Inflamm 2013:723269. 2013
    ..3 PUFAs have a major impact on the modulation of the APR in RTT, thus providing new insights into the role of inflammation in autistic disorders and paving the way for novel therapeutic strategies. ..
  24. doi request reprint Rottlerin and curcumin: a comparative analysis
    Emanuela Maioli
    Department of Physiology, University of Siena, Siena, Italy
    Ann N Y Acad Sci 1259:65-76. 2012
    ..Like curcumin, rottlerin could be a promising candidate in the fight against a variety of human diseases...
  25. doi request reprint NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells
    Alessandra Pecorelli
    Department of Molecular and Developmental Medicine, University of Siena, Italy
    Toxicol Appl Pharmacol 267:30-40. 2013
    ....
  26. pmc A plasma proteomic approach in Rett syndrome: classical versus preserved speech variant
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Via A Moro 2, 53100 Siena, Italy Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy
    Mediators Inflamm 2013:438653. 2013
    ..Therefore, the examined RTT siblings pairs proved to be an important benchmark model to test the molecular basis of phenotypical expression variability and to identify potential therapeutic targets of the disease. ..
  27. doi request reprint The physiological behaviour of IMR-32 neuroblastoma cells is affected by a 12-h hypoxia/24-h reoxygenation period
    Carlo Aldinucci
    Department of Physiology, University of Siena, Siena, Italy
    Neurochem Res 35:1691-9. 2010
    ....
  28. doi request reprint Rottlerin: a multifaced regulator of keratinocyte cell cycle
    Giuseppe Valacchi
    Department of Biomedical Sciences, University of Siena, Siena, Italy
    Exp Dermatol 18:516-21. 2009
    ..These results open the way to further investigation on the Rottlerin therapeutic potential against keratinocyte hyper-proliferative disorders...
  29. pmc Redox imbalance and morphological changes in skin fibroblasts in typical rett syndrome
    Cinzia Signorini
    Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy
    Oxid Med Cell Longev 2014:195935. 2014
    ..Our findings indicate the presence of a redox imbalance and previously unrecognized morphological skin fibroblast abnormalities in RTT patients. ..
  30. doi request reprint Cigarette smoke exposure causes changes in Scavenger Receptor B1 level and distribution in lung cells
    Giuseppe Valacchi
    Department of Biomedical Sciences, University of Siena, Siena, Italy
    Int J Biochem Cell Biol 43:1065-70. 2011
    ....
  31. doi request reprint Unrecognized lung disease in classic Rett syndrome: a physiologic and high-resolution CT imaging study
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Universitaria Senese of Siena, Siena, Italy
    Chest 138:386-92. 2010
    ..The aim of the present study was to determine if there are RS-associated pulmonary abnormalities...
  32. ncbi request reprint Cutaneous MMPs are differently modulated by environmental stressors in old and young mice
    Vittoria Fortino
    Department of Physiology, University of Siena, Via Aldo Moro, 7 Siena, Siena 53100, Italy
    Toxicol Lett 173:73-9. 2007
    ..The current study demonstrates the ability of certain environmental pollutants to affect the ECM turnover through modulation of specific MMPs, and confirms the higher susceptibility of old subjects to exogenous pro-oxidant insults...
  33. pmc Antiangiogenic VEGF isoform in inflammatory myopathies
    Nila Volpi
    Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy
    Mediators Inflamm 2013:219313. 2013
    ....
  34. doi request reprint Novel PKCs activate ERK through PKD1 in MCF-7 cells
    Claudia Torricelli
    Department of Physiology, University of Siena, via Aldo Moro 7, Siena, Italy
    In Vitro Cell Dev Biol Anim 47:73-81. 2011
    ..We conclude that the nPKCs/PKD1 cascade is determinant for ERK activation by PMA in MCF-7 cells...
  35. doi request reprint Emerging topics in cutaneous wound repair
    Giuseppe Valacchi
    Dipartimento di Biologia ed Evoluzione, Universita degli Studi di Ferrara, Italy
    Ann N Y Acad Sci 1259:136-44. 2012
    ..The future challenges for both the best targeting and optimization of these potential treatments are also described...
  36. pmc Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy
    Claudia Torricelli
    Department of Physiology, University of Siena, Via Aldo Moro, 7 53100 Siena, Italy
    Evid Based Complement Alternat Med 2012:980658. 2012
    ..These findings suggest that Rottlerin could be cytotoxic for different cancer cell types, both apoptosis competent and apoptosis resistant...
  37. pmc Inflammatory lung disease in rett syndrome
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy
    Mediators Inflamm 2014:560120. 2014
    ..Our findings indicate that GEA is a key feature of RTT and that terminal bronchioles are a likely major target of the disease. ..
  38. doi request reprint Proteomic profiling and post-translational modifications in human keratinocytes treated with Mucuna pruriens leaf extract
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Siena, Italy Child Neuropsychiatry Unit, University Hospital AOUS, Siena, Italy
    J Ethnopharmacol 151:873-81. 2014
    ..The aim was to investigate the effects of Mp leaf methanolic extract (MPME) on human keratinocytes protein expression and its role in preventing proteins oxidation after oxidative stress (OS) exposure...
  39. pmc Ozonation of human blood induces a remarkable upregulation of heme oxygenase-1 and heat stress protein-70
    Velio Bocci
    Department of Physiology, University of Siena, 53100 Siena, Italy
    Mediators Inflamm 2007:26785. 2007
    ..At this concentration, there is also induction of Hsp-70. The results clarify another positive effect achievable by the use of ozone therapy...
  40. pmc Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment
    Carlo Cervellati
    Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy
    Biomed Res Int 2014:309507. 2014
    ..Overall, these results suggest that systemic OxS might be a precocious feature of MCI and LOAD. However, the role of OxS as an early prognostic marker of progression to LOAD needs further investigations. ..
  41. pmc 17-β-estradiol counteracts the effects of high frequency electromagnetic fields on trophoblastic connexins and integrins
    Franco Cervellati
    Department of Life Science and Biotechnology, Section of General Physiology, University of Ferrara, Ferrara, Italy
    Oxid Med Cell Longev 2013:280850. 2013
    ..We demonstrate that 17-β-estradiol modulates Cxs and Ints as well as ER-β expression induced by HF-EMF, suggesting an influence of both stimuli on trophoblast differentiation and migration...