Research Topics
Species | D VairaSummaryAffiliation: University of Bologna Country: Italy Publications
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Publications
Routes of transmission of Helicobacter pylori infectionD Vaira
First Medical Clinic, University of Bologna, S Orsola Hospital, Bologna, Italy
Ital J Gastroenterol Hepatol 30:S279-85. 1998..The mode of transmission of Helicobacter pylori, as is yet, not known. Available information support the hypothesis of spread through close personal contact, considering humans as the only significant reservoir of infection...- Peptic ulcer and Helicobacter pylori: update on testing and treatmentDino Vaira
University of Bologna S Orsola Malpighi Hospital, Italy
Postgrad Med 117:17-22, 46. 2005..In this article, the authors discuss the association between H pylori and peptic ulcer disease, the available tests for detecting the infection, and the latest treatment strategies for effective eradication... 
Effect of Helicobacter pylori eradication on development of dyspeptic and reflux disease in healthy asymptomatic subjectsD Vaira
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Gut 52:1543-7. 2003..The aim of this study was to assess the effect of eradication therapy on the development of dyspeptic and gastro-oesophageal reflux disease in a cohort of asymptomatic individuals observed over a prolonged period...- Noninvasive tests to diagnose Helicobacter pylori infectionLuigi Gatta
Department of Internal Medicine and Gastroenterology, Nuove Patologie, Via Massarenti 9, 40138, Bologna, Italy
Curr Gastroenterol Rep 5:351-2. 2003 - [Non-invasive analyses for the diagnosis of Helicobacter pylori infection. A critical review of the literature]Dino Vaira
Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi, Policlinico S Orsola Malpighi di Bologna
Ann Ital Med Int 20:23-7. 2005..The available non-invasive tests are reviewed in this article... - Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized trialDino Vaira
University of Bologna, Bologna, Italy
Ann Intern Med 146:556-63. 2007..Antimicrobial resistance has decreased eradication rates for Helicobacter pylori infection worldwide... - How to proceed in Helicobacter pylori-positive chronic gastritis refractory to first- and second-line eradication therapyDino Vaira
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Dig Dis 25:203-5. 2007..A third-line treatment with rifabutin-based regimen has been proposed... - Stool test for Helicobacter pyloriD Vaira
Department of Internal Medicine and Gastroenterology, University of Bologna, S. Orsola Hospital, 40138 Bologna, Italy
Dig Liver Dis 36:446-7. 2004 - Review article: Helicobacter pylori infection from pathogenesis to treatment--a critical reappraisalD Vaira
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
Aliment Pharmacol Ther 16:105-13. 2002..pylori to gastro-oesophageal reflux disease; infection in the very young and very old; diagnostic techniques; and management of H. pylori infections with particular emphasis on eradication regimens and antibiotic resistance... - [Treatment for Helicobacter pylori: current criteria]Dino Vaira
Dipartimento di Medicina Interna e Gastroenterologia, Universita, Bologna
Recenti Prog Med 98:574-82; quiz 602. 2007.... - Review article: diagnosis of Helicobacter pylori infectionD Vaira
Department of Internal Medicine and Gastroenterology, S Orsola Hospital, Nuove Patologie, Bologna, Italy
Aliment Pharmacol Ther 16:16-23. 2002..Indeed, a number of clinical guidelines recommend noninvasive testing followed by treatment of H. pylori for dyspeptic patients in primary care based on clinical and economic analyses... - The stool antigen test for detection of Helicobacter pylori after eradication therapyDino Vaira
Department of Internal Medicine and Gastroenterology, S Orsola Hospital, Via Massarenti 9, 40138 Bologna, Italy
Ann Intern Med 136:280-7. 2002..Current noninvasive tests to confirm the eradication of Helicobacter pylori must be performed 4 weeks or more after eradication therapy is completed... - Helicobacter pylori: diseases, tests and treatmentU Vaira
Department of Internal Medicine and Gastroenterology, S Orsola Hospital, University of Bologna, Italy
Dig Liver Dis 33:788-94. 2001..The challenge of Helicobacter pylori eradication is not very easy to obtain. The possible scenario and the use of a new proton pump inhibitor (esomeprazole) are reviewed and discussed... - How valuable is the application on consensus guidelines in the management of functional gastrointestinal disorders?D Vaira
1st Medical Clinic, S Orsola Hospital, Nuove Patologie, University of Bologna, Via Massarenti 9, I 40138 Bologna, Italy
Dig Dis 19:225-31. 2001..Symptoms have in common disturbances in sensory and/or motor gastrointestinal function, which sometimes may overlap across anatomic regions. Nevertheless, several studies provide evidence for site-specific syndromes... - Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European study groupD Vaira
Clinica Medica I, Universita di Bologna, Italy
Lancet 354:30-3. 1999..Helicobacter pylori is a common human pathogen implicated in certain gastrointestinal diseases. In the search for new non-invasive techniques to diagnose H. pylori infection, we evaluated an EIA for H. pylori antigen in stool (HpSA)... - Accurate diagnosis of Helicobacter pylori. Stool testsD Vaira
Department of Internal Medicine, University of Bologna, Bologna, Italy
Gastroenterol Clin North Am 29:917-23. 2000..pylori stool assay has the potential to become the preferred diagnostic tool in many different clinical settings from epidemiologic studies to pediatric investigations, from pre-endoscopic screening policies to posttherapy monitoring... - Review article:invasive and non-invasive tests for Helicobacter pylori infectionD Vaira
Ist Medical Clinic, University of Bologna, Italy
Aliment Pharmacol Ther 14:13-22. 2000..pylori, and a combination of two is recommended if this is feasible. The choice of the test to be used is not straightforward and may vary according to the clinical condition and local expertise... - The clinical role of cytochrome p450 genotypes in Helicobacter pylori managementA Sapone
Department of Pharmacology, Pharmacogenomic Unit St Orsola Hospital, University of Bologna, Bologna, Italy
Am J Gastroenterol 98:1010-5. 2003..The aim of this pharmacogenomics study was to investigate the influence of different cytochrome P450 (CYP) genotypes in Helicobacter pylori eradication therapy... - A rapid immunochromatographic assay for Helicobacter pylori in stool before and after treatmentL Gatta
Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
Aliment Pharmacol Ther 20:469-74. 2004..CONCLUSIONS: The novel immunochromatographic stool test is fast, easy to perform and provides good differentiation between positive and negative results. It might become a rapid near patients test easily performed in the doctor office... - Review article: the transmission of Helicobacter pylori from stomach to stomachD Vaira
Department of Internal Medicine, Nuove Patologie, St Orsola Hospital, University of Bologna, Via Massarenti 9 40138 Bologna, Italy
Aliment Pharmacol Ther 15:33-42. 2001..Evidence suggests close personal contact is important and that acquisition occurs mainly in childhood. This article reviews the evidence for the source of infection and the route of transmission of H. pylori... - Best cut-off values for [14C]-urea breath tests for Helicobacter pylori detectionL Gatta
Dept. of Internal Medicine and Gastroenterology, University of Bologna, S. Orsola Hospital, Bologna, Italy
Scand J Gastroenterol 38:1144-8. 2003..5. CONCLUSION: A low dose [14C]-UBT, with a short collecting time, is a reliable method to evaluate H. pylori infection in both the pre- and post-treatment setting... - A 10-day levofloxacin-based triple therapy in patients who have failed two eradication coursesL Gatta
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Aliment Pharmacol Ther 22:45-9. 2005..CONCLUSIONS: In patients who failed previous regimens, the 10-day levofloxacin-based triple therapy is safe and effective, allowing eradication in almost 80% of the patients... - Levofloxacin-based triple therapy for Helicobacter pylori re-treatment: role of bacterial resistanceF Perna
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Dig Liver Dis 39:1001-5. 2007..This study aimed to assess the efficacy of a levofloxacin-amoxycillin triple therapy as a second-line treatment, and the role of primary levofloxacin resistance... - Accuracy of breath tests using low doses of 13C-urea to diagnose Helicobacter pylori infection: a randomised controlled trialL Gatta
Department of Internal Medicine and Gastroenterology, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
Gut 55:457-62. 2006..9% (95% CI 94.3-99.8). DISCUSSION: UBTs using 25 and 15 mg of 13C-urea were both accurate in the diagnosis of H pylori infection in untreated patients. 13C-UBT 15 mg was also accurate for follow up of patients after treatment... 
Accuracy of a new ultrafast rapid urease test to diagnose Helicobacter pylori infection in 1000 consecutive dyspeptic patientsD Vaira
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
Aliment Pharmacol Ther 31:331-8. 2010..Rapid diagnostic tools for Helicobacter pylori are important in endoscopy...- A rapid, low-dose, 13C-urea tablet for the detection of Helicobacter pylori infection before and after treatmentL Gatta
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Aliment Pharmacol Ther 17:793-8. 2003..49 and 1.56 gave a sensitivity and specificity of 100%. CONCLUSIONS: New 10-min 13C-UBTs using tablet formulations of 13C-urea with citric acid are reliable for the assessment of H. pylori status pre- and post-treatment... - Diagnostic accuracy of a new rapid urease test (Pronto Dry), before and after treatment of Helicobacter pylori infectionF Perna
Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
Minerva Gastroenterol Dietol 51:247-54. 2005..6%, 37.5%, 55.3%73.2%, 92.8% for liquid phase rapid urease test. CONCLUSIONS: Pronto Dry showed to have higher sensitivity in pre and post treatment setting compared to liquid phase-rapid urease test within 3 hours of incubation time... - Effect of proton pump inhibitors and antacid therapy on 13C urea breath tests and stool test for Helicobacter pylori infectionLuigi Gatta
Department of Internal Medicine and Gastroenterology, University of Bologna, S. Orsola Halpighi Hospital, Bologna, Italy
Am J Gastroenterol 99:823-9. 2004..CONCLUSIONS: False negative breath and stool tests are equally common in patients taking proton pump inhibitors. Antacids do not impair the sensitivity of the breath tests or the stool test... - Non-invasive techniques for the diagnosis of Helicobacter pylori infectionL Gatta
Department of Internal Medicine and Gastroenterology, Nuove Patologie, Bologna, Italy
Clin Microbiol Infect 9:489-96. 2003..Nevertheless, two non-invasive tests are commonly used: the urea breath test, and the stool antigen test... - Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux diseaseL Gatta
Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Aliment Pharmacol Ther 25:385-92. 2007..Many investigators have proposed an association between gastro-oesophageal reflux disease and laryngo-pharyngeal symptoms, suggesting that medical or surgical therapy for reflux may be useful... - Growth and adult height in atypical coeliac patients, with or without growth hormone deficiencySilvana Salardi
Department of Pediatrics, University of Bologna, Bologna, Italy
J Pediatr Endocrinol Metab 18:769-75. 2005..To evaluate the effect of a gluten-free diet on growth and adult height, when available, in coeliac children without gastrointestinal symptoms... - A comparison amongst three rapid urease tests to diagnose Helicobacter pylori infection in 375 consecutive dyspepticDino Vaira
Department of Internal Medicine and Gastroenterology, S Orsola Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
Intern Emerg Med 5:41-7. 2010..Reading the test results at 1 min may increase false-negative results with decreasing sensitivity... - Susceptibility of Helicobacter pylori to metronidazoleFederico Perna
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Am J Gastroenterol 98:2157-61. 2003..CONCLUSIONS: The E-Test and disk diffusion method are very good alternatives to agar dilution. Mixed infections are a possible cause of the discrepancies between these tests and the reference method... - Serological markers for gastric atrophy in asymptomatic patients infected with Helicobacter pyloriChiara Ricci
Department of Internal Medicine and Gastroenterology, University of Bologna, University Hospital S. Orsola-Malpighi, Bologna, Italy
Am J Gastroenterol 99:1910-5. 2004..20 to 0.65. CONCLUSION: In an asymptomatic population, serum gastrin (total and G-17) and pepsinogens I-II (and their ratio) do not discriminate nonatrophic versus antrum-restricted/predominant atrophic gastritis... - Antimicrobial activity of esomeprazole versus omeprazole against Helicobacter pyloriLuigi Gatta
Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
J Antimicrob Chemother 51:439-42. 2003..CONCLUSIONS: The increased antimicrobial activity in vitro of esomeprazole against H. pylori could contribute to improving the outcome of the eradication treatment of such an infection... - Efficacy of 5-ASA in the treatment of colonic diverticular diseaseLuigi Gatta
Versilia Hospital, Lido di Camaiore, Department of Clinical Science, University of Parma, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
J Clin Gastroenterol 44:113-9. 2010..To assess the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in patients with colonic diverticular disease performing a systematic review of the literature... - 13C-urea breath test values and Helicobacter pylori eradicationAngelo Zullo
Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Via E Morosini, 30, Rome 00153, Italy
Dig Dis Sci 53:370-4. 2008..This large analysis failed to demonstrate a role for DOB value in H. pylori eradication with either a 10-day triple or sequential therapy... - Errors in a meta-analysis of treatments for Helicobacter pylori infectionLuigi Gatta
Ann Intern Med 149:686; author reply 686. 2008 - Helicobacter pylori antigen stool test and 13C-urea breath test in patients after eradication treatmentsFrancesco Perri
Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, Istituto di Ricovero e Cuva a Cavattere Scientifico, San Giovanni Rotondo, Italy
Am J Gastroenterol 97:2756-62. 2002..CONCLUSIONS: UBT and HpSA test give discordant or indeterminate results in nearly 8% of patients after treatment. The HpSA test is less accurate than the UBT. Coccoid forms do not cause false positive HpSA results... - Helicobacter: a paradigm shift in peptic ulcer disease and more?Christelle Basset
Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences
Sci Prog 85:13-31. 2002..This is a major shift in medical practice. Continued investigations on Helicobacter pylori are bringing to light other possible associations with disease as well as delineating plausible biological mechanisms for disease pathogenesis... - Sequential therapy for Helicobacter pylori: time to consider making the switch?Nimish Vakil
University of Wisconsin School of Medicine and Public Health, Madison
JAMA 300:1346-7. 2008 - Update on the treatment of patients with Helicobacter pyloriAngelo Zullo
Am Fam Physician 76:633. 2007 - The sequential therapy regimen for Helicobacter pylori eradication: a pooled-data analysisAngelo Zullo
Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy
Gut 56:1353-7. 2007..However, a critical fall in the H pylori eradication rate following these therapies has been observed in the last few years. The sequential regimen is a novel, promising therapeutic approach... - CagA and VacA are immunoblot markers of past Helicobacter pylori infection in atrophic body gastritisBruno Annibale
Department of Digestive and Liver Disease, University La Sapienza, Ospedale Sant Andrea, Rome, Italy
Helicobacter 12:23-30. 2007..pylori infection is detectable. We aimed to investigate whether patients with ABG, classified as H. pylori-negative by conventional methods (ELISA serology and Giemsa stain histology), have been previously exposed to the infection... - Non-invasive tests for the diagnosis of H. pylori infectionNimish Vakil
University of Wisconsin Medical School, Milwaukee, Wisconsin, USA
Rev Gastroenterol Disord 4:1-6. 2004..The choice of an appropriate test depends on the pre-test probability of infection, the characteristics of the test being used, and the cost-effectiveness of the test. This article reviews available non-invasive tests... - Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesisGerardo Nardone
Department of Clinical and Experimental Medicine, Gastroenterology Unit, University Federico II, Naples, Italy
J Pathol 202:305-12. 2004..In conclusion, H pylori-dependent induction of COX-2 and mPGES1 is associated with enhanced production of P-gp and Bcl-xL that may contribute to gastric tumourigenesis and resistance to therapy... - Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease?Christelle Basset
Centre for Infectious Diseases and International Health, Windeyer Institute of Medical Sciences, Royal Free and University College London Medical School, The Windeyer Building, 46 Cleveland Street, London WIT 4JF, United Kingdom
Dig Dis Sci 49:1425-32. 2004..In conclusion, Helicobacter was not associated with IBD in our population of patients, although ETBF may be associated with active disease... - Diagnosis of Helicobacter pylori: invasive and non-invasive testsChiara Ricci
Gastroenterology Unit, University of Brescia, Italy
Best Pract Res Clin Gastroenterol 21:299-313. 2007..The choice of appropriate test depends on the pre-test probability of infection, the characteristics of the test being used and its cost-effectiveness... - Role of noninvasive tests (C-urea breath test and stool antigen test) as additional tools in diagnosis of Helicobacter pylori infection in patients with atrophic body gastritisEdith Lahner
Digestive and Liver Disease Unit, II Medical School, University La Sapienza, Rome, Italy
Helicobacter 9:436-42. 2004..pylori infection, but these noninvasive tests may be important in combination with histology and serology to define the H. pylori status in some atrophic body gastritis patients... - Helicobacter pylori: current status and future prospectsDino Vaira
Centre for Infectious Diseases and International Health, RF and UCL Medical School, UK
Sci Prog 87:269-96. 2004.... - Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pyloriRachel O'Mahony
Centre for Infectious Diseases and International Health, Royal Free and University College London Medical School, Windeyer Building, 46 Cleveland Street, London, W1P 6DB, United Kingdom
World J Gastroenterol 11:7499-507. 2005..To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H. pylori)... - Helicobacter pylori and pancreatic diseaseGianpiero Manes
JOP 4:111-6. 2003 - Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopyRachel O'Mahony
Centre for Infectious Diseases and International Health, Royal Free and University College London Medical School, The Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK
J Microbiol Methods 61:105-26. 2005..The method can be applied to organisms ranging in size from small bacteria to larger yeast cells...