Fulvio Ursini

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Wine polyphenols and optimal nutrition
    Fulvio Ursini
    Department of Biological Chemistry, University of Padova, Padova, Italy
    Ann N Y Acad Sci 957:200-9. 2002
  2. ncbi request reprint Atherosclerosis: another protein misfolding disease?
    Fulvio Ursini
    Dept of Biological Chemistry, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
    Trends Mol Med 8:370-4. 2002
  3. ncbi request reprint Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidase
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, Italy
    J Biol Chem 280:38395-402. 2005
  4. doi request reprint The catalytic site of glutathione peroxidases
    Silvio C E Tosatto
    Department of Biology and CRIBI Biotechnology Centre, Padova, Italy
    Antioxid Redox Signal 10:1515-26. 2008
  5. ncbi request reprint The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, I 35121 Padova, Italy
    J Mol Biol 365:1033-46. 2007
  6. doi request reprint Differential liquid phase proteomic analysis of the effect of selenium supplementation in LNCaP cells
    Antonella Roveri
    Department of Biological Chemistry, University of Padova, I 35131 Padova, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 865:63-73. 2008
  7. doi request reprint Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme
    Stefano Toppo
    Department of Biological Chemistry, Viale G Colombo, 3, University of Padova, I 35121 Padova, Italy
    Biochim Biophys Acta 1790:1486-500. 2009
  8. ncbi request reprint Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels
    Andrea Garolla
    Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Fertil Steril 83:355-61. 2005
  9. ncbi request reprint Primary structure of the nuclear forms of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat spermatozoa
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, Viale G Colombo 3, I 35121 Padova, Italy
    FEBS Lett 579:667-70. 2005
  10. ncbi request reprint Genetic variations of gpx-4 and male infertility in humans
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, I 35121 Padova, Italy
    Biol Reprod 68:1134-41. 2003

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Wine polyphenols and optimal nutrition
    Fulvio Ursini
    Department of Biological Chemistry, University of Padova, Padova, Italy
    Ann N Y Acad Sci 957:200-9. 2002
    ..Drinking wine at meals provides this kind of protection, and the final benefits are realized by the prevention of the development of atheromatous lesions even under conditions of hypercholesterolemia...
  2. ncbi request reprint Atherosclerosis: another protein misfolding disease?
    Fulvio Ursini
    Dept of Biological Chemistry, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
    Trends Mol Med 8:370-4. 2002
    ..Based on these analogies, we propose that atherogenesis could be considered as a disease produced by the accumulation of cytotoxic and pro-inflammatory misfolded lipoproteins...
  3. ncbi request reprint Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidase
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, Italy
    J Biol Chem 280:38395-402. 2005
    ..This study suggests a new mechanism where selenium catalysis drives the cross-linking of structural elements of the cytoskeleton via the oxidation of a keratin-associated protein...
  4. doi request reprint The catalytic site of glutathione peroxidases
    Silvio C E Tosatto
    Department of Biology and CRIBI Biotechnology Centre, Padova, Italy
    Antioxid Redox Signal 10:1515-26. 2008
    ..These data disclose that the catalytic site of GPxs has to be redrawn as a tetrad, including Asn136, and suggest a mechanism accounting for the extraordinary catalytic efficiency of GPxs...
  5. ncbi request reprint The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, I 35121 Padova, Italy
    J Mol Biol 365:1033-46. 2007
    ..Based of these characteristics, most of the non-mammalian CysGPxs, in functional terms, are thioredoxin peroxidases...
  6. doi request reprint Differential liquid phase proteomic analysis of the effect of selenium supplementation in LNCaP cells
    Antonella Roveri
    Department of Biological Chemistry, University of Padova, I 35131 Padova, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 865:63-73. 2008
    ..Results are consistent, at least in part, with the less oxidant environment brought about by the synthesis of Se-dependent peroxidases, keeping low the steady-state concentration of hydrogen peroxide...
  7. doi request reprint Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme
    Stefano Toppo
    Department of Biological Chemistry, Viale G Colombo, 3, University of Padova, I 35121 Padova, Italy
    Biochim Biophys Acta 1790:1486-500. 2009
    ..Heterodimer formation of yeast GPx with a transcription factor is discussed as paradigm of a redox sensing that might also be valid in vertebrates...
  8. ncbi request reprint Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels
    Andrea Garolla
    Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    Fertil Steril 83:355-61. 2005
    ..To clarify the role of carnitine supplementation in idiopathic asthenozoospermia and to look for a rationale for its use in asthenozoospermic patients...
  9. ncbi request reprint Primary structure of the nuclear forms of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat spermatozoa
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, Viale G Colombo 3, I 35121 Padova, Italy
    FEBS Lett 579:667-70. 2005
    ..9 kDa enzyme, although the alternate use of a downstream ATG, at least in rodents, could not be unequivocally ruled out...
  10. ncbi request reprint Genetic variations of gpx-4 and male infertility in humans
    Matilde Maiorino
    Department of Biological Chemistry, University of Padova, I 35121 Padova, Italy
    Biol Reprod 68:1134-41. 2003
    ....
  11. doi request reprint Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7
    Valentina Bosello-Travain
    Department of Molecular Medicine, University of Padova, Padua, Italy
    Biochim Biophys Acta 1830:3846-57. 2013
    ..Although containing a peroxidatic Cys (CP) it lacks the resolving Cys (CR), that confers fast reactivity with thioredoxin (Trx) or related proteins to most other CysGPxs...
  12. ncbi request reprint Distinct promoters determine alternative transcription of gpx-4 into phospholipid-hydroperoxide glutathione peroxidase variants
    Matilde Maiorino
    Department of Biological Chemistry, Viale G Colombo 3, University of Padova, I 35121 Padova, Italy
    J Biol Chem 278:34286-90. 2003
    ..Transcripts encoding nPHGPx were most abundant in testis although not restricted to this organ. This observation points to a general role of the nuclear PHGPx variant in regulating cell division...
  13. ncbi request reprint Effect of mercury on selenium utilization and selenoperoxidase activity in LNCaP cells
    Cristiana Bulato
    Department of Biological Chemistry, Viale G Colombo 3, I 35121 Padova, Italy
    Free Radic Biol Med 42:118-23. 2007
    ....
  14. doi request reprint Redox pioneer: Professor Leopold Flohé
    Fulvio Ursini
    Department of Biological Chemistry, University of Padova, Padova, Italy
    Antioxid Redox Signal 13:1617-22. 2010
    ....
  15. doi request reprint MPA: a multiple peak alignment algorithm to perform multiple comparisons of liquid-phase proteomic profiles
    Stefano Toppo
    Department of Biological Chemistry, University of Padua, Via G Colombo, Padua, Italy
    Proteomics 8:250-3. 2008
    ..The tool is available at http://grup.cribi.unipd.it/people/stefano/mpa/...
  16. ncbi request reprint Phospholipid-hydroperoxide glutathione peroxidase in sperm
    Antonella Roveri
    Department of Biological Chemistry, University of Padova, I 35121 Padova, Italy
    Methods Enzymol 347:208-12. 2002
  17. ncbi request reprint Postprandial oxidative stress
    Fulvio Ursini
    Department of Biological Chemistry, University of Padova, Italy
    Biol Chem 383:599-605. 2002
    ..These modified particles could account for a relevant link between nutrition and early biological processes that foster the development of atherosclerosis...
  18. ncbi request reprint Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase
    Carlo Foresta
    Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, I 35128 Padova, Italy
    Biol Reprod 67:967-71. 2002
    ..Because the content of PHGPx, irrespective of the cause of alteration, is correlated with fertility-related parameters, PHGPx can be considered a predictive measure for fertilization capacity...
  19. doi request reprint Low density lipoprotein misfolding and amyloidogenesis
    Tiziana Parasassi
    Istituto di Neurobiologia e Medicina Molecolare, CNR, Via del Fosso del Cavaliere 100, 00133 Rome, Italy
    FASEB J 22:2350-6. 2008
    ..Apoprotein misfolding well represents an LDL modification able to transform this cholesterol carrier into a trigger for a response-to-injury in the artery wall...
  20. ncbi request reprint The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin
    Madia Trujillo
    Departamento de Bioquimica, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, UY 11800 Montevideo, Uruguay
    J Biol Chem 281:20555-66. 2006
    ..The role of Cys(93) is likely to conserve the oxidation equivalents of the sulfenic acid state of C(P) as a disulfide bond to prevent overoxidation of Cys(60) under a restricted supply of reducing substrate...
  21. ncbi request reprint Versatility of selenium catalysis in PHGPx unraveled by LC/ESI-MS/MS
    Pierluigi Mauri
    Institute for Biomedical Technologies, National Research Council, Viale F lli Cervi 93, 1 20090 Segrate Milano, Italy
    Biol Chem 384:575-88. 2003
    ..We conclude that the same catalytic principles, depending on the conditions, can drive the diverse actions of PHGPx, i.e. hydroperoxide reduction, GSSG reduction, S-derivatization and self-incorporation into biological structures...
  22. ncbi request reprint Selenium supplementation prevents the increase in atherogenic electronegative LDL (LDL minus) in the postprandial phase
    Fausta Natella
    Free Radical Research Group, National Research Institute for Food and Nutrition, Via Ardeatina 546, 00178 Roma, Italy
    Nutr Metab Cardiovasc Dis 17:649-56. 2007
    ....
  23. doi request reprint Peroxidase: a term of many meanings
    Leopold Flohe
    Antioxid Redox Signal 10:1485-90. 2008
    ..The present Forum Editorial tries to guide the reader through the 190 years of equally bewildering and fascinating research on peroxidases up to the topical frontiers of the field that are addressed in this issue...
  24. ncbi request reprint Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans
    Fausta Natella
    Free Radical Research Group, National Research Institute for Food and Nutrition, INRAN, Via Ardeatina 546, 00178 Rome, Italy
    J Agric Food Chem 50:7720-5. 2002
    ....
  25. ncbi request reprint Preface
    Dipak K Das
    Ann N Y Acad Sci 957:xi-xiii. 2002
  26. ncbi request reprint Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples
    Fulvio Ursini
    Int J Androl 28:61-2; author reply 63-4. 2005
  27. ncbi request reprint Metamorphosis of the selenoprotein PHGPx during spermatogenesis
    Leopold Flohe
    Department of Biochemistry, Technical University of Braunschweig D 38124 Braunschweig, Germany
    Ann N Y Acad Sci 973:287-8. 2002
  28. ncbi request reprint One site on the apoB-100 specifically binds 17-beta-estradiol and regulates the overall structure of LDL
    Roberto Brunelli
    Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, Universita di Roma La Sapienza, Roma, Italy
    FASEB J 17:2127-9. 2003
    ....
  29. pmc Low density lipoprotein aged in plasma forms clusters resembling subendothelial droplets: aggregation via surface sites
    Marco De Spirito
    Istituto di Fisica, Facolta di Medicina e Chirurgia, Universita Cattolica del Sacro Cuore, Rome, Italy
    Biophys J 90:4239-47. 2006
    ....
  30. ncbi request reprint Topical alpha-tocopherol acetate in the bulk phase: eight years of experience in skin treatment
    Giorgio Panin
    Hulka s r l, Rovigo, Italy
    Ann N Y Acad Sci 1031:443-7. 2004
    ..This effect combines well with the antioxidant capacity of alpha-tocopherol released from the ester, and the recently emerging effect on reprogramming of gene expression...