Research Topics
Genomes and Genes | Fulvio UrsiniSummaryAffiliation: University of Padova Country: Italy Publications
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Publications
Wine polyphenols and optimal nutritionFulvio Ursini
Department of Biological Chemistry, University of Padova, Padova, Italy
Ann N Y Acad Sci 957:200-9. 2002..Drinking wine at meals provides this kind of protection, and the final benefits are realized by the prevention of the development of atheromatous lesions even under conditions of hypercholesterolemia...- Atherosclerosis: another protein misfolding disease?Fulvio Ursini
Dept of Biological Chemistry, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
Trends Mol Med 8:370-4. 2002..Based on these analogies, we propose that atherogenesis could be considered as a disease produced by the accumulation of cytotoxic and pro-inflammatory misfolded lipoproteins... - Functional interaction of phospholipid hydroperoxide glutathione peroxidase with sperm mitochondrion-associated cysteine-rich protein discloses the adjacent cysteine motif as a new substrate of the selenoperoxidaseMatilde Maiorino
Department of Biological Chemistry, University of Padova, Italy
J Biol Chem 280:38395-402. 2005..This study suggests a new mechanism where selenium catalysis drives the cross-linking of structural elements of the cytoskeleton via the oxidation of a keratin-associated protein... 
The catalytic site of glutathione peroxidasesSilvio C E Tosatto
Department of Biology and CRIBI Biotechnology Centre, Padova, Italy
Antioxid Redox Signal 10:1515-26. 2008..These data disclose that the catalytic site of GPxs has to be redrawn as a tetrad, including Asn136, and suggest a mechanism accounting for the extraordinary catalytic efficiency of GPxs...- The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidasesMatilde Maiorino
Department of Biological Chemistry, University of Padova, I 35121 Padova, Italy
J Mol Biol 365:1033-46. 2007..Based of these characteristics, most of the non-mammalian CysGPxs, in functional terms, are thioredoxin peroxidases... - Differential liquid phase proteomic analysis of the effect of selenium supplementation in LNCaP cellsAntonella Roveri
Department of Biological Chemistry, University of Padova, I 35131 Padova, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 865:63-73. 2008..Results are consistent, at least in part, with the less oxidant environment brought about by the synthesis of Se-dependent peroxidases, keeping low the steady-state concentration of hydrogen peroxide... - Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levelsAndrea Garolla
Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
Fertil Steril 83:355-61. 2005..CONCLUSION(S): Phospholipid hydroperoxide glutathione peroxidase has an important role in male infertility, and carnitine treatment might improve sperm motility in the presence of normal mitochondrial function... - Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic schemeStefano Toppo
Department of Biological Chemistry, Viale G Colombo, 3, University of Padova, I 35121 Padova, Italy
Biochim Biophys Acta 1790:1486-500. 2009..Heterodimer formation of yeast GPx with a transcription factor is discussed as paradigm of a redox sensing that might also be valid in vertebrates... - Genetic variations of gpx-4 and male infertility in humansMatilde Maiorino
Department of Biological Chemistry, University of Padova, I 35121 Padova, Italy
Biol Reprod 68:1134-41. 2003.... - Primary structure of the nuclear forms of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in rat spermatozoaMatilde Maiorino
Department of Biological Chemistry, University of Padova, Viale G Colombo 3, I 35121 Padova, Italy
FEBS Lett 579:667-70. 2005..9 kDa enzyme, although the alternate use of a downstream ATG, at least in rodents, could not be unequivocally ruled out... - Distinct promoters determine alternative transcription of gpx-4 into phospholipid-hydroperoxide glutathione peroxidase variantsMatilde Maiorino
Department of Biological Chemistry, Viale G Colombo 3, University of Padova, I 35121 Padova, Italy
J Biol Chem 278:34286-90. 2003..Transcripts encoding nPHGPx were most abundant in testis although not restricted to this organ. This observation points to a general role of the nuclear PHGPx variant in regulating cell division... - Redox pioneer: Professor Leopold FlohéFulvio Ursini
Department of Biological Chemistry, University of Padova, Padova, Italy
Antioxid Redox Signal 13:1617-22. 2010.... - Effect of mercury on selenium utilization and selenoperoxidase activity in LNCaP cellsCristiana Bulato
Department of Biological Chemistry, Viale G Colombo 3, I 35121 Padova, Italy
Free Radic Biol Med 42:118-23. 2007.... - MPA: a multiple peak alignment algorithm to perform multiple comparisons of liquid-phase proteomic profilesStefano Toppo
Department of Biological Chemistry, University of Padua, Via G Colombo, Padua, Italy
Proteomics 8:250-3. 2008..The tool is available at http://grup.cribi.unipd.it/people/stefano/mpa/... - Phospholipid-hydroperoxide glutathione peroxidase in spermAntonella Roveri
Department of Biological Chemistry, University of Padova, I-35121 Padova, Italy
Methods Enzymol 347:208-12. 2002 - Postprandial oxidative stressFulvio Ursini
Department of Biological Chemistry, University of Padova, Italy
Biol Chem 383:599-605. 2002..These modified particles could account for a relevant link between nutrition and early biological processes that foster the development of atherosclerosis... - Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidaseCarlo Foresta
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, I 35128 Padova, Italy
Biol Reprod 67:967-71. 2002..Because the content of PHGPx, irrespective of the cause of alteration, is correlated with fertility-related parameters, PHGPx can be considered a predictive measure for fertilization capacity... - Peroxidase: a term of many meaningsLeopold Flohe
Antioxid Redox Signal 10:1485-90. 2008..The present Forum Editorial tries to guide the reader through the 190 years of equally bewildering and fascinating research on peroxidases up to the topical frontiers of the field that are addressed in this issue... - Low density lipoprotein misfolding and amyloidogenesisTiziana Parasassi
Istituto di Neurobiologia e Medicina Molecolare, CNR, Via del Fosso del Cavaliere 100, 00133 Rome, Italy
FASEB J 22:2350-6. 2008..Apoprotein misfolding well represents an LDL modification able to transform this cholesterol carrier into a trigger for a response-to-injury in the artery wall... - Selenium supplementation prevents the increase in atherogenic electronegative LDL (LDL minus) in the postprandial phaseFausta Natella
Free Radical Research Group, National Research Institute for Food and Nutrition, Via Ardeatina 546, 00178 Roma, Italy
Nutr Metab Cardiovasc Dis 17:649-56. 2007.... - Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humansFausta Natella
Free Radical Research Group, National Research Institute for Food and Nutrition, INRAN, Via Ardeatina 546, 00178 Rome, Italy
J Agric Food Chem 50:7720-5. 2002.... - The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxinMadia Trujillo
, Facultad de Medicina, , Avda. General Flores 2125, UY-11800 Montevideo, Uruguay
J Biol Chem 281:20555-66. 2006..The role of Cys(93) is likely to conserve the oxidation equivalents of the sulfenic acid state of C(P) as a disulfide bond to prevent overoxidation of Cys(60) under a restricted supply of reducing substrate... - Versatility of selenium catalysis in PHGPx unraveled by LC/ESI-MS/MSPierluigi Mauri
Institute for Biomedical Technologies, National Research Council, Viale F.lli Cervi 93, 1-20090 Segrate (Milano, Italy
Biol Chem 384:575-88. 2003..We conclude that the same catalytic principles, depending on the conditions, can drive the diverse actions of PHGPx, i.e. hydroperoxide reduction, GSSG reduction, S-derivatization and self-incorporation into biological structures... - Metamorphosis of the selenoprotein PHGPx during spermatogenesisLeopold Flohe
Department of Biochemistry, Technical University of Braunschweig D 38124 Braunschweig, Germany
Ann N Y Acad Sci 973:287-8. 2002 
Low density lipoprotein aged in plasma forms clusters resembling subendothelial droplets: aggregation via surface sitesMarco De Spirito
Istituto di Fisica, , , Rome, Italy
Biophys J 90:4239-47. 2006....- Topical alpha-tocopherol acetate in the bulk phase: eight years of experience in skin treatmentGiorgio Panin
Hulka s r l, Rovigo, Italy
Ann N Y Acad Sci 1031:443-7. 2004..This effect combines well with the antioxidant capacity of alpha-tocopherol released from the ester, and the recently emerging effect on reprogramming of gene expression... - PrefaceDipak K Das
Ann N Y Acad Sci 957:xi-xiii. 2002 - One site on the apoB-100 specifically binds 17-beta-estradiol and regulates the overall structure of LDLRoberto Brunelli
Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, , Roma, Italy
FASEB J 17:2127-9. 2003.... - Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samplesFulvio Ursini
Int J Androl 28:61-2; author reply 63-4. 2005