A Uccelli

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi request reprint Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis
    Ezio Gerdoni
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genova, Italy
    Ann Neurol 61:219-27. 2007
  2. pmc Patient adherence to and tolerability of self-administered interferon β-1a using an electronic autoinjection device: a multicentre, open-label, phase IV study
    Alessandra Lugaresi
    Department of Neuroscience and Imaging, University G, D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    BMC Neurol 12:7. 2012
  3. doi request reprint Mesenchymal stem cells exert a remarkable regenerative effect requiring minimal CNS integration: Commentary on: "Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function" by Voulg
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy Advanced Biotechnology Center ABC, Genoa, Italy Center of Excellence for Biomedical Research, University of Genoa, Italy Electronic address
    Exp Neurol 247:292-5. 2013
  4. doi request reprint Mesenchymal stem cells as treatment for MS - progress to date
    Antonio Uccelli
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Italy
    Mult Scler 19:515-9. 2013
  5. pmc Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis
    Antonio Uccelli
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Mol Med 18:794-804. 2012
  6. pmc The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms
    Sara Morando
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Stem Cell Res Ther 3:3. 2012
  7. pmc The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse
    Enrico Pedemonte
    Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA
    BMC Genomics 8:65. 2007
  8. pmc Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
  9. ncbi request reprint Immunoregulatory function of mesenchymal stem cells
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
    Eur J Immunol 36:2566-73. 2006
  10. doi request reprint Is there a role for mesenchymal stem cells in autoimmune diseases?
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Autoimmunity 41:592-5. 2008

Detail Information

Publications56

  1. ncbi request reprint Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis
    Ezio Gerdoni
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genova, Italy
    Ann Neurol 61:219-27. 2007
    ..To evaluate the ability of mesenchymal stem cells (MSCs), a subset of adult stem cells from bone marrow, to cure experimental autoimmune encephalomyelitis...
  2. pmc Patient adherence to and tolerability of self-administered interferon β-1a using an electronic autoinjection device: a multicentre, open-label, phase IV study
    Alessandra Lugaresi
    Department of Neuroscience and Imaging, University G, D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    BMC Neurol 12:7. 2012
    ..We sought to assess short-term adherence to, and tolerability of, interferon (IFN) β-1a administered via electronic autoinjection device in patients with relapsing-remitting multiple sclerosis (RRMS)...
  3. doi request reprint Mesenchymal stem cells exert a remarkable regenerative effect requiring minimal CNS integration: Commentary on: "Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function" by Voulg
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy Advanced Biotechnology Center ABC, Genoa, Italy Center of Excellence for Biomedical Research, University of Genoa, Italy Electronic address
    Exp Neurol 247:292-5. 2013
    ..Future studies will have to resolve if stem cell transplantation is still preferable over the administration of their secreted factors. ..
  4. doi request reprint Mesenchymal stem cells as treatment for MS - progress to date
    Antonio Uccelli
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Italy
    Mult Scler 19:515-9. 2013
    ....
  5. pmc Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis
    Antonio Uccelli
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Mol Med 18:794-804. 2012
    ..These findings suggest that intravenous administration of MSCs significantly improves the clinical outcome and pathological scores of mutant SOD1/G93A mice, thus providing the rationale for their exploitation for the treatment of ALS...
  6. pmc The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms
    Sara Morando
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Stem Cell Res Ther 3:3. 2012
    ..These results paved the road for the utilization of MSCs for the treatment of multiple sclerosis...
  7. pmc The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse
    Enrico Pedemonte
    Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA
    BMC Genomics 8:65. 2007
    ....
  8. pmc Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
    ..This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts...
  9. ncbi request reprint Immunoregulatory function of mesenchymal stem cells
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
    Eur J Immunol 36:2566-73. 2006
    ..Thus, it is likely that MSC effects on the immune system may be deeply influenced not only by cell-to-cell interactions, but also by environmental factors shaping their phenotype and functions...
  10. doi request reprint Is there a role for mesenchymal stem cells in autoimmune diseases?
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Autoimmunity 41:592-5. 2008
    ..Despite the absolute need for caution related to several clinical and technical issues, MSCs are now on the edge of a new era of clinical applications...
  11. ncbi request reprint Stem cells in inflammatory demyelinating disorders: a dual role for immunosuppression and neuroprotection
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Expert Opin Biol Ther 6:17-22. 2006
    ..Overall, it is proposed that limited subsets of adult stem cells may have a dual function that may be effective for the treatment of MS, an autoimmune disease of the CNS where degeneration of neural cells follows inflammation...
  12. doi request reprint Mesenchymal stem cells in health and disease
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Nat Rev Immunol 8:726-36. 2008
    ..This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches...
  13. doi request reprint Stem cell transplantation in multiple sclerosis
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, Italy
    Curr Opin Neurol 23:218-25. 2010
    ..Here, we provide an overview of the current status of stem cell research in MS focusing on secured actuality, reasonable hopes and unrealistic myths...
  14. ncbi request reprint Mesenchymal stem cells for multiple sclerosis: does neural differentiation really matter?
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Curr Stem Cell Res Ther 6:69-72. 2011
    ....
  15. ncbi request reprint EAE in the common marmoset Callithrix jacchus
    A Uccelli
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics and Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
    Int MS J 10:6-12. 2003
    ....
  16. ncbi request reprint Characterization of the response to myelin basic protein in a non human primate model for multiple sclerosis
    A Uccelli
    Department of Neurological Sciences and Vision, Gaslini Institute, University of Genoa, Italy
    Eur J Immunol 31:474-9. 2001
    ....
  17. doi request reprint Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Italy
    Lancet Neurol 10:649-56. 2011
    ..Small clinical studies in different neurological diseases have suggested that MSCs are safe, paving the road for larger phase 2 studies addressing the effect of MSCs on clinical outcomes and markers of disease activity...
  18. doi request reprint Neuroprotective features of mesenchymal stem cells
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Best Pract Res Clin Haematol 24:59-64. 2011
    ..This review discusses the targets and mechanisms of BM-MSC mediated neuroprotection...
  19. doi request reprint Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?
    Antonio Uccelli
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Italy
    Curr Opin Immunol 22:768-74. 2010
    ..The data will be reviewed in terms of the potentials of MSCs for therapy of autoimmune diseases...
  20. ncbi request reprint Unveiling the enigma of the CNS as a B-cell fostering environment
    Antonio Uccelli
    Neuroimmunology Unit, Department of Neurosciences, Centre of Excellence for Biomedical Research, University of Genoa, Italy
    Trends Immunol 26:254-9. 2005
    ....
  21. doi request reprint Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experience
    G L Mancardi
    Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Mult Scler 18:835-42. 2012
    ..The clinical outcome and the toxicity of AHSCT can be diverse, depending on the various types of conditioning protocols and on the disease phase...
  22. ncbi request reprint Demyelination and axonal damage in a non-human primate model of multiple sclerosis
    G Mancardi
    Department of Neurological Sciences and Vision, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    J Neurol Sci 184:41-9. 2001
    ..These findings are of relevance for the development of therapies, which can protect axons and enhance their function and survival...
  23. doi request reprint Autologous haematopoietic stem-cell transplantation in multiple sclerosis: benefits and risks
    E Capello
    Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Genoa, Italy
    Neurol Sci 30:S175-7. 2009
    ..The risk of mortality, which dropped in the last years to 2-3%, is still the main problem of this powerful therapy...
  24. ncbi request reprint Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients
    M Iester
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Eye (Lond) 23:407-12. 2009
    ....
  25. ncbi request reprint Restricted immune responses lead to CNS demyelination and axonal damage
    G Mancardi
    Department of Neurological Sciences and Vision, University of Genova, Via De Toni 5, 16132, Genoa, Italy
    J Neuroimmunol 107:178-83. 2000
    ....
  26. doi request reprint Surrogate endpoints for EDSS worsening in multiple sclerosis. A meta-analytic approach
    M P Sormani
    Department of Health Sciences, Via Pastore 1, Genoa, Italy
    Neurology 75:302-9. 2010
    ....
  27. ncbi request reprint Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosis
    E Capello
    Department of Neurological Sciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, I 16132, Genoa, Italy
    Neurol Sci 26:S200-3. 2005
    ..These results support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving MS cases unresponsive to conventional therapies...
  28. ncbi request reprint Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis
    Giovanni Luigi Mancardi
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Mult Scler 11:367-71. 2005
    ..These results support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving malignant MS cases unresponsive to conventional therapies...
  29. ncbi request reprint Mechanisms of the adaptive immune response inside the central nervous system during inflammatory and autoimmune diseases
    Enrico Pedemonte
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Pharmacol Ther 111:555-66. 2006
    ....
  30. doi request reprint Urinary JCV-DNA testing during natalizumab treatment may increase accuracy of PML risk stratification
    A Laroni
    Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Via De Toni 5, 16132, Genoa, Italy
    J Neuroimmune Pharmacol 7:665-72. 2012
    ..In conclusion, testing JCV-DNA in urine is complementary to testing anti-JCV antibodies in identifying patients at risk of PML...
  31. doi request reprint Association of melanoma and natalizumab therapy in the Italian MS population: a second case report
    A Laroni
    Multiple Sclerosis Center, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Neurol Sci 32:181-2. 2011
    ..Here we report a case of melanoma in a patient who developed melanoma after 77 infusions of natalizumab, without known risk factors. Pharmacovigilance programs of new drugs can help to monitor adverse events in patients at risk...
  32. ncbi request reprint Central and peripheral nervous system complications following allogeneic bone marrow transplantation
    C Solaro
    Department of Neurological Sciences and Vision, University of Genoa, Italy
    Eur J Neurol 8:77-80. 2001
    ..Clinical course and laboratory findings correlated with relapses of systemic GvDH, thus suggesting the possibility that involvement of CNS and PNS may be sustained by a similar pathogenic mechanism...
  33. ncbi request reprint B-cell differentiation in the CNS of patients with multiple sclerosis
    Anna Corcione
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, Scientific G Gaslini Institute, Genoa, Italy
    Autoimmun Rev 4:549-54. 2005
    ..Thus, B cells are likely to expand and mature inside the CNS, giving rise to ASC, which may play an effector role in the pathogenesis of MS...
  34. ncbi request reprint Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosis
    C Solaro
    Department of Neurological Sciences and Rehabilitation, University of Genoa, Genoa, Italy
    Eur Neurol 44:45-8. 2000
    ..Combining drugs with complementary modes of action may provide a rational pharmacological approach to the management of TN in MS...
  35. ncbi request reprint Biological markers of the inflammatory phase of multiple sclerosis
    A Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Neurol Sci 24:S271-4. 2003
    ..In this review we briefly discuss the biological markers available to date...
  36. ncbi request reprint Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
    Emanuela Zappia
    Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Blood 106:1755-61. 2005
    ..These data suggest that the immunoregulatory properties of MSCs effectively interfere with the autoimmune attack in the course of EAE inducing an in vivo state of T-cell unresponsiveness occurring within secondary lymphoid organs...
  37. ncbi request reprint Mesenchymal stem cells: a new strategy for immunosuppression?
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
    Trends Immunol 28:219-26. 2007
    ..In immune-mediated diseases, the protective effects might function in concert with the immunosuppressive and anti-inflammatory activities...
  38. ncbi request reprint Conventional perimetry, short-wavelength automated perimetry, frequency-doubling technology, and visual evoked potentials in the assessment of patients with multiple sclerosis
    G Corallo
    Eye Clinic, Dept of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
    Eur J Ophthalmol 15:730-8. 2005
    ....
  39. ncbi request reprint Immunological patterns identifying disease course and evolution in multiple sclerosis patients
    Roberto Furlan
    Neuroimmunology Unit, San Raffaele, Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Neuroimmunol 165:192-200. 2005
    ....
  40. ncbi request reprint Human mesenchymal stem cells promote survival of T cells in a quiescent state
    Federica Benvenuto
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Stem Cells 25:1753-60. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  41. pmc Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE
    Santina Bruzzone
    Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy
    PLoS ONE 4:e7897. 2009
    ..In conclusion, Nampt inhibitors (and possibly Sirt6 inhibitors) could be used to modulate T cell-mediated immune responses and thereby be beneficial in immune-mediated disorders...
  42. doi request reprint Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo
    Cristina Lanza
    Department of Biology, University of Genoa, Genoa 16132, Italy
    J Neurochem 110:1674-84. 2009
    ..These results support an antioxidant and neuroprotective activity for MSCs that was also confirmed in vitro on neuroblastoma cells exposed to an oxidative insult...
  43. doi request reprint Reciprocal interactions between human mesenchymal stem cells and gammadelta T cells or invariant natural killer T cells
    Ignazia Prigione
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genoa, Italy
    Stem Cells 27:693-702. 2009
    ..In contrast, MSCs were lysed by activated Vdelta2(+) T cells through a T-cell receptor-dependent mechanism. These results are translationally relevant in view of the increasing interest in MSC-based therapy of autoimmune diseases...
  44. ncbi request reprint Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS
    Debora Giunti
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    J Leukoc Biol 73:584-90. 2003
    ..These cells are recruited into the CSF by inducible chemokines. Thus, CSF represents a transitional station for T cells trafficking to and from the NS...
  45. ncbi request reprint Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis
    Monica Morini
    Molecular Oncology Laboratory, National Cancer Research Institute, Genoa, Italy
    J Neuroimmunol 148:146-53. 2004
    ....
  46. ncbi request reprint Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice
    Roberto Furlan
    Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
    Brain 126:285-91. 2003
    ..Our results indicate that vaccination with Abeta could determine, under certain circumstances, an aberrant autoimmune-type reaction to Abeta resulting in a perivenular inflammatory encephalomyelitis...
  47. doi request reprint Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis
    Antonella Marte
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    J Neurochem 115:343-52. 2010
    ..p.i., whereas no differences could be detected at 13 d.p.i. Our data indicate that glutamatergic neurotransmission is altered in the spinal cord of EAE mice...
  48. ncbi request reprint Relapses after treatment with rituximab in a patient with multiple sclerosis and anti myelin-associated glycoprotein polyneuropathy
    Luana Benedetti
    Department of Neurosciences, Ophthalmology, and Genetics, University of Genova, Via De Toni 5, 16132 Genova, Italy
    Arch Neurol 64:1531-3. 2007
    ..To describe the unique case of a patient with multiple sclerosis (MS) and anti-myelin-associated glycoprotein (MAG) polyneuropathy who developed MS relapses after treatment with rituximab...
  49. doi request reprint Contact with the bone marrow microenvironment readdresses the fate of transplanted hematopoietic stem cells
    Michela Massollo
    Nuclear Medicine, University of Genoa, Azienda Ospedaliera San Martino, Genoa, Italy
    Exp Hematol 38:968-77. 2010
    ..However, the mechanisms underlying the benefit provided by this procedure remain unknown. This study aims to evaluate the effect of IB on HSCs trafficking and homing features in the living rat...
  50. ncbi request reprint Investigation of paroxysmal dystonia in a patient with multiple sclerosis: a transcranial magnetic stimulation study
    Carlo Trompetto
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genova, Italy
    Clin Neurophysiol 119:63-70. 2008
    ..To study the pathogenesis of paroxysmal dystonia affecting the right body side in a patient with a demyelinating lesion in the descending motor pathways, also involving the basal ganglia...
  51. pmc Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
    Anna Corcione
    Laboratory of Oncology, Scientific Direction, G Gaslini Institute, 16148 Genoa, Italy
    Proc Natl Acad Sci U S A 101:11064-9. 2004
    ..The presence of lymphotoxin-alpha, CXCL12, and CXCL13 in the CNS may provide favorable microenvironmental conditions for these events...
  52. doi request reprint Immunotherapy for neurological diseases
    Pablo Villoslada
    Department of Neuroscience, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Clin Immunol 128:294-305. 2008
    ....
  53. ncbi request reprint Stem cells for multiple sclerosis: promises and reality
    Antonio Uccelli
    Regen Med 2:7-9. 2007
  54. ncbi request reprint Human mesenchymal stem cells modulate B-cell functions
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Blood 107:367-72. 2006
    ..These results further support the potential therapeutic use of hMSCs in immune-mediated disorders, including those in which B cells play a major role...
  55. doi request reprint Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical application
    Nadia Sessarego
    Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, L go R Benzi 10, 16132 Genova Italy
    Haematologica 93:339-46. 2008
    ..In this study, mesenchymal stromal cells were successfully isolated from second trimester amniotic fluid and analyzed for chromosomal stability to validate their safety for potential utilization as a cell therapy product...
  56. ncbi request reprint Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
    Lisa F Barcellos
    Division of Epidemiology, School of Public Health, University of California, Berkeley 94720, USA, and Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, UK
    Hum Mol Genet 15:2813-24. 2006
    ....