Research Topics
| A UccelliSummaryAffiliation: University of Genoa Country: Italy Publications
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Detail Information
Publications
Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitisEzio Gerdoni
Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genova, Italy
Ann Neurol 61:219-27. 2007..To evaluate the ability of mesenchymal stem cells (MSCs), a subset of adult stem cells from bone marrow, to cure experimental autoimmune encephalomyelitis...
Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosisAntonio Uccelli
Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Genoa, Italy
Mol Med 18:794-804. 2012..These findings suggest that intravenous administration of MSCs significantly improves the clinical outcome and pathological scores of mutant SOD1/G93A mice, thus providing the rationale for their exploitation for the treatment of ALS...- The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanismsSara Morando
Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
Stem Cell Res Ther 3:3. 2012..These results paved the road for the utilization of MSCs for the treatment of multiple sclerosis... - The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapseEnrico Pedemonte
Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA
BMC Genomics 8:65. 2007.... - Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005Alan Tyndall
Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
Arthritis Res Ther 9:301. 2007..This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts... - Stem cells in inflammatory demyelinating disorders: a dual role for immunosuppression and neuroprotectionAntonio Uccelli
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
Expert Opin Biol Ther 6:17-22. 2006..Overall, it is proposed that limited subsets of adult stem cells may have a dual function that may be effective for the treatment of MS, an autoimmune disease of the CNS where degeneration of neural cells follows inflammation... - Immunoregulatory function of mesenchymal stem cellsAntonio Uccelli
Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
Eur J Immunol 36:2566-73. 2006..Thus, it is likely that MSC effects on the immune system may be deeply influenced not only by cell-to-cell interactions, but also by environmental factors shaping their phenotype and functions... 
Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseasesAntonio Uccelli
Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Italy
Lancet Neurol 10:649-56. 2011..Small clinical studies in different neurological diseases have suggested that MSCs are safe, paving the road for larger phase 2 studies addressing the effect of MSCs on clinical outcomes and markers of disease activity...- Unveiling the enigma of the CNS as a B-cell fostering environmentAntonio Uccelli
Neuroimmunology Unit, Department of Neurosciences, Centre of Excellence for Biomedical Research, University of Genoa, Italy
Trends Immunol 26:254-9. 2005.... - Is there a role for mesenchymal stem cells in autoimmune diseases?Antonio Uccelli
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
Autoimmunity 41:592-5. 2008..Despite the absolute need for caution related to several clinical and technical issues, MSCs are now on the edge of a new era of clinical applications... - Neuroprotective features of mesenchymal stem cellsAntonio Uccelli
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
Best Pract Res Clin Haematol 24:59-64. 2011..This review discusses the targets and mechanisms of BM-MSC mediated neuroprotection... - Stem cell transplantation in multiple sclerosisAntonio Uccelli
Department of Neurosciences, Ophthalmology and Genetics, Italy
Curr Opin Neurol 23:218-25. 2010..Here, we provide an overview of the current status of stem cell research in MS focusing on secured actuality, reasonable hopes and unrealistic myths... - Characterization of the response to myelin basic protein in a non human primate model for multiple sclerosisA Uccelli
Department of Neurological Sciences and Vision, Gaslini Institute, University of Genoa, Italy
Eur J Immunol 31:474-9. 2001.... - Mesenchymal stem cells in health and diseaseAntonio Uccelli
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
Nat Rev Immunol 8:726-36. 2008..This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches... - Mesenchymal stem cells for multiple sclerosis: does neural differentiation really matter?Antonio Uccelli
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
Curr Stem Cell Res Ther 6:69-72. 2011.... - Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?Antonio Uccelli
Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Italy
Curr Opin Immunol 22:768-74. 2010..The data will be reviewed in terms of the potentials of MSCs for therapy of autoimmune diseases... - EAE in the common marmoset Callithrix jacchusA Uccelli
Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics and Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
Int MS J 10:6-12. 2003.... - Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experienceG L Mancardi
Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
Mult Scler 18:835-42. 2012..The clinical outcome and the toxicity of AHSCT can be diverse, depending on the various types of conditioning protocols and on the disease phase... - Demyelination and axonal damage in a non-human primate model of multiple sclerosisG Mancardi
Department of Neurological Sciences and Vision, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
J Neurol Sci 184:41-9. 2001..These findings are of relevance for the development of therapies, which can protect axons and enhance their function and survival... - Autologous haematopoietic stem-cell transplantation in multiple sclerosis: benefits and risksE Capello
Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Genoa, Italy
Neurol Sci 30:S175-7. 2009..The risk of mortality, which dropped in the last years to 2-3%, is still the main problem of this powerful therapy... - Surrogate endpoints for EDSS worsening in multiple sclerosis. A meta-analytic approachM P Sormani
Department of Health Sciences, Via Pastore 1, Genoa, Italy
Neurology 75:302-9. 2010.... - Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patientsM Iester
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
Eye (Lond) 23:407-12. 2009.... - Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosisE Capello
Department of Neurological Sciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, I 16132, Genoa, Italy
Neurol Sci 26:S200-3. 2005..These results support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving MS cases unresponsive to conventional therapies... - Restricted immune responses lead to CNS demyelination and axonal damageG Mancardi
Department of Neurological Sciences and Vision, University of Genova, Via De Toni 5, 16132, Genoa, Italy
J Neuroimmunol 107:178-83. 2000.... - Mechanisms of the adaptive immune response inside the central nervous system during inflammatory and autoimmune diseasesEnrico Pedemonte
Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
Pharmacol Ther 111:555-66. 2006.... - Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosisGiovanni Luigi Mancardi
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
Mult Scler 11:367-71. 2005..These results support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving malignant MS cases unresponsive to conventional therapies... - Urinary JCV-DNA testing during natalizumab treatment may increase accuracy of PML risk stratificationA Laroni
Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Via De Toni 5, 16132, Genoa, Italy
J Neuroimmune Pharmacol 7:665-72. 2012..In conclusion, testing JCV-DNA in urine is complementary to testing anti-JCV antibodies in identifying patients at risk of PML... - Association of melanoma and natalizumab therapy in the Italian MS population: a second case reportA Laroni
Multiple Sclerosis Center, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
Neurol Sci 32:181-2. 2011..Here we report a case of melanoma in a patient who developed melanoma after 77 infusions of natalizumab, without known risk factors. Pharmacovigilance programs of new drugs can help to monitor adverse events in patients at risk... - Central and peripheral nervous system complications following allogeneic bone marrow transplantationC Solaro
Department of Neurological Sciences and Vision, University of Genoa, Italy
Eur J Neurol 8:77-80. 2001..Clinical course and laboratory findings correlated with relapses of systemic GvDH, thus suggesting the possibility that involvement of CNS and PNS may be sustained by a similar pathogenic mechanism... - B-cell differentiation in the CNS of patients with multiple sclerosisAnna Corcione
Laboratory of Oncology, Department of Experimental and Laboratory Medicine, Scientific G. Gaslini Institute, Genoa, Italy
Autoimmun Rev 4:549-54. 2005..Thus, B cells are likely to expand and mature inside the CNS, giving rise to ASC, which may play an effector role in the pathogenesis of MS... - Biological markers of the inflammatory phase of multiple sclerosisA Uccelli
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
Neurol Sci 24:S271-4. 2003..In this review we briefly discuss the biological markers available to date... - Low-dose gabapentin combined with either lamotrigine or carbamazepine can be useful therapies for trigeminal neuralgia in multiple sclerosisC Solaro
Department of Neurological Sciences and Rehabilitation, University of Genoa, Genoa, Italy
Eur Neurol 44:45-8. 2000..Combining drugs with complementary modes of action may provide a rational pharmacological approach to the management of TN in MS... - Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergyEmanuela Zappia
Department of Neurosciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132-Genoa, Italy
Blood 106:1755-61. 2005..These data suggest that the immunoregulatory properties of MSCs effectively interfere with the autoimmune attack in the course of EAE inducing an in vivo state of T-cell unresponsiveness occurring within secondary lymphoid organs... - Mesenchymal stem cells: a new strategy for immunosuppression?Antonio Uccelli
Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
Trends Immunol 28:219-26. 2007..In immune-mediated diseases, the protective effects might function in concert with the immunosuppressive and anti-inflammatory activities... - Conventional perimetry, short-wavelength automated perimetry, frequency-doubling technology, and visual evoked potentials in the assessment of patients with multiple sclerosisG Corallo
Eye Clinic, Dept of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
Eur J Ophthalmol 15:730-8. 2005.... - Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAESantina Bruzzone
Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy
PLoS ONE 4:e7897. 2009..In conclusion, Nampt inhibitors (and possibly Sirt6 inhibitors) could be used to modulate T cell-mediated immune responses and thereby be beneficial in immune-mediated disorders... - Human mesenchymal stem cells promote survival of T cells in a quiescent stateFederica Benvenuto
Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
Stem Cells 25:1753-60. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivoCristina Lanza
Department of Biology, University of Genoa, Genoa 16132, Italy
J Neurochem 110:1674-84. 2009..These results support an antioxidant and neuroprotective activity for MSCs that was also confirmed in vitro on neuroblastoma cells exposed to an oxidative insult... - Immunological patterns identifying disease course and evolution in multiple sclerosis patientsRoberto Furlan
Neuroimmunology Unit, San Raffaele, Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
J Neuroimmunol 165:192-200. 2005.... - Reciprocal interactions between human mesenchymal stem cells and gammadelta T cells or invariant natural killer T cellsIgnazia Prigione
Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genoa, Italy
Stem Cells 27:693-702. 2009..In contrast, MSCs were lysed by activated Vdelta2(+) T cells through a T-cell receptor-dependent mechanism. These results are translationally relevant in view of the increasing interest in MSC-based therapy of autoimmune diseases... - Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNSDebora Giunti
Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
J Leukoc Biol 73:584-90. 2003..These cells are recruited into the CSF by inducible chemokines. Thus, CSF represents a transitional station for T cells trafficking to and from the NS... - Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitisMonica Morini
Molecular Oncology Laboratory, National Cancer Research Institute, Genoa, Italy
J Neuroimmunol 148:146-53. 2004.... - Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitisAntonella Marte
Department of Experimental Medicine, University of Genoa, Genoa, Italy
J Neurochem 115:343-52. 2010..p.i., whereas no differences could be detected at 13 d.p.i. Our data indicate that glutamatergic neurotransmission is altered in the spinal cord of EAE mice... - Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 miceRoberto Furlan
Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy
Brain 126:285-91. 2003..Our results indicate that vaccination with Abeta could determine, under certain circumstances, an aberrant autoimmune-type reaction to Abeta resulting in a perivenular inflammatory encephalomyelitis... - Investigation of paroxysmal dystonia in a patient with multiple sclerosis: a transcranial magnetic stimulation studyCarlo Trompetto
Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genova, Italy
Clin Neurophysiol 119:63-70. 2008..To study the pathogenesis of paroxysmal dystonia affecting the right body side in a patient with a demyelinating lesion in the descending motor pathways, also involving the basal ganglia... - Relapses after treatment with rituximab in a patient with multiple sclerosis and anti myelin-associated glycoprotein polyneuropathyLuana Benedetti
Department of Neurosciences, Ophthalmology, and Genetics, University of Genova, Via De Toni 5, 16132 Genova, Italy
Arch Neurol 64:1531-3. 2007..To describe the unique case of a patient with multiple sclerosis (MS) and anti-myelin-associated glycoprotein (MAG) polyneuropathy who developed MS relapses after treatment with rituximab... - Contact with the bone marrow microenvironment readdresses the fate of transplanted hematopoietic stem cellsMichela Massollo
Nuclear Medicine, University of Genoa, Azienda Ospedaliera San Martino, Genoa, Italy
Exp Hematol 38:968-77. 2010..However, the mechanisms underlying the benefit provided by this procedure remain unknown. This study aims to evaluate the effect of IB on HSCs trafficking and homing features in the living rat... - Stem cells for multiple sclerosis: promises and realityAntonio Uccelli
Regen Med 2:7-9. 2007 - Human mesenchymal stem cells modulate B-cell functionsAnna Corcione
Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
Blood 107:367-72. 2006..These results further support the potential therapeutic use of hMSCs in immune-mediated disorders, including those in which B cells play a major role... - Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosisAnna Corcione
Laboratory of Oncology, Scientific Direction, G Gaslini Institute, 16148 Genoa, Italy
Proc Natl Acad Sci U S A 101:11064-9. 2004..The presence of lymphotoxin-alpha, CXCL12, and CXCL13 in the CNS may provide favorable microenvironmental conditions for these events... - Immunotherapy for neurological diseasesPablo Villoslada
Department of Neuroscience, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Clin Immunol 128:294-305. 2008.... - Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosisLisa F Barcellos
Division of Epidemiology, School of Public Health, University of California, Berkeley 94720, USA, and Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, UK
Hum Mol Genet 15:2813-24. 2006.... - Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical applicationNadia Sessarego
Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, L go R Benzi 10, 16132 Genova Italy
Haematologica 93:339-46. 2008..In this study, mesenchymal stromal cells were successfully isolated from second trimester amniotic fluid and analyzed for chromosomal stability to validate their safety for potential utilization as a cell therapy product...