Affiliation: University of Genoa
Vigo T, La Rocca C, Faicchia D, Procaccini C, Ruggieri M, Salvetti M, et al
. IFNβ enhances mesenchymal stromal (Stem) cells immunomodulatory function through STAT1-3 activation and mTOR-associated promotion of glucose metabolism. Cell Death Dis. 2019;10:85 pubmed publisher
..Altogether, these findings support the idea of a combined treatment for MS, in which the immunomodulatory and possibly regenerative activity of MSC could be enhanced by the administration of IFNβ. ..
Novi G, Gastaldi M, Franciotta D, Pesce G, Benedetti L, Uccelli A. Tocilizumab in MOG-antibody spectrum disorder: a case report. Mult Scler Relat Disord. 2019;27:312-314 pubmed publisher
..Our observations suggest that TCZ could induce clinico-radiologic improvements, which make it as an option for the treatment of MOG-SD. ..
Uccelli A, Milanese M, Principato M, Morando S, Bonifacino T, Vergani L, et al
. Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis. Mol Med. 2012;18:794-804 pubmed publisher
..These findings suggest that intravenous administration of MSCs significantly improves the clinical outcome and pathological scores of mutant SOD1/G93A mice, thus providing the rationale for their exploitation for the treatment of ALS. ..
Tacchino A, Bove M, Roccatagliata L, Luigi Mancardi G, Uccelli A, Bonzano L. Selective impairments of motor sequence learning in multiple sclerosis patients with minimal disability. Brain Res. 2014;1585:91-8 pubmed publisher
..These findings could suggest an involvement of different circuits in implicit and explicit sequence learning that could deteriorate at different disease stages. ..
Uccelli A. Adult stem cells for spinal cord injury: what types and how do they work?. Cytotherapy. 2008;10:541-2 pubmed publisher
Laroni A, de Rosbo N, Uccelli A. Mesenchymal stem cells for the treatment of neurological diseases: Immunoregulation beyond neuroprotection. Immunol Lett. 2015;168:183-90 pubmed publisher
..Here we will review the evidence, mostly deriving from preclinical studies, that MSC, beyond their ability to foster neurorepair, can ameliorate neurodegenerative diseases through their effect on associated immune responses. ..
Benvenuto F, Voci A, Carminati E, Gualandi F, Mancardi G, Uccelli A, et al
. Human mesenchymal stem cells target adhesion molecules and receptors involved in T cell extravasation. Stem Cell Res Ther. 2015;6:245 pubmed publisher
..This could suggest a new mechanism through which MSC modulate T cell responses. ..
Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008;8:726-36 pubmed publisher
..This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches. ..
Laroni A, Armentani E, Kerlero de Rosbo N, Ivaldi F, Marcenaro E, Sivori S, et al
. Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis. J Autoimmun. 2016;72:8-18 pubmed publisher
..The defect in controlling autologous T cells by CD56(bright) NK cells in MS/CIS might contribute to the excess of autoimmune response that is associated to disease development. ..