Rosa Tundis

Summary

Affiliation: University of Calabria
Country: Italy

Publications

  1. ncbi request reprint Biological and pharmacological activities of iridoids: recent developments
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende CS, Italy
    Mini Rev Med Chem 8:399-420. 2008
  2. ncbi request reprint Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update
    R Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, 87036 I Rende CS, Italy
    Mini Rev Med Chem 10:315-31. 2010
  3. doi request reprint Angiotensin-converting enzyme inhibitory activity and antioxidant properties of Nepeta crassifolia Boiss & Buhse and Nepeta binaludensis Jamzad
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 27:572-80. 2013
  4. ncbi request reprint Antioxidant and anti-cholinesterase activity of Globularia meridionalis extracts and isolated constituents
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, I 87030 Rende CS, Italy
    Nat Prod Commun 7:1015-20. 2012
  5. doi request reprint Studies on the potential antioxidant properties of Senecio stabianus Lacaita (Asteraceae) and its inhibitory activity against carbohydrate-hydrolysing enzymes
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Arcavacata di Rende CS, Italy
    Nat Prod Res 26:393-404. 2012
  6. doi request reprint A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I 87030, Rende CS, Italy
    J Enzyme Inhib Med Chem 24:818-24. 2009
  7. doi request reprint In vitro cytotoxic activity of extracts and isolated constituents of Salvia leriifolia Benth. against a panel of human cancer cell lines
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, I 87036 Rende
    Chem Biodivers 8:1152-62. 2011
  8. ncbi request reprint In vitro cytotoxic activity of Salsola oppositifolia Desf. (Amaranthaceae) in a panel of tumour cell lines
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I 87030 Rende CS, Italy
    Z Naturforsch C 63:347-54. 2008
  9. ncbi request reprint Comparative study on the chemical composition, antioxidant properties and hypoglycaemic activities of two Capsicum annuum L. cultivars (Acuminatum small and Cerasiferum)
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende, CS, Italy
    Plant Foods Hum Nutr 66:261-9. 2011
  10. doi request reprint Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae)
    Rosa Tundis
    Department of Pharmaceutical Science, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende, CS, Italy
    Bioorg Med Chem 17:4542-7. 2009

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Biological and pharmacological activities of iridoids: recent developments
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende CS, Italy
    Mini Rev Med Chem 8:399-420. 2008
    ..The aim of the present review is to discuss the recent developments on biological and pharmacological activities of iridoids, supporting the new therapeutic possibilities for the use of these compounds...
  2. ncbi request reprint Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update
    R Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, 87036 I Rende CS, Italy
    Mini Rev Med Chem 10:315-31. 2010
    ..This article reviews recent data on plant extracts and isolated natural compounds that are being tested for their hypglycaemic activity, highlights ongoing research and considers the future persepctives...
  3. doi request reprint Angiotensin-converting enzyme inhibitory activity and antioxidant properties of Nepeta crassifolia Boiss & Buhse and Nepeta binaludensis Jamzad
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 27:572-80. 2013
    ..Apigenin-7-O-glucoside, 8-hydroxycirsimaritin and cirsimaritin were furthermore identified in N. crassifolia ethyl acetate-soluble fraction. Nepetanudoside B was isolated from the n-butanol fraction of N. binaludensis...
  4. ncbi request reprint Antioxidant and anti-cholinesterase activity of Globularia meridionalis extracts and isolated constituents
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, I 87030 Rende CS, Italy
    Nat Prod Commun 7:1015-20. 2012
    ..The n-hexane fraction of the roots exhibited the highest activity against both AChE and BChE with IC50 values of 65.5 and 70.4 microg/mL, respectively...
  5. doi request reprint Studies on the potential antioxidant properties of Senecio stabianus Lacaita (Asteraceae) and its inhibitory activity against carbohydrate-hydrolysing enzymes
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Arcavacata di Rende CS, Italy
    Nat Prod Res 26:393-404. 2012
    ..Through bioassay-guided fractionation processes seven fractions (A-G) were obtained and tested. Based on the phytochemical analysis, the activity of n-hexane extract may be related to the presence of monoterpenes and sesquiterpenes...
  6. doi request reprint A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I 87030, Rende CS, Italy
    J Enzyme Inhib Med Chem 24:818-24. 2009
    ..soda and S. oppositifolia exhibited a selective inhibitory activity against BChE with IC(50) values of 34.3 microg/mL and 32.7 microg/mL, respectively. Tetrahydroisoquinoline alkaloids were identified and quantified by GC/MS analysis...
  7. doi request reprint In vitro cytotoxic activity of extracts and isolated constituents of Salvia leriifolia Benth. against a panel of human cancer cell lines
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, I 87036 Rende
    Chem Biodivers 8:1152-62. 2011
    ..7, and 33.4 μM, resp.), compared to vinblastine (IC(50) values of 3.3, 32.2, 50.0 μM, resp.). None of the tested compounds affected the proliferation of skin fibroblasts (142BR), suggesting a selective activity against tumor cells...
  8. ncbi request reprint In vitro cytotoxic activity of Salsola oppositifolia Desf. (Amaranthaceae) in a panel of tumour cell lines
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I 87030 Rende CS, Italy
    Z Naturforsch C 63:347-54. 2008
    ..2 microg/ml, respectively. Compound 2 exhibited a strong activity against the hormone-dependent prostate carcinoma LNCaP cell line with an IC50 of 20.5 microg/ml. Constituents of S. oppositifolia were identified by GC-MS and NMR analyses...
  9. ncbi request reprint Comparative study on the chemical composition, antioxidant properties and hypoglycaemic activities of two Capsicum annuum L. cultivars (Acuminatum small and Cerasiferum)
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende, CS, Italy
    Plant Foods Hum Nutr 66:261-9. 2011
    ..1 μg/ml). The lipophilic fraction of both C. annuum var. acuminatum and C. annuum var. cerasiferum exhibited an interesting and selective inhibitory activity against α-amylase (IC(50) of 6.9 and 20.1 μg/ml, respectively)...
  10. doi request reprint Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae)
    Rosa Tundis
    Department of Pharmaceutical Science, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende, CS, Italy
    Bioorg Med Chem 17:4542-7. 2009
    ..Moreover, buddlejasaponin IV (2) and songarosaponin D (3) exerted significant inhibition of NO production in LPS induced RAW 264.7 macrophages with IC(50) of 4.2 and 10.4 microM, respectively...
  11. doi request reprint In vitro cytotoxic effects of Senecio stabianus Lacaita (Asteraceae) on human cancer cell lines
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Italy
    Nat Prod Res 23:1707-18. 2009
    ..Here we report the isolation, structural elucidation and identification of nine PAs...
  12. doi request reprint Protective effect of Pimpinella anisoides ethanolic extract and its constituents on oxidative damage and its inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264.7 macrophages
    Filomena Conforti
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende, Italy
    J Med Food 13:137-41. 2010
    ..7 microg/mL and 70.1 microg/mL, respectively. The cytotoxic effect of P. anisoides extract and pure compounds in the presence of lipopolysaccharide (1 microg/mL) was evaluated but found to be negligible...
  13. doi request reprint Phytochemical profile, antioxidant, anti-inflammatory and hypoglycemic potential of hydroalcoholic extracts from Citrus medica L. cv Diamante flowers, leaves and fruits at two maturity stages
    Federica Menichini
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, I 87036 Arcavacata di Rende CS, Italy
    Food Chem Toxicol 49:1549-55. 2011
    ..The obtained results suggest a potential use of C. medica L. cv Diamante as new valuable Citrus species with functional properties for food or nutraceutical product on the basis of high content of phytochemicals...
  14. doi request reprint Comparative chemical composition and antiproliferative activity of aerial parts of Salvia leriifolia Benth. and Salvia acetabulosa L. essential oils against human tumor cell in vitro models
    Monica R Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende CS, Italy
    J Med Food 13:62-9. 2010
    ..Consequently, the minor components may be involved in some type of synergism with the other active compounds...
  15. doi request reprint Influence of drying and cooking process on the phytochemical content, antioxidant and hypoglycaemic properties of two bell Capsicum annum L. cultivars
    Monica Rosa Loizzo
    Department of Pharmacy, Health Sciences and Nutrition, University of Calabria, 87036 Rende CS, Italy
    Food Chem Toxicol 53:392-401. 2013
    ..3 μg/mL. Our results indicate that C. annuum cultivars Roggiano and Senise have an interestingly potential health benefits not influenced by processes that are used before consumption...
  16. doi request reprint Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I 87036 Rende CS, Italy
    J Sci Food Agric 92:2960-7. 2012
    ....
  17. doi request reprint Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of Citrus aurantifolia Swingle, C. aurantium L., and C. bergamia Risso and Poit. peel essential oils
    Rosa Tundis
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende CS, Italy
    J Food Sci 77:H40-6. 2012
    ..Obtained data suggest a potential use of Citrus oils as a valuable new flavor with functional properties for food or nutraceutical products with particular relevance to supplements for the elderly...
  18. ncbi request reprint In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimer's disease
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy
    J Oleo Sci 58:443-6. 2009
    ..Moreover, this oil inhibited LPS-induced NO production with an IC(50) value of 165 microg/mL. The absence of cytotoxicity at 1000 microg/mL was evaluated by MTT assay in 142BR cells...
  19. doi request reprint Acetylcholinesterase and butyrylcholinesterase inhibitory activity of Pinus species essential oils and their constituents
    Marco Bonesi
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende CS, Italy
    J Enzyme Inhib Med Chem 25:622-8. 2010
    ..trans-Caryophyllene and terpinen-4-ol inhibited BChE with IC(50) values of 78.6 and 107.6 microg/mL, respectively. beta-Phellandrene was selective against AChE (IC(50) value of 120.2 microg/mL)...
  20. doi request reprint Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species
    Monica R Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Health Sciences and Nutrition, University of Calabria, I 87036 Rende CS
    Chem Biodivers 5:461-70. 2008
    ..J. oxycedrus ssp. oxycedrus oil, in which alpha-pinene and beta-myrcene were the major constituents, revealed antiviral activity against HSV-1 with an IC(50) value of 200 microg/ml and a SI of 5...
  21. ncbi request reprint In vitro inhibitory activities of plants used in Lebanon traditional medicine against angiotensin converting enzyme (ACE) and digestive enzymes related to diabetes
    Monica R Loizzo
    Faculty of Pharmacy, Nutrition and Health Sciences, Department of Pharmaceutical Sciences, University of Calabria, I 87036 Rende CS, Italy
    J Ethnopharmacol 119:109-16. 2008
    ....
  22. doi request reprint Antioxidant and antiproliferative activity of Diospyros lotus L. extract and isolated compounds
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, 87036 Rende, CS, Italy
    Plant Foods Hum Nutr 64:264-70. 2009
    ..6 microg/ml). Overall, the results of this study suggest that D. lotus displays a good antioxidant activity and has antiproliferative effects. Both activities are related to identified phenolic compounds...
  23. ncbi request reprint Protective effect of Hypericum calabricum Sprengel on oxidative damage and its inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264.7 macrophages
    Giancarlo A Statti
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy
    Biol Res 44:213-8. 2011
    ..7. The ethyl acetate fraction had significant activity with an IC50 value of 102 jig/ml and this might indicate that it would have an anti-inflammatory effect in vivo...
  24. doi request reprint Salvia leriifolia Benth (Lamiaceae) extract demonstrates in vitro antioxidant properties and cholinesterase inhibitory activity
    Monica R Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Health Sciences and Nutrition, University of Calabria, I 87036 Rende CS, Italy
    Nutr Res 30:823-30. 2010
    ..These results suggest potential health benefits of S leriifolia extracts. However, this finding requires additional investigation in vivo...
  25. doi request reprint In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines
    Marco Bonesi
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, I 87036 Rende CS, Italy
    Bioorg Med Chem Lett 18:5431-4. 2008
    ..A structure-activity relationship analysis of synthesized compounds was performed. None of the tested compounds affected the proliferation of skin fibroblasts 142BR suggesting a selective activity against tumor cells...
  26. doi request reprint Chemical composition and protective effect of oregano (Origanum heracleoticum L.) ethanolic extract on oxidative damage and on inhibition of NO in LPS-stimulated RAW 264.7 macrophages
    Filomena Conforti
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I 87036 Rende CS, Italy
    J Enzyme Inhib Med Chem 26:404-11. 2011
    ..5 μg/mL. The cytotoxic effect of O. heracleoticum extract in presence of lipopolysaccharide (LPS) (1 μg/mL) was evaluated but found to be negligible...
  27. doi request reprint Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. (Apiaceae)
    Federica Menichini
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Italy
    Fitoterapia 80:297-300. 2009
    ..7 and 209.6 microg/ml, respectively. The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC(50) of 176.5 microg/ml) and BChE (IC(50) of 218.6 microg/ml)...
  28. doi request reprint Chemical composition and bioactivity of Citrus medica L. cv. Diamante essential oil obtained by hydrodistillation, cold-pressing and supercritical carbon dioxide extraction
    Federica Menichini
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Italy
    Nat Prod Res 25:789-99. 2011
    ..7 macrophages. The oil obtained by hydrodistillation exerted a significant inhibition of NO production with an IC₅₀ value of 17 µg mL⁻¹ (IC₅₀ of positive control 53 µg mL⁻¹)...
  29. doi request reprint Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils
    Monica Rosa Loizzo
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende CS, Italy
    Food Chem Toxicol 59:586-94. 2013
    ..7, 29.1 and 34.2 μg/mL, respectively. Overall our results could promote the use of the essential oil of different Cistus species as food additives and for formulation of herbal infusion or nutraceutical products...
  30. ncbi request reprint Antiproliferative activities on renal, prostate and melanoma cancer cell lines of Sarcopoterium spinosum aerial parts and its major constituent tormentic acid
    Monica R Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, I 87036 Arcavacata di Rende CS, Italy
    Anticancer Agents Med Chem 13:768-76. 2013
    ..Tormentic acid, the major constituent isolated from S. spinosum, play an important role in the cytotoxicity exhibited by the extract...
  31. doi request reprint Chelating, antioxidant and hypoglycaemic potential of Muscari comosum (L.) Mill. bulb extracts
    Monica R Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, Rende, Italy
    Int J Food Sci Nutr 61:780-91. 2010
    ..These activities may be of interest from a functional point of view and for the revalorization of this ancient non-cultivated vegetable of Mediterranean traditional gastronomy...
  32. ncbi request reprint Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf
    Rosa Tundis
    Department of Pharmaceutical Science, University of Calabria, I 87030 Rende CS, Italy
    Bioorg Med Chem Lett 15:4757-60. 2005
    ..03, 6.18, and 7.17 microM. Similar activities were recorded for the three natural monoacetyl pectolinarin derivatives linariin, isolinariin A, and isolinariin B. In contrast, peracetylpectolinarin displayed only marginal activity...
  33. ncbi request reprint Jacaranone: a cytotoxic constituent from Senecio ambiguus subsp. ambiguus (biv.) DC. against renal adenocarcinoma ACHN and prostate carcinoma LNCaP cells
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, 1 87036 Arcavata di Rende, CS, Italy
    Arch Pharm Res 30:701-7. 2007
    ..23 microg/mL against LNCaP. Three compounds identified in the n-hexane extract such as nerolidol, a-humulene and g-tocopherol were found to be active aginst LNCAP with IC50 values ranged from 11.24 to 15.56 microg/mL...
  34. ncbi request reprint An overview on chemical aspects and potential health benefits of limonoids and their derivatives
    Rosa Tundis
    a Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, I 87036 Rende CS, Italy
    Crit Rev Food Sci Nutr 54:225-50. 2014
    ....
  35. ncbi request reprint In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease
    Filomena Conforti
    Department of Pharmaceutical Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 21:427-33. 2007
    ..Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect...
  36. doi request reprint Influence of ripening stage on health benefits properties of Capsicum annuum var. acuminatum L.: in vitro studies
    Monica R Loizzo
    Department of Pharmaceutical Sciences, Nutrition and Health Science, Faculty of Pharmacy, University of Calabria, Rende CS, Italy
    J Med Food 11:184-9. 2008
    ..30 microg/mL), using the Ellman method. This study highlights the biochemical rationale for chemopreventive significance in health benefits when consuming this variety of pepper...
  37. ncbi request reprint Pyrrolizidine alkaloid profiles of the Senecio cineraria group (Asteraceae)
    Rosa Tundis
    Department of Pharmaceutical Sciences, University of Calabria, I 87036 Arcavacata di Rende, CS, Italy
    Z Naturforsch C 62:467-72. 2007
    ..It is interesting that only S. ambiguus subsp. nebrodensis was characterized by a high content of the alkaloids jacobine, jacoline, jaconine, and jacozine...
  38. ncbi request reprint Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models
    Monica Rosa Loizzo
    Faculty of Pharmacy, Nutrition and Health Sciences, Department of Pharmaceutical Sciences, University of Calabria, 1 87036 Rende CS, Italy
    Anticancer Res 27:3293-9. 2007
    ..The aim of this work was to study the cytotoxicity of essential oils and their identified constituents from Sideritis perfoliata, Satureia thymbra, Salvia officinalis, Laurus nobilis and Pistacia palestina...
  39. doi request reprint In vitro photo-induced cytotoxic activity of Citrus bergamia and C. medica L. cv. Diamante peel essential oils and identified active coumarins
    Federica Menichini
    Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health Sciences, University of Calabria, Rende, Italy
    Pharm Biol 48:1059-65. 2010
    ..The search for innovative therapeutic approaches is gaining more interest in clinical oncology...
  40. ncbi request reprint Hypotensive natural products: current status
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I 87036 Rende CS Italy
    Mini Rev Med Chem 8:828-55. 2008
    ..In this mini-review we will discuss the medicinal chemistry of these compounds...
  41. ncbi request reprint Phytochemical analysis and in vitro evaluation of the biological activity against herpes simplex virus type 1 (HSV-1) of Cedrus libani A. Rich
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, I 87036 Rende CS, Italy
    Phytomedicine 15:79-83. 2008
    ..Cones and leaves ethanol extracts exhibited an interesting activity with IC50 of 0.50 and 0.66 mg/ml, respectively, at non-cytotoxic concentration. A comparable activity was found when essential oil was tested (IC50 of 0.44 mg/ml)...
  42. ncbi request reprint In vitro angiotensin converting enzyme inhibiting activity of Salsola oppositifolia Desf., Salsola soda L. and Salsola tragus L
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende, CS, Italy
    Nat Prod Res 21:846-51. 2007
    ..EtOAc extracts of S. oppositifolia and S. soda exhibited an interesting activity with an IC(50) of 181.04 and 284.27 microg mL(-1), respectively...
  43. ncbi request reprint Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I 87036 Rende CS, Italy
    Curr Med Chem 15:1209-28. 2008
    ....
  44. ncbi request reprint Chemical composition, antioxidant properties and anti-cholinesterase activity of Cordia gilletii (Boraginaceae) leaves essential oil
    Marco Bonesi
    Faculty of Pharmacy, Nutrition and Health Sciences, Department of Pharmaceutical Sciences, University of Calabria, 1 87036 Rende CS, Italy
    Nat Prod Commun 6:253-7. 2011
    ..0 and 129.9 microg/mL on DPPH radical and beta-carotene decoloration tests, respectively. Moreover, C. gilletii inhibited AChE enzyme with an IC50 value of 105.6 microg/mL...
  45. ncbi request reprint Antibacterial and antifungal activity of Senecio inaequidens DC. and Senecio vulgaris L
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 18:777-9. 2004
    ..and Senecio vulgaris L. were assayed. The hexane extract of Senecio vulgaris L. (MIC 0.031 mg/ml) showed significant activity against Trichophyton tonsurans...
  46. doi request reprint The effect of domestic processing on the content and bioaccessibility of carotenoids from chili peppers (Capsicum species)
    Alessandro Pugliese
    Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Rende CS, Italy
    Food Chem 141:2606-13. 2013
    ....
  47. doi request reprint In vitro assessment of the bioaccessibility of carotenoids from sun-dried chilli peppers
    Alessandro Pugliese
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, CS, Italy
    Plant Foods Hum Nutr 69:8-17. 2014
    ..Xanthophylls showed greater bioaccessibility than carotenes. Our findings confirm that dried chilli peppers are a good source of carotenoids. ..
  48. ncbi request reprint In vitro investigation of the bioaccessibility of carotenoids from raw, frozen and boiled red chili peppers (Capsicum annuum)
    Alessandro Pugliese
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, CS, Italy
    Eur J Nutr 53:501-10. 2014
    ..Carotenoid-rich foods are associated with antioxidant activity and the ability to alleviate chronic diseases...
  49. doi request reprint Berberis aetnensis and B. libanotica: a comparative study on the chemical composition, inhibitory effect on key enzymes linked to Alzheimer's disease and antioxidant activity
    Marco Bonesi
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende CS, Italy
    J Pharm Pharmacol 65:1726-35. 2013
    ..Presl. and Berberis libanotica Ehrenb. ex C.K. Schneid. roots for anticholinesterase and antioxidant properties, with the aim to search compounds possibly useful for the treatment of Alzheimer's disease (AD)...
  50. doi request reprint Antimicrobial and antioxidant properties of Betula aetnensis Rafin. (Betulaceae) leaves extract
    Rosaria Acquaviva
    Department of Pharmaceutical Sciences, Biochemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Nat Prod Res 27:475-9. 2013
    ..0 µg mL(-1) after 30 min of incubation. The total phenol and flavonoid contents were determined with the purpose to evaluate the relationship with the observed bioactivities...
  51. ncbi request reprint Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)
    Monica Rosa Loizzo
    Department of Pharmaceutical Sciences, University of Calabria, Rende CS, Italy
    Phytother Res 21:32-6. 2007
    ..All the flavonoids tested exhibited ACE inhibitory activity, in particular the most active compound was kaempferol-3-O-beta-galactopyranoside with an IC(50) value of 260 microm...
  52. ncbi request reprint Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco and Citrullara
    Monica R Loizzo
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, I 87030, Rende, CS, Italy
    J Sci Food Agric 94:2179-86. 2014
    ..The aim of this study is to evaluate, for the first time, the chemical profile, antioxidant properties and cholinesterase inhibitory activity of dried fruits and honey of Ficus carica (fig) cultivars Dottato, Citrullara, and San Francesco...
  53. doi request reprint Fatty acids, coumarins and polyphenolic compounds of Ficus carica L. cv. Dottato: variation of bioactive compounds and biological activity of aerial parts
    Mariangela Marrelli
    a Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, I 87036 Rende CS, Italy
    Nat Prod Res 28:271-4. 2014
    ..Harvest III of leaves showed the best inhibition of lipid peroxidation (IC50 = 1.48 ± 0.04 μg/mL). Leaf samples of F. carica showed also the best antiproliferative activity in comparison with bark and woody part of F. carica. ..
  54. ncbi request reprint Antimicrobial activity and cytotoxicity of Cirsium tenoreanum
    Monica Rosa Loizzo
    Dipartimento di Scienze Farmaceutiche, Universita della Calabria, 87036 Rende CS, Italy
    Fitoterapia 75:577-80. 2004
    ..Three flavonoids, apigenin, quercetin-3-O-galactoside and kaempferol-3-O-ramnoside, were isolated. The ethyl acetate extract showed a good antiproliferative activity...
  55. ncbi request reprint Phytochemical and biological studies of Stachys species in relation to chemotaxonomy: a review
    Rosa Tundis
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende CS, Italy Electronic address
    Phytochemistry 102:7-39. 2014
    ..Diversity of chemical constituents is discussed in relationship with current Stachys infrageneric taxonomy, classification and relationships with systematically close genera. ..
  56. ncbi request reprint Antioxidant activity of methanolic extract of Hypericum triquetrifolium Turra aerial part
    Filomena Conforti
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi della Calabria, 87036 Rende CS, Italy
    Fitoterapia 73:479-83. 2002
    ..The IC(50) resulted between 0.062 and 1 mg/ml...
  57. ncbi request reprint Variability in the content of active constituents and biological activity of Glycyrrhiza glabra
    Giancarlo A Statti
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi della Calabria, Via Pietro Bucci, I 87036 Arcavacata di Rende CS, Italy
    Fitoterapia 75:371-4. 2004
    ..The samples showed remarkable differences in chemical composition and biological activity...