Oriana Trubiani


Affiliation: University of Chieti
Country: Italy


  1. Chiricosta L, Diomede F, Trubiani O, Bramanti P, Mazzon E. Physiological Expression of Ion Channel Receptors in Human Periodontal Ligament Stem Cells. Cells. 2019;8: pubmed publisher
    ..Our results show that hPDLSCs express physiologically genes associated with ion channel receptors maintaining multipotent features which are useful for neurogenesis. ..
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    Trubiani O, Fulle S, Traini T, Paludi M, La Rovere R, Orciani M, et al. Functional assay, expression of growth factors and proteins modulating bone-arrangement in human osteoblasts seeded on an anorganic bovine bone biomaterial. Eur Cell Mater. 2010;20:72-83 pubmed
    ..These results encourage us to consider GBO an adequate biocompatible three-dimensional biomaterial, indicating its potential use for the development of tissue-engineering techniques. ..
  3. Pizzicannella J, Cavalcanti M, Trubiani O, Diomede F. MicroRNA 210 Mediates VEGF Upregulation in Human Periodontal Ligament Stem Cells Cultured on 3DHydroxyapatite Ceramic Scaffold. Int J Mol Sci. 2018;19: pubmed publisher
  4. Lanza Cariccio V, Scionti D, Raffa A, Iori R, Pollastro F, Diomede F, et al. Treatment of Periodontal Ligament Stem Cells with MOR and CBD Promotes Cell Survival and Neuronal Differentiation via the PI3K/Akt/mTOR Pathway. Int J Mol Sci. 2018;19: pubmed publisher
    ..In conclusion, hPDLSCs treated with Moringin and Cannabidiol showed an improved survival capacity and neuronal differentiation potential. ..
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    Trubiani O, Recchioni R, Moroni F, Pizzicannella J, Caputi S, Di Primio R. Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation. J Pineal Res. 2005;39:425-31 pubmed
    ..Taken together, our study indicates that melatonin may play a role as potential therapeutic drug in specific lymphoproliferative diseases. ..
  6. Trubiani O, Diomede F. Xeno-free culture of human periodontal ligament stem cells. Methods Mol Biol. 2015;1283:87-92 pubmed publisher
  7. Diomede F, D Aurora M, Gugliandolo A, Merciaro I, Orsini T, Gatta V, et al. Biofunctionalized Scaffold in Bone Tissue Repair. Int J Mol Sci. 2018;19: pubmed publisher
    ..These results suggest a promising potential application of CM from hPDLSCs and scaffolds for bone defect restoration and in particular for calvarial repair in case of trauma. ..
  8. Diomede F, Gugliandolo A, Cardelli P, Merciaro I, Ettorre V, Traini T, et al. Three-dimensional printed PLA scaffold and human gingival stem cell-derived extracellular vesicles: a new tool for bone defect repair. Stem Cell Res Ther. 2018;9:104 pubmed publisher
    ..The re-establishing of the integrity of the bone lesions could be a promising strategy in the treatment of accidental or surgery trauma, especially for cranial bones. ..
  9. Libro R, Diomede F, Scionti D, Piattelli A, Grassi G, Pollastro F, et al. Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016;18: pubmed publisher
    ..Therefore, we suggested that GMSCs preconditioned with CBD possess a molecular profile that might be more beneficial for the treatment of AD. ..

More Information


  1. Diomede F, Gugliandolo A, Scionti D, Merciaro I, Cavalcanti M, Mazzon E, et al. Biotherapeutic Effect of Gingival Stem Cells Conditioned Medium in Bone Tissue Restoration. Int J Mol Sci. 2018;19: pubmed publisher
    ..Especially, hGMSCs derived CM played a key role in the induction of the osteogenic process and in bone regeneration. ..
  2. Trubiani O, Giacoppo S, Ballerini P, Diomede F, Piattelli A, Bramanti P, et al. Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis. Stem Cell Res Ther. 2016;7:1 pubmed publisher
    ..These cells could have considerable implication for future therapies for multiple sclerosis and this study may represent the starting point for further investigations. ..
  3. Mazzoni S, Mohammadi S, Tromba G, Diomede F, Piattelli A, Trubiani O, et al. Role of Cortico-Cancellous Heterologous Bone in Human Periodontal Ligament Stem Cell Xeno-Free Culture Studied by Synchrotron Radiation Phase-Contrast Microtomography. Int J Mol Sci. 2017;18: pubmed publisher
  4. Trubiani O, Zalzal S, Paganelli R, Marchisio M, Giancola R, Pizzicannella J, et al. Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells. J Cell Physiol. 2010;225:123-31 pubmed publisher
    ..Taken together, these data indicate the presence of immature MSCs in PDL and suggest that the frizzled-9/Wnt pathway plays an important role in regulating proliferation and differentiation of these cells. ..
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    Trubiani O, Toniato E, Di Iorio D, Diomede F, Merciaro I, D Arcangelo C, et al. Morphological analysis and interleukin release in human gingival fibroblasts seeded on different denture base acrylic resins. Int J Immunopathol Pharmacol. 2012;25:637-43 pubmed