M Trojano

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi request reprint Age-related disability in multiple sclerosis
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Ann Neurol 51:475-80. 2002
  2. ncbi request reprint European validation of a standardized clinical description of multiple sclerosis
    Maria Pia Amato
    Department of Neurological Sciences, University of Florence, Viale Morgagni, 85, 50134, Florence, Italy
    J Neurol 251:1472-80. 2004
  3. ncbi request reprint Atypical forms of multiple sclerosis or different phases of a same disease?
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Neurol Sci 25:S323-5. 2004
  4. doi request reprint Real-life impact of early interferon beta therapy in relapsing multiple sclerosis
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Ann Neurol 66:513-20. 2009
  5. pmc Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis
    Damiano Paolicelli
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Biologics 3:369-76. 2009
  6. pmc Impact of natalizumab on cognitive performances and fatigue in relapsing multiple sclerosis: a prospective, open-label, two years observational study
    Pietro Iaffaldano
    Department of Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
    PLoS ONE 7:e35843. 2012
  7. pmc Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study
    Luisa Pastò
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    BMC Neurol 12:165. 2012
  8. pmc Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric study
    Marta Giannini
    Department of Neurology, University of Florence, Florence, Italy
    BMC Neurol 12:124. 2012
  9. pmc Geographical variations in sex ratio trends over time in multiple sclerosis
    Maria Trojano
    Department of Neuroscience and Sense Organs, University of Bari, Bari, Italy
    PLoS ONE 7:e48078. 2012
  10. pmc Changes in magnetic resonance imaging disease measures over 3 years in mildly disabled patients with relapsing-remitting multiple sclerosis receiving interferon β-1a in the COGnitive Impairment in MUltiple Sclerosis (COGIMUS) study
    Stefano Bastianello
    National Neurological Institute, C Mondino Foundation, Pavia, Italy
    BMC Neurol 11:125. 2011

Detail Information

Publications69

  1. ncbi request reprint Age-related disability in multiple sclerosis
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Ann Neurol 51:475-80. 2002
    ....
  2. ncbi request reprint European validation of a standardized clinical description of multiple sclerosis
    Maria Pia Amato
    Department of Neurological Sciences, University of Florence, Viale Morgagni, 85, 50134, Florence, Italy
    J Neurol 251:1472-80. 2004
    ....
  3. ncbi request reprint Atypical forms of multiple sclerosis or different phases of a same disease?
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Neurol Sci 25:S323-5. 2004
    ..This paper aims to demonstrate that the different clinical phenotypes in young and old patients might simply reflect different phases of a same pathological process...
  4. doi request reprint Real-life impact of early interferon beta therapy in relapsing multiple sclerosis
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Ann Neurol 66:513-20. 2009
    ..We aimed to evaluate the effectiveness of early IFNbeta treatment in definite relapsing-remitting MS (RRMS) and to assess the optimal time to initiate IFNbeta treatment with regard to the greatest benefits on disability progression...
  5. pmc Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis
    Damiano Paolicelli
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Biologics 3:369-76. 2009
    ..In spite of the emergence of new agents for the treatment of MS, IFNbeta-1b still remains a first-line therapy with a fundamental role in all stages of the disease...
  6. pmc Impact of natalizumab on cognitive performances and fatigue in relapsing multiple sclerosis: a prospective, open-label, two years observational study
    Pietro Iaffaldano
    Department of Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
    PLoS ONE 7:e35843. 2012
    ..The aim of this prospective, open-label, observational study was to evaluate the possible effects of natalizumab on cognition and fatigue measures in RRMS patients treated for up to two years...
  7. pmc Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study
    Luisa Pastò
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    BMC Neurol 12:165. 2012
    ..The objective of this study was to assess the impact of epidural analgesia (EA) and caesarean delivery (CD) on the risk of post-partum relapses and disability in women with MS...
  8. pmc Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric study
    Marta Giannini
    Department of Neurology, University of Florence, Florence, Italy
    BMC Neurol 12:124. 2012
    ....
  9. pmc Geographical variations in sex ratio trends over time in multiple sclerosis
    Maria Trojano
    Department of Neuroscience and Sense Organs, University of Bari, Bari, Italy
    PLoS ONE 7:e48078. 2012
    ..So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out...
  10. pmc Changes in magnetic resonance imaging disease measures over 3 years in mildly disabled patients with relapsing-remitting multiple sclerosis receiving interferon β-1a in the COGnitive Impairment in MUltiple Sclerosis (COGIMUS) study
    Stefano Bastianello
    National Neurological Institute, C Mondino Foundation, Pavia, Italy
    BMC Neurol 11:125. 2011
    ..In clinical trials, MRI has been found to detect treatment effects with greater sensitivity than clinical measures; however, clinical and MRI outcomes tend to correlate poorly...
  11. doi request reprint Natural history of multiple sclerosis: have available therapies impacted long-term prognosis?
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Policlinico di Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Neurol Clin 29:309-21. 2011
    ..Whether DMDs may significantly alter the development of long-term disability remains uncertain, thus it remains challenging how to best approach the issue of long-term benefits from these treatments...
  12. ncbi request reprint observational studies: propensity score analysis of non-randomized data
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11 70124, Bari, Italy
    Int MS J 16:90-7. 2009
    ..However, since PS cannot adjust for unmeasured or unknown confounders, the conclusions from an observational study may not be considered as strong as those from RCTs...
  13. ncbi request reprint Italian Multiple Sclerosis Database Network
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Neurol Sci 27:S358-61. 2006
    ..055 for each year of follow-up in comparison with the untreated group. These results provide significant information on the effectiveness of IFNbeta treatment on long-term disability progression in MS...
  14. ncbi request reprint Can databasing optimise patient care?
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy
    J Neurol 251:v79-v82. 2004
    ..In this paper, the Italian Multiple Sclerosis Database Network (MSDN) and the international web-based MSBase registry are described...
  15. doi request reprint Post-marketing of disease modifying drugs in multiple sclerosis: an exploratory analysis of gender effect in interferon beta treatment
    M Trojano
    Department of Neurological and Psychiatric Sciences University of Bari, Bari, Italy
    J Neurol Sci 286:109-13. 2009
    ..Observational studies may be especially valuable for answering effectiveness questions in subgroups not studied in RCTs...
  16. doi request reprint Postmarketing evidence of disease-modifying drugs in multiple sclerosis
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Neurol Sci 29:S225-6. 2008
    ..Moreover, some of the methodological improvements that may be useful to enhance the quality of observational studies will also be discussed...
  17. ncbi request reprint The IFNbeta treatment of multiple sclerosis (MS) in clinical practice: the experience at the MS Center of Bari, Italy
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124, Bari, Italy
    Neurol Sci 26:S179-82. 2005
    ..05) increase of EDSS was observed in all treatment groups from baseline to 48 months, followed thereafter by a plateau. The IFNbeta-1b group showed more withdrawals (19%) compared with Avonex (6%) and Rebif (7%) at 6 years...
  18. ncbi request reprint New natural history of interferon-beta-treated relapsing multiple sclerosis
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Ann Neurol 61:300-6. 2007
    ..To investigate the impact of interferon-beta (IFNbeta) on disease progression in relapsing-remitting multiple sclerosis patients...
  19. ncbi request reprint The Italian Multiple Sclerosis Database Network (MSDN): the risk of worsening according to IFNbeta exposure in multiple sclerosis
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mult Scler 12:578-85. 2006
    ..0001) in patients exposed to IFNbeta for up to two years than in other groups. A clinical stabilization over two years of IFNbeta exposure may predict a subsequent good clinical response to treatment...
  20. ncbi request reprint Interferon beta in relapsing-remitting multiple sclerosis: an independent postmarketing study in southern Italy
    Maria Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mult Scler 9:451-7. 2003
    ..05) than IFNbeta-1a groups, and more withdrawals (10%) compared with Avonex (5%) at 24 months. IFNbeta products are equally effective in low disability RRMS, but IFNbeta-1a may have a more favorable efficacy/tolerability ratio...
  21. ncbi request reprint Changes of serum sICAM-1 and MMP-9 induced by rIFNbeta-1b treatment in relapsing-remitting MS
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Neurology 53:1402-8. 1999
    ....
  22. ncbi request reprint Inhibition of protein kinase C counteracts TNFalpha-induced intercellular adhesion molecule 1 expression and fluid phase endocytosis on brain microvascular endothelial cells
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124, Bari, Italy
    Brain Res 863:245-8. 2000
    ..5-10 nM) did not. These findings indicate that a PKC-dependent mechanism may affect TNFalpha signalling on different barrier properties of BMECs...
  23. ncbi request reprint Interferon beta-1a downregulates TNFalpha-induced intercellular adhesion molecule 1 expression on brain microvascular endothelial cells through a tyrosine kinase-dependent pathway
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124, Bari, Italy
    Brain Res 881:227-30. 2000
    ..These findings indicate that a TK- rather than a PKC-dependent mechanism is involved in the modulation of TNFalpha response by IFbeta-1a on BMECs...
  24. doi request reprint The impact of neutralizing antibodies on the risk of disease worsening in interferon β-treated relapsing multiple sclerosis: a 5 year post-marketing study
    D Paolicelli
    Department of Neurosciences and Sense Organs, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy
    J Neurol 260:1562-8. 2013
    ..94; p = 0.0879). This long-term post-marketing observational study further confirms that the occurrence of NAbs significantly affects the risk of disease worsening in IFNβ- treated RRMS...
  25. ncbi request reprint The transition from relapsing-remitting MS to irreversible disability: clinical evaluation
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124, Bari, Italy
    Neurol Sci 24:S268-70. 2003
    ..This review discusses the clinical studies that provided important findings relating to our understanding on different mechanisms that may contribute to irreversible disability in MS...
  26. doi request reprint Verbal fluency deficits in clinically isolated syndrome suggestive of multiple sclerosis
    R G Viterbo
    Department of Basic Medical Sciences, Neurosciences and Sense organs, University of Bari Aldo Moro, Bari, Italy
    J Neurol Sci 330:56-60. 2013
    ..The aim of this study was to assess the extent of verbal fluency deficits and their predictive value for the presence of a CI in a population of CIS patients...
  27. doi request reprint Load-dependent dysfunction of the putamen during attentional processing in patients with clinically isolated syndrome suggestive of multiple sclerosis
    C Tortorella
    Department of Neuroscience and Sense Organs, University of Bari, Italy
    Mult Scler 19:1153-60. 2013
    ..No data are available in clinically isolated syndrome (CIS) suggestive of MS...
  28. ncbi request reprint Glatiramer acetate induces pro-apoptotic mechanisms involving Bcl-2, Bax and Cyt-c in peripheral lymphocytes from multiple sclerosis patients
    M Ruggieri
    Dept of Neurological and Psychiatric Sciences, University of Bari, Policlinico, Piazza Giulio Cesare, Italy
    J Neurol 253:231-6. 2006
    ..Our findings suggest that GA exerts a regulatory effect on peripheral T lymphocytes through pro-apoptosis mechanisms involving mitochondria and cytosolic proteins...
  29. ncbi request reprint The differential diagnosis of multiple sclerosis: classification and clinical features of relapsing and progressive neurological syndromes
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Neurol Sci 22:S98-102. 2001
    ..The key to the accurate diagnosis of MS is vigilance for atypical features, suggesting the possibility of an alternative diagnosis...
  30. ncbi request reprint Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment
    C Avolio
    Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
    Mult Scler 11:441-6. 2005
    ..85; P < 0.05) of the numbers of MRI Gd-TD active lesions. These data confirm that serum MMP-9/TMIP-1 ratio may be viewed as a reliable marker and may be predictive of MRI activity in RR MS...
  31. ncbi request reprint Adhesion molecules and matrix metalloproteinases in Multiple Sclerosis: effects induced by Interferon-beta
    C Avolio
    Neurology Unit, University of Foggia, Foggia, Italy
    Brain Res Bull 61:357-64. 2003
    ..This review will highlight the effects induced by rIFNbeta, both in vitro and in vivo, on cell-bound and soluble forms of AMs and on MMPs...
  32. ncbi request reprint LFA-1 expression on CD4(+)CD45RO(+) peripheral blood T-lymphocytes in RR MS: effects induced by rIFNbeta-1a
    C Avolio
    Chair of Neurology, University of Foggia, Foggia, Italy
    J Neurol Sci 186:65-73. 2001
    ....
  33. doi request reprint A case report of double filtration plasmapheresis in an acute episode of multiple sclerosis
    Alfonso Ramunni
    Nephrology Section, Department of Internal and Public Medicine, University of Bari, Bari, Italy
    Ther Apher Dial 12:250-4. 2008
    ..DFPP, adopted for the first time in MS, seems to foster a short-term improvement in both the clinical and magnetic resonance images during an acute MS episode...
  34. ncbi request reprint Glatiramer acetate in multiple sclerosis: a review
    Maddalena Ruggieri
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    CNS Drug Rev 13:178-91. 2007
    ..In addition, it was recently shown that GA-reactive T cells produce neurotrophic factors (e.g., brain-derived neurotrophic factor [BDNF]) that protect neurons and axons in the area of injury...
  35. ncbi request reprint IFN-beta1a modulates the expression of CTLA-4 and CD28 splice variants in human mononuclear cells: induction of soluble isoforms
    M Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    J Interferon Cytokine Res 21:809-12. 2001
    ..Because soluble CD28 and CTLA-4 molecules might affect T cell activation, our findings suggest an additional means whereby IFN-beta therapy might exert its immunomodulatory effects in multiple sclerosis (MS)...
  36. doi request reprint Overexpression of autophagic proteins in the skeletal muscle of sporadic inclusion body myositis
    F Girolamo
    Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari School of Medicine, Bari, Italy
    Neuropathol Appl Neurobiol 39:736-49. 2013
    ..When autophagy is blocked aggregates accumulate, resulting in abnormal rimmed vacuole formation. This study investigated the autophagy-lysosome pathway contribution to rimmed vacuole accumulation...
  37. doi request reprint Serum and CSF N-acetyl aspartate levels differ in multiple sclerosis and neuromyelitis optica
    C Tortorella
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    J Neurol Neurosurg Psychiatry 82:1355-9. 2011
    ....
  38. doi request reprint Safety profile of Tysabri: international risk management plan
    P Iaffaldano
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Neurol Sci 30:S159-62. 2009
    ..Data so far obtained from these observational programs confirm the already demonstrated risk-benefit profile of natalizumab in clinical trials...
  39. ncbi request reprint Intrathecal synthesis of matrix metalloproteinase-9 in patients with multiple sclerosis: implication for pathogenesis
    G M Liuzzi
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    Mult Scler 8:222-8. 2002
    ....
  40. doi request reprint The relationship between group A streptococcal infections and Tourette syndrome: a study on a large service-based cohort
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Dev Med Child Neurol 53:951-7. 2011
    ..To evaluate the relationship between diagnosis and clinical course of Tourette syndrome and group A Streptococcus (GAS)...
  41. doi request reprint Combination treatment of Glatiramer Acetate and Minocycline affects phenotype expression of blood monocyte-derived dendritic cells in Multiple Sclerosis patients
    Maddalena Ruggieri
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    J Neuroimmunol 197:140-6. 2008
    ..The present data demonstrate possible combination effects of GA and MIN on peripheral blood monocyte-derived DCs in MS patients...
  42. ncbi request reprint Differential regulation of membrane bound and soluble ICAM 1 in human endothelium and blood mononuclear cells: effects of interferon beta-1a
    Maurizio Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    Cell Commun Adhes 9:259-72. 2002
    ..We show that IFNbeta-1a is strong regulator of the ICAM 1 RNA splicing machinery. Effect of IFNbeta-1a over expression of the ICAM 1 isoforms might have a relevant immunomoregulatory role in Multiple Sclerosis...
  43. ncbi request reprint Dopamine fails to regulate activation of peripheral blood lymphocytes from multiple sclerosis patients: effects of IFN-beta
    Maurizio Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    J Interferon Cytokine Res 25:395-406. 2005
    ..Failure of the dopaminergic system of lymphocytes may lessen the threshold of T cell activation and sustain the pathogenic cascade of MS...
  44. ncbi request reprint Immunomodulatory properties of increased levels of liver X receptor beta in peripheral blood mononuclear cells from multiple sclerosis patients
    Maurizio Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, and Casa della Divina Provvidenza, Via Bovio 84, Bisceglie, Bari, Italy
    Exp Neurol 204:759-66. 2007
    ..Secretion of IL-4 is not affected. Our findings suggest that regulation of cholesterol metabolism not strictly related to inhibition of HMGCoA reductase can modulate activity of lymphocytes in MS...
  45. ncbi request reprint Age-related gadolinium-enhancement of MRI brain lesions in multiple sclerosis
    Carla Tortorella
    Neurophysiopathology Unit, San Paolo Hospital, Bari, Italy
    J Neurol Sci 239:95-9. 2005
    ..0001) and current age (p=0.0003) were the best predictors of the number of enhancing lesions. This information can be used to increase the statistical power of clinical trials using Gd-enhancing lesions as an outcome measure...
  46. ncbi request reprint Post-receptorial mechanisms underlie functional disregulation of beta2-adrenergic receptors in lymphocytes from Multiple Sclerosis patients
    Maurizio Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124 Bari, Italy
    J Neuroimmunol 155:143-9. 2004
    ..Disregulation downstream the cAMP-associated signalling may underlie such a phenomenon...
  47. doi request reprint Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies
    Grazia Paola Nicchia
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
    Glia 57:1363-73. 2009
    ..Finally, water transport measurements show that NMO-IgG treatment does not significantly affect AQP4 function. In conclusion, our results suggest for the first time that OAP assemblies are required for NMO-IgG to recognize AQP4...
  48. ncbi request reprint Subclinical visual involvement in multiple sclerosis: a study by MRI, VEPs, frequency-doubling perimetry, standard perimetry, and contrast sensitivity
    Dario Sisto
    Department of Ophthalmology and Otorhinolaringology, Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Invest Ophthalmol Vis Sci 46:1264-8. 2005
    ....
  49. ncbi request reprint Interferon beta-1a counteracts effects of activation on the expression of G-protein-coupled receptor kinases 2 and 3, beta-arrestin-1, and regulators of G-protein signalling 2 and 16 in human mononuclear leukocytes
    Maurizio Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124 Bari, Italy
    Cell Signal 14:673-8. 2002
    ..Furthermore, IFN beta-1a quenches the effects of PHA on the isoproterenol-induced accumulation of cyclic AMP (cAMP). We suggest that regulation of GPCRs responsiveness may be a relevant property of IFN beta-1a in MS...
  50. ncbi request reprint Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis
    Eva Akesson
    Neurology Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Neuroimmunol 143:31-8. 2003
    ..This additional genotyping increased the information extraction in the region from 52% to 79% and revealed increased support for linkage (MLS 2.5) peaking at 10p15...
  51. ncbi request reprint Clinical characteristics, course and prognosis of relapsing Devic's Neuromyelitis Optica
    Angelo Ghezzi
    Centro Studi Sclerosi Multipla Ospedale di Gallarate, Via Pastori 4, 21013 Gallarate, Italy
    J Neurol 251:47-52. 2004
    ..To evaluate the clinical characteristics, course and prognosis of Devic's neuromyelitis optica (DNO), to evaluate the prognostic role of demographic and clinical features, to evaluate the current DNO diagnostic criteria...
  52. ncbi request reprint The costs of multiple sclerosis: a cross-sectional, multicenter cost-of-illness study in Italy
    Maria Pia Amato
    Department of Neurological Sciences, University of Florence, Italy
    J Neurol 249:152-63. 2002
    ..To estimate the socio-economic impact of multiple sclerosis (MS) in Italy...
  53. ncbi request reprint Apolipoprotein E genotype does not influence the progression of multiple sclerosis
    Giovanni Savettieri
    Institute of Neuropsychiatry, University of Palermo, Palermo, Italy
    J Neurol 250:1094-8. 2003
    ..To investigate the association between apolipoprotein E (APOE) polymorphisms and the progression of MS...
  54. ncbi request reprint A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population
    Maria Liguori
    Dipartimento di Scienze Neurologiche e Psichiatriche, Univ Bari, Italy
    J Neuroimmunol 143:97-100. 2003
    ..After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association...
  55. ncbi request reprint Osteopontin gene haplotypes correlate with multiple sclerosis development and progression
    Annalisa Chiocchetti
    Interdisciplinary Research Center of Autoimmune Diseases IRCAD and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Via Solaroli 17, I 28100 Novara, Italy
    J Neuroimmunol 163:172-8. 2005
    ..These data suggest that OPN genotypes may influence MS development and progression due to their influence on OPN levels...
  56. pmc Early prediction of the long term evolution of multiple sclerosis: the Bayesian Risk Estimate for Multiple Sclerosis (BREMS) score
    Roberto Bergamaschi
    Multiple Sclerosis Centre, Department of Clinical Neurology, Neurological Institute C Mondino, Via Mondino 2, 27100 Pavia, Italy
    J Neurol Neurosurg Psychiatry 78:757-9. 2007
    ..To propose a simple tool for early prediction of unfavourable long term evolution of multiple sclerosis (MS)...
  57. ncbi request reprint Pharmacodynamics of interferon beta in multiple sclerosis patients with or without serum neutralizing antibodies
    Carolina Scagnolari
    Dept of Experimental Medicine Virology Section, La Sapienza University, Rome, Italy
    J Neurol 254:597-604. 2007
    ..In summary, our findings confirm that NABs affect absolute concentrations of IFN-beta induced markers and suggest that such an effect occurs in a titer-dependent manner...
  58. ncbi request reprint Is it time to use observational data to estimate treatment effectiveness in multiple sclerosis?
    Maria Trojano
    Neurology 69:1478-9. 2007
  59. pmc Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study
    Mauro Manconi
    Sleep Disorders Center, Scientific Institute and Ospedale San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
    Sleep 31:944-52. 2008
    ..To verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors...
  60. ncbi request reprint Serial immunoprecipitation assays for interferon--(IFN)-beta antibodies in multiple sclerosis patients
    Vito Lampasona
    Department of Clinical Chemistry, San Raffaele Scientific Institute, Milan, Italy
    Eur Cytokine Netw 14:154-7. 2003
    ..However, in our series of MS patients, both titres and frequency of detection of BAB or NAB did not differ between IFN-b responders and non-responders...
  61. ncbi request reprint Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus
    Marta Mellai
    Laboratorio di Genetica Umana, Dipartimento Scienze Mediche and I R C A D, Universita del Piemonte Orientale, Novara, Italy
    Hum Immunol 64:274-84. 2003
    ..No statistically significant difference in the allele distribution was observed for any of the tested variations...
  62. ncbi request reprint Serum MMP-2 and MMP-9 are elevated in different multiple sclerosis subtypes
    Carlo Avolio
    Neurology Unit, University of Foggia, Italy
    J Neuroimmunol 136:46-53. 2003
    ..These results show that an increase in MMP-2/TIMP-2 ratio marks chronic progression in MS, but it is as high as in HC, and also confirm that high MMP-9 activity characterizes short duration relapsing and active forms of the disease...
  63. ncbi request reprint Adrenergic mechanisms in multiple sclerosis: the neuro-immune connection?
    Marco Cosentino
    Trends Pharmacol Sci 25:350-1; author reply 351-2. 2004
  64. ncbi request reprint Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients
    Mehdi Alizadeh
    Laboratoire Universitaire d Immunologie UPRES EA 1257, IFR 97 and Etablissement Français du Sang Bretagne, Faculte de Medecine, Rennes, France
    Ann Neurol 54:119-22. 2003
    ..Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119-122..
  65. ncbi request reprint CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers
    Macarena Gomez-Lira
    Dipartimento Materno Infantile e di Biologia Genetica, Sezione di Biologia e Genetica, Universita di Verona, Verona, Italy
    J Neuroimmunol 140:216-21. 2003
    ..11. None of the four newly identified nucleotide substitutions, namely C77T (Pro59Pro) in exon 4, G69C (Asp121His) in exon 5, T127A (Ile187Asn) and A138G (Thr191Ala) in exon 6, was significantly associated to MS...
  66. ncbi request reprint Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis
    Giovanni Savettieri
    Institute of Neuropsychiatry, University of Palermo, Palermo, Italy
    J Neurol 251:1208-14. 2004
    ..The APOE-epsilon4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer's Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons...
  67. ncbi request reprint Benign multiple sclerosis: cognitive, psychological and social aspects in a clinical cohort
    Maria Pia Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol 253:1054-9. 2006
    ..Clinical correlates of cognitive impairment were determined by multiple logistic regression analysis...
  68. ncbi request reprint Association between Synapsin III gene promoter polymorphisms and multiple sclerosis
    Maria Liguori
    Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy
    J Neurol 251:165-70. 2004
    ....
  69. ncbi request reprint Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
    Maria Ban
    University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    J Neuroimmunol 179:108-16. 2006
    ..Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1...