A Tripodi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, Milan, Italy
    Aliment Pharmacol Ther 26:141-8. 2007
  2. doi Testing for lupus anticoagulants: all that a clinician should know
    A Tripodi
    Department of Internal Medicine, University Medical School, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Lupus 18:291-8. 2009
  3. doi How the direct oral anticoagulant apixaban affects thrombin generation parameters
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, MiIano, ltaly IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy Electronic address
    Thromb Res 135:1186-90. 2015
  4. doi Thrombin generation and other coagulation parameters in a patient with homozygous congenital protein S deficiency on treatment with rivaroxaban
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Universita degli Studi di Milano, Via Pace 9, 20122, Milan, Italy
    Int J Hematol 103:165-72. 2016
  5. doi Procoagulant imbalance in patients with non-alcoholic fatty liver disease
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milano, Italy IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy Electronic address
    J Hepatol 61:148-54. 2014
  6. doi Statins decrease thrombin generation in patients with hypercholesterolemia
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, IRCCS Cà Granda Ospedale Maggiore Foundation, Milano, Italy Electronic address
    Eur J Intern Med 25:449-51. 2014
  7. doi Thrombin generation in patients with idiopathic sudden sensorineural hearing loss
    Armando Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy Electronic address
    Thromb Res 133:1130-4. 2014
  8. doi Global coagulation in myeloproliferative neoplasms
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Via Pace 9, 20122, Milan, Italy
    Ann Hematol 92:1633-9. 2013
  9. doi Evidence that low protein C contributes to the procoagulant imbalance in cirrhosis
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milano, Italy
    J Hepatol 59:265-70. 2013
  10. doi The laboratory and the direct oral anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and Istituto di Ricerca e Cura a Carattere Scientifico Cà Granda Ospedale Maggiore Foundation, Milan, Italy
    Blood 121:4032-5. 2013

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. ncbi Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, Milan, Italy
    Aliment Pharmacol Ther 26:141-8. 2007
    ..Recent studies cast doubt on the validity of the assumptions that form the basis for these applications...
  2. doi Testing for lupus anticoagulants: all that a clinician should know
    A Tripodi
    Department of Internal Medicine, University Medical School, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Lupus 18:291-8. 2009
    ..This article is aimed at reviewing the current situation and the light and shadows associated with this diagnostic procedure...
  3. doi How the direct oral anticoagulant apixaban affects thrombin generation parameters
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, MiIano, ltaly IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy Electronic address
    Thromb Res 135:1186-90. 2015
    ..However, little information is available on the influence that apixaban may have on the parameters of thrombin generation...
  4. doi Thrombin generation and other coagulation parameters in a patient with homozygous congenital protein S deficiency on treatment with rivaroxaban
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Universita degli Studi di Milano, Via Pace 9, 20122, Milan, Italy
    Int J Hematol 103:165-72. 2016
    ..In conclusion, these preliminary results suggest that PS may be a determinant of velocity and peak-thrombin, but not of the total amount of thrombin generated. ..
  5. doi Procoagulant imbalance in patients with non-alcoholic fatty liver disease
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milano, Italy IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy Electronic address
    J Hepatol 61:148-54. 2014
    ..We investigated 113 patients with varying histological liver damage [steatosis (n=32), steatohepatitis (n=51), metabolic-cirrhosis (n=30)], 54 with alcoholic/viral-cirrhosis and 179 controls...
  6. doi Statins decrease thrombin generation in patients with hypercholesterolemia
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, IRCCS Cà Granda Ospedale Maggiore Foundation, Milano, Italy Electronic address
    Eur J Intern Med 25:449-51. 2014
    ..Traditional global coagulation tests failed, however, to reveal clinically relevant change after treatment. We therefore sought to investigate whether statins were able to modify thrombin generation in hypercholesterolemia...
  7. doi Thrombin generation in patients with idiopathic sudden sensorineural hearing loss
    Armando Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Milano, Italy Electronic address
    Thromb Res 133:1130-4. 2014
    ..The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSNHL) is still unknown. Systemic hemostasis derangement causing local vascular occlusion might be one of the pathogenetic mechanisms...
  8. doi Global coagulation in myeloproliferative neoplasms
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Via Pace 9, 20122, Milan, Italy
    Ann Hematol 92:1633-9. 2013
    ..These tests might be useful in the frame of clinical trials to assess their association with the occurrence of thrombosis and with the effect of therapeutic strategies in MPN...
  9. doi Evidence that low protein C contributes to the procoagulant imbalance in cirrhosis
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milano, Italy
    J Hepatol 59:265-70. 2013
    ..To test this hypothesis we analyzed plasma from 50 patients with cirrhosis before and after in vitro addition of purified protein C meant to restore normal levels...
  10. doi The laboratory and the direct oral anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and Istituto di Ricerca e Cura a Carattere Scientifico Cà Granda Ospedale Maggiore Foundation, Milan, Italy
    Blood 121:4032-5. 2013
    ..Choice of tests should be primarily based on their prompt availability. Accordingly, the dilute-thrombin or the ecarin clotting times are best suited for dabigatran and the prothrombin time or the anti-FXa for rivaroxaban...
  11. pmc Results expression for tests used to measure the anticoagulant effect of new oral anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di Milano and IRCCS Cà Granda Maggiore Hospital Foundation, Via Pace 9, Milano, 20122, Italy
    Thromb J 11:9. 2013
    ..This article is aimed at discussing different options of results reporting of tests for NOA and their merits/pitfalls. ..
  12. doi Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di, Milano, Milano, Italy
    Liver Int 33:362-7. 2013
    ..However, in vitro studies showed that patients with cirrhosis generate as much thrombin as healthy individuals provided that their platelet count is at least 100 × 10(9) /L...
  13. ncbi Position paper on laboratory testing for patients taking new oral anticoagulants. Consensus document of FCSA, SIMeL, SIBioC and CISMEL1)
    Armando Tripodi
    Department of Clinical Sciences and Community Health, Universit à degli Studi di Milano, Milan, Italy
    Clin Chem Lab Med 50:2137-40. 2012
    ..e., dabigatran, rivaroxaban and apixaban); 2) the patients to be investigated; and 3) the timing of investigation...
  14. doi The laboratory and the new oral anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy
    Clin Chem 59:353-62. 2013
    ..This demonstrated efficacy does not necessarily mean that the laboratory, considered the mainstay for the management of the old anticoagulants, will no longer play a role in treatment with NOAs...
  15. doi Problems and solutions for testing hemostasis assays while patients are on anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Cà Granda Maggiore Hospital Foundation and Università degli Studi di Milano, Milano, Italy
    Semin Thromb Hemost 38:586-92. 2012
    ....
  16. doi Laboratory tests and the new oral anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milano, Italy
    Thromb Res 130:S95-7. 2012
    ..This article is aimed at reviewing the current tests, their characteristics and the most appropriate choice...
  17. doi Standardization of lupus anticoagulant. The Lupus Anticoagulant Sensitivity Index (LASI)
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Department of Internal Medicine, IRCCS Cà Granda Ospedale Maggiore Policlinico Foundation and Università degli Studi di Milano, Italy
    Lupus 21:715-7. 2012
    ....
  18. doi To mix or not to mix in lupus anticoagulant testing? That is the question
    Armando Tripodi
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Cà Granda Ospedale Maggiore Policlinico Foundation Università degli Studi di Milano, Via Pace 9, Milan, Italy
    Semin Thromb Hemost 38:385-9. 2012
    ....
  19. doi New anticoagulant drugs for treatment of venous thromboembolism and stroke prevention in atrial fibrillation
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Cà Granda Maggiore Hospital Foundation and Università degli Studi di Milano, Milano, Italy
    J Intern Med 271:554-65. 2012
    ....
  20. doi Thrombin generation in plasma from patients with cirrhosis supplemented with normal plasma: considerations on the efficacy of treatment with fresh-frozen plasma
    Armando Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Via Pace 9, 20122, Milan, Italy
    Intern Emerg Med 7:139-44. 2012
    ..These results question the validity of the PT as a stand-alone test to guide transfusion of FFP in the setting of chronic liver disease...
  21. ncbi Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Ospedale Maggiore, Mangiagalli and Regina Elena Foundation, Via Pace 9, 20122 Milano, Italy
    J Hepatol 46:727-33. 2007
    ....
  22. doi The history of phenotypic testing in thrombosis and hemostasis
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Semin Thromb Hemost 34:585-92. 2008
    ..The challenge in the future will be to devise newer tests mimicking more closely what occurs in vivo...
  23. doi Laboratory testing for lupus anticoagulants: diagnostic criteria and use of screening, mixing, and confirmatory studies
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Semin Thromb Hemost 34:373-9. 2008
    ..The aim of this article is to review the diagnostic criteria and the many issues that may affect test results...
  24. ncbi Hemostasis abnormalities in liver cirrhosis: myth or reality?
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Pol Arch Med Wewn 118:445-8. 2008
    ..Recent evidence from the literature disputes the above paradigm and open new directions for laboratory and clinical research in this field...
  25. doi Second international collaborative study evaluating performance characteristics of methods measuring the von Willebrand factor cleaving protease (ADAMTS-13)
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Maggiore Hospital, Milan, Italy
    J Thromb Haemost 6:1534-41. 2008
    ..Over the last 4 years ADAMTS-13 measurement underwent dramatic progress with newer and simpler methods...
  26. doi High thrombin generation measured in the presence of thrombomodulin is associated with an increased risk of recurrent venous thromboembolism
    A Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan
    J Thromb Haemost 6:1327-33. 2008
    ..Because of the large numbers of such putative parameters, the assessment in individual patients is complex. Application of global assays reflecting the pro-/anti-coagulant balance in vivo would be desirable...
  27. ncbi The international normalized ratio to prioritize patients for liver transplantation: problems and possible solutions
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 6:243-8. 2008
    ....
  28. ncbi Thrombin generation in patients with cirrhosis: the role of platelets
    Armando Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Ospedale Maggiore, Milano, Italy
    Hepatology 44:440-5. 2006
    ..These findings might justify platelet transfusion in patients with low platelet counts when they bleed spontaneously or before undergoing surgery or liver biopsy. Controlled clinical trials supporting this indication are warranted...
  29. ncbi Interference of factor V Leiden on protein S activity: evaluation of a new prothrombin time-based assay
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Blood Coagul Fibrinolysis 18:543-6. 2007
    ..Protein S activity measurement for FVL-positive patients should be performed on diluted plasma and the results interpreted on the basis of the cut-off value specifically determined for diluted plasmas...
  30. ncbi Laboratory testing for lupus anticoagulants: a review of issues affecting results
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Clin Chem 53:1629-35. 2007
    ....
  31. ncbi The international normalized ratio calibrated for cirrhosis (INR(liver)) normalizes prothrombin time results for model for end-stage liver disease calculation
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Milan, Italy
    Hepatology 46:520-7. 2007
    ..001). Conversely, the mean INR(liver) were not. Similarly, the mean MELD(vka) were significantly different (P < 0.001), but those differences were abrogated for the MELD(liver)...
  32. ncbi The endogenous thrombin potential and the risk of venous thromboembolism
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Thromb Res 121:353-9. 2007
    ....
  33. doi The coagulopathy of cirrhosis assessed by thromboelastometry and its correlation with conventional coagulation parameters
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Ospedale Maggiore, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Thromb Res 124:132-6. 2009
    ..The technique is used as a near-patient-testing device to guide transfusion in cardiac surgery or liver transplantation and less to investigate hemostasis in acquired or congenital coagulopathies...
  34. doi Tests of coagulation in liver disease
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University Medical School and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Via Pace 9, 20122 Milano, Italy
    Clin Liver Dis 13:55-61. 2009
    ..Alternative tests more closely mimicking what occurs in vivo should be developed and investigated in appropriate clinical trials to determine their value in the management of bleeding in cirrhosis...
  35. doi Hypercoagulability in cirrhosis: causes and consequences
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Cà Granda Ospedale Maggiore Policlinico Foundation and Università degli Studi di Milan, Milan, Italy
    J Thromb Haemost 9:1713-23. 2011
    ..There may be subgroups of patients who benefit from anticoagulation to treat or prevent thrombosis and to slow hepatic fibrosis. Clinical studies are warranted to explore these therapeutic options...
  36. doi D-dimer testing in laboratory practice
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ca Granda Ospedale Maggiore Policlinico and Università degli Studi di Milano, Milano, Italy
    Clin Chem 57:1256-62. 2011
    ..As such, its presence in plasma should be indicative of thrombus formation. There are many conditions unrelated to thrombosis in which D-dimer concentrations are high, however, making its positive predictive value rather poor...
  37. doi Standardization of lupus anticoagulant. Feasibility study of a calibration model to minimize between-method variability
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, Milano, Italy
    Thromb Res 127:589-94. 2011
    ..We hypothesized that the standardization model currently used for the INR for patients on oral-anticoagulants (OAT) would be of value also for LA standardization...
  38. doi Antiphospholipid syndrome: laboratory detection, mechanisms of action and treatment
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Cà Granda Ospedale Maggiore Policlinico Foundation and Università degli Studi di Milano, Milan, Italy
    J Intern Med 270:110-22. 2011
    ....
  39. doi Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, IRCCS Cà Granda Ospedale Maggiore Policlinico Foundation and Università degli Studi di Milano, Via Pace 9, 20122 Milan, Italy
    J Thromb Thrombolysis 31:165-72. 2011
    ..These findings might explain the relatively high risk of atherothrombosis and VTE described in these patients...
  40. doi Detection of the imbalance of procoagulant versus anticoagulant factors in cirrhosis by a simple laboratory method
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Universita degli Studi di Milano, Milan, Italy
    Hepatology 52:249-55. 2010
    ..59). The PICI% values were correlated with the levels of protein C (rho = 0.728, P < 0.001) or factor VIII (rho = -0.517, P < 0.001). Finally, the PICI% values were correlated with the predicate assay (rho = -0.580, P < 0.001)...
  41. doi Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Intern Emerg Med 5:7-12. 2010
    ..In this article, we review recent evidence from the literature that disputes the above paradigm, and opens new venues for laboratory/clinical research and patient management in this field...
  42. doi An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis
    Armando Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy
    Gastroenterology 137:2105-11. 2009
    ..We investigated whether plasma from cirrhotic patients has an imbalance of pro- vs anti-coagulation factors...
  43. doi Acquired coagulation disorders: revisited using global coagulation/anticoagulation testing
    Armando Tripodi
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Internal Medicine, University of Milano Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Br J Haematol 147:77-82. 2009
    ..Thrombin generation assays are more suitable than PT and APTT for use in acquired coagulation defects...
  44. doi Point-of-care coagulation monitors calibrated for the international normalized ratio for cirrhosis (INRliver) can help to implement the INRliver for the calculation of the MELD score
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Ospedale Maggiore, Mangiagalli and Regina Elena Foundation, Via Pace 9, 20122 Milan, Italy
    J Hepatol 51:288-95. 2009
    ..This study aimed to assess whether easy-to-run whole-blood coagulation monitors (widely used for patients on VKA) can be calibrated to measure efficiently the INR(liver) and minimize the interlaboratory variability...
  45. doi Laboratory monitoring of anticoagulation: where do we stand?
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Semin Thromb Hemost 35:34-41. 2009
    ..Accordingly, clinical laboratories should still be prepared to monitor patients, although the numbers may hopefully decrease sharply in the next decade or so...
  46. doi Abnormal Protac-induced coagulation inhibition chromogenic assay results are associated with an increased risk of recurrent venous thromboembolism
    Armando Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Universita degli Studi di Milano, Via Pace 9, 20122 Milan, Italy
    J Thromb Thrombolysis 30:215-9. 2010
    ..Advantages of PICI over thrombin generation tests are easy performance in general clinical laboratories, easy standardization and no special equipment...
  47. ncbi Alpha(2)-macroglobulin levels are high in adult patients with congenital antithrombin deficiency
    A Tripodi
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Res 98:117-22. 2000
    ..Furthermore, the high levels were found more often in asymptomatic than symptomatic men. Whether this increase provides protection against thrombosis should be evaluated in a prospective study...
  48. ncbi A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism
    Armando Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Blood 104:3631-4. 2004
    ..In conclusion, hypercoagulability detected by a shortened APTT is independently associated with VTE. This inexpensive and simple test should be considered in the evaluation of the risk of VTE...
  49. ncbi Prothrombin time international normalized ratio monitoring by self-testing
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Via Pace 9, 20122 Milan, Italy
    Curr Opin Hematol 11:141-5. 2004
    ..This article reviews the literature on use of portable coagulometers...
  50. ncbi Quality assurance program for whole blood prothrombin time-international normalized ratio point-of-care monitors used for patient self-testing to control oral anticoagulation
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Via Pace 9, 20122 Milan, Italy
    Thromb Res 113:35-40. 2004
    ..During each visit, the clinic may check the monitors and patient self-testing performance as described. Such comprehensive QA system would make monitoring of oral anticoagulant treatment by self-testing safer and more effective...
  51. ncbi Lupus anticoagulant (LA) testing: performance of clinical laboratories assessed by a national survey using lyophilized affinity-purified immunoglobulin with LA activity
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, 20122 Milan, Italy
    Clin Chem 49:1608-14. 2003
    ..The control plasmas used in these surveys were from LA-positive or -negative patients or were normal plasmas with monoclonal antibodies against human beta(2)-glycoprotein I (beta(2)-GPI) added...
  52. ncbi Standardization of activated protein C resistance testing: effect of residual platelets in frozen plasmas assessed by commercial and home-made methods
    Armando Tripodi
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milan, Italy
    Br J Haematol 120:825-8. 2003
    ..When frozen platelet-poor plasma was centrifuged at high speed after thawing and before testing, there was no significant decrease in the APC ratio, in comparison with fresh platelet-poor plasma using the home-made and modified methods...
  53. ncbi Levels of coagulation factors and venous thromboembolism
    Armando Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milan, Italy
    Haematologica 88:705-11. 2003
    ..Altered levels of coagulation factors have been included among the abnormalities that may increase the risk of venous thromboembolism (VTE) in otherwise healthy subjects...
  54. ncbi How to evaluate the influence of blood collection systems on the international sensitivity index. Protocol applied to two new evacuated tubes and eight coagulometer/thromboplastin combinations
    Armando Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Via Pace 9, Milan 20122, Italy
    Thromb Res 108:85-9. 2002
    ..In conclusion, the study shows that the evaluation tubes compare well with the control tubes from the same manufacturer. The protocol described here should be adopted for the evaluation of other blood collection systems...
  55. ncbi Laboratory diagnosis of lupus anticoagulants for patients on oral anticoagulant treatment. Performance of dilute Russell viper venom test and silica clotting time in comparison with Staclot LA
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 88:583-6. 2002
    ..Advantages of SCT and Drvvt over Staclot LA are easy automation, no need for normal plasma and relatively low cost...
  56. ncbi Laboratory diagnosis of thrombophilic states: where do we stand?
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, University of Milano, Italy
    Pathophysiol Haemost Thromb 32:245-8. 2002
    ..Hyperhomocysteinemia may be assessed by high-pressure liquid chromatography methods, or by fluorescence polarization immunoassays...
  57. ncbi Laboratory control of oral anticoagulant treatment by the INR system in patients with the antiphospholipid syndrome and lupus anticoagulant. Results of a collaborative study involving nine commercial thromboplastins
    A Tripodi
    The Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Br J Haematol 115:672-8. 2001
    ..New thromboplastins, especially those made of relipidated tissue factor, should be checked for their responsiveness to LA before they are used to monitor oral anticoagulant treatment in patients with APS...
  58. ncbi Laboratory investigation of thrombophilia
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Via Pace 9, 20122 Milan, Italy
    Clin Chem 47:1597-606. 2001
    ..Hyperhomocysteinemia can be diagnosed by HPLC methods or by fluorescence polarization immunoassays...
  59. ncbi A review of the clinical and diagnostic utility of laboratory tests for the detection of congenital thrombophilia
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milan, Italy
    Semin Thromb Hemost 31:25-32. 2005
    ....
  60. ncbi Issues concerning the laboratory investigation of inherited thrombophilia
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University and IRCCS Maggiore Hospital, Milan, Italy
    Mol Diagn 9:181-6. 2005
    ..Phenotypic testing should be performed no sooner than three months after acute thrombotic events and at least 2 weeks after discontinuation of oral anticoagulant treatment...
  61. ncbi Multicenter study of homocysteine measurement--performance characteristics of different methods, influence of standards on interlaboratory agreement of results
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 85:291-5. 2001
    ..Between-lab comparability of results is still a problem. The establishment of an international plasma standard would be of help to harmonize tHcy measurement across laboratories...
  62. ncbi Activated partial thromboplastin time (APTT). New indications for an old test?
    A Tripodi
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 4:750-1. 2006
  63. ncbi Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University and IRCCS Maggiore Hospital, Milan, Italy
    Hepatology 41:553-8. 2005
    ..For a clinical validation of these findings, a prospective clinical trial is warranted where the results of thrombin generation in the presence of thrombomodulin are related to the occurrence of bleeding...
  64. ncbi Lupus anticoagulants and their relationship with the inhibitors against coagulation factor VIII: considerations on the differentiation between the 2 circulating anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University and Foundation IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Clin Chem 51:1883-5. 2005
  65. doi Severe hemophilia with mild bleeding phenotype: molecular characterization and global coagulation profile
    E Santagostino
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Department of Medicine and Medical Specialties, IRCCS Ca Granda Foundation, Policlinico Maggiore Hospital, Luigi Villa Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 8:737-43. 2010
    ..Such global coagulation tests as thrombin generation assays are tools with which to investigate different coagulation profiles among severe hemophiliacs...
  66. ncbi Laboratory screening of thrombophilia. Evaluation of the diagnostic efficacy of a global test to detect congenital deficiencies of the protein C anticoagulant pathway
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milan, Italy
    Blood Coagul Fibrinolysis 9:485-9. 1998
    ....
  67. ncbi Risk of venous thromboembolism and clinical manifestations in carriers of antithrombin, protein C, protein S deficiency, or activated protein C resistance: a multicenter collaborative family study
    P Bucciarelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy
    Arterioscler Thromb Vasc Biol 19:1026-33. 1999
    ..AT deficiency seems to have a higher risk for VTE than the other genetic defects. There is a relation between age and occurrence of thrombosis for both men and women. The latter had the peak of incidence earlier than the former...
  68. ncbi International collaborative study for the calibration of a proposed international standard for thromboplastin, rabbit, plain
    V Chantarangkul
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Ospedale Maggiore, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 4:1339-45. 2006
    ....
  69. ncbi Oral anticoagulant monitoring by laboratory or near-patient testing: what a clinician should be aware of
    A Tripodi
    Bonomi Hemophilia and Thrombosis Centre, University and IRCCS Maggiore Hospital, Milan, Italy
    Semin Vasc Med 3:243-54. 2003
    ..Each center should maintain an appropriate scheme of internal and external quality control for the laboratory INR measurement as well as the individual point-of-care coagulation monitors used by the center and patients for self-testing...
  70. ncbi Familial dysfunction of protein S
    P M Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milano, Italy
    Thromb Haemost 62:763-6. 1989
    ..We postulate that the defect is due to a dysfunctional protein S present in plasma in normal amounts and with normal proportions of the free and complexed forms of the protein...
  71. ncbi International collaborative study for the calibration of a proposed reference preparation for thromboplastin, human recombinant, plain. On behalf of the Subcommittee on Control of Anticoagulation
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 79:439-43. 1998
    ..The assigned ISI (SE of the mean) value is 0.940 (0.0060) and the interlaboratory coefficient of variation 4.7%...
  72. ncbi Changes of prothrombin fragment 1+2 (F 1+2) as a function of increasing intensity of oral anticoagulation--considerations on the suitability of F 1+2 to monitor oral anticoagulant treatment
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 79:571-3. 1998
    ..0. Since the risk of bleeding increases at INR greater than 4.5, our results suggest that F 1+2 is of little value to assess the hemorrhagic risk in patients on OAT...
  73. ncbi Thrombin generation assessed as endogenous thrombin potential in patients with hyper- or hypo-coagulability
    Veena Chantarangkul
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Haematologica 88:547-54. 2003
    ..As a preliminary step to larger clinical studies we investigated the effect on ETP of phospholipids, tissue factor (TF) and residual platelets in frozen plasma...
  74. ncbi Standardization of the APC resistance test. Effects of normalization of results by means of pooled normal plasma
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 79:564-6. 1998
    ..APC ratios for PNP A by all methods were significantly lower than those for PNP B. Thus, the presence of mutant FV in a proportion as low as 2.5% may reduce the APC ratio of the PNP...
  75. ncbi Measurement of von Willebrand factor cleaving protease (ADAMTS-13): results of an international collaborative study involving 11 methods testing the same set of coded plasmas
    A Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milan, Italy
    J Thromb Haemost 2:1601-9. 2004
    ..We report on a survey evaluating 11 methods for ADAMTS-13 measurement performed in different labs...
  76. ncbi International sensitivity index calibration of the near-patient testing prothrombin time monitor, ProTime
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and Istituto Ricovero e Cura a Carattere Scientifico Maggiore Hospital, Milano, Italy
    Am J Clin Pathol 119:241-5. 2003
    ..Confirmation of these results in a large multicenter study is warranted...
  77. pmc Hypercoagulability in splenectomized thalassemic patients detected by whole-blood thromboelastometry, but not by thrombin generation in platelet-poor plasma
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Haematologica 94:1520-7. 2009
    ..They might be related to the effects of red blood cell or endothelial cell derangements, increased numbers of platelets as well as abnormal plasma coagulation...
  78. ncbi Hemostasis in chronic liver disease
    A Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 4:2064-5. 2006
  79. doi Increased thrombin generation in inflammatory bowel diseases
    Simone Saibeni
    Department of Internal Medicine and Hepatology, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy
    Thromb Res 125:278-82. 2010
    ..Endogenous thrombin potential (ETP), a parameter of the thrombin generation curve, represents a new tool in the evaluation of thrombotic and bleeding disorders...
  80. ncbi Determination of total homocysteine in plasma: comparison of the Abbott IMx immunoassay with high performance liquid chromatography
    Maddalena Loredana Zighetti
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Via Pace 9, 20122 Milan, Italy
    Haematologica 87:89-94. 2002
    ..The aim of this study was to compare the performance of a commercially available IMx immunoassay with that of a reversed-phase high performance liquid chromatography (HPLC) method for measuring plasma total homocysteine (tHcy)...
  81. ncbi Laboratory diagnosis of lupus anticoagulants--effect of residual platelets in plasma, assessed by Staclot LA and silica clotting time
    Veena Chantarangkul
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 87:854-8. 2002
    ..However, the fact that the percentage correction for SCT and the clotting time difference for Staclot LA are reduced by residual platelets, suggests that weak LA may be lost upon freezing-thawing non-filtered plasmas...
  82. doi Normal thrombin generation in neonates in spite of prolonged conventional coagulation tests
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Haematologica 93:1256-9. 2008
    ..The restored balance can be shown in vitro by the endogenous thrombin potential test that includes thrombomodulin, but not by conventional coagulation tests...
  83. ncbi Standardization of the endogenous thrombin potential measurement: how to minimize the effect of residual platelets in stored plasma
    Veena Chantarangkul
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, University and IRCCS Maggiore Hospital, Via Pace 9, Milan 20122, Italy
    Br J Haematol 124:355-7. 2004
    ....
  84. ncbi Usefulness of lyophilized calibration plasmas for International Normalized Ratio determination with the bovine combined thromboplastin (Thrombotest): results of a collaborative study
    Veena Chantarangkul
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Blood Coagul Fibrinolysis 16:157-63. 2005
    ..Whether this bias is of practical significance is to be determined...
  85. ncbi Measurement of warfarin in plasma by high performance liquid chromatography (HPLC) and its correlation with the international normalized ratio
    Rossana Lombardi
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Via Pace 9, Milan 20122, Italy
    Thromb Res 111:281-4. 2003
    ..The method displayed between-run CV of 11.8%. Recovery was 99%. The coefficients of correlation between warfarin concentration in 50 patients and weekly dosage or INR were 0.55 (p<0.0001) or 0.25 (p=0.079)...
  86. doi More on: laboratory investigation of lupus anticoagulants: mixing studies are sometimes required
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Cà Granda Ospedale Maggiore Policlinico Foundation and Università degli Studi di Milano, Milan Clinical Cardiology, Thrombosis Center, University Hospital, Padova, Italy
    J Thromb Haemost 9:2126-7. 2011
    ..See also Favaloro EJ, Bonar R, Zebeljan D, Kershaw G, Marsden K. Laboratory investigation of lupus anticoagulants: mixing studies are sometimes required. J Thromb Haemost 2010; 8: 2828-31...
  87. doi False-negative or false-positive: laboratory diagnosis of lupus anticoagulant at the time of commencement of anticoagulant: a rebuttal
    A Tripodi
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Cà Granda Ospedale Maggiore Policlinico Foundation and Università degli Studi di Milano, Milan Clinical Cardiology, Thrombosis Center, University Hospital, Padova, Italy
    J Thromb Haemost 9:1435-6. 2011
    ..False negative or false positive: laboratory diagnosis of lupus anticoagulant at the time of commencement of anticoagulant: reply to a rebuttal. This issue, pp 1436-7...
  88. ncbi A comparison of lupus anticoagulant-positive patients with clinical picture of antiphospholipid syndrome and those without
    Vittorio Pengo
    Arterioscler Thromb Vasc Biol 27:e309-10. 2007
  89. ncbi European concerted action on anticoagulation. Quality assessment of the CoaguChek Mini and TAS PT-NC point-of-care whole-blood prothrombin time monitors
    Leon Poller
    European Concerted Action on Anticoagulation Central Facility, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom
    Clin Chem 50:537-44. 2004
    ..There is therefore a need for local quality assessment (QA) of the two systems...
  90. ncbi Long-term stability of relationships between reference materials for thromboplastins
    Thomas P J Linsinger
    EC JRC, Institute for Reference Materials and Measurements, Geel, Belgium
    Thromb Haemost 96:210-4. 2006
    ..No significant changes were observed in the relationships between these reference materials when all results were included (5% significance level)...
  91. ncbi Performance of clinical laboratories for DNA analyses to detect thrombophilia mutations
    Armando Tripodi
    Clin Chem 51:1310-1. 2005
  92. ncbi Minimum numbers of fresh whole blood and plasma samples from patients and healthy subjects for ISI calibration of CoaguChek and RapidPointCoag monitors
    Leon Poller
    European Concerted Action on Anticoagulation, Central Facility, School of Biological Sciences, University of Manchester, England
    Am J Clin Pathol 117:892-9. 2002
    ....
  93. ncbi Hyperprothrombinaemia-induced APC resistance: differential influence on fibrin formation and fibrinolysis
    Bianca M Binetti
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy
    Thromb Haemost 95:606-11. 2006
    ..These data might help to better understand the relationship between thrombin formation and fibrinolysis down-regulation...
  94. ncbi D-dimer testing to determine the duration of anticoagulation therapy
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation, S Orsola Malpighi University Hospital, Bologna, Italy
    N Engl J Med 355:1780-9. 2006
    ..The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation...
  95. doi Different cut-off values of quantitative D-dimer methods to predict the risk of venous thromboembolism recurrence: a post-hoc analysis of the PROLONG study
    Cristina Legnani
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    Haematologica 93:900-7. 2008
    ..The objective of this study was to evaluate the possible advantage of using quantitative D-dimer assays...
  96. doi How to implement the modified international normalized ratio for cirrhosis (INR(liver)) for model for end-stage liver disease calculation
    Armando Tripodi
    Hepatology 47:1423-4; author reply 1424. 2008
  97. ncbi A national field study of quality assessment of CoaguChek point-of-care testing prothrombin time monitors
    Piet Meijer
    European Concerted Action on Thrombosis ECAT Foundation, Leiden, The Netherland
    Am J Clin Pathol 126:756-61. 2006
    ..There is need for large scale QA of CoaguChek monitors. The importance of the 5 CoaguChek certified INR QA plasma samples being tested on a single occasion is demonstrated...
  98. ncbi European concerted action on anticoagulation. Use of plasma samples to derive international sensitivity index for whole-blood prothrombin time monitors
    Leon Poller
    European Concerted Action on Anticoagulation ECAA Central Facility, School of Biological Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
    Clin Chem 48:255-60. 2002
    ....
  99. ncbi Antiphospholipid antibody ELISAs: survey on the performance of clinical laboratories assessed by using lyophilized affinity-purified IgG with anticardiolipin and anti-beta2-Glycoprotein I activity
    Vittorio Pengo
    Clinical Cardiology, Thrombosis Centre, University of Padova School of Medicine, Ex Busonera Hospital, Via Gattamelata 64, I 35128 Padova, Italy
    Thromb Res 120:127-33. 2007
    ..Nonetheless the high variability of reported data remains a major problem that only a consensus on the part of laboratories and manufacturers to utilize standard, uniform materials and procedures can hope to overcome...
  100. pmc Reliability of international normalised ratios from two point of care test systems: comparison with conventional methods
    Leon Poller
    European Concerted Action on Anticoagulation Central Facility, School of Biological Sciences, University of Manchester, Manchester M13 9PT
    BMJ 327:30. 2003
    ..To find out how accurately two point of care test systems--CoaguChek Mini and TAS PT-NC (RapidPointCoag)--display international normalised ratios (INRs)...
  101. ncbi European concerted action on anticoagulation. Minimum numbers of lyophilized plasma samples for ISI calibration of CoaguChek and TAS point-of-care whole blood prothrombin time monitors
    Leon Poller
    ECAA Central Facility, School of Biological Sciences, University of Manchester, Manchester, England
    Am J Clin Pathol 119:232-40. 2003
    ....