E Tramontano

Summary

Affiliation: University of Cagliari
Country: Italy

Publications

  1. request reprint
    Tramontano E. HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target. Mini Rev Med Chem. 2006;6:727-37 pubmed
    ..All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site. ..
  2. Poongavanam V, Corona A, Steinmann C, Scipione L, Grandi N, Pandolfi F, et al. Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies. Medchemcomm. 2018;9:562-575 pubmed publisher
    ..The structural insights obtained from this work provide the bases for further lead optimization. ..
  3. Fanunza E, Frau A, Sgarbanti M, Orsatti R, Corona A, Tramontano E. Development and Validation of a Novel Dual Luciferase Reporter Gene Assay to Quantify Ebola Virus VP24 Inhibition of IFN Signaling. Viruses. 2018;10: pubmed publisher
    ..62 and 0.53 for IFN-α stimulation assay and VP24 inhibition assay, respectively, indicative of robust assay performance. ..
  4. request reprint
    Tramontano E, Piras G, Mellors J, Putzolu M, Bazmi H, La Colla P. Biochemical characterization of HIV-1 reverse transcriptases encoding mutations at amino acid residues 161 and 208 involved in resistance to phosphonoformate. Biochem Pharmacol. 1998;56:1583-9 pubmed
    ..Overall, these results suggest that codons 161 and 208 of the HIV-1 RT gene are involved in substrate binding as well as in NRTI recognition, and provide more insights into the mechanism by which HIV-1 becomes resistant to PFA. ..
  5. Esposito F, Tintori C, Martini R, Christ F, Debyser Z, Ferrarese R, et al. Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation. Chembiochem. 2015;16:2507-12 pubmed publisher
    ..Overall, docking and biochemical results suggest that kuwanon-L binds to an allosteric binding pocket and can be considered an attractive lead for the development of new allosteric IN antiviral agents. ..
  6. Vargiu L, Rodriguez Tomé P, Sperber G, Cadeddu M, Grandi N, Blikstad V, et al. Classification and characterization of human endogenous retroviruses; mosaic forms are common. Retrovirology. 2016;13:7 pubmed publisher
    ..A comprehensive HERV classification and characterization approach was undertaken. It should be applicable for classification of all ERVs. Recombination was common among HERV ancestors. ..
  7. Tintori C, Corona A, Esposito F, Brai A, Grandi N, Ceresola E, et al. Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules. Chembiochem. 2016;17:683-8 pubmed publisher
    ..Two inhibitors were identified with improved activity compared to MAS0. This study lays the basis for the rational design of more potent inhibitors of RT dimerization. ..
  8. Corona A, Desantis J, Massari S, Distinto S, Masaoka T, Sabatini S, et al. Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors. ChemMedChem. 2016;11:1709-20 pubmed publisher
    ..Mechanistic studies suggested selective inhibition of the RNase H through binding to an innovative allosteric site, which could be further exploited to enrich this class of inhibitors. ..
  9. Pala N, Esposito F, Rogolino D, Carcelli M, Sanna V, Palomba M, et al. Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities. Int J Mol Sci. 2016;17: pubmed publisher

More Information

Publications17

  1. request reprint
    Tramontano E. The exploding field of the HCV polymerase non-nucleoside inhibitors: summary of a first generation compounds. Mini Rev Med Chem. 2008;8:1298-310 pubmed
    ..All small molecules which have been identified to be selective non-nucleoside inhibitors (NNI) of the HCV RdRp to date are reported. ..
  2. Esposito F, Carli I, Del Vecchio C, Xu L, Corona A, Grandi N, et al. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine. 2016;23:1383-1391 pubmed publisher
    ..Viral DNA production and time of addition studies showed that Sennoside A targets the HIV-1 reverse transcription process. Sennoside A is a new scaffold for the development of HIV-1 dual RT inhibitors. ..
  3. Grandi N, Tramontano E. Type W Human Endogenous Retrovirus (HERV-W) Integrations and Their Mobilization by L1 Machinery: Contribution to the Human Transcriptome and Impact on the Host Physiopathology. Viruses. 2017;9: pubmed publisher
    ..In this review, we summarize the current knowledge on the HERV-W group presence within the human genome and its expression in physiological tissues as well as in the main pathological contexts. ..
  4. Ramaswamy V, di Palma F, Vargiu A, Corona A, Piano D, Ruggerone P, et al. Insights into the homo-oligomerization properties of N-terminal coiled-coil domain of Ebola virus VP35 protein. Virus Res. 2018;247:61-70 pubmed publisher
    ..Our model advances the understanding of how VP35 may associate in different homo-oligomeric species, a crucial process for EBOV replication and pathogenicity. ..
  5. Sun Y, Luo H, Li Y, Sun C, Song J, Niu Y, et al. Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport. BMC Genomics. 2011;12:533 pubmed publisher
    ..Despite its importance, little is known about the transcriptome of C. acuminata and the mechanism of CPT biosynthesis, as only few nucleotide sequences are included in the GenBank database...
  6. Grandi N, Cadeddu M, Blomberg J, Mayer J, Tramontano E. HERV-W group evolutionary history in non-human primates: characterization of ERV-W orthologs in Catarrhini and related ERV groups in Platyrrhini. BMC Evol Biol. 2018;18:6 pubmed publisher
  7. Grandi N, Cadeddu M, Blomberg J, Tramontano E. Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes. Retrovirology. 2016;13:67 pubmed publisher
  8. Corona A, Di Leva F, Rigogliuso G, Pescatori L, Madia V, Subra F, et al. New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H. Antiviral Res. 2016;134:236-243 pubmed publisher
    ..Furthermore, this study provides new structural information to modulate IN and RNase H inhibitory activities for development of dual-acting anti-HIV agents. ..