Pier Angelo Tovo

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. pmc The second generation of HIV-1 vertically exposed infants: a case series from the Italian Register for paediatric HIV infection
    Carmelina Calitri
    Department of Paediatrics, University of Turin, Turin, Italy
    BMC Infect Dis 14:277. 2014
  2. ncbi request reprint Zidovudine administration during pregnancy and mitochondrial disease in the offspring
    Pier Angelo Tovo
    Department of Pediatrics, University of Turin, Turin, Italy
    Antivir Ther 10:697-9. 2005
  3. ncbi request reprint Hepatitis B virus and hepatitis C virus infections in children
    Pier Angelo Tovo
    Department of Pediatrics, University of Turin, Turin, Italy
    Curr Opin Infect Dis 18:261-6. 2005
  4. ncbi request reprint Changing patterns of clinical events in perinatally HIV-1-infected children during the era of HAART
    Elena Chiappini
    Department of Paediatrics, University of Florence, Via Luca Giordano 13, I 50132 Florence, Italy
    AIDS 21:1607-15. 2007
  5. pmc Five-year follow-up of children with perinatal HIV-1 infection receiving early highly active antiretroviral therapy
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    BMC Infect Dis 9:140. 2009
  6. pmc Persistently high IgA serum levels are a marker of immunological or virological failure of combined antiretroviral therapy in children with perinatal HIV-1 infection
    Elena Chiappini
    Department of Paediatrics, University of Florence, Via Luca Giordano, 13, I 50132 Florence, Italy
    Clin Exp Immunol 140:320-4. 2005
  7. ncbi request reprint Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: a study by the Italian Register for HIV Infection in Children
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    J Clin Oncol 25:97-101. 2007
  8. ncbi request reprint Lower mother-to-child HIV-1 transmission in boys is independent of type of delivery and antiretroviral prophylaxis: the Italian Register for HIV Infection in Children
    Luisa Galli
    Department of Pediatrics, University of Florence, Florence, Italy
    J Acquir Immune Defic Syndr 40:479-85. 2005
  9. ncbi request reprint The HIV protease inhibitors nelfinavir and saquinavir, but not a variety of HIV reverse transcriptase inhibitors, adversely affect human proteasome function
    Marco Piccinini
    Department of Medicine and Experimental Oncology, University of Turin, Turin, Italy
    Antivir Ther 10:215-23. 2005
  10. ncbi request reprint Virologic, immunologic, and clinical benefits from early combined antiretroviral therapy in infants with perinatal HIV-1 infection
    Elena Chiappini
    Department of Paediatrics, University of Florence, Florence, Italy
    AIDS 20:207-15. 2006

Detail Information

Publications44

  1. pmc The second generation of HIV-1 vertically exposed infants: a case series from the Italian Register for paediatric HIV infection
    Carmelina Calitri
    Department of Paediatrics, University of Turin, Turin, Italy
    BMC Infect Dis 14:277. 2014
    ....
  2. ncbi request reprint Zidovudine administration during pregnancy and mitochondrial disease in the offspring
    Pier Angelo Tovo
    Department of Pediatrics, University of Turin, Turin, Italy
    Antivir Ther 10:697-9. 2005
    ..Fetal exposure to ZDV may have caused the mtDNA depletion, which, although temporary, led to irreversible but not progressive brain damage...
  3. ncbi request reprint Hepatitis B virus and hepatitis C virus infections in children
    Pier Angelo Tovo
    Department of Pediatrics, University of Turin, Turin, Italy
    Curr Opin Infect Dis 18:261-6. 2005
    ....
  4. ncbi request reprint Changing patterns of clinical events in perinatally HIV-1-infected children during the era of HAART
    Elena Chiappini
    Department of Paediatrics, University of Florence, Via Luca Giordano 13, I 50132 Florence, Italy
    AIDS 21:1607-15. 2007
    ..The introduction of HAART has decreased mortality and progression to AIDS in perinatally HIV-1-infected children, but information on modification of the rate of specific clinical events is limited...
  5. pmc Five-year follow-up of children with perinatal HIV-1 infection receiving early highly active antiretroviral therapy
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    BMC Infect Dis 9:140. 2009
    ..Nevertheless, data about long-term follow-up of early treated children are lacking...
  6. pmc Persistently high IgA serum levels are a marker of immunological or virological failure of combined antiretroviral therapy in children with perinatal HIV-1 infection
    Elena Chiappini
    Department of Paediatrics, University of Florence, Via Luca Giordano, 13, I 50132 Florence, Italy
    Clin Exp Immunol 140:320-4. 2005
    ..In conclusion, IgA serum level is a cheap and low-complexity marker of immunological or virological failure of combined-ART which might be adopted in poor-resource settings...
  7. ncbi request reprint Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: a study by the Italian Register for HIV Infection in Children
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    J Clin Oncol 25:97-101. 2007
    ..To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period...
  8. ncbi request reprint Lower mother-to-child HIV-1 transmission in boys is independent of type of delivery and antiretroviral prophylaxis: the Italian Register for HIV Infection in Children
    Luisa Galli
    Department of Pediatrics, University of Florence, Florence, Italy
    J Acquir Immune Defic Syndr 40:479-85. 2005
    ..A possible explanation is that, among infected fetuses, more girls survive up to the end of pregnancy and may take advantage of the benefits of preventive strategies...
  9. ncbi request reprint The HIV protease inhibitors nelfinavir and saquinavir, but not a variety of HIV reverse transcriptase inhibitors, adversely affect human proteasome function
    Marco Piccinini
    Department of Medicine and Experimental Oncology, University of Turin, Turin, Italy
    Antivir Ther 10:215-23. 2005
    ..Proteasomes constitute the central protease of the ubiquitin ATP-dependent pathway involved in many cellular processes, as well as in HIV maturation and aggressiveness...
  10. ncbi request reprint Virologic, immunologic, and clinical benefits from early combined antiretroviral therapy in infants with perinatal HIV-1 infection
    Elena Chiappini
    Department of Paediatrics, University of Florence, Florence, Italy
    AIDS 20:207-15. 2006
    ....
  11. doi request reprint Clinical features of hospitalised children with 2009 H1N1 influenza virus infection
    Carmelina Calitri
    Department of Paediatrics, University of Turin, Regina Margherita Children s Hospital, Piazza Polonia 94, 10126 Turin, Italy
    Eur J Pediatr 169:1511-5. 2010
    ..In conclusions, 2009 H1N1 influenza virus infection in children is associated with a wide spectrum of clinical manifestations. Neurological disorders are not exceptional complications. Oseltamivir therapy seems safe also in infants...
  12. pmc Drug use and upper gastrointestinal complications in children: a case-control study
    Manuela Bianciotto
    Regina Margherita Children s Hospital, Turin, Italy
    Arch Dis Child 98:218-21. 2013
    ..To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population...
  13. ncbi request reprint Surveillance study of healthcare-associated infections in a pediatric neurosurgery unit in Italy
    Irene Raffaldi
    Department of Pediatrics, Regina Margherita Children s Hospital, Turin, Italy
    Pediatr Neurosurg 47:261-5. 2011
    ..This prospective surveillance study was designed to estimate the incidence of healthcare-associated infections (HAIs) and to analyze the risk factors for their development in a pediatric neurosurgical unit...
  14. doi request reprint Use of linezolid in infants and children: a retrospective multicentre study of the Italian Society for Paediatric Infectious Diseases
    Silvia Garazzino
    Department of Paediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children s Hospital, Turin, Italy
    J Antimicrob Chemother 66:2393-7. 2011
    ..However, clinical experience in the paediatric population is still limited. We undertook a multicentre study to analyse the use of linezolid in children...
  15. ncbi request reprint Natural history of vertically acquired HCV infection and associated autoimmune phenomena
    Silvia Garazzino
    Department of Pediatrics, University of Turin, Regina Margherita Children s Hospital, Turin, Italy
    Eur J Pediatr 173:1025-31. 2014
    ..Chronic infection is generally asymptomatic, although hepatomegaly and mild fibrosis may develop. Autoantibodies and cryoglobulins are frequent, whereas the associated clinical manifestations are rare. ..
  16. ncbi request reprint Management of fever in children: summary of the Italian Pediatric Society guidelines
    Elena Chiappini
    Department of Pediatrics, University of Florence, I 50139 Florence, Italy
    Clin Ther 31:1826-43. 2009
    ..This article summarizes the Italian Pediatric Society guideline on the management of the signs and symptoms of fever in children, prepared as part of the National Guideline Program (NGLP)...
  17. ncbi request reprint An atypical deep neck infection in a two-year-old child
    Irene Raffaldi
    Department of Paediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children Hospital Department of Paediatric Otorhinolaryngology, Regina Margherita Children Hospital, Turin, Italy
    Infez Med 22:136-9. 2014
    ..The surgical wound healed completely, with normal overlying skin and a good aesthetic result. The clinical management of atypical mycobacteria lymphadenitis and retropharyngeal abscess in children is discussed. ..
  18. ncbi request reprint Community-acquired bloodstream infections among paediatric patients admitted to an Italian tertiary referral centre: a prospective survey
    Carmelina Calitri
    Department of Paediatrics II, Infectious Diseases Unit, University of Turin, Regina Margherita Children s Hospital, Turin, Italy
    Infez Med 20:176-81. 2012
    ..Implementation of vaccinations against the major responsible pathogens remains the most important prevention strategy...
  19. ncbi request reprint Antileishmanial activity of HIV protease inhibitors
    Dianella Savoia
    Laboratory of Microbiology, Department of Clinical and Biological Sciences, University of Torino at S Luigi Gonzaga Hospital, 10043 Orbassano, Torino, Italy
    Int J Antimicrob Agents 26:92-4. 2005
    ....
  20. ncbi request reprint The human 26S proteasome is a target of antiretroviral agents
    Marco Piccinini
    Department of Medicine and Experimental Oncology, Section of Biochemistry, University of Turin, Turin, Italy
    AIDS 16:693-700. 2002
    ....
  21. doi request reprint Fulminant hepatitis after 10 days of acetaminophen treatment at recommended dosage in an infant
    Francesco Savino
    Department of Paediatrics, Ospedale Infantile Regina Margherita, Turin, Italy
    Pediatrics 127:e494-7. 2011
    ..Health care providers should be aware that multiple doses of acetaminophen in infants may lead to acute hepatic failure. N-acetylcysteine therapy should be initiated in cases of drug-induced acute liver failure...
  22. doi request reprint Moxifloxacin for the treatment of pulmonary tuberculosis in children: a single center experience
    Silvia Garazzino
    Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children s Hospital, Turin, Italy
    Pediatr Pulmonol 49:372-6. 2014
    ..To report our experience on the safety and tolerability of moxifloxacin for treating children affected by pulmonary TB...
  23. ncbi request reprint A strange gingival swelling in an Italian child: a case of oral myiasis
    Irene Raffaldi
    Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Childrens Hospital, Turin, Italy
    Infez Med 21:56-9. 2013
    ..This case is reported as a reminder to consider oral myiasis in the event of suspected gingival swelling in children, especially if they have predisposing factors or if they come from an endemic area...
  24. doi request reprint Clinical experience with linezolid in infants and children
    Silvia Garazzino
    Department of Paediatrics, University of Turin, Regina Margherita Children s Hospital, Infectious Diseases Unit, Piazza Polonia 94, Turin, Italy
    J Antimicrob Chemother 66:iv23-iv41. 2011
    ..Further studies are needed to establish novel paediatric indications for linezolid use and to assess the tolerability of long-term treatments...
  25. pmc In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms
    Elisa Lupino
    Department of Medicine and Experimental Oncology, Section of Biochemistry, University of Turin, Turin, Italy
    Immunology 131:231-41. 2010
    ....
  26. ncbi request reprint Interleukin 28B rs12979860 Single-Nucleotide Polymorphism Predicts Spontaneous Clearance of Hepatitis C Virus in Children
    Giuseppe Indolfi
    Pediatric and Liver Unit Immunology Unit and Laboratory at Meyer Children s University Hospital of Florence Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children s Hospital, Turin Department of Health Sciences, University of Florence, Firenze, Italy
    J Pediatr Gastroenterol Nutr 58:666-8. 2014
    ..The aim of the present collaborative study was to evaluate the rs12979860 SNP in a large cohort of Italian children with perinatal acquisition of hepatitis C...
  27. doi request reprint New antibiotics for paediatric use: a review of a decade of regulatory trials submitted to the European Medicines Agency from 2000--why aren't we doing better?
    Silvia Garazzino
    Division of Paediatrics, Regina Margherita Children s Hospital, University of Turin, Piazza Polonia 94, Turin, Italy
    Int J Antimicrob Agents 42:99-118. 2013
    ....
  28. pmc An uncommon cause of seizures in children living in developed countries: neurocysticercosis--a case report
    Irene Raffaldi
    Department of Pediatrics, Division of Infectious Diseases, University of Turin, Regina Margherita Children s Hospital, Piazza Polonia 94, 10126, Turin, Italy
    Ital J Pediatr 37:9. 2011
    ..This case accentuates the need to consider neurocysticercosis in a child presenting with non febrile seizures, mainly if he emigrated from an area of high prevalence or if he had long-term stay in endemic regions...
  29. doi request reprint Saquinavir in steroid-dependent and -resistant nephrotic syndrome: a pilot study
    Rosanna Coppo
    Nephrology, Dialysis and Transplantation Unit, Regina Margherita University Hospital, Turin, Italy
    Nephrol Dial Transplant 27:1902-10. 2012
    ..The objective of this study was to limit nuclear factor κB (NF-κB) activation which is up-regulated in these patients, aiming at decreasing proteinuria and prednisone need...
  30. doi request reprint Two pediatric cases of multidrug-resistant tuberculosis treated with linezolid and moxifloxacin
    Michele Pinon
    Clinic of Infectious Diseases, Department of Pediatrics, University of Turin, Regina Margherita Children s Hospital, Turin, Italy
    Pediatrics 126:e1253-6. 2010
    ....
  31. ncbi request reprint Immunomodulatory effects of two HIV protease inhibitors, Saquinavir and Ritonavir, on lymphocytes from healthy seronegative individuals
    Ottavia M Delmonte
    Department of Pediatrics, University of Turin, Piazza Polonia 94, 10126 Torino Turin, Italy
    Immunol Lett 111:111-5. 2007
    ..Immunological and clinical benefits of highly active antiretroviral therapy (HAART) do not always correlate with its efficacy in controlling HIV replication. This could be due to biological effects on the cell of retroviral agents...
  32. ncbi request reprint Intracranial aspergillosis in children successfully treated with antifungal therapy and surgical intervention
    Mareva Giacchino
    Department of Infectious Diseases, Immuno Rheumatology and Onco Hematology, University of Turin, Italy
    Pediatr Infect Dis J 25:379-81. 2006
    ..Most cases previously reported in immunocompromised children were fatal. We describe 4 immunosuppressed children with intracranial aspergillosis successfully treated with surgery and antifungal long-term therapy...
  33. pmc Genetic factors associated with rheumatoid arthritis and systemic vasculitis: Evaluation of a panel of polymorphisms
    Elisa Menegatti
    Department of Experimental Medicine and Oncology, University of Turin, Italy
    Dis Markers 27:217-23. 2009
    ..02) coupled with an increase in homozygous c.-1837CC in the NF-kappaB2 gene (p=0.02). Our data suggest that genetic variation in UG and NF-kappaB2 pathways could have effects in connective tissue disease susceptibility...
  34. doi request reprint Age-related lymphocyte and neutrophil levels in children of hepatitis C-infected women
    Lucy Pembrey
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health and Great Ormond Hospital for Children NHS Trust, University College London, London, UK
    Pediatr Infect Dis J 27:800-7. 2008
    ....
  35. ncbi request reprint Pregnancy and HIV infection: A european consensus on management
    Oriol Coll
    Hospital Clinic, University of Barcelona, Spain
    AIDS 16:S1-18. 2002
  36. ncbi request reprint The management of HCV infected pregnant women and their children European paediatric HCV network
    Lucy Pembrey
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Hepatol 43:515-25. 2005
    ..As evidence accumulates relating to mother-to-child (vertical) transmission of hepatitis C virus (HCV), it is timely to draw up guidelines for the clinical management of HCV infected pregnant women and their children...
  37. ncbi request reprint Accuracy of HCV-RNA PCR tests for diagnosis or exclusion of vertically acquired HCV infection
    Susanne Polywka
    Institute for Infectious Diseases, University Hospital Eppendorf, Martinistrasse, Hamburg, Germany
    J Med Virol 78:305-10. 2006
    ....
  38. ncbi request reprint The male : female ratio does not explain a higher risk of vertically acquired hepatitis C virus infection in girls
    Lucy Pembrey
    J Infect Dis 193:1188-9. 2006
  39. ncbi request reprint Inter-laboratory comparison of HCV-RNA assay results: implications for multi-centre research
    Lucy Pembrey
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
    J Med Virol 69:195-201. 2003
    ..Multivariate analysis of data collected in multi-centre studies should therefore allow for centre and/or assay used...
  40. ncbi request reprint Early triple therapy vs mono or dual therapy for children with perinatal HIV infection
    Elena Chiappini
    JAMA 295:626-8. 2006
  41. ncbi request reprint Growth in the first 5 years of life is unaffected in children with perinatally-acquired hepatitis C infection
    Kristy England
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, United Kingdom
    J Pediatr 147:227-32. 2005
    ..To identify the effect of vertical hepatitis C virus (HCV) infection or exposure on growth in childhood...
  42. pmc Evolution of hepatitis C viral quasispecies and hepatic injury in perinatally infected children followed prospectively
    Patrizia Farci
    Department of Medical Sciences, University of Cagliari, SS 554 Bivio Sestu, 09042 Cagliari, Italy
    Proc Natl Acad Sci U S A 103:8475-80. 2006
    ..The sequences reported in this paper have been deposited in the GenBank database (accession nos. DQ 504441-DQ 507112)...
  43. ncbi request reprint Excluding hepatitis C virus (HCV) infection by serology in young infants of HCV-infected mothers
    Kirsty England
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Acta Paediatr 94:444-50. 2005
    ..To identify the age at which HCV infection can be accurately excluded by serology in young children born to HCV-infected mothers and to determine an appropriate schedule of antibody testing, most informative to clinical practice...
  44. doi request reprint Response to combination antiretroviral therapy: variation by age
    Caroline A Sabin
    AIDS 22:1463-73. 2008
    ..To provide information on responses to combination antiretroviral therapy in children, adolescents and older HIV-infected persons...