Antonio Torroni

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. pmc Phylogeography of mtDNA haplogroup R7 in the Indian peninsula
    Gyaneshwer Chaubey
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    BMC Evol Biol 8:227. 2008
  2. pmc The phylogeny of the four pan-American MtDNA haplogroups: implications for evolutionary and disease studies
    Alessandro Achilli
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    PLoS ONE 3:e1764. 2008
  3. pmc Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans
    Mait Metspalu
    Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia
    BMC Genet 5:26. 2004
  4. ncbi Harvesting the fruit of the human mtDNA tree
    Antonio Torroni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Trends Genet 22:339-45. 2006
  5. pmc A signal, from human mtDNA, of postglacial recolonization in Europe
    A Torroni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 69:844-52. 2001
  6. pmc Do the four clades of the mtDNA haplogroup L2 evolve at different rates?
    A Torroni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 69:1348-56. 2001
  7. pmc Mitochondrial DNA haplogroups do not play a role in the variable phenotypic presentation of the A3243G mutation
    Antonio Torroni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 72:1005-12. 2003
  8. ncbi The mtDNA legacy of the Levantine early Upper Palaeolithic in Africa
    Anna Olivieri
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Science 314:1767-70. 2006
  9. doi Distinctive Paleo-Indian migration routes from Beringia marked by two rare mtDNA haplogroups
    Ugo A Perego
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, 27100 Pavia, Italy
    Curr Biol 19:1-8. 2009
  10. pmc Saami and Berbers--an unexpected mitochondrial DNA link
    Alessandro Achilli
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 76:883-6. 2005

Detail Information

Publications54

  1. pmc Phylogeography of mtDNA haplogroup R7 in the Indian peninsula
    Gyaneshwer Chaubey
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    BMC Evol Biol 8:227. 2008
    ....
  2. pmc The phylogeny of the four pan-American MtDNA haplogroups: implications for evolutionary and disease studies
    Alessandro Achilli
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    PLoS ONE 3:e1764. 2008
    ..In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds...
  3. pmc Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans
    Mait Metspalu
    Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia
    BMC Genet 5:26. 2004
    ..The results were integrated and analyzed together with published data from South, Southeast Asia and West Eurasia...
  4. ncbi Harvesting the fruit of the human mtDNA tree
    Antonio Torroni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Trends Genet 22:339-45. 2006
    ..Here we illustrate the phylogeographic approach with two case studies: the initial dispersal out of Africa, and the colonization of Europe...
  5. pmc A signal, from human mtDNA, of postglacial recolonization in Europe
    A Torroni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 69:844-52. 2001
    ..Mass screening of a few markers identified using complete mtDNA sequences promises to be an efficient strategy for inferring features of human prehistory...
  6. pmc Do the four clades of the mtDNA haplogroup L2 evolve at different rates?
    A Torroni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 69:1348-56. 2001
    ....
  7. pmc Mitochondrial DNA haplogroups do not play a role in the variable phenotypic presentation of the A3243G mutation
    Antonio Torroni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 72:1005-12. 2003
    ....
  8. ncbi The mtDNA legacy of the Levantine early Upper Palaeolithic in Africa
    Anna Olivieri
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Science 314:1767-70. 2006
    ....
  9. doi Distinctive Paleo-Indian migration routes from Beringia marked by two rare mtDNA haplogroups
    Ugo A Perego
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, 27100 Pavia, Italy
    Curr Biol 19:1-8. 2009
    ..In this study, we have instead identified and analyzed mtDNAs belonging to two rare Native American haplogroups named D4h3 and X2a...
  10. pmc Saami and Berbers--an unexpected mitochondrial DNA link
    Alessandro Achilli
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 76:883-6. 2005
    ....
  11. pmc Mitogenomes from two uncommon haplogroups mark late glacial/postglacial expansions from the near east and neolithic dispersals within Europe
    Anna Olivieri
    Dipartimento di Biologia e Biotecnologie L Spallanzani, Universita di Pavia, Pavia, Italy
    PLoS ONE 8:e70492. 2013
    ....
  12. pmc Ancient migratory events in the Middle East: new clues from the Y-chromosome variation of modern Iranians
    Viola Grugni
    Dipartimento di Biologia e Biotecnologie, Universita di Pavia, Pavia, Italy
    PLoS ONE 7:e41252. 2012
    ..In addition, our results evidence the important role of the Iranian plateau as source and recipient of gene flow between culturally and genetically distinct populations...
  13. pmc Y-chromosomal evidence of the cultural diffusion of agriculture in Southeast Europe
    Vincenza Battaglia
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Eur J Hum Genet 17:820-30. 2009
    ..The ensuing range expansions of E-V13 and I-M423 parallel in space and time the diffusion of Neolithic Impressed Ware, thereby supporting a case of cultural diffusion using genetic evidence...
  14. pmc The multifaceted origin of taurine cattle reflected by the mitochondrial genome
    Alessandro Achilli
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    PLoS ONE 4:e5753. 2009
    ....
  15. pmc Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation
    Simona Fornarino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    BMC Evol Biol 9:154. 2009
    ..Until now, however, investigations on their genetic structure have been scarce mainly identifying East Asian signatures...
  16. pmc Mitochondrial DNA variation of modern Tuscans supports the near eastern origin of Etruscans
    Alessandro Achilli
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 80:759-68. 2007
    ..Such a genetic contribution has been extensively diluted by admixture, but it appears that there are still locations in Tuscany, such as Murlo, where traces of its arrival are easily detectable...
  17. doi Mitochondrial haplogroup C4c: a rare lineage entering America through the ice-free corridor?
    Baharak Hooshiar Kashani
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Italy
    Am J Phys Anthropol 147:35-9. 2012
    ....
  18. pmc Mitochondrial haplogroup U5b3: a distant echo of the epipaleolithic in Italy and the legacy of the early Sardinians
    Maria Pala
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 84:814-21. 2009
    ....
  19. pmc The enigmatic origin of bovine mtDNA haplogroup R: sporadic interbreeding or an independent event of Bos primigenius domestication in Italy?
    Silvia Bonfiglio
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    PLoS ONE 5:e15760. 2010
    ..These uncommon haplogroups represent excellent tools to evaluate if sporadic interbreeding or even additional events of cattle domestication occurred...
  20. pmc The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool
    Alessandro Achilli
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Pavia, Italy
    Am J Hum Genet 75:910-8. 2004
    ..The survey revealed that the previously reported excess of H among these families is caused entirely by H3 and is due to a major, probably nonrecent, founder event...
  21. pmc The first peopling of South America: new evidence from Y-chromosome haplogroup Q
    Vincenza Battaglia
    Dipartimento di Biologia e Biotecnologie Lazzaro Spallanzani, Universita di Pavia, Pavia, Italy
    PLoS ONE 8:e71390. 2013
    ....
  22. pmc In search of the genetic footprints of Sumerians: a survey of Y-chromosome and mtDNA variation in the Marsh Arabs of Iraq
    Nadia Al-Zahery
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    BMC Evol Biol 11:288. 2011
    ..Popular tradition, however, considers the Marsh Arabs as a foreign group, of unknown origin, which arrived in the marshlands when the rearing of water buffalo was introduced to the region...
  23. pmc Origin and spread of Bos taurus: new clues from mitochondrial genomes belonging to haplogroup T1
    Silvia Bonfiglio
    Dipartimento di Biologia e Biotecnologie L Spallanzani, Universita di Pavia, Pavia, Italy
    PLoS ONE 7:e38601. 2012
    ..Whole mitochondrial genome sequence analysis, with its proven effectiveness in improving the resolution of phylogeographic studies, is the most appropriate tool to investigate the origin and structure of haplogroup T1...
  24. pmc Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area
    Ornella Semino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, 27100 Pavia, Italy
    Am J Hum Genet 74:1023-34. 2004
    ..A 7%-22% contribution of Y chromosomes from Greece to southern Italy was estimated by admixture analysis...
  25. pmc Mitochondrial DNA signals of late glacial recolonization of Europe from near eastern refugia
    Maria Pala
    School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, UK
    Am J Hum Genet 90:915-24. 2012
    ....
  26. pmc Y-chromosome diversity in modern Bulgarians: new clues about their ancestry
    Sena Karachanak
    Department of Medical Genetics, Medical University of Sofia, Sofia, Bulgaria
    PLoS ONE 8:e56779. 2013
    ....
  27. ncbi Does mitochondrial DNA predispose to neuromyelitis optica (Devic's disease)?
    Gavin Hudson
    Brain 131:e93. 2008
  28. pmc Clinical expression of Leber hereditary optic neuropathy is affected by the mitochondrial DNA-haplogroup background
    Gavin Hudson
    Mitochondrial Research Group, Department of Ophthalmology and Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Am J Hum Genet 81:228-33. 2007
    ..Substitutions on MTCYB provide an explanation for these findings, which demonstrate that common genetic variants have a marked effect on the expression of an ostensibly monogenic mtDNA disorder...
  29. ncbi Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy
    Valerio Carelli
    Istituto di Clinica Neurologica, Universita di Bologna, Bologna, Italy
    Biochim Biophys Acta 1588:7-14. 2002
    ....
  30. ncbi Human mtDNA site-specific variability values can act as haplogroup markers
    Matteo Accetturo
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Bari, Bari, Italy
    Hum Mutat 27:965-74. 2006
    ....
  31. ncbi Molecular dissection of the Y chromosome haplogroup E-M78 (E3b1a): a posteriori evaluation of a microsatellite-network-based approach through six new biallelic markers
    Fulvio Cruciani
    Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
    Hum Mutat 27:831-2. 2006
    ....
  32. ncbi The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy
    Maria Lucia Valentino
    Dipartimento di Scienze Neurologiche, Universita di Bologna, Italy
    Ann Neurol 56:631-41. 2004
    ..This finding shows that, in addition to ND6, the ND1 subunit gene is also a mutational hot spot for LHON...
  33. pmc Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in europe
    Siiri Rootsi
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Riia, Tartu, Estonia
    Am J Hum Genet 75:128-37. 2004
    ..In contrast, I1b2 most likely arose in southern France/Iberia. Similarly to the other subclades, it underwent a postglacial expansion and marked the human colonization of Sardinia approximately 9,000 years ago...
  34. pmc Where west meets east: the complex mtDNA landscape of the southwest and Central Asian corridor
    Lluis Quintana-Murci
    Centre National de la Recherche Scientifique CNRS URA 1961, Institut Pasteur, 75724 Paris Cedex 15, France
    Am J Hum Genet 74:827-45. 2004
    ....
  35. pmc Phylogeographic analysis of haplogroup E3b (E-M215) y chromosomes reveals multiple migratory events within and out of Africa
    Fulvio Cruciani
    Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185 Rome, Italy
    Am J Hum Genet 74:1014-22. 2004
    ....
  36. pmc Origin and diffusion of mtDNA haplogroup X
    Maere Reidla
    Department of Evolutionary Biology, Institute of Molecular and Cell Biology, Tartu University and Estonian Biocentre, Tartu, Estonia
    Am J Hum Genet 73:1178-90. 2003
    ..The position of X2a in the phylogenetic tree suggests an early split from the other X2 clades, likely at the very beginning of their expansion and spread from the Near East...
  37. ncbi Linkage disequilibrium analysis of the human adenosine deaminase (ada) gene provides evidence for a lack of correlation between hot spots of equal and unequal homologous recombination
    Fulvio Cruciani
    Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
    Genomics 82:20-33. 2003
    ..This observation provides the first evidence for an absence of correlation between hot spots of equal and unequal homologous recombination...
  38. pmc Extensive female-mediated gene flow from sub-Saharan Africa into near eastern Arab populations
    Martin Richards
    Department of Chemical and Biological Sciences, University of Huddersfield, Huddersfield, United Kingdom
    Am J Hum Genet 72:1058-64. 2003
    ....
  39. pmc In search of geographical patterns in European mitochondrial DNA
    Martin Richards
    Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, United Kingdom
    Am J Hum Genet 71:1168-74. 2002
    ..However, the more detailed analyses afforded by molecular sequence data suggest that the explanations for these gradients are likely to be much more complex than those proposed for classical markers...
  40. pmc Founding mothers of Jewish communities: geographically separated Jewish groups were independently founded by very few female ancestors
    Mark G Thomas
    Departments of Biology and Anthropology, The Centre for Genetic Anthropology, University College London, Gower Street, London WC1E 6BT, UK
    Am J Hum Genet 70:1411-20. 2002
    ....
  41. ncbi Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups
    Elena B Starikovskaya
    Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia Federation
    Ann Hum Genet 69:67-89. 2005
    ....
  42. ncbi Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes
    Vincent Macaulay
    Department of Statistics, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Science 308:1034-6. 2005
    ..There was an early offshoot, leading ultimately to the settlement of the Near East and Europe, but the main dispersal from India to Australia approximately 65,000 years ago was rapid, most likely taking only a few thousand years...
  43. ncbi Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations
    Qing Peng Kong
    Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Hum Mol Genet 15:2076-86. 2006
    ..g. appropriate association studies. Following a guideline based on the phylogenetic knowledge as proposed here could help avoiding similar problems in the future...
  44. ncbi Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians
    Daniele Ghezzi
    Unit of Molecular Neurogenetics, National Neurological Institute, Carlo Besta, Milan, Italy
    Eur J Hum Genet 13:748-52. 2005
    ..Our study suggests that haplogroup K might confer a lower risk for PD in Italians, corroborating the idea that the mitochondrial oxidative phosphorylation pathway is involved in the susceptibility to idiopathic PD...
  45. pmc Haplogroup effects and recombination of mitochondrial DNA: novel clues from the analysis of Leber hereditary optic neuropathy pedigrees
    Valerio Carelli
    Dipartimento di Scienze Neurologiche, Universita di Bologna, Bologna, Italy
    Am J Hum Genet 78:564-74. 2006
    ..The survey of the two sites in 12 of the Brazilian subjects revealed triplasmy in most cases, but there was no evidence of the tetraplasmy that would be expected in the case of mtDNA recombination...
  46. pmc The role of selection in the evolution of human mitochondrial genomes
    Toomas Kivisild
    Department of Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Genetics 172:373-87. 2006
    ..We introduce a new calibration method of the mutation rate of synonymous transitions to estimate the coalescent times of mtDNA haplogroups...
  47. ncbi Low "penetrance" of phylogenetic knowledge in mitochondrial disease studies
    Hans Jurgen Bandelt
    Department of Mathematics, University of Hamburg, Germany
    Biochem Biophys Res Commun 333:122-30. 2005
    ..To further validate our phylogenetic deductions, we completely sequenced two mtDNAs from healthy subjects that nearly match the mtDNAs of two patients, whose sequences gave problematic results...
  48. pmc A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes
    Fulvio Cruciani
    Dipartimenti di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
    Am J Hum Genet 70:1197-214. 2002
    ..Haplogroup IX Y chromosomes appear to have been involved in such a migration, the traces of which can now be observed mostly in northern Cameroon...
  49. pmc The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event
    Doron M Behar
    Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
    Am J Hum Genet 78:487-97. 2006
    ..We conclude that four founding mtDNAs, likely of Near Eastern ancestry, underwent major expansion(s) in Europe within the past millennium...
  50. pmc The African diaspora: mitochondrial DNA and the Atlantic slave trade
    Antonio Salas
    Unidad de Genética Forense, Instituto de Medicina Legal, Universidad de Santiago de Compostela, Galicia, Spain
    Am J Hum Genet 74:454-65. 2004
    ..However, they also indicate that, at least for the moment, considerable caution is warranted when assessing claims to be able to trace the ancestry of particular lineages to a particular locality within modern-day Africa...
  51. doi Mitochondrial genomes of extinct aurochs survive in domestic cattle
    Alessandro Achilli
    Curr Biol 18:R157-8. 2008
  52. pmc The mystery of Etruscan origins: novel clues from Bos taurus mitochondrial DNA
    Marco Pellecchia
    Istituto di Zootecnica, Laboratorio di Genetica Animale, Universita Cattolica del Sacro Cuore, Piacenza, Italy
    Proc Biol Sci 274:1175-9. 2007
    ..As the Latin philosopher Seneca wrote: Asia Etruscos sibi vindicat (Asia claims the Etruscans back)...
  53. ncbi 'Distorted' mitochondrial DNA sequences in schizophrenic patients
    Hans Jurgen Bandelt
    Eur J Hum Genet 15:400-2; author reply 402-4. 2007
  54. ncbi Mitochondrial DNA nucleotide changes C14482G and C14482A in the ND6 gene are pathogenic for Leber's hereditary optic neuropathy
    Maria Lucia Valentino
    Dipartimento di Scienze Neurologiche, Universita di Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy
    Ann Neurol 51:774-8. 2002
    ....